Abstract:
:An increased incidence of E. coli sepsis has been observed in neonates given intramuscular iron-dextran for prevention of iron deficiency. Mechanisms for this apparent effect on susceptibility to infection were investigated by comparing phagocytic and antibacterial functions in paired samples of venous blood from 7 infants, median age 5 days, before and after iron-dextran. Post-treatment sera had increased inhibitory effects on leucocyte chemotaxis and markedly reduced bacteriostatic effects agaainst E. coli. The clinical relevance of the effects on chemotaxis is uncertain. The reduction in serum bacteriostasis is similar to that observed in other forms of hyperferraemia not associated with saturation of transferrin, and is a likely cause of the increased susceptibility to infection in vivo. We consider that prophylactic treatment with parenteral iron-dextran is contraindicated in early infancy.
journal_name
Arch Dis Childjournal_title
Archives of disease in childhoodauthors
Becroft DM,Dix MR,Farmer Kdoi
10.1136/adc.52.10.778subject
Has Abstractpub_date
1977-10-01 00:00:00pages
778-81issue
10eissn
0003-9888issn
1468-2044journal_volume
52pub_type
杂志文章abstract::Samples of saliva and nasal secretions were collected sequentially from 15 breast fed and 15 bottle fed infants on five occasions between 6 days and 9 months of age. Total immunoglobulin concentrations of G, M, and A classes, and class specific antibodies to tetanus toxoid and a pool of commensal strains of Escherichi...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.61.3.263
更新日期:1986-03-01 00:00:00
abstract:BACKGROUND:Previous research has indicated that children who have received treatment for leukaemia which includes cranial irradiation exhibit deficits in their ability to focus attention. It has been suggested that the use of cranial irradiation may have a role to play in long term sequelae. AIMS:To investigate neurop...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.88.2.147
更新日期:2003-02-01 00:00:00
abstract::An infant with severe hypertension who had a nephroblastoma which was secreting active renin is described. Nephroblastoma must be included in the differential diagnosis of hypertension associated with increased renin concentrations, even in the absence of an abdominal mass. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.66.4.525
更新日期:1991-04-01 00:00:00
abstract:AIMS:To evaluate the performance of the Paediatric Risk of Mortality (PRISM) score in a population of UK children and to use this score to examine severity of illness adjusted mortality of critically ill children <16 years old in a defined geographical region. METHODS:Observational study of a defined population of cri...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.86.3.194
更新日期:2002-03-01 00:00:00
abstract::A double blind crossover trial of 20 micrograms intranasal 1-deamino-8-d-arginine vasopressin (DDAVP) versus placebo was carried out in 17 children with intractable enuresis aged between 6 and 13 years who had failed to respond to drugs and an enuresis alarm. Fluid intake was not restricted. There was a significant re...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章
doi:10.1136/adc.61.11.1104
更新日期:1986-11-01 00:00:00
abstract:AIM:To assess the value and safety of fasts for investigating hypoglycaemia or suspected metabolic disease. STUDY DESIGN:Review of all diagnostic fasts performed over a 2.5 year period. SETTING:The neonatal intensive care unit and programmed investigation unit at a tertiary referral centre for endocrinology and metab...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.75.2.115
更新日期:1996-08-01 00:00:00
abstract::A boy with the dysmorphic features of Noonan's syndrome and pulmonary valve stenosis who had evidence of hypoparathyroidism and abnormal T lymphocyte numbers in the neonatal period is reported. He had a normal karyotype but molecular analysis revealed a submicroscopic deletion within chromosome 22q11, the region delet...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.68.2.187
更新日期:1993-02-01 00:00:00
abstract::Twenty six children with hypoglycaemia were diagnosed and followed between 1975 and 1995. Diagnosis was confirmed by a high insulin:glucose ratio, and low free fatty acid and 3-hydroxybutyrate on fasting. All patients were treated with diazoxide at a maximum dose of 20 mg/kg/day. Requirement of a higher dose was consi...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.79.5.440
更新日期:1998-11-01 00:00:00
abstract::Two investigations of paediatric manpower in England, Wales, and Northern Ireland were carried out, each using a different method. The first survey located registrars and senior registrars and checked on their occupational status 3 years later in order to see which ones had been promoted. Loss factors--such as emigrat...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.57.9.702
更新日期:1982-09-01 00:00:00
abstract::A CAUSAL ASSOCIATION BETWEEN MEASLES: mumps-rubella (MMR) vaccine and idiopathic thrombocytopenic purpura (ITP) was confirmed using immunisation/hospital admission record linkage. The absolute risk within six weeks of immunisation was 1 in 22 300 doses, with two of every three cases occurring in the six week post-immu...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.84.3.227
更新日期:2001-03-01 00:00:00
abstract::Three paediatric pathologists, one perinatal paediatrician, one obstetrician, and one epidemiologist separately used information collected on 239 babies in an attempt to validate the Wigglesworth classification of perinatal deaths. This was first done using clinical data only, then using the combination of clinical an...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.64.10_spec_no.1345
更新日期:1989-10-01 00:00:00
abstract::This study aimed to examine the overnight temperature pattern of babies during the prodromal phase of minor illnesses. The overnight rectal temperature pattern of 123 babies was recorded weekly from about 6 to at least 16 weeks old, while parents maintained detailed records of signs of illness. By analysis of patterns...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.71.1.80
更新日期:1994-07-01 00:00:00
abstract::Doppler ultrasound measurements of pulmonary blood flow in 20 babies with severe respiratory distress syndrome treated in a randomised controlled trial of surfactant replacement showed that the immediate improvement of oxygenation was not associated with a significant increase in pulmonary blood flow. Reduction in ven...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/adc.64.1_spec_no.13
更新日期:1989-01-01 00:00:00
abstract::Production of platelet thromboxane B2, a stable metabolite of thromboxane A2, was measured in seven newborn infants with pulmonary hypertension during the first day of life. Platelet thromboxane B2 production was significantly lower than in 12 healthy controls but did not correlate with simultaneous blood gas values. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.62.2.195
更新日期:1987-02-01 00:00:00
abstract:OBJECTIVE:Congenital hypothyroidism (CHT) is a common cause of preventable mental retardation, and the quantification of intellectual disability due to CHT is needed to assess the public health benefit of newborn screening. DESIGN:Review of published studies conducted among children born prior to the introduction of n...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/adc.2010.190280
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Therapeutic hypothermia, a safe and effective treatment for neonatal encephalopathy in an intensive care setting, is not available in low-resource settings. Aims/ METHODS:To assess two low-tech, low-cost cooling devices for use in low-resource settings: (i) commercially available water bottles filled with t...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2008.143602
更新日期:2009-05-01 00:00:00
abstract:AIMS:To prospectively evaluate sinopulmonary disease in 24 patients with primary humoral immunodeficiency (11 with agammaglobulinaemia, nine with isolated IgA deficiency, and two with common variable immunodeficiency) and chronic productive cough, ascertain the usefulness of chest high resolution computed tomography (H...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.88.12.1101
更新日期:2003-12-01 00:00:00
abstract:BACKGROUND:Mauriac syndrome is characterised by growth failure, cushingoid appearance and hepatomegaly which occurs in patients with insulin dependent diabetes and was first described shortly after the introduction of insulin as a treatment for the condition. OBJECTIVE:To describe the clinical features, histological f...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2013-304426
更新日期:2014-04-01 00:00:00
abstract::Blood pressure (BP) values and the phenomenon of tracking were evaluated in a group of 481 schoolchildren over a nine year period starting at age 6 years. BP values were obtained yearly by taking the mean of two measurements at one visit, measurements were taken by only two observers during the study. For both systoli...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.81.2.169
更新日期:1999-08-01 00:00:00
abstract::Two very preterm infants (born at 29 and 25 weeks, respectively) were found to have abnormal ribs. Though this was thought unimportant at the time, it was subsequently shown to indicate that some members of their families had a dominantly inherited risk of developing skin cancer and other serious problems. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.66.10_spec_no.1162
更新日期:1991-10-01 00:00:00
abstract::Urinary glycosaminoglycan (GAG) excretion was measured in children with idiopathic urolithiasis (15 girls and 10 boys; mean (SD) age 6.2 (2.4) years) and in healthy controls (10 girls and 14 boys; mean (SD) age 6.8 (3.8) years). GAG excretion was expressed as a GAG/creatinine (mg/g) ratio and was evaluated using dimet...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.80.3.271
更新日期:1999-03-01 00:00:00
abstract:AIMS:To investigate a population of individuals with 22q11 deletion syndrome for hypocalcaemia. METHODS:A detailed clinical history enquiring into symptoms of hypocalcaemia and blood sampling to assess for hypocalcaemia and hypoparathyroidism, of patients outside the neonatal period known to have the 22q11 microdeleti...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.88.6.520
更新日期:2003-06-01 00:00:00
abstract::New charts for height, weight, height velocity, and weight velocity are presented for clinical (as opposed to population survey) use. They are based on longitudinal-type growth curves, using the same data as in the British 1965 growth standards. In the velocity standards centiles are given for children who are early- ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.51.3.170
更新日期:1976-03-01 00:00:00
abstract::We describe a child with primary defect of polymorph bacterial killing associated with systemic lungs erythematosus. We suggest that her autoimmune disease results from chronic bacterial antigen stimulation and propose a hypothetical model linking immunodeficiency with autoimmunity. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.56.5.382
更新日期:1981-05-01 00:00:00
abstract::Eight hospitals reported 781 non-iatrogenic accidents occurring to patients and visitors under 16 years of age during an 18 month period up to October 1989. Accidents more often involved boys and children aged 3 to 5 years old. Falls from a height, slips, and striking accidents were common by day and falls by night. A...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.66.9.1047
更新日期:1991-09-01 00:00:00
abstract:AIM:To determine the outcome and identify predictive factors in children with psychogenic non-epileptic seizures (PNES). METHOD:The biographies of 35 children with PNES, attending a tertiary paediatric neurology centre, were reviewed. RESULTS:Thirty five children attending the department between 1987 and 1997 were ev...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.82.6.474
更新日期:2000-06-01 00:00:00
abstract::The transport characteristics of the placenta, which favour higher phenylalanine concentrations in the fetus than in the mother, and regression data of head circumference at birth against phenylalanine concentration at conception in maternal phenylketonuria (PKU), suggest that treatment of maternal PKU should ideally ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.66.11.1346
更新日期:1991-11-01 00:00:00
abstract::Circulatory adaptation was studied serially in 11 healthy term neonates on days 1, 3, and 5 by cross sectional and pulsed Doppler echocardiography. Changes in the determinants of blood viscosity (packed cell volume, plasma viscosity, red cell aggregation, and red cell deformability) were studied on day 1 and day 5. Th...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.66.4_spec_no.391
更新日期:1991-04-01 00:00:00
abstract:OBJECTIVE:To describe the pathways by which children with cancer present to a shared care oncology unit. DESIGN:A population-based retrospective cohort study of children diagnosed with cancer between the years 2004 and 2014. SETTING:District General Hospital with a level 2 Paediatric Oncology Shared Care Unit. PATIE...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2015-308765
更新日期:2015-12-01 00:00:00
abstract:AIMS:To investigate socioeconomic inequalities in the risk of congenital anomalies, focusing on risk of specific anomaly subgroups. METHODS:A total of 858 cases of congenital anomaly and 1764 non-malformed control births were collected between 1986 and 1993 from four UK congenital malformation registers, for the purpo...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究
doi:10.1136/adc.82.5.349
更新日期:2000-05-01 00:00:00