Abstract:
:Histological examination of the breasts of 26 infants and young children who died suddenly between the ages of 3 weeks and 2 years was performed. The glands were composed of well formed lobules surrounded by dense interlobular stroma, while within the lobules there was looser connective tissue. The lobules contained ducts, many of which were dilated and contained secretions. Foci of extramedullary haematopoiesis were found, and in the older infants, fat was prominent within the connective tissue of the breast. Myoepithelial cells were regularly present. No sex differences in breast development at this time were noted. Newborn breast development did not regress rapidly after birth and secretory activity continued for many months in both sexes. This study shows that the human mammary gland remains active for many months after birth and may continue to grow and secrete. The findings are not consistent with the current view that breast development in infancy results from stimulation from 'pregnancy hormones.' It is more likely that the infant's own gonadal secretions are responsible.
journal_name
Arch Dis Childjournal_title
Archives of disease in childhoodauthors
McKiernan J,Coyne J,Cahalane Sdoi
10.1136/adc.63.2.136subject
Has Abstractpub_date
1988-02-01 00:00:00pages
136-9issue
2eissn
0003-9888issn
1468-2044journal_volume
63pub_type
杂志文章abstract::The prevalence of thyroid disease in 134 children, adolescents, and young adults with diabetes mellitus beginning in childhood is described. Clustering of a family history of thyroid disease and the presence of thyrogastric antibodies in some patients supports the concept of familial autoimmunity. In 4 children a diag...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.57.8.622
更新日期:1982-08-01 00:00:00
abstract::In 20 children needing treatment for symptomatic sick sinus syndrome, the average age at presentation was 7.1 years and ranged from 9 months to 18 years. Symptoms were never precise but, in retrospect, 5 children had syncope, 7 had a rapid heart action, 6 had dyspnoea or tachypnoea, 2 had nonspecific chest pains, 2 ha...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.50.11.879
更新日期:1975-11-01 00:00:00
abstract:OBJECTIVES:Describe cases of female genital mutilation (FGM) presenting to consultant paediatricians and sexual assault referral centres (SARCs), including demographics, medical symptoms, examination findings and outcome. DESIGN:The well-established epidemiological surveillance study performed through the British Paed...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2020-319569
更新日期:2020-10-06 00:00:00
abstract::Ten patients with biotinidase deficiency were studied. Clinical findings at presentation varied with dermatological signs (dermatitis and alopecia), neurological abnormalities (fits, hypotonia, and ataxia), and recurrent infections being the most common features, although none of these occurred in every case. Biochemi...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.63.10.1244
更新日期:1988-10-01 00:00:00
abstract:OBJECTIVE:The aim was to compare quality of life (QoL) among children and adolescents with different stages of chronic kidney disease (CKD) and determine factors associated with changes in QoL. DESIGN:Cross-sectional. SETTING:The Kids with CKD study involved five of eight paediatric nephrology units in Australia and ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究
doi:10.1136/archdischild-2018-314934
更新日期:2019-02-01 00:00:00
abstract::The development of a scale to measure perceived illness experience in young people with cancer is described. Areas of concern were first identified through semistructured interviews conducted with children and adolescents. As a result, 78 items were generated to cover the main areas identified (physical appearance, in...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.72.4.302
更新日期:1995-04-01 00:00:00
abstract::Previously, quality of formulations information provided for oral medications used in paediatric clinical trials published in 10 highly cited journals between 2002 and 2004 raised concerns. This short report explores if there was any subsequent improvement on how the formulations used in trials involving children <12 ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2009.175661
更新日期:2010-09-01 00:00:00
abstract::Circulatory adaptation was studied serially in 11 healthy term neonates on days 1, 3, and 5 by cross sectional and pulsed Doppler echocardiography. Changes in the determinants of blood viscosity (packed cell volume, plasma viscosity, red cell aggregation, and red cell deformability) were studied on day 1 and day 5. Th...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.66.4_spec_no.391
更新日期:1991-04-01 00:00:00
abstract::We describe a prospective study in which we investigated why children fail to get vaccinated against whooping cough, including an assessment of the attitudes of parents and professionals and the impact of different views of the contraindications. There was considerable disagreement among the professionals on the inter...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.61.4.382
更新日期:1986-04-01 00:00:00
abstract::Obesity is becoming a common clinical headache for child health professionals, as the increase in professional and media concern has not been matched by effective clinical solutions. Added to this is considerable confusion about both the definitions of obesity and about which groups of children and adolescents actuall...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/adc.2004.062224
更新日期:2005-04-01 00:00:00
abstract:AIM:To determine the outcome and identify predictive factors in children with psychogenic non-epileptic seizures (PNES). METHOD:The biographies of 35 children with PNES, attending a tertiary paediatric neurology centre, were reviewed. RESULTS:Thirty five children attending the department between 1987 and 1997 were ev...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.82.6.474
更新日期:2000-06-01 00:00:00
abstract::In preterm babies both haemoglobin and total neutrophil count values from capillary sites are significantly and variably higher than those from simultaneous arterial samples. Comparing simultaneous venous and arterial samples, the mean haemoglobin was slightly higher but the total neutrophil counts were similar. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.62.1.74
更新日期:1987-01-01 00:00:00
abstract::To assess the bacteriological quality of unpooled expressed breast milk, a pilot bottle sample of each donation was examined before the milk was given to the neonate. Provided the milk did not contain greater than 2500 organisms/ml or potential pathogens it was used unheated. Milk containing between 2500 and 5000 orga...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.54.10.760
更新日期:1979-10-01 00:00:00
abstract::National trends in the survival of low birthweight infants for the years 1953 to 1979 were examined. While stillbirth and day 1-28 mortality rates improved steadily throughout this period, day 0 mortality did not start to fall until the mid-1960s and then it improved in all birthweight groups. This suggests that speci...
journal_title:Archives of disease in childhood
pub_type: 历史文章,杂志文章
doi:10.1136/adc.56.2.86
更新日期:1981-02-01 00:00:00
abstract::The transport characteristics of the placenta, which favour higher phenylalanine concentrations in the fetus than in the mother, and regression data of head circumference at birth against phenylalanine concentration at conception in maternal phenylketonuria (PKU), suggest that treatment of maternal PKU should ideally ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.66.11.1346
更新日期:1991-11-01 00:00:00
abstract::Maternal transmission of hepatitis B virus infection in relation to the hepatitis B e antigen/antibody system and serum hepatitis B virus-DNA were evaluated. Results indicate that hepatitis B virus-DNA analysis can identify hepatitis B serum antigen positive mothers who may transmit infection to their offspring. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.60.1.56
更新日期:1985-01-01 00:00:00
abstract::Human immunodeficiency virus (HIV) related cancers in children are not as common and as well described as in adults. An HIV epidemic has been prevalent in Zambia since 1983-1984. To study the effect of the epidemic on the epidemiology of cancers in children a retrospective study was undertaken at the University Teachi...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.73.2.100
更新日期:1995-08-01 00:00:00
abstract:AIMS:Out-of-hospital sudden cardiac arrest (SCA) is a rare but devastating event in children and adolescents. The risk is assumed to be higher in children with congenital heart defects (CHDs) than in healthy individuals. The aim of the present study was to investigate the rate of and survival after out-of-hospital card...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2017-312621
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:To ascertain the relationship between prelacteal feeding, early formula feeding and adverse health outcomes, especially hospitalisation during the first year of life. DESIGN:Multicentre prospective cohort study. SETTING:Six hospitals across three cities in Vietnam. PATIENTS:A total of 2030 pregnant women w...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究
doi:10.1136/archdischild-2019-316937
更新日期:2020-02-01 00:00:00
abstract::The improvement in audiological testing of children post-meningitis with one retrospective and two prospective audit cycles, is described. Direct referral by telephone prior to discharge and liaison with public health colleagues resulted in an increased assessment from 50% to 99% and 89% in successive audits. The prop...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.88.11.976
更新日期:2003-11-01 00:00:00
abstract::Total DNA was estimated in the lungs of 80 fetuses and newborn infants varying in gestation from 14 weeks to term. In fetuses of appropriate weight for gestational age total lung DNA increased at a constant rate from about 35 mg at 17 weeks' gestation to 480 mg at term. The lungs of immature fetuses were heavier and c...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.56.8.601
更新日期:1981-08-01 00:00:00
abstract::The communication development in 11 children with Angelman's syndrome is described. The clinical observation that these children appear to have a greater ability with receptive rather than expressive language is investigated and these skills assessed using published communication schedules. In addition the understandi...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.69.1.148
更新日期:1993-07-01 00:00:00
abstract::Eighteen children with pneumocystis carinii pneumonia diagnosed over a period of 16 years at a children's hospital are reviewed. All had an underlying disease, either congenital immunodeficiency or a malignancy. 15 patients were treated, 10 with pentamidine isethionate alone, 2 with both pentamidine and co-trimoxazole...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.52.4.314
更新日期:1977-04-01 00:00:00
abstract::Twenty-one babies of 34-41 weeks' gestational age with birth asphyxia (5 minute Apgar score less than or equal to 5 or umbilical artery pH less than or equal to 7.2) were studied during the first two days of life to find out whether the urinary excretion of tubular markers of renal function is of value in the early di...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.65.10_spec_no.1021
更新日期:1990-10-01 00:00:00
abstract::Seven children with precocious puberty were treated with cyproterone acetate and their adrenal function studied. In each child the drug caused significant adrenal hypofunction which was secondary to adrenocorticotrophic hormone suppression. None of these children had clinical evidence of adrenal hypofunction and it is...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.56.3.218
更新日期:1981-03-01 00:00:00
abstract:OBJECTIVES:To develop and validate a new allergy-specific patient-reported experience measure (PREM) for children and their parents, and to collect feedback in an integrated care setting. DESIGN:Two allergy-specific PREMs were produced using focus groups, cognitive testing, two prospective validation studies (collabor...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2015-309598
更新日期:2016-10-01 00:00:00
abstract::Ten intubated neonates (weights 0.90 to 2.58 kg) recovering from respiratory disease had lung mechanics, respiratory patterns, and functional residual capacity measured at 0 cmH2O continuous positive airways pressure and then after application of serially increasing levels of external expiratory resistance. At an exte...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.56.11.869
更新日期:1981-11-01 00:00:00
abstract::Two infants presented with a salt-losing syndrome, the presenting features of which were subtle. One case appeared to be transient. Deficient production of aldosterone was shown by plasma renin activity and plasma aldosterone profile. Gas chromatography-mass spectrometry of urine indicated a defect in 18-dehydrogenati...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.52.7.580
更新日期:1977-07-01 00:00:00
abstract:BACKGROUND:Acute respiratory infections (ARI) cause 3 million deaths in children worldwide each year. Most of these deaths occur from pneumonia in developing countries, and hypoxaemia is the most common fatal complication. Simple and adaptable indications for oxygen therapy are important in the management of ARI. The c...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/adc.2008.138362
更新日期:2009-01-01 00:00:00
abstract::New charts for height, weight, height velocity, and weight velocity are presented for clinical (as opposed to population survey) use. They are based on longitudinal-type growth curves, using the same data as in the British 1965 growth standards. In the velocity standards centiles are given for children who are early- ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.51.3.170
更新日期:1976-03-01 00:00:00