Abstract:
OBJECTIVE:To establish whether changes of lung transfer for carbon monoxide (TLCO) are related to the phase of IgA nephropathy. METHODS:Respiratory function was tested in 12 children with IgA nephropathy assessed by percutaneous renal biopsy. This was done during acute exacerbations or haematuria-free phases of the disease. RESULTS:TLCO was low in 12/13 measurements made in the haematuric phase of IgA nephropathy or during the month following gross haematuria (mean TLCO 64% of expected values). Lung volumes and blood gas values were normal and only minor radiological signs of interstial lung involvement were observed in 11/12 patients. When respiratory tests were performed more than three months after gross haematuria, TLCO was low in 4/9 patients, with no relation to the significance of residual proteinuria or severity of findings at renal biopsy. There was a significant difference between tests performed when haematuria was present or recent and those performed more than three months after an episode of gross haematuria (p < 0.01). CONCLUSIONS:The decrease of TLCO in the acute phases of the disease is probably related to alterations of the lung alveolarcapillary membrane by immune complexes containing IgA. This non-invasive technique, easy to perform and repeat, could be of value in the diagnosis of IgA nephropathy in haematuric children.
journal_name
Arch Dis Childjournal_title
Archives of disease in childhoodauthors
Ravilly S,Chaussain M,Iniguez JL,Lenhert A,Kalifa G,Brun P,Niaudet P,Gendrel Ddoi
10.1136/adc.74.3.236subject
Has Abstractpub_date
1996-03-01 00:00:00pages
236-8issue
3eissn
0003-9888issn
1468-2044journal_volume
74pub_type
临床试验,杂志文章abstract:OBJECTIVE:To develop and test patient-reported experience measures (PREMs) for children and young people in a specialist paediatric hospital setting. DESIGN:Six PREMs were developed and tested by children and young people for children and young people aged 8-11, 12-13 and 14-16 years in inpatient and outpatient settin...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2017-313032
更新日期:2018-03-01 00:00:00
abstract::Coeliac disease occurred at the same age in MZ twins. The diagnosis was confirmed by histology of the small intestine, rapid response to a gluten-free diet, and relapse after reintroduction of gluten. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.54.5.395
更新日期:1979-05-01 00:00:00
abstract::This review focuses on recent advances of topical interest regarding the diagnosis and treatment of common causes of bacterial meningitis occurring in children beyond the neonatal period. Tuberculous meningitis is beyond the scope of this review. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/adc.88.7.615
更新日期:2003-07-01 00:00:00
abstract:AIMS:To compare the effectiveness of short course (2-4 days) with standard duration oral antibiotic treatment (7-14 days) for urinary tract infection (UTI). METHODS:Meta-analysis of randomised controlled trials using a random effects model. Ten trials were eligible, involving 652 children with lower tract UTI recruite...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,meta分析,评审
doi:10.1136/adc.87.2.118
更新日期:2002-08-01 00:00:00
abstract::Breast fed infants may be at greater risk of mother to infant hepatitis B virus infection compared with formula fed infants. We studied 85 infants born to 84 hepatitis B surface antigen positive mothers (only two of whom were hepatitis B e positive), and who had received immunisation against hepatitis B virus. Our res...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.60.10.972
更新日期:1985-10-01 00:00:00
abstract:BACKGROUND:A paucity of evidence regarding the natural history of congenital pulmonary airway malformations (CPAMs) and pulmonary sequestration (PS) has resulted in a divergence in management strategy of asymptomatic cases. METHODS:We describe the long-term clinical course of 119 children diagnosed with these lesions ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2016-311233
更新日期:2017-09-01 00:00:00
abstract::Measurements of the resistance, time constant, and compliance of the respiratory system were made in 25 mechanically ventilated, preterm babies on 32 occasions, using the single breath technique. Patients were classified according to the level of respiratory resistance by reference to a population of 36 babies studied...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.61.12.1178
更新日期:1986-12-01 00:00:00
abstract::Obesity is becoming a common clinical headache for child health professionals, as the increase in professional and media concern has not been matched by effective clinical solutions. Added to this is considerable confusion about both the definitions of obesity and about which groups of children and adolescents actuall...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/adc.2004.062224
更新日期:2005-04-01 00:00:00
abstract:OBJECTIVE:Anaphylaxis is a severe, potentially fatal allergic reaction best treated with intramuscular epinephrine via epinephrine auto-injectors (AAIs). Our published concerns over laceration injuries to young children associated with AAIs led to this service evaluation of the two administration methods: swing and jab...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2020-318898
更新日期:2021-01-01 00:00:00
abstract::Ninety one patients with urinary tract abnormalities diagnosed before birth were reviewed. Diagnoses based on prenatal and postnatal ultrasound scans alone were compared with the final diagnoses after full urological investigations, with operative or necropsy confirmation in 79 cases. The results confirmed that ultras...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.64.4.578
更新日期:1989-04-01 00:00:00
abstract::Therapeutic drug monitoring (TDM) aims to integrate drug measurement results into clinical decision making. The basic rules apply when using TDM in neonates (aminoglycosides, vancomycin, phenobarbital, digoxin), but additional factors should also be taken into account. First, due to both pharmacokinetic variability an...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/archdischild-2013-305309
更新日期:2016-04-01 00:00:00
abstract::When prescribing drugs for children, it is fundamental to acknowledge that they are distinct from adults with a different physiology and metabolism. They are also still maturing. The development of drugs with a primarily paediatric indication thus requires the trialling of these drugs in a paediatric population to ass...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/adc.2004.059378
更新日期:2005-02-01 00:00:00
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.80.5.443
更新日期:1999-05-01 00:00:00
abstract:BACKGROUND:National and international recommendations for the age of introducing solid foods (weaning) are founded on insufficient evidence and little is known about the short and medium term consequences associated with early or late weaning. AIMS AND METHODS:Data from over 1600 infants from five prospective randomis...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章,meta分析,随机对照试验
doi:10.1136/adc.2003.036137
更新日期:2004-08-01 00:00:00
abstract::Mechanisms of gastro-oesophageal reflux were studied by oesophageal manometry and pH monitoring in 33 children: nine controls, 15 with gastro-oesophageal reflux alone, and nine with reflux oesophagitis. A total of 122 episodes of reflux were analysed in detail: 82 (67%) were synchronous with swallowing and 40 (33%) as...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.63.11.1333
更新日期:1988-11-01 00:00:00
abstract::The output of the drug and the particle size produced by various nebulisers were assessed, and sensible nebulisation times for sodium cromoglycate calculated. Three of the four nebuliser systems tested produced over 80% of total drug output within the first five minutes of nebulisation. We suggest that five minutes is...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.64.9.1270
更新日期:1989-09-01 00:00:00
abstract::Two Japanese outbreaks of erythema infectiosum were investigated for evidence of human parvovirus infection by a solid phase antibody capture radioimmunoassay based on a monoclonal antibody to human parvovirus. Specific IgM and high concentrations of specific IgG were detected in 37 sera from 27 children with erythema...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.59.11.1016
更新日期:1984-11-01 00:00:00
abstract::An increased incidence of E. coli sepsis has been observed in neonates given intramuscular iron-dextran for prevention of iron deficiency. Mechanisms for this apparent effect on susceptibility to infection were investigated by comparing phagocytic and antibacterial functions in paired samples of venous blood from 7 in...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.52.10.778
更新日期:1977-10-01 00:00:00
abstract::Necrotising pneumonia in young, previously healthy patients due to Panton-Valentine leucocidin (PVL) producing Staphylococcus aureus has been increasingly recognised. PVL pneumonia is often associated with influenza co-infection and high mortality. This case report describes the successful management of the first docu...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2009.175281
更新日期:2010-04-01 00:00:00
abstract::Preductal and postductal oxygen saturation were compared in 20 ventilated preterm infants with hyaline membrane disease to establish the frequency of right to left shunting and to assess the accuracy of postductus arteriosus blood gas sampling. One hundred and thirty eight comparisons were made and the frequency of ri...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.67.10_spec_no.1166
更新日期:1992-10-01 00:00:00
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.56.6.474
更新日期:1981-06-01 00:00:00
abstract:OBJECTIVE:To study the temporal relationship between socioeconomic disadvantage and onset of chronic disabling conditions in childhood. METHOD:Using parent reported data from the Longitudinal Study of Australian Children, we compared children who developed a chronic disabling condition between the ages of 6/7 and 10/1...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2013-305634
更新日期:2015-04-01 00:00:00
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2019-317997
更新日期:2020-06-01 00:00:00
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.63.6.606
更新日期:1988-06-01 00:00:00
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journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章
doi:10.1136/adc.61.11.1104
更新日期:1986-11-01 00:00:00
abstract:BACKGROUND:Sodium phenylbutyrate (NaPB) is used as a treatment for urea cycle disorders (UCD). However, the available, licensed granule form has an extremely bad taste, which can compromise compliance and metabolic control. OBJECTIVES:A new, taste-masked, coated-granule formulation (Luc 01) under development was chara...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2012-302398
更新日期:2012-12-01 00:00:00
abstract::A 5.7 year old boy with alpha 1-antitrypsin deficiency developed intractable ascites after liver transplantation. Conservative treatment was unsuccessful and after 18 days concentrated ascitic fluid was reinfused intravenously using a Gambro haemofilter. The ascitic loss resolved rapidly. This new method of ultrafiltr...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.66.8.988
更新日期:1991-08-01 00:00:00
abstract::Interstitial nephritis was diagnosed at renal biopsy in 10 previously healthy children. All had identical clinical symptoms: anaemia, raised sedimentation rate, low glomerular filtration rate, protein and leucocytes in the urine, but no bacteria; nine also had glycosuria. Six of the children had a history of recent in...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.60.8.752
更新日期:1985-08-01 00:00:00
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.59.6.575
更新日期:1984-06-01 00:00:00
abstract::Hospital clowning is a programme in healthcare facilities involving visits from specially trained actors. In the paediatric intensive care unit (PICU), clowning may appear inappropriate and less intuitive. The patient could appear too ill and/or sedated, the environment too crowded or chaotic and the parents too stres...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/archdischild-2016-311583
更新日期:2017-07-01 00:00:00