Respiratory function in patients with thalassaemia major: relation with iron overload.

Abstract:

AIMS:(1) To determine the pattern of respiratory impairment in children with thalassaemia major (TM); (2) to assess the relation between the degree of respiratory impairment and total body iron content. METHODS:Twenty nine TM patients were recruited. All underwent physical examination, standardised pulmonary function tests (spirometry, lung volume, and single breath diffusion capacity for carbon monoxide), and magnetic resonance imaging measurements of the liver. Serum ferritin was measured. The signal intensity ratio of liver to that of paraspinal muscle (T1 weighted sequence) and serum ferritin were used as surrogate index of body iron content. RESULTS:Sixteen boys and 13 girls (median age 14.2 years) were studied. None had clinical evidence of congestive heart failure. Sixteen had normal lung function. Impairment of diffusion capacity (median DL(co) 83.5% predicted) was the most common abnormality, being observed in 34% of patients. Pure restrictive and obstructive ventilatory impairment was found in one and two patients respectively. Five patients had a combination of ventilation and diffusion defects. There was no correlation between the degree of impairment of each respiratory abnormality and body iron content. CONCLUSION:Diffusion impairment was the commonest abnormality found in our cohort of paediatric TM patients. Our data did not support the notion that respiratory function impairment was correlated with body iron content.

journal_name

Arch Dis Child

authors

Li AM,Chan D,Li CK,Wong E,Chan YL,Fok TF

doi

10.1136/adc.87.4.328

subject

Has Abstract

pub_date

2002-10-01 00:00:00

pages

328-30

issue

4

eissn

0003-9888

issn

1468-2044

journal_volume

87

pub_type

杂志文章
  • Modified nasopharyngeal tube for upper airway obstruction.

    abstract::A modified nasopharyngeal tube is described that does not add airway dead space and resistance, is well tolerated, highly successful, and allows simultaneous use of oxygen prongs. This potentially reduces the need for surgical intervention to relieve high upper airway obstruction from Pierre-Robin syndrome and other c...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.80.2.186

    authors: Masters IB,Chang AB,Harris M,O'Neil MC

    更新日期:1999-02-01 00:00:00

  • Prader-Willi syndrome in siblings, due to unbalanced translocation between chromosomes 15 and 22.

    abstract::In a family in which the father carried a balanced translocation between chromosomes 15 and 22 two of his children had Prader-Willi syndrome and an unbalanced chromosome complement, having lost the proximal bands from the long arm of chromosome 15. His four other surviving children were normal but carried a balanced t...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.62.8.841

    authors: Fernandez F,Berry C,Mutton D

    更新日期:1987-08-01 00:00:00

  • Primary school accident reporting in one education authority.

    abstract:BACKGROUND:Studies have shown a correlation between increased accident rates and levels of deprivation in the community. School accident reporting is one area where an association might be expected. AIMS:To investigate differences in primary school accident rates in deprived and more affluent wards, in an area managed...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.86.2.91

    authors: Latif AH,Williams WR,Sibert J

    更新日期:2002-02-01 00:00:00

  • Neonatal urinary ascites.

    abstract::Two neonates with spontaneous rupture of the bladder and an otherwise normal genitourinary tract are described. Conservative management resulted in complete resolution of the lesion in one but the other child died from a coliform septicaemia. Necropsy showed a discrete ischaemic lesion in the fundus of the bladder. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.60.7.676

    authors: Morrell P,Coulthard MG,Hey EN

    更新日期:1985-07-01 00:00:00

  • Two hundred glass injuries.

    abstract::Two hundred children with glass injuries were investigated; 48 were injured in falls through architectural glass and 87 by broken bottles. Nine children had serious lacerations--7 of which were sustained at home. Radiographs were important in diagnosing retained fragments but prophylactic antibiotics were unnecessary....

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.59.7.672

    authors: Bell D

    更新日期:1984-07-01 00:00:00

  • Intramuscular iron-dextran and susceptibility of neonates to bacterial infections. In vitro studies.

    abstract::An increased incidence of E. coli sepsis has been observed in neonates given intramuscular iron-dextran for prevention of iron deficiency. Mechanisms for this apparent effect on susceptibility to infection were investigated by comparing phagocytic and antibacterial functions in paired samples of venous blood from 7 in...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.52.10.778

    authors: Becroft DM,Dix MR,Farmer K

    更新日期:1977-10-01 00:00:00

  • Inferior vena cava thrombosis as a complication of femoral vein catheterisation.

    abstract::Indwelling femoral venous catheters were prospectively studied by ultrasonography to define the frequency and evolution of inferior vena cava (IVC) thrombosis. IVC thrombosis was identified in six of 56 catheters (54 children). Only one patient with a positive ultrasound scan had clinical signs of thrombosis. All chil...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.72.4.343

    authors: Shefler A,Gillis J,Lam A,O'Connell AJ,Schell D,Lammi A

    更新日期:1995-04-01 00:00:00

  • Capillary refill: prognostic value in Kenyan children.

    abstract:AIMS:To determine whether delayed capillary refill time (>3 seconds) is a useful prognostic indicator in Kenyan children admitted to hospital. METHODS:A total of 4160 children admitted to Kilifi District Hospital with malaria, malarial anaemia, acute respiratory tract infection (ARI), severe anaemia (haemoglobin <50 g...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2003.032516

    authors: Pamba A,Maitland K

    更新日期:2004-10-01 00:00:00

  • Congenital midline scalp and skull defect.

    abstract::A family with multiple congenital scalp defects, over two generations and probably genetically determined, is described. Although alarming in appearance, surgical intervention is not indicated at least for small lesions. The risk of haemorrhage and meningitis is emphasized. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.50.12.958

    authors: Lassman LP,Sims DG

    更新日期:1975-12-01 00:00:00

  • Chorioamnionitis and funisitis due to Corynebacterium kutscheri.

    abstract::When isolated from the female genital tract, diphtheroids are usually regarded as commensal organisms. Corynebacterium kutscheri however is a pathogen in laboratory rodents. We report a case in which C. kutscheri was isolated as a pure culture from the umbilical cord and from other surface sites in an infant. Histolog...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.54.9.710

    authors: Fitter WF,de Sa DJ,Richardson H

    更新日期:1979-09-01 00:00:00

  • Effect of obesity on endogenous secretion of growth hormone in Turner's syndrome.

    abstract::Nocturnal growth hormone secretion over a 12 hour period was assessed at 20 minute intervals in 25 prepubertal subjects with Turner's syndrome and 11 normal prepubertal girls of short stature to try and elucidate the relationship between body weight and endogenous secretion of growth hormone in Turner's syndrome. Ther...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.66.10.1184

    authors: Lu PW,Cowell CT,Jimenez M,Simpson JM,Silink M

    更新日期:1991-10-01 00:00:00

  • Energy metabolism in relation to body composition and gender in adolescents.

    abstract:OBJECTIVE:To study the effect of body composition on average daily metabolic rate (ADMR) and basal metabolic rate (BMR) in adolescence, and to examine current BMR prediction equations. STUDY:Dutch adolescents were pooled with previously reported American and British subjects (n = 90 overall). BMR and ADMR were analyse...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.85.1.73

    authors: van Mil EG,Westerterp KR,Kester AD,Saris WH

    更新日期:2001-07-01 00:00:00

  • Symptoms and transmission of intestinal cryptosporidiosis.

    abstract::Cryptosporidium spp are a cause of diarrhoea in toddlers. Symptoms and routes of transmission were investigated in a prospective case-control study in the city and surroundings of Basel, Switzerland. Twenty one (4.6%) out of 455 children with diarrhoea who attended paediatric and general practices from June to Septemb...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.65.4.445

    authors: Egger M,Mäusezahl D,Odermatt P,Marti HP,Tanner M

    更新日期:1990-04-01 00:00:00

  • Length measurement in small neonates.

    abstract::The Prematometer is a new instrument for the accurate measurement of the length of small neonates inside incubators. It is capable of giving precise results. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.60.9.837

    authors: Smith RA,Newcombe RG,Coggins AM,Gray OP

    更新日期:1985-09-01 00:00:00

  • Simultaneous measurement of preductal and postductal oxygen saturation by pulse oximetry in hyaline membrane disease.

    abstract::Preductal and postductal oxygen saturation were compared in 20 ventilated preterm infants with hyaline membrane disease to establish the frequency of right to left shunting and to assess the accuracy of postductus arteriosus blood gas sampling. One hundred and thirty eight comparisons were made and the frequency of ri...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.67.10_spec_no.1166

    authors: Macdonald PD,Yu VY

    更新日期:1992-10-01 00:00:00

  • Realities of paediatric pharmacotherapy in the developing world.

    abstract::Diseases causing high mortality in children under 5 years of age in resource limited settings (RLS) could be treated if children in these countries had access to existing medicines. It took 30 years before the WHO Essential Medicines List (EML) considered the issue of medicines for children, with the first EML for chi...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/adc.2009.180000

    authors: Hoppu K,Sri Ranganathan S,Dodoo AN

    更新日期:2011-08-01 00:00:00

  • Rice: a common and severe cause of food protein-induced enterocolitis syndrome.

    abstract:OBJECTIVE:To examine and compare the characteristics of food protein-induced enterocolitis syndrome (FPIES) caused by rice and cow's milk/soy. DESIGN:Retrospective study of children presenting with FPIES to the Children's Hospital at Westmead, NSW, Australia, over a 16-year period. RESULTS:There were 14 children with...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2008.145144

    authors: Mehr SS,Kakakios AM,Kemp AS

    更新日期:2009-03-01 00:00:00

  • External hydrocephalus and subdural bleeding in infancy associated with transplacental anti-Ro antibodies.

    abstract:BACKGROUND:The isolated finding of an unexplained chronic subdural haematoma in an infant may suggest non-accidental head injury (NAHI). The authors report a previously undescribed cause of multifocal chronic subdural haematoma in infancy which could result in a misdiagnosis of previous NAHI. METHODS:Two infants, aged...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2010.194746

    authors: Edwards RJ,Allport TD,Stoodley NG,O'Callaghan F,Lock RJ,Carter MR,Ramanan AV

    更新日期:2012-04-01 00:00:00

  • Minor congenital anomalies and ataxic cerebral palsy.

    abstract::The incidence of minor congenital anomalies was examined in 36 patients with ataxic cerebral palsy, in unaffected family members, and in 100 unrelated control subjects. None of the control subjects or family members had more than four anomalies, and 25 of 36 (69%) of the patients had more than four. The distribution o...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.64.4.557

    authors: Miller G

    更新日期:1989-04-01 00:00:00

  • Combined test of anterior pituitary function in children.

    abstract::A combined test of anterior pituitary function was used on 21 normal children. It shows that a comprehensive evaluation can be made of growth hormone, thyroid stimulating hormone, adrenocorticotrophic hormone, and gonadotrophin reserve. Simultaneous assessment of those peripheral glands associated with the anterior pi...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.53.4.301

    authors: Savage DC,Swift PG,Johnston PG,Goldie DJ,Murphy D

    更新日期:1978-04-01 00:00:00

  • Ethics, governance and consent in the UK: implications for research into the longer-term outcomes of congenital heart defects.

    abstract:OBJECTIVE:To explore the effect of research ethics, governance and consent requirements and recent reforms on UK-wide follow-up of children with congenital heart defects (CHD). DESIGN:Prospective cohort study. SETTING:UK National Health Service. PATIENTS:3897 children with CHD requiring intervention, or resulting in...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/adc.2008.152975

    authors: Knowles RL,Bull C,Wren C,Dezateux C

    更新日期:2011-01-01 00:00:00

  • Corticosteroid-induced cataracts in idiopathic nephrotic syndrome.

    abstract::Th incidence and severity of posterior subcapsular cataracts were studied in 58 children with steroid-sensitive nephrotic syndrome. Eight (14%) children had cataracts. Visual acuity was normal in all but one child. There was no relationship between total dose or mean daily dose of prednisolone (corrected for body surf...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:

    authors: Brocklebank JT,Harcourt RB,Meadow SR

    更新日期:1982-01-01 00:00:00

  • Evidence-based training of health professionals to inform families about disability.

    abstract:OBJECTIVE:The development, delivery and evaluation of a training programme for medical and nursing professionals on best practice for informing families of their child's disability. DESIGN:A 2 h training course on 'Best practice guidelines for informing families of their child's disability' was designed based on the f...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2012-303037

    authors: Harnett A,Bettendorf E,Tierney E,Guerin S,O'Rourke M,Hourihane JO

    更新日期:2013-06-01 00:00:00

  • T cell lymphocytosis with neutropenia.

    abstract::A gross T cell lymphocytosis developed in an otherwise healthy 5 year old girl and has persisted for nearly 3 years. It is associated with neutropenia and seems to be typical of a rare adult disorder that may be a type of T cell chronic lymphocytic leukaemia. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.58.8.635

    authors: Murray JA,Lilleyman JS

    更新日期:1983-08-01 00:00:00

  • Prevalence of microcephaly in eight south-eastern and midwestern Brazilian neonatal intensive care units: 2011-2015.

    abstract:OBJECTIVE:To describe the prevalence of microcephaly in infants admitted to the neonatal intensive care units (NICUs) in eight private hospitals in south-eastern and midwestern Brazil, from 2011 to 2015. DESIGN:Observational, cross-sectional study in a cohort of neonates. SETTING:Eight private NICUs situated in the c...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/archdischild-2016-311541

    authors: de Magalhães-Barbosa MC,Prata-Barbosa A,Robaina JR,Raymundo CE,Lima-Setta F,Antonio José Ledo Alves da Cunha

    更新日期:2017-08-01 00:00:00

  • Coeliac disease in identical twins.

    abstract::Coeliac disease occurred at the same age in MZ twins. The diagnosis was confirmed by histology of the small intestine, rapid response to a gluten-free diet, and relapse after reintroduction of gluten. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.54.5.395

    authors: Penna FJ,Mota JA,Roquete ML,de Carvalho AS,de Oliveira Lemos AT,Barbosa AJ,Leao E,Ferreira RA,de Paula Castro L

    更新日期:1979-05-01 00:00:00

  • MRSA screening on a paediatric intensive care unit.

    abstract::The accuracies of chromogenic agar and the GeneXpert real-time PCR system (Cepheid, Sunnyvale, California, USA) for admission methicillin-resistant Staphylococcus aureus (MRSA) screening of 1336 consecutive paediatric intensive care unit patients (1282 evaluable swab results) were determined using enrichment culture a...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2010.185785

    authors: Gray J,Patel M,Turner H,Reynolds F

    更新日期:2012-03-01 00:00:00

  • Chest physiotherapy in acute bronchiolitis.

    abstract::Forty four children with acute bronchiolitis were given twice daily chest physiotherapy in addition to standard supportive measures and were compared with 46 controls who were not given physiotherapy. There was no clinically discernable benefit on the course of their illness. ...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/adc.60.11.1078

    authors: Webb MS,Martin JA,Cartlidge PH,Ng YK,Wright NA

    更新日期:1985-11-01 00:00:00

  • Alteration of lung diffusion capacity in IgA nephropathy.

    abstract:OBJECTIVE:To establish whether changes of lung transfer for carbon monoxide (TLCO) are related to the phase of IgA nephropathy. METHODS:Respiratory function was tested in 12 children with IgA nephropathy assessed by percutaneous renal biopsy. This was done during acute exacerbations or haematuria-free phases of the di...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章

    doi:10.1136/adc.74.3.236

    authors: Ravilly S,Chaussain M,Iniguez JL,Lenhert A,Kalifa G,Brun P,Niaudet P,Gendrel D

    更新日期:1996-03-01 00:00:00

  • An observational study to evaluate micronutrient status during enteral feeding.

    abstract:BACKGROUND:There are few data on the optimal micronutrient composition of paediatric enteral feeds. The recent European Directive on Foods for Special Medical Purposes (1999/21/EC) did not distinguish between the composition of adult and paediatric feeds. AIMS:To evaluate, in an open, observational study, the long ter...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.86.6.411

    authors: Johnson TE,Janes SJ,MacDonald A,Elia M,Booth IW

    更新日期:2002-06-01 00:00:00