Management and outcome of severe head injuries in the Trent region 1985-90.

Abstract:

:In a five year period, 39 children (29 boys, 10 girls) aged 2 months to 13 years (mean 7.8 years) were studied who had suffered a major head injury (29 road traffic accidents, six falls, and four non-accidental injury). The injury had been assessed clinically and by cranial computed tomography or cranial ultrasound (in a single baby of 2 months). Initial Glasgow coma scores for all subjects ranged from 3-11 (mean 5.5), intact survivors 5-11 (7.4), minor handicap 4-11 (6.1), major handicap 3-6 (4.3), fatalities 3-6 (4.1). All were treated with sedation, paralysis, hyperventilation (arterial carbon dioxide tension 3.0-3.5 kPa), intracranial pressure monitoring and moderate body surface hypothermia to 32 degrees C. Nine children died and 30 survived (nine intact, 13 minor disability, and eight major disability). The worst cerebral perfusion pressure was over 40 mm Hg in all but one survivor, and less than 40 mm Hg in seven of nine fatalities. Severe hypocapnia both in the first 24 hours and overall was correlated with poor outcomes (dead or major disability), as were bilateral contusions or diffuse axonal injury.

journal_name

Arch Dis Child

authors

Elias-Jones AC,Punt JA,Turnbull AE,Jaspan T

doi

10.1136/adc.67.12.1430

subject

Has Abstract

pub_date

1992-12-01 00:00:00

pages

1430-5

issue

12

eissn

0003-9888

issn

1468-2044

journal_volume

67

pub_type

杂志文章
  • Evidence for persistence of upper airway narrowing during sleep, 12 years after adenotonsillectomy.

    abstract:AIMS:To establish whether subjects with previous evidence of sleep apnoea prior to adenotonsillectomy continue to have evidence of narrower upper airways during sleep, 12 years later. METHODS:Twenty subjects (median age 16 years) underwent repeat sleep studies at home, 12 years after such studies had shown significant...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.86.1.34

    authors: Tasker C,Crosby JH,Stradling JR

    更新日期:2002-01-01 00:00:00

  • Non-cardiac benefits of human recombinant erythropoietin in end stage renal failure and anaemia.

    abstract::Recombinant human erythropoietin (r-HuEpo) is now available to correct the anaemia of end stage renal failure. The clinical consequences of increasing the haemoglobin concentration in children on dialysis are incompletely documented; a placebo controlled study is essential when assessing subjective changes, for exampl...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/adc.69.5.580

    authors: Morris KP,Sharp J,Watson S,Coulthard MG

    更新日期:1993-11-01 00:00:00

  • Promoting research for children.

    abstract::Concerns have been expressed in recent years about the decline in children's clinical and biomedical research in the UK, and in the paediatric academic workforce. Here I consider the extent to which these concerns are justified, the sweeping changes that have taken place in research funding, governance and organisatio...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2009.178160

    authors: Modi N

    更新日期:2010-11-01 00:00:00

  • Histology of breast development in early life.

    abstract::Histological examination of the breasts of 26 infants and young children who died suddenly between the ages of 3 weeks and 2 years was performed. The glands were composed of well formed lobules surrounded by dense interlobular stroma, while within the lobules there was looser connective tissue. The lobules contained d...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.63.2.136

    authors: McKiernan J,Coyne J,Cahalane S

    更新日期:1988-02-01 00:00:00

  • Breast milk jaundice. Effect of inhibitory breast milk and 3 alpha, 20 abeta-pregnanediol on glucuronyl transferase.

    abstract::1 case study and a clinical study with laboratory rats examined the question of breast milk jaundice. The case study confirmed clinical diagnosis of breast milk jaundice. The clinical study compared the effects of breast milk and 3alpha, 20beta-pregnanediol on the conjugation of bilirubin and o-aminophenol by rat li...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.46.246.195

    authors: Hargreaves T,Piper RF

    更新日期:1971-04-01 00:00:00

  • Peer mentoring: evaluation of a novel programme in paediatrics.

    abstract:BACKGROUND:Mentoring is important for personal and professional development of doctors. Peer mentoring is a core skill in the UK paediatric postgraduate curriculum. However, there is a paucity of peer mentoring programmes aimed at postgraduate doctors in training (postgraduate trainees), and there are no such schemes w...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2013-304277

    authors: Eisen S,Sukhani S,Brightwell A,Stoneham S,Long A

    更新日期:2014-02-01 00:00:00

  • Salt-losing syndrome in 2 infants with defective 18-dehydrogenation in aldosterone biosynthesis.

    abstract::Two infants presented with a salt-losing syndrome, the presenting features of which were subtle. One case appeared to be transient. Deficient production of aldosterone was shown by plasma renin activity and plasma aldosterone profile. Gas chromatography-mass spectrometry of urine indicated a defect in 18-dehydrogenati...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.52.7.580

    authors: Milla PJ,Trompeter R,Dillon MJ,Robins D,Shackleton C

    更新日期:1977-07-01 00:00:00

  • Patterns of scald injuries.

    abstract:OBJECTIVES:To describe common patterns of bath water scald injuries in children, to examine differences between accidental and non-accidental bath water scalds in children, and to examine potential for prevention. DESIGN:A two year six month retrospective analysis of admissions to a specialist burns unit. SETTING:The...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.71.2.156

    authors: Yeoh C,Nixon JW,Dickson W,Kemp A,Sibert JR

    更新日期:1994-08-01 00:00:00

  • Echocardiographic assessment of cardiac function in shocked very low birthweight infants.

    abstract::The contribution of abnormal cardiac function to hypotension and metabolic acidosis, which affect approximately 40% of ventilated very low birthweight infants in the first 24 hours after birth was assessed using M mode, two dimensional, and Doppler echocardiography in 75 very low birthweight infants during the first f...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.68.1_spec_no.17

    authors: Gill AB,Weindling AM

    更新日期:1993-01-01 00:00:00

  • Pyrexia after diphtheria/tetanus/pertussis and diphtheria/tetanus vaccines.

    abstract::The temperatures of 587 children were taken before and after diphtheria/tetanus/pertussis (DTP) or diphtheria/tetanus (DT) vaccine. Only slight temperature increases were found but these were notably more frequent after plain than adsorbed DTP vaccine preparations and the frequency increased with each successive dose....

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.58.11.921

    authors: Waight PA,Pollock TM,Miller E,Coleman EM

    更新日期:1983-11-01 00:00:00

  • Intestinal lymphangiectasia. Long-term results with MCT diet.

    abstract::The clinical course of 6 children with primary intestinal lymphangiectuasia who have been treated with low fat medium chain triglyceride-supplemented diets for between 3 and 8 years (4 for longer than 5 years) is described. Though laboratory findings indicate continuing chyle leak, evidence for long-term benefit from ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.50.4.269

    authors: Tift WL,Lloyd JK

    更新日期:1975-04-01 00:00:00

  • Reye's syndrome; diagnosis by muscle biopsy?

    abstract::Three children with Reye's syndrome are described. One child died, the second had mild and transient illness, and the third had recurrent episodes. In all 3 children a muscle biopsy showed pronounced infiltration of the myofibres with fat microdroplets as shown by the oil red O stain and by electron microscopical exam...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.56.4.287

    authors: Shapira Y,Deckelbaum R,Statter M,Tennenbaum A,Aker M,Yarom R

    更新日期:1981-04-01 00:00:00

  • Late outcomes in children with Langerhans cell histiocytosis.

    abstract:INTRODUCTION:Langerhans cell histiocytosis (LCH) is a rare disease with diverse clinical courses. Despite improvement in survival outcomes in the recent decades, sequelae of the disease remain a concern. This study aimed to provide information on the long-term outcomes in patients with LCH, particularly on the sequelae...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2016-312185

    authors: Chow TW,Leung WK,Cheng FWT,Kumta SM,Chu WCW,Lee V,Shing MMK,Li CK

    更新日期:2017-09-01 00:00:00

  • Ketamine anaesthesia for medical procedures in children.

    abstract::Ketamine hydrochloride 2 mg/kg, together with atropine 0.2 mg, has been given intravenously on 100 occasions on a general paediatric ward. No serious side effects occurred. Dreams followed in 4 children but did not reduce acceptability of the drug. In our hands it has greatly reduced the pain and distress of children ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.51.1.56

    authors: Elliott E,Hanid TK,Arthur LJ,Kay B

    更新日期:1976-01-01 00:00:00

  • Children and adolescents' experiences of primary lymphoedema: semistructured interview study.

    abstract:BACKGROUND:Congenital lymphoedema is a lifelong condition that has detrimental physical and psychosocial outcomes for young patients and burdensome treatment responsibilities that may hamper patients' motivation for self-management. There is limited research from the perspective of young people with primary lymphoedema...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/archdischild-2017-313856

    authors: Hanson CS,Newsom J,Singh-Grewal D,Henschke N,Patterson M,Tong A

    更新日期:2018-07-01 00:00:00

  • Choice of antibiotics in management of acute osteomyelitis and acute septic arthritis in children.

    abstract::A survey of 158 children with acute haematogenous osteomyelitis, and of 94 children with acute septic arthritis over an 8-year period was made to determine which bacteria cause these infections. In the osteomyelitis group the organism most frequently detected was Staphylococcus aureus (74% of cases). In 16% of cases s...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.52.9.679

    authors: Nade S

    更新日期:1977-09-01 00:00:00

  • Amino acid and protein requirements in a preterm infant with classic phenylketonuria.

    abstract::A preterm infant with classic phenylketonuria required rather less than 90 mg/kg of phenylalanine and between 270 and 290 mg/kg tyrosine daily to achieve a rate of weight gain of around 20 g/kg per day. Using Lofenalac as the low phenylalanine food, the intake of tyrosine, an essential amino acid for patients with phe...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.60.3.263

    authors: Shortland D,Smith I,Francis DE,Ersser R,Wolff OH

    更新日期:1985-03-01 00:00:00

  • Family implications of neonatal Gorlin's syndrome.

    abstract::Two very preterm infants (born at 29 and 25 weeks, respectively) were found to have abnormal ribs. Though this was thought unimportant at the time, it was subsequently shown to indicate that some members of their families had a dominantly inherited risk of developing skin cancer and other serious problems. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.66.10_spec_no.1162

    authors: Evans DG,Sims DG,Donnai D

    更新日期:1991-10-01 00:00:00

  • Severe neonatal pertussis treated by salbutamol.

    abstract::Two neonates with severe culture proven pertussis were successfully treated with salbutamol 0.5 mg three times daily. There was a demonstrable decrease in the total number of coughing spasms, their mean duration and severity. In one baby this was shown by the transcutaneous oxygen tension measurements. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.61.6.600

    authors: Tam AY,Yeung CY

    更新日期:1986-06-01 00:00:00

  • Age distribution of anginose mononucleosis.

    abstract::The age distribution of anginose infectious mononucleosis in children was analysed retrospectively for the years 1966-85. During that period the disease became significantly more common in children of a young age and less common in older children. This shift could not be attributed either to socioeconomic conditions o...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.62.6.617

    authors: Spirer Z,Holtzman M,Melamed I,Shalit I

    更新日期:1987-06-01 00:00:00

  • Management of developmental speech and language disorders. Part 2: acquired conditions.

    abstract::Many children who present with these acquired impairments of communication have a clear preceding event such as an acquired brain injury from a road traffic accident. Children often respond differently in this situation to adult presentations. They may have a period of mutism when the prognosis might look poor and yet...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/archdischild-2014-306153

    authors: O'Hare A

    更新日期:2016-03-01 00:00:00

  • Parental food allergy information needs: a qualitative study.

    abstract:OBJECTIVE:To examine information needs and preferences of parents regarding food allergy. DESIGN:Qualitative study including in-depth semi-structured interviews and focus group discussions. Data were audio-recorded, transcribed verbatim and analysed using the constant comparative method, aided by participant checking ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/adc.2006.114975

    authors: Hu W,Grbich C,Kemp A

    更新日期:2007-09-01 00:00:00

  • A new paradigm for developing drugs in children: atomoxetine as a model.

    abstract::When prescribing drugs for children, it is fundamental to acknowledge that they are distinct from adults with a different physiology and metabolism. They are also still maturing. The development of drugs with a primarily paediatric indication thus requires the trialling of these drugs in a paediatric population to ass...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/adc.2004.059378

    authors: Prasad S

    更新日期:2005-02-01 00:00:00

  • Should hepatitis B surface antigen positive mothers breast feed?

    abstract::Breast fed infants may be at greater risk of mother to infant hepatitis B virus infection compared with formula fed infants. We studied 85 infants born to 84 hepatitis B surface antigen positive mothers (only two of whom were hepatitis B e positive), and who had received immunisation against hepatitis B virus. Our res...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.60.10.972

    authors: de Martino M,Appendino C,Resti M,Rossi ME,Muccioli AT,Vierucci A

    更新日期:1985-10-01 00:00:00

  • Radiological abnormalities in infants with urinary tract infections.

    abstract::An intravenous urogram and micturating cystourethrogram were carried out in 100 infants presenting with documented urinary tract infections. Ninety three cases were identified by suprapubic aspiration and 7 by culture of two voided urine samples containing greater than 100 X 10(6) organisms per litre. The urinary trac...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.59.7.620

    authors: Bourchier D,Abbott GD,Maling TM

    更新日期:1984-07-01 00:00:00

  • Intrauterine supraventricular tachyarrhythmias and transplacental digitalisation.

    abstract::Six newborn infants with intrauterine supraventricular tachyarrhythmias (five cases of atrial flutter and one of supraventricular tachycardia) are described. Transplacental digitalisation was attempted in three cases. Supraventricular tachycardia associated with hydrops fetalis, detected in a fetus at a gestation of 3...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.61.10.996

    authors: Nagashima M,Asai T,Suzuki C,Matsushima M,Ogawa A

    更新日期:1986-10-01 00:00:00

  • Pharmacokinetics of paracetamol after cardiac surgery.

    abstract::Plasma concentration was measured after rectal and nasogastric administration of paracetamol 15 mg/kg to 28 febrile children aged between 9 days to 7 years who had undergone cardiac surgery. After equivalent doses, rectal administration in neonates and children on the first postoperative day was found to produce plasm...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章

    doi:10.1136/adc.65.9.971

    authors: Hopkins CS,Underhill S,Booker PD

    更新日期:1990-09-01 00:00:00

  • Long term outcome of ventilated asthmatics.

    abstract::Over a 25 year period, 31 asthmatic children received artificial ventilation for acute asthma at Alder Hey Children's Hospital on 48 occasions. Altogether 47 episodes occurred from 1971-89, with no decline in the number of episodes per year (mean 2.5) over this period. Eight children died during intermittent positive ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.65.12.1324

    authors: Seddon PC,Heaf DP

    更新日期:1990-12-01 00:00:00

  • Sonographic long-term study: paediatric growth charts for single kidneys.

    abstract:AIMS:To explore the clinical course of children with "single kidney" (defined as either a solitary or single functioning kidney) with reference to renal function (glomerular filtration rate (GFR) and proteinuria), body height and particularly sonomorphological features. PATIENTS AND METHODS:This retrospective monocent...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2008.153601

    authors: Spira EM,Jacobi C,Frankenschmidt A,Pohl M,von Schnakenburg C

    更新日期:2009-09-01 00:00:00

  • Value of cystography in urinary tract infections.

    abstract::Fifty-one children with a bacteriologically proven urinary tract infection had both an intravenous urogram (IVU) and a micturating cystogram. The IVU was normal in 35. Only 6 of these children showed reflux in the cystogram, affecting 7 of the 70 ureters at risk. Since reflux on its own does not cause renal damage, wh...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.51.11.893

    authors: Moncrieff MW,Whitelaw R

    更新日期:1976-11-01 00:00:00