Abstract:
:The incidence of transient hypogammaglobulinaemia of infancy (THI) detected in a major paediatric centre over a 10 year period was examined. A total of 2468 subjects less than 2 years of age had an IgG measurement taken between July 1979 and March 1990. Subjects with known immunodeficiencies were excluded. Fifteen patients were classified as having THI with an initial IgG level less than the fifth centile followed by a second measurement within the normal range. A further 24 patients were identified as having possible THI with a single low IgG concentration. There were 60,174 live births each year in Victoria in the years 1979-88. This gives an incidence of proved THI of 23 per 10(6) births, and including proved and probable THI an incidence of 61 per 10(6) live births. Of those patients with proved THI 12/15 had symptoms of either atopic disease or food allergy/intolerance and three had gastrointestinal symptoms without any evidence of atopic disease. At presentation 12/15 (80%) were IgA deficient and 9/15 had IgM concentrations less than the 20th centile for age. It is suggested that in view of the preponderance of atopic and food intolerant patients that subclinical protein loss from the bowel due to allergic inflammation may be a contributing factor to the development of THI in some patients.
journal_name
Arch Dis Childjournal_title
Archives of disease in childhoodauthors
Walker AM,Kemp AS,Hill DJ,Shelton MJdoi
10.1136/adc.70.3.183subject
Has Abstractpub_date
1994-03-01 00:00:00pages
183-6issue
3eissn
0003-9888issn
1468-2044journal_volume
70pub_type
杂志文章abstract::A 14-month-old girl with invasive perineal amoebiasis is reported. There was destruction of the anus, the rectovaginal septum, the pelvic floor, and the perineum. The rapid progress and destructive potential of perineal amoebiasis is noted and the benefits of diagnostic awareness emphasised. Treatment with metronidazo...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.55.3.234
更新日期:1980-03-01 00:00:00
abstract::Coeliac disease occurred at the same age in MZ twins. The diagnosis was confirmed by histology of the small intestine, rapid response to a gluten-free diet, and relapse after reintroduction of gluten. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.54.5.395
更新日期:1979-05-01 00:00:00
abstract:AIMS:(1) To determine the pattern of respiratory impairment in children with thalassaemia major (TM); (2) to assess the relation between the degree of respiratory impairment and total body iron content. METHODS:Twenty nine TM patients were recruited. All underwent physical examination, standardised pulmonary function ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.87.4.328
更新日期:2002-10-01 00:00:00
abstract::An outbreak of adenovirus type 8 conjunctivitis occurred in seven premature infants who had undergone ophthalmological examination four to seven days previously. Three of the affected infants, treated with steroids because of bronchopulmonary dysplasia, showed systemic manifestations and deterioration of their respira...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.68.5_spec_no.610
更新日期:1993-05-01 00:00:00
abstract::Concerns have been expressed in recent years about the decline in children's clinical and biomedical research in the UK, and in the paediatric academic workforce. Here I consider the extent to which these concerns are justified, the sweeping changes that have taken place in research funding, governance and organisatio...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2009.178160
更新日期:2010-11-01 00:00:00
abstract::The fall in body temperature that occurs in babies soon after birth is influenced by the baby's weight and its environmental conditions. The rate of oxygen consumption 1 1/2 hours after birth was unrelated to body temperature and only slightly raised, indicating a limited thermogenic capacity. A radiant heater effecti...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.53.1.58
更新日期:1978-01-01 00:00:00
abstract:OBJECTIVE:We systematically evaluated health and nutrition programmes to identify context-specific interventional packages that might help to prioritise the implementation of programmes for reducing stunting in low and middle income countries (LMICs). METHODS:Electronic databases were used to systematically review the...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/archdischild-2016-311050
更新日期:2017-10-01 00:00:00
abstract::Clinical observations and findings on imaging are reported in six newborns with symmetrical thalamic lesions (STL). In three cases the diagnosis was confirmed by postmortem examination. Characteristic observations in this series and 17 previously reported cases include no evidence of perinatal asphyxia, high incidence...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.67.1_spec_no.15
更新日期:1992-01-01 00:00:00
abstract::At the mid-radius, pre-pubertal asthmatic children had smaller periosteal and endosteal circumferences and thicker cortical shells compared to controls, when assessed by peripheral quantitative computed tomography. Asthmatics had diminished periosteal expansion for muscle size, suggesting that asthma, its treatment, o...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2005.084996
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVE:We assessed whether maternal mental health problems increased rates for child injury during the preschool years and mid-childhood, and the extent to which associations could be accounted for by a range of potential explanatory factors. DESIGN:We analysed the UK Millennium Cohort Study, a nationally represent...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2017-313809
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:Clinical examination, while useful, has been shown to be insufficient as the sole screening method in infants. Ultrasound examination at 8 weeks in high risk infants is an integral part of the screening process in some units. AIMS:To show the efficiency of hip sonography in detection of developmental dyspla...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2003.033597
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:Studies have shown a correlation between increased accident rates and levels of deprivation in the community. School accident reporting is one area where an association might be expected. AIMS:To investigate differences in primary school accident rates in deprived and more affluent wards, in an area managed...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.86.2.91
更新日期:2002-02-01 00:00:00
abstract::To use a combined single document clinical case sheet/computer record which can form the basic document for a life medical record is a practical proposition. With adequate briefing doctors and nurses soon become familiar with the record and appreciate its value. Secretarial and clerical requirements are reduced to a m...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.52.6.452
更新日期:1977-06-01 00:00:00
abstract:OBJECTIVE:To describe the pathways by which children with cancer present to a shared care oncology unit. DESIGN:A population-based retrospective cohort study of children diagnosed with cancer between the years 2004 and 2014. SETTING:District General Hospital with a level 2 Paediatric Oncology Shared Care Unit. PATIE...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2015-308765
更新日期:2015-12-01 00:00:00
abstract::Interleukin-2 (IL-2) and T cell subpopulations were evaluated in children with rheumatic heart disease (RHD). Three groups were included: 13 patients with active RHD, 12 with non-active RHD, and 14 control children. Serum IL-2 and T cell subpopulations were measured by radioimmunoassay and monoclonal antibodies respec...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.67.11.1373
更新日期:1992-11-01 00:00:00
abstract::Skinfold standards provide a useful indication of subcutaneous fat. To evaluate skinfold thickness of 252 Cambridge infants over the first 2 years of age, SD scores relative to the Tanner standards were calculated, taking account of skewness in the standards. Cambridge SD scores were low, varying according to age from...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.78.4.354
更新日期:1998-04-01 00:00:00
abstract:BACKGROUND AND AIMS:The case fatality rate from meningococcal disease (MD) has remained relatively unchanged in the post antibiotic era, with 20-50% of patients who develop shock still dying. In 1992 a new paediatric intensive care unit (PICU) specialising in MD was opened. Educational information was disseminated to l...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.85.5.386
更新日期:2001-11-01 00:00:00
abstract:OBJECTIVE:To evaluate genetic disease among children referred to a community paediatric clinic. DESIGN:Retrospective cohort study. SETTING:Community paediatric clinic, Tower Hamlets, London. PATIENTS:All patients seen for first time in the Child Development Team (CDT) clinic between 1999 and 2013. INTERVENTIONS:Cli...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2017-312739
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:To describe the significance of pericardial effusion (PE), mitral regurgitation (MR) and impaired systolic function in predicting coronary artery lesions (CAL) at diagnosis and follow-up in Kawasaki disease (KD). DESIGN:Echocardiographic records on admission, at 1-3 weeks of illness, and at 6-8 weeks of illn...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2011-301256
更新日期:2013-02-01 00:00:00
abstract::A retrospective study of Scottish hospital inpatients aged 15 years or less has revealed, over a 4-year period, 36 cases of venous thrombosis or phlebitis. Of these 10 were considered to have deep venous thrombosis; 2 cases were associated with obvious pulmonary embolism and 2 cases developed chronic venous insufficie...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.50.2.153
更新日期:1975-02-01 00:00:00
abstract::Two newborn infants, male (A) and female (B), with lethal hyperammonaemia are described in the same family. In both, symptoms started on the second day of life. Lethargy and hypotonia were the most prominent initial findings and were followed by convulsions and coma. In both, blood ammonia levels rose to 570 mumol/u (...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.53.3.230
更新日期:1978-03-01 00:00:00
abstract::Fifty nine preterm infants of between 1.0 and 2.0 kg birthweight who were fed 250 ml/kg/day of breast milk or standard formulas gained weight at the intrauterine rate without complications. It is suggested that high volume feeding is a satisfactory alternative to low birthweight formula milks and is more desirable in ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.59.8.779
更新日期:1984-08-01 00:00:00
abstract:AIMS:To compare physiological and autonomic responses to acute hypoglycaemia in diabetic children in pre-, mid-, and post-pubertal stages of development. METHODS:Twenty seven children (8 pre-pubertal, 7 mid-pubertal, 12 post-pubertal) with type 1 diabetes were studied. Hypoglycaemia was induced by insulin infusion unt...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2004.052035
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND:Congenital facial palsy (CFP) is clinically defined as facial palsy present at birth. It is associated with considerable disfigurement and causes functional and emotional problems for the affected child. The aetiology of the majority of cases however, remains elusive. AIMS:To investigate the role of a neuro...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.83.3.256
更新日期:2000-09-01 00:00:00
abstract::Samples of breast milk collected from mothers of infants with breast milk jaundice were analysed for 5 beta-pregnane-3 alpha, 20 beta-diol, and other pregnanediols using gas chromatography-high resolution mass spectrometry. None was detected in any of the specimens and therefore it is unlikely to be the inhibitory fac...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.56.6.474
更新日期:1981-06-01 00:00:00
abstract::Primary human herpesvirus 6 (HHV-6) and 7 (HHV-7) infections were identified in febrile children by qualitative and quantitative polymerase chain reaction (PCR) assays. Diagnosis was based on the differential detection of viral DNA in peripheral blood mononuclear cells (PBMC), but not in saliva. Six of 41 febrile infa...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.77.1.42
更新日期:1997-07-01 00:00:00
abstract::The clinical profile, malignant potential, and management of 17 children with juvenile polyposis (more than five juvenile polyps) were evaluated clinically and endoscopically. Colonoscopy and polypectomy were done three weekly until colonic clearance was achieved, and thereafter two yearly. All polyps were subjected t...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.78.3.264
更新日期:1998-03-01 00:00:00
abstract:OBJECTIVE:To review the work of one tertiary paediatric palliative care service in facilitating planned withdrawal of ventilatory support outside the intensive care setting, with the purpose of developing local guidance for practice. METHODS:Retrospective 10-year (2003-2012) case note review of intensive care patients...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2013-305492
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVE:To determine risk factors for childhood overweight that can be identified during the first year of life to facilitate early identification and targeted intervention. DESIGN:Systematic review and meta-analysis. SEARCH STRATEGY:Electronic database search of MEDLINE, EMBASE, PubMed and CAB Abstracts. ELIGIBIL...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,meta分析,评审
doi:10.1136/archdischild-2012-302263
更新日期:2012-12-01 00:00:00
abstract::Growth was studied in 83 children with cleft lip and/or palate aged 0-4 years attending a specialist regional centre. Information was collected by a personal interview, postal questionnaire, and record review. The group as a whole grew relatively poorly in early infancy but subsequently recovered, attaining both expec...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.75.4.327
更新日期:1996-10-01 00:00:00