Effect of taurine supplementation on fat and energy absorption in cystic fibrosis.

Abstract:

:In 10 children with cystic fibrosis and persisting steatorrhoea, supplementation with taurine (30-40 mg/kg/day) was given for two months as an adjunct to the usual pancreatic enzyme treatment. A three day fat and energy balance was performed in patients with cystic fibrosis, before and after the supplementation, and in seven healthy controls who did not receive taurine. Faecal fat was measured by a gravimetric method and stool energy was determined using a bomb calorimeter. Patients with cystic fibrosis, before and after taurine, and healthy controls received the same fat and energy intake (calculated by a dietitian). In patients with cystic fibrosis taurine did not produce any improvement of steatorrhoea (mean (SD) faecal fat 8.7 (3.3) v 11.2 (7.0) g/day, respectively before and after the supplementation), of faecal energy loss (0.978 (0.468) v 1.133 (0.539) MJ/day), of faecal fat expressed as percent of fat intake (13.4 (5.6) v 15.1 (9.8)%), and of faecal energy expressed as percent of energy intake (9.9 (3.6) v 11.2 (5.7)%). Healthy controls had significant lower fat (3.5 (2.3) g/day) and energy 0.576 (0.355) MJ/day faecal losses. In conclusion, taurine failed to decrease significantly fat and energy losses. Our study does not support the use of taurine supplementation in the nutritional management of cystic fibrosis.

journal_name

Arch Dis Child

authors

De Curtis M,Santamaria F,Ercolini P,Vittoria L,De Ritis G,Garofalo V,Ciccimarra F

doi

10.1136/adc.67.9.1082

subject

Has Abstract

pub_date

1992-09-01 00:00:00

pages

1082-5

issue

9

eissn

0003-9888

issn

1468-2044

journal_volume

67

pub_type

杂志文章
  • Osteoid osteoma and benign osteoblastoma in childhood.

    abstract::Three cases of osteoid osteoma and one of benign osteoblastoma in children are described. The main complaint was severe pain which was worse at night; it was relieved by aspirin or other analgesics. The diagnosis was made on clinical and radiological grounds and was confirmed on histological examination of the central...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.54.6.459

    authors: Black JA,Levick RK,Sharrard WJ

    更新日期:1979-06-01 00:00:00

  • Assessment of doctors' consultation skills in the paediatric setting: the Paediatric Consultation Assessment Tool.

    abstract:OBJECTIVE:To determine the utility of a novel Paediatric Consultation Assessment Tool (PCAT). DESIGN:Developed to measure clinicians' communication behaviour with children and their parents/guardian, PCAT was designed according to consensus guidelines and refined at a number of stages. Volunteer clinicians provided vi...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/adc.2008.146191

    authors: Howells RJ,Davies HA,Silverman JD,Archer JC,Mellon AF

    更新日期:2010-05-01 00:00:00

  • Upper intestinal bacterial flora during transpyloric feeding.

    abstract::Samples from the pharynx, stomach, duodenum or jejunum, and faeces were collected on 7 days between 1st and 28th day from neonates weighing less than 1.5 kg at birth who were fed by transpyloric tube. These were cultured on selective and non-selective media, and the results were expressed in a semi-quantitative manner...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.58.2.115

    authors: Dellagrammaticas HD,Duerden BI,Milner RD

    更新日期:1983-02-01 00:00:00

  • Familial insulin-resistant diabetes, multiple somatic anomalies, and pineal hyperplasia.

    abstract::West, R. J., Lloyd, J. K., and Turner, W. M. L. (1975). Archives of Disease in Childhood, 50, 703. Familial insulin-resistant diabetes, multiple somatic anomalies, and pineal hyperplasia. A syndrome comprising unusual facies, dry skin, acanthosis nigricans, thickened nails, hirsutism, dental precocity and dysplasia, a...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.50.9.703

    authors: West RJ,Lloyd JK,Turner WM

    更新日期:1975-09-01 00:00:00

  • Relation between insulin-like growth factor-I, body mass index, and clinical status in cystic fibrosis.

    abstract:OBJECTIVES:Despite improved nutrition and intensive treatment, subjects with cystic fibrosis have difficulty in maintaining anabolism during intercurrent infections, which can result in reduced body mass index and impaired skeletal growth. Insulin-like growth factor-I (IGF-I) and its binding protein IGFBP3 are sensitiv...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.76.4.304

    authors: Taylor AM,Bush A,Thomson A,Oades PJ,Marchant JL,Bruce-Morgan C,Holly J,Ahmed L,Dunger DB

    更新日期:1997-04-01 00:00:00

  • Cows' milk-sensitive enteropathy.

    abstract::Serial small intestinal biopsies related to withdrawal and challenge with cows' milk are described in 5 infants with cows' milk protein intolerenace. On the basis of these serial observations the existence of a cows' milk-sensitive enteropathy in infancy is clearly established. The cows' milk-sensitive mucosal lesion ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.53.5.375

    authors: Walker-Smith J,Harrison M,Kilby A,Phillips A,France N

    更新日期:1978-05-01 00:00:00

  • Area of lateral ventricles measured on cranial ultrasonography in preterm infants: association with outcome.

    abstract::The association between measurements of lateral ventricle area (determined by serial ultrasound scans) and outcome was studied in 70 preterm neonates of 33 weeks' gestation or less. The study group was subdivided into four groups according to cranial ultrasonographic findings at 2 weeks postnatal age: group A (n = 15)...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.65.10_spec_no.1033

    authors: Saliba E,Bertrand P,Gold F,Marchand S,Laugier J

    更新日期:1990-10-01 00:00:00

  • Aggravating effect of INSIG2 and FTO on overweight reduction in a one-year lifestyle intervention.

    abstract:OBJECTIVE:Obesity is considered a polygenic and multifactorial disorder and different single nucleotide polymorphisms (SNP) are involved. Studies concerning their impact on weight loss in lifestyle intervention are scarce. METHODS:The effect of two different SNP (INSIG2: rs7566605, FTO: rs9939609) was analysed on the ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/adc.2008.147652

    authors: Reinehr T,Hinney A,Toschke AM,Hebebrand J

    更新日期:2009-12-01 00:00:00

  • Fifteen years of genetic testing from a London developmental clinic.

    abstract:OBJECTIVE:To evaluate genetic disease among children referred to a community paediatric clinic. DESIGN:Retrospective cohort study. SETTING:Community paediatric clinic, Tower Hamlets, London. PATIENTS:All patients seen for first time in the Child Development Team (CDT) clinic between 1999 and 2013. INTERVENTIONS:Cli...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2017-312739

    authors: Best S,Rosser E,Bajaj M

    更新日期:2017-11-01 00:00:00

  • Diagnosis of interstitial lung disease by a percutaneous lung biopsy sample.

    abstract::A percutaneous lung biopsy sample was used to diagnose interstitial lung disease in nine children aged less than 42 months. Fibrosing alveolitis was diagnosed in eight children and Pneumocystis carinii pneumonia in one child. Complications associated with the procedure were minimal and the results of the biopsy sample...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.70.2.143

    authors: Smyth RL,Carty H,Thomas H,van Velzen D,Heaf D

    更新日期:1994-02-01 00:00:00

  • The 'happy puppet' syndrome of Angelman: review of the clinical features.

    abstract::Thirty six children with typical features of Angelman's syndrome, including global developmental delay, ataxia, episodes of paroxysmal laughter, seizures, and microcephaly were studied. The series included three sibships of three affected sisters, two affected brothers, and two affected sisters, respectively. The faci...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.64.1.83

    authors: Robb SA,Pohl KR,Baraitser M,Wilson J,Brett EM

    更新日期:1989-01-01 00:00:00

  • Minor congenital anomalies and ataxic cerebral palsy.

    abstract::The incidence of minor congenital anomalies was examined in 36 patients with ataxic cerebral palsy, in unaffected family members, and in 100 unrelated control subjects. None of the control subjects or family members had more than four anomalies, and 25 of 36 (69%) of the patients had more than four. The distribution o...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.64.4.557

    authors: Miller G

    更新日期:1989-04-01 00:00:00

  • Paediatric pharmacogenomics: an overview.

    abstract::Pharmacogenomics research is becoming more prevalent in both academia and the pharmaceutical industry. While some discoveries have been integrated into practice and are benefiting patient care, these successes have been limited given the vast amount of research undertaken. However, the advances in high-throughput geno...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/archdischild-2012-302852

    authors: Hawcutt DB,Thompson B,Smyth RL,Pirmohamed M

    更新日期:2013-03-01 00:00:00

  • Features of transient hypogammaglobulinaemia in infants screened for immunological abnormalities.

    abstract::The incidence of transient hypogammaglobulinaemia of infancy (THI) detected in a major paediatric centre over a 10 year period was examined. A total of 2468 subjects less than 2 years of age had an IgG measurement taken between July 1979 and March 1990. Subjects with known immunodeficiencies were excluded. Fifteen pat...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.70.3.183

    authors: Walker AM,Kemp AS,Hill DJ,Shelton MJ

    更新日期:1994-03-01 00:00:00

  • Obesity and respiratory symptoms in primary school.

    abstract::The association of weight for height and triceps skinfold with seven respiratory symptoms has been examined using logistic regression analysis in 7800 5 to 11 year old children (6200 in England and 1600 in Scotland). The results support the view that overweight children have a greater liability to some respiratory sym...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.59.10.940

    authors: Somerville SM,Rona RJ,Chinn S

    更新日期:1984-10-01 00:00:00

  • Indirect quantification of lipid peroxidation in steroid responsive nephrotic syndrome.

    abstract:AIMS:To test the hypothesis that oxygen free radicals are mediators of excessive protein permeability in steroid responsive nephrotic syndrome. DESIGN:Case control study. SUBJECTS: PATIENTS:20 children with steroid responsive nephrotic syndrome; controls: 20 children admitted for elective surgery. SETTING:The paedi...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.82.1.76

    authors: Kinra S,Rath B,Kabi BC

    更新日期:2000-01-01 00:00:00

  • Overwhelming sepsis presenting as sudden unexpected death.

    abstract::Four children, including three infants, who died suddenly and unexpectedly are described. In three of the cases group A beta haemolytic streptococcus was cultured and in the fourth Streptococcus pneumoniae. The organism was grown from multiple sites including blood in two of them. Without microbiological investigation...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.69.3.381

    authors: Sharief N,Khan K,Conlan P

    更新日期:1993-09-01 00:00:00

  • Urinary glycosaminoglycan excretion in urolithiasis.

    abstract::Urinary glycosaminoglycan (GAG) excretion was measured in children with idiopathic urolithiasis (15 girls and 10 boys; mean (SD) age 6.2 (2.4) years) and in healthy controls (10 girls and 14 boys; mean (SD) age 6.8 (3.8) years). GAG excretion was expressed as a GAG/creatinine (mg/g) ratio and was evaluated using dimet...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.80.3.271

    authors: Akçay T,Konukoğlu D,Dínçer Y

    更新日期:1999-03-01 00:00:00

  • How accurate is the diagnosis of exercise induced asthma among Vancouver schoolchildren?

    abstract:BACKGROUND:Limited access to exercise testing facilities means that the diagnosis of exercise induced asthma (EIA) is mainly based on self-reported respiratory symptoms. This is open to error since the correlation between exercise related symptoms and subsequent exercise testing has been shown to be poor. AIM:To study...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2004.063974

    authors: Seear M,Wensley D,West N

    更新日期:2005-09-01 00:00:00

  • Acute renal failure in early life.

    abstract::Data are presented on 25 children under 2 years of age with acute renal failure treated by peritoneal dialysis. The clinical features, treatment, complications, and outcome of the illnesses are described. 22 (88%) survived, and though the incidence of serious complications during the illness was high most regained ful...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.51.6.459

    authors: Griffin NK,McElnea J,Barratt M

    更新日期:1976-06-01 00:00:00

  • Should hepatitis B surface antigen positive mothers breast feed?

    abstract::Breast fed infants may be at greater risk of mother to infant hepatitis B virus infection compared with formula fed infants. We studied 85 infants born to 84 hepatitis B surface antigen positive mothers (only two of whom were hepatitis B e positive), and who had received immunisation against hepatitis B virus. Our res...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.60.10.972

    authors: de Martino M,Appendino C,Resti M,Rossi ME,Muccioli AT,Vierucci A

    更新日期:1985-10-01 00:00:00

  • The doctor, the father, and the social scientist.

    abstract::Life was sorted. With membership of the college under my belt, and my paediatric training completed, I needed a new challenge. I decided to launch into the deep waters of qualitative research. Stepping out with some trepidation into semistructured interviews and grounded theory, I soon found that the water was neither...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.88.1.44

    authors: Sidebotham P

    更新日期:2003-01-01 00:00:00

  • Glaucoma as an early complication of Hurler's disease.

    abstract::We report three cases of Hurler's disease in which glaucoma developed in early childhood. We draw attention to the fact that glaucoma may be a commonly unrecognised early complication of this condition. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.63.9.1091

    authors: Nowaczyk MJ,Clarke JT,Morin JD

    更新日期:1988-09-01 00:00:00

  • Delayed visual maturation.

    abstract::Sixteen blind babies who were considered to be showing the characteristics of delayed visual maturation were studied prospectively. The diagnosis was made on clinical grounds, and the criteria for this are discussed. All of these infants developed visual responses between 4 and 6 months of age and had normal or near n...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.59.2.107

    authors: Cole GF,Hungerford J,Jones RB

    更新日期:1984-02-01 00:00:00

  • No increased risk of relapse after meningococcal C conjugate vaccine in nephrotic syndrome.

    abstract:OBJECTIVES:To investigate whether meningococcal C conjugate vaccine (MCCV) caused relapse in children with steroid-responsive nephrotic syndrome. DESIGN:A population-based study was conducted using an active surveillance system, developed to assess adverse events following vaccination, which linked hospital record inf...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2006.105247

    authors: Taylor B,Andrews N,Stowe J,Hamidi-Manesh L,Miller E

    更新日期:2007-10-01 00:00:00

  • Functional outcomes in children with anatomically repaired transposition of the great arteries with regard to congenital ventricular septal defect and coronary pattern.

    abstract:OBJECTIVE:Despite decreasing mortality, functional impairments in children with transposition of the great arteries (TGA) are still a concern. This study analyses health-related physical fitness (HRPF), arterial stiffness and health-related quality of life (HRQoL) in children with anatomically repaired TGA regarding co...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2018-316444

    authors: Häcker AL,Reiner B,Oberhoffer R,Hager A,Ewert P,Müller J

    更新日期:2019-09-01 00:00:00

  • Use of DNA estimation for growth assessment in normal and hypoplastic fetal lungs.

    abstract::Total DNA was estimated in the lungs of 80 fetuses and newborn infants varying in gestation from 14 weeks to term. In fetuses of appropriate weight for gestational age total lung DNA increased at a constant rate from about 35 mg at 17 weeks' gestation to 480 mg at term. The lungs of immature fetuses were heavier and c...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.56.8.601

    authors: Wigglesworth JS,Desai R

    更新日期:1981-08-01 00:00:00

  • Severe ventilatory failure in asthma in children. Experience of 13 episodes over 6 years.

    abstract::During the 6-year period from 1 October 1971 to 30 September 1977, 13 (about 1%) of 1225 admissions to hospital with asthma developed severe ventilatory failure (peak arterial PCO 2 greater than 8 kPa). Mean age was 4.1 years (2.3--7.9), and on average each patient had been admitted to hospital on 5 occasions during t...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.53.9.714

    authors: Simpson H,Mitchell I,Inglis JM,Grubb DJ

    更新日期:1978-09-01 00:00:00

  • Young people's experiences of managing asthma and diabetes at school.

    abstract:PURPOSE:To examine the experiences and concerns of young people and their parents regarding the management of medication for asthma or diabetes whilst at school. METHODS:Face-to-face semi-structured interviews were conducted with 69 young people aged 8-15 years (43 with asthma and 26 with diabetes) and their parents (...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2006.110536

    authors: Newbould J,Francis SA,Smith F

    更新日期:2007-12-01 00:00:00

  • Cord blood IgE and month of birth.

    abstract::If cord blood IgE is used to detect those predisposed to become allergic it is important to define appropriately the normal values for this measurement. A commonly cited cut off point is 1.0 IU/ml. We analysed 5353 cord blood samples for IgE by means of an enzyme linked immunosorbent assay. Descriptive statistics of t...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.62.5.478

    authors: Kimpen J,Callaert H,Embrechts P,Bosmans E

    更新日期:1987-05-01 00:00:00