Childhood cancers in Zambia before and after the HIV epidemic.

Abstract:

:Human immunodeficiency virus (HIV) related cancers in children are not as common and as well described as in adults. An HIV epidemic has been prevalent in Zambia since 1983-1984. To study the effect of the epidemic on the epidemiology of cancers in children a retrospective study was undertaken at the University Teaching Hospital (UTH), Lusaka, Zambia. All the histopathological records from 1980 to 1992 were reviewed and all cases of cancers in children less than 14 years of age were analysed. In order to define the effect of the HIV epidemic, the epidemiological features of various childhood cancers occurring before (during the years 1980-1982) and after (during the years 1990-1992) the onset of the HIV epidemic were compared. A significant increase in the occurrence of total childhood cancers was found. This is mostly due to a highly significant increase in the incidence of paediatric Kaposi's sarcoma (p = 0.000016), which is causally related to HIV infection, and a significant increase in the incidence of retinoblastoma (p = 0.02), which has an unknown relation to HIV infection. Though not yet statistically significant, there has also been a gradual and sustained increase in the incidence of non-Hodgkin's lymphoma, nasopharyngeal carcinoma, and rhabdomyosarcoma. There has been a significant reduction in the incidence of Burkitt's lymphoma. A prospective in depth epidemiological study of HIV related childhood cancers in Africa is urgently needed.

journal_name

Arch Dis Child

authors

Chintu C,Athale UH,Patil PS

doi

10.1136/adc.73.2.100

subject

Has Abstract

pub_date

1995-08-01 00:00:00

pages

100-4; discussion 104-5

issue

2

eissn

0003-9888

issn

1468-2044

journal_volume

73

pub_type

杂志文章
  • Standards for the predictive accuracy of short term body height and lower leg length measurements on half annual growth rates.

    abstract::Determinations of body height and calculations of growth velocity are still the major parameters for the assessment of normal and aberrant growth. The present study was performed to investigate the minimum time interval between consecutive measurements that is necessary for a statement on significant length increment ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.64.2.259

    authors: Hermanussen M,Burmeister J

    更新日期:1989-02-01 00:00:00

  • Maternal phenylketonuria: abnormal baby despite low phenylalanine diet during pregnancy.

    abstract::During a screening programme of 10000 pregnant women by the Guthrie test, a previously unrecognised phenylketonuric woman was detected. A low phenylalanine diet introduced from the 16th week of gestation failed to prevent fetal abnormality and mental retardation. Maternal phenylketonuria requires earlier diagnosis tha...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.55.8.634

    authors: Scott TM,Fyfe WM,Hart DM

    更新日期:1980-08-01 00:00:00

  • Neonatal renal candidal bezoar.

    abstract::Renal candidal bezoar is uncommonly encountered in neonatal intensive care. An affected neonate who improved only after surgical removal of obstructive fungus from the renal pelvis and local irrigation with amphotericin B is described. The need for early consideration of surgical intervention is stressed. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.67.1_spec_no.63

    authors: Rehan VK,Davidson DC

    更新日期:1992-01-01 00:00:00

  • Quality of life of children and adolescents with chronic kidney disease: a cross-sectional study.

    abstract:OBJECTIVE:The aim was to compare quality of life (QoL) among children and adolescents with different stages of chronic kidney disease (CKD) and determine factors associated with changes in QoL. DESIGN:Cross-sectional. SETTING:The Kids with CKD study involved five of eight paediatric nephrology units in Australia and ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/archdischild-2018-314934

    authors: Francis A,Didsbury MS,van Zwieten A,Chen K,James LJ,Kim S,Howard K,Williams G,Bahat Treidel O,McTaggart S,Walker A,Mackie F,Kara T,Nassar N,Teixeira-Pinto A,Tong A,Johnson D,Craig JC,Wong G

    更新日期:2019-02-01 00:00:00

  • Measurement of social inequalities in health and use of health services among children in Northumberland.

    abstract::Social inequalities in a variety of indicators of child health were measured using a 'small area' geographical method of social classification. Cross sectional analyses of routine child health information and of a population survey of the height of primary school children were used. Social classification was by census...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.68.5.626

    authors: Reading R,Jarvis S,Openshaw S

    更新日期:1993-05-01 00:00:00

  • Diagnosis of primary human herpesvirus 6 and 7 infections in febrile infants by polymerase chain reaction.

    abstract::Primary human herpesvirus 6 (HHV-6) and 7 (HHV-7) infections were identified in febrile children by qualitative and quantitative polymerase chain reaction (PCR) assays. Diagnosis was based on the differential detection of viral DNA in peripheral blood mononuclear cells (PBMC), but not in saliva. Six of 41 febrile infa...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.77.1.42

    authors: Clark DA,Kidd IM,Collingham KE,Tarlow M,Ayeni T,Riordan A,Griffiths PD,Emery VC,Pillay D

    更新日期:1997-07-01 00:00:00

  • Rapid diagnosis of glucocorticoid suppressible hyperaldosteronism in infants and adolescents.

    abstract::Glucocorticoid suppressible hyperaldosteronism (GSH) is an uncommon form of dominantly inherited hypertension. Presentation with hypertension and complications such as stroke in early life are well recognised. The use of a simple genetic test carried out on blood or placenta facilitates the detection of infants and ch...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.71.1.40

    authors: Jamieson A,Inglis GC,Campbell M,Fraser R,Connell JM

    更新日期:1994-07-01 00:00:00

  • Inequalities in provision of the Disability Living Allowance for Down syndrome.

    abstract:OBJECTIVES:To assess factors associated with granting of the Disability Living Allowance (DLA) for Down syndrome. DESIGN:Cross-sectional survey. SETTING:Families with a child with Down syndrome enrolled in a community-based trial of vitamin supplementation. PARTICIPANTS:156 children with trisomy 21 (59% male, 20% no...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2006.112839

    authors: Ellis J,Logan S,Pumphrey R,Tan HK,Henley W,Edwards V,Moy R,Gilbert R

    更新日期:2008-01-01 00:00:00

  • The natural history of prenatally diagnosed congenital cystic lung lesions: long-term follow-up of 119 cases.

    abstract:BACKGROUND:A paucity of evidence regarding the natural history of congenital pulmonary airway malformations (CPAMs) and pulmonary sequestration (PS) has resulted in a divergence in management strategy of asymptomatic cases. METHODS:We describe the long-term clinical course of 119 children diagnosed with these lesions ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2016-311233

    authors: Cook J,Chitty LS,De Coppi P,Ashworth M,Wallis C

    更新日期:2017-09-01 00:00:00

  • Facilities for the school health team.

    abstract::Results of a questionnaire returned by 20 doctors giving information of 249 schools showed that many of the rooms made available to school health services are inadequate in terms of physical resources and privacy. A higher set of standards is recommended to enable schools and pupils to derive maximum benefit from comm...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.70.6.542

    authors: Henshelwood J,Polnay L

    更新日期:1994-06-01 00:00:00

  • Growth and nutrition in children with ataxia telangiectasia.

    abstract:BACKGROUND:Ataxia telangiectasia (A-T) is a rare multisystem disease with high early mortality from lung disease and cancer. Nutritional failure adversely impacts outcomes in many respiratory diseases. Several factors influence nutrition in children with A-T. We hypothesised that children with A-T have progressive grow...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2015-310373

    authors: Stewart E,Prayle AP,Tooke A,Pasalodos S,Suri M,Bush A,Bhatt JM

    更新日期:2016-12-01 00:00:00

  • Impact of age and drug resistance on mortality in typhoid fever.

    abstract::The risk factors for mortality were analysed in a consecutive group of 1158 children presenting to the Aga Khan University Medical Center, Karachi, with multidrug resistant typhoid fever that had been proved on culture. There were 19 deaths, representing an overall case fatality rate of 1.6%. Multidrug resistant typho...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.75.3.214

    authors: Bhutta ZA

    更新日期:1996-09-01 00:00:00

  • Incubation of very immature infants.

    abstract::The range of thermal control and the thermoneutral range of preterm infants under 30 weeks' gestation was calculated by extrapolation of data from studies on more mature infants. Even assuming some thermoregulatory capacity, the range of control is less than 3 degrees C, the thermoneutral range is less than 0.5 degree...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.58.7.504

    authors: Wheldon AE,Hull D

    更新日期:1983-07-01 00:00:00

  • Caregiver experiences of racism and child healthcare utilisation: cross-sectional analysis from New Zealand.

    abstract:OBJECTIVES:Children's exposure to racism via caregiver experience (vicarious racism) is associated with poorer health and development. However, the relationship with child healthcare utilisation is unknown. We aimed to investigate (1) the prevalence of vicarious racism by child ethnicity; (2) the association between ca...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2017-313866

    authors: Paine SJ,Harris R,Stanley J,Cormack D

    更新日期:2018-09-01 00:00:00

  • Is there a role for treatment of asthma with omalizumab?

    abstract::The allergic response is distinct from other immune reactions in its reliance on IgE, its high affinity receptor, Fc epsilon RI, and the primary effector cell--the tissue mast cell. Positive skin tests or raised concentrations of specific immunoglobulin E (IgE) in the serum define IgE sensitisation or "atopy". IgE par...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/adc.88.1.71

    authors: Milgrom H

    更新日期:2003-01-01 00:00:00

  • Social adversities and anxiety disorders in the Gaza Strip.

    abstract:AIM:To investigate the rate and nature of anxiety symptoms and disorders in children, and their relation to social adversities in a cultural sample not previously researched. METHODS:237 children aged 9 to 13 years living in the Gaza Strip were selected randomly from 112 schools. Children completed the revised manifes...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.78.5.439

    authors: Thabet AA,Vostanis P

    更新日期:1998-05-01 00:00:00

  • Outcome in congenital stridor (laryngomalacia).

    abstract::Twenty-one children who had been diagnosed as having laryngomalacia by direct laryngoscopy in infancy were reviewed 7 to 12 years later. The natural history of the disease is documented. A wide variation in the time of onset and duration of the stridor was found and there was a high incidence of feeding difficulties. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.52.3.215

    authors: McSwiney PF,Cavanagh NP,Languth P

    更新日期:1977-03-01 00:00:00

  • Paediatric emergency department anaphylaxis: different patterns from adults.

    abstract:BACKGROUND AND AIMS:Data on acute paediatric anaphylaxis presentations to the emergency department (ED) are limited. All allergic presentations to one Australian paediatric ED were studied to determine epidemiological, clinical, and outcome data. METHODS:Retrospective, case based study of patients under 16 years atten...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2004.069914

    authors: Braganza SC,Acworth JP,Mckinnon DR,Peake JE,Brown AF

    更新日期:2006-02-01 00:00:00

  • Renal scarring after acute pyelonephritis.

    abstract::Seventy six children, 18 boys and 58 girls, aged 0-15.9 (median 1.0) years, with acute pyelonephritis were prospectively studied with a technetium-99m dimercaptosuccinic acid (DMSA) scan during infection and two months later. Fifty nine of these children were also studied two years after the infection. Seventeen child...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.70.2.111

    authors: Jakobsson B,Berg U,Svensson L

    更新日期:1994-02-01 00:00:00

  • The fifth UK paediatric diabetes services survey: meeting guidelines and recommendations?

    abstract:AIM:To assess the provision of UK paediatric and adolescent diabetes services and examine changes in service delivery since 2002. METHOD:Questionnaires were sent to the lead paediatric consultant from all paediatric and adolescent diabetes services (n=205). Questions were based on National Institute for Health and Cli...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/adc.2009.176925

    authors: Gosden C,Edge JA,Holt RI,James J,Turner B,Winocour P,Walton C,Nagi D,Williams R,Matyka K

    更新日期:2010-10-01 00:00:00

  • Initial evaluation of congenital hypothyroidism: a survey of general paediatricians in East Anglia.

    abstract::The practice of general paediatricians in the initial evaluation of congenital hypothyroidism (CHT) was assessed. This was performed by a questionnaire survey of paediatricians in East Anglia of whom 84% responded. Nineteen of 25 clinicians based in seven district hospitals managed children with CHT. The median number...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.77.4.339

    authors: Ahmed SF,Barnes ND,Hughes IA

    更新日期:1997-10-01 00:00:00

  • Cardiovascular abnormalities in end stage renal failure: the effect of anaemia or uraemia?

    abstract::Children with end stage renal failure and anaemia have an increased cardiac index and often gross ventricular hypertrophy. Correction of anaemia with recombinant human erythropoietin (r-HuEpo) for less than six months results in a reduction in the cardiac index without a significant reduction in left ventricular hyper...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.71.2.119

    authors: Morris KP,Skinner JR,Hunter S,Coulthard MG

    更新日期:1994-08-01 00:00:00

  • Ultrastructural abnormalities of bronchial cilia in children with recurrent airway infections and bronchiectasis.

    abstract::Anomalies of the bronchial cilia were studied in 5 children with recurrent pulmonary infections. Case 1 had Kartagener's syndrome and an absence of the inner and outer dynein arms in most cilia, although a few shortened and even some normal arms could be seen. Cases 2 and 3 had unilateral bronchiectasis without family...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.56.12.929

    authors: Corbeel L,Cornillie F,Lauweryns J,Boel M,van den Berghe G

    更新日期:1981-12-01 00:00:00

  • Vitamin D metabolites in idiopathic infantile hypercalcaemia.

    abstract::Metabolites of vitamin D were measured in plasma from 83 patients with idiopathic infantile hypercalcaemia syndrome who were mentally handicapped but had normal calcium values at the time of the study. No significant difference was detected in the mean plasma concentrations of 25-hydroxyvitamin D2, 1,25-dihydroxyvitam...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.60.12.1140

    authors: Martin ND,Snodgrass GJ,Cohen RD,Porteous CE,Coldwell RD,Trafford DJ,Makin HL

    更新日期:1985-12-01 00:00:00

  • MELATONIN - WORKING IN COLLABERATION WITH THE CCG TO REDUCE COSTS.

    abstract:AIM:To reduce the overall expenditure on melatonin for the local health economy by working collaboratively with the CCG's. To ensure that all paediatric patients prescribed melatonin have been clinically assessed by a specialist and the most appropriate formulation is dispensed. METHOD:Evaluation of GP melatonin presc...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2016-311535.49

    authors: Haley H

    更新日期:2016-09-01 00:00:00

  • Female genital mutilation: what every paediatrician should know.

    abstract::Female genital mutilation (FGM) is almost always performed on children and consequently paediatricians should have a central role in the detection and prevention of FGM. FGM has no health benefits and can cause lifelong damage to physical and psychological health. Extensive migration of FGM practising communities mean...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/archdischild-2014-307234

    authors: Creighton SM,Hodes D

    更新日期:2016-03-01 00:00:00

  • Relationship between the chest radiograph, regional lung function studies, exercise tolerance, and clinical condition in cystic fibrosis.

    abstract::This study evaluated the accuracy of the interpretation of the chest film in delineating localised abnormalities of ventilation and perfusion, as well as the overall severity of airways obstruction, exercise tolerance, and clinical condition in children with cystic fibrosis. Radiographic findings in various regions of...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.56.2.106

    authors: Coates AL,Boyce P,Shaw DG,Godfrey S,Mearns M

    更新日期:1981-02-01 00:00:00

  • Why do children hospitalised with pneumonia not receive antibiotics in primary care?

    abstract:BACKGROUND:Although antibiotics are recommended for the primary care management of community-acquired pneumonia, a recent UK study reported that most children admitted to hospital had not received antibiotics. OBJECTIVE:To describe primary care antibiotic use for children subsequently hospitalised with community-acqui...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2011-300604

    authors: Grant CC,Harnden A,Mant D,Emery D,Coster G

    更新日期:2012-01-01 00:00:00

  • Interstitial nephritis of acute onset.

    abstract::Interstitial nephritis was diagnosed at renal biopsy in 10 previously healthy children. All had identical clinical symptoms: anaemia, raised sedimentation rate, low glomerular filtration rate, protein and leucocytes in the urine, but no bacteria; nine also had glycosuria. Six of the children had a history of recent in...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.60.8.752

    authors: Koskimies O,Holmberg C

    更新日期:1985-08-01 00:00:00

  • Effect of bacterial filters on spirometry measurements.

    abstract::Lung function measurements with and without a disposable bacterial filter were compared in 60 children. Although statistically significant, the reduction of lung function measurements caused by using bacterial filters was small and clinically irrelevant (2-4% of predicted for forced expiratory volume in one second and...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.85.4.346

    authors: Kamps AW,Vermeer K,Roorda RJ,Brand PL

    更新日期:2001-10-01 00:00:00