Insulin response to intravenous glucagon in children with familial constitutional short stature.

Abstract:

:An intravenous glucagon test was performed in 8 children with familial constitutional short stature who were also lean. These children were randomly selected from a larger group of children with the same clinical manifestation and who had been shown to have a low insulin response to an oral glucose tolerance test and to an intravenous arginine test, without glucose intolerance. 7 out of 8 children showed a normal insulin response to intravenous glucagon, with a peak level of 53--180 millimicron/ml 2 minutes after the injection. It is assumed that these insulin responses represent an intact 'rapid' pool of insulin within the beta-cell, and can explain the absence of glucose intolerance in all the children so far studied.

journal_name

Arch Dis Child

authors

Karp M,Laron Z,Doron M

doi

10.1136/adc.50.10.805

subject

Has Abstract

pub_date

1975-10-01 00:00:00

pages

805-8

issue

10

eissn

0003-9888

issn

1468-2044

journal_volume

50

pub_type

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