Abstract:
BACKGROUND:Therapeutic hypothermia, a safe and effective treatment for neonatal encephalopathy in an intensive care setting, is not available in low-resource settings. Aims/ METHODS:To assess two low-tech, low-cost cooling devices for use in low-resource settings: (i) commercially available water bottles filled with tepid water (25 degrees C); (ii) a mattress made of phase changing material (PCM) with a melting point of 32 degrees C (PCM works as a heat buffer at this temperature). Eleven anaesthetised newborn piglets were studied following transient hypoxia-ischaemia. The cooling device was applied 2-26 h after hypoxia-ischaemia with a target rectal temperature (T(rectal)) of 33-34 degrees C. T(rectal) undershoot was adjusted using cotton blankets; the cooling device was renewed when T(rectal) rose above 35 degrees C. T(rectal) data during cooling were dichotomised (within or without target) to assess: (a) the total period within the target T(rectal) range; (b) the stability and fluctuation of T(rectal) during cooling. RESULTS:Therapeutic hypothermia was achieved with both water bottles (n = 5) and the PCM mattress (n = 6). The mean (SD) time to reach target T(rectal) was 1.8 (0.5) h with water bottles and 1.9 (0.3) h with PCM. PCM cooling led to a longer period within the target T(rectal) range (p<0.01) and more stable cooling (p<0.05). Water bottle cooling required device renewal (in four out of five piglets). CONCLUSION:Simple, low-tech cooling devices can induce and maintain therapeutic hypothermia effectively in a porcine model of neonatal encephalopathy, although frequent fine tuning by adjusting the number of blankets insulating the piglet was required to maintain a stable temperature. PCM may induce more stable cooling compared with water bottles.
journal_name
Arch Dis Childjournal_title
Archives of disease in childhoodauthors
Iwata S,Iwata O,Olson L,Kapetanakis A,Kato T,Evans S,Araki Y,Kakuma T,Matsuishi T,Setterwall F,Lagercrantz H,Robertson NJdoi
10.1136/adc.2008.143602subject
Has Abstractpub_date
2009-05-01 00:00:00pages
387-91issue
5eissn
0003-9888issn
1468-2044pii
adc.2008.143602journal_volume
94pub_type
杂志文章abstract:PURPOSE:To estimate the minimum incidence of congenital Zika syndrome (CZS) and severe microcephaly in Canada and describe key clinical, epidemiological, aetiological and outcome features of these conditions. METHODS:Two separate national surveillance studies were conducted on CZS and severe microcephaly using the wel...
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journal_title:Archives of disease in childhood
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journal_title:Archives of disease in childhood
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journal_title:Archives of disease in childhood
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更新日期:1982-07-01 00:00:00
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journal_title:Archives of disease in childhood
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更新日期:2014-09-01 00:00:00
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journal_title:Archives of disease in childhood
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pub_type: 杂志文章
doi:10.1136/adc.86.3.164
更新日期:2002-03-01 00:00:00
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journal_title:Archives of disease in childhood
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journal_title:Archives of disease in childhood
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.78.4.354
更新日期:1998-04-01 00:00:00
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.64.3.369
更新日期:1989-03-01 00:00:00
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journal_title:Archives of disease in childhood
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journal_title:Archives of disease in childhood
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journal_title:Archives of disease in childhood
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journal_title:Archives of disease in childhood
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更新日期:2018-09-01 00:00:00
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
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更新日期:1991-09-01 00:00:00