Abstract：
BACKGROUND:A paucity of evidence regarding the natural history of congenital pulmonary airway malformations (CPAMs) and pulmonary sequestration (PS) has resulted in a divergence in management strategy of asymptomatic cases. METHODS:We describe the long-term clinical course of 119 children diagnosed with these lesions treated at Great Ormond Street Hospital (GOSH). Cases were identified via the GOSH patient database. Study entry required the identification of a cystic lung lesion on prenatal ultrasound and confirmation of CPAM/PS on postnatal CT imaging. Patients followed up for at least 5 years were included. RESULTS:51 (43%) patients were managed surgically; 8 (6.7%) as an emergency during the neonatal period, 6 (5.1%) electively due to concerning features on CT scan, 20 (17%) following medical advice, 1 (0.8%) following a severe respiratory infection and in 5 (4.2%) the indication was unclear. The indication in 11 (9.2%) was recurrent respiratory infection and median age at surgery was 1.6 years (range 0.4 to 4.6 years). No cases of malignancy were identified on histological examination of resected lesions. 68 (57%) patients were managed conservatively for a median period of 9.9 years (range 5.2 years to 18 years). Seven (10%) were discharged, one was followed-up elsewhere (1.5%) and eight (11%) were lost to follow-up. In four patients (5.9%), the lesion resolved spontaneously. 52 (76%) continue to be followed-up and remain asymptomatic. CONCLUSIONS:This is one of the largest case series documenting the natural history of CPAMs and PS following a prenatal diagnosis and demonstrates that conservative management is a reasonable option in selected cases.
journal_name
Arch Dis Childjournal_title
Archives of disease in childhoodauthors
Cook J,Chitty LS,De Coppi P,Ashworth M,Wallis Cdoi
10.1136/archdischild-2016-311233subject
Has Abstractpub_date
2017-09-01 00:00:00pages
798-803issue
9eissn
0003-9888issn
1468-2044pii
archdischild-2016-311233journal_volume
102pub_type
杂志文章abstract：:Acute viral respiratory illness during infancy has been implicated as a precursor for subsequent lower respiratory morbidity in childhood. A prospective, longitudinal study of respiratory function, airway responsiveness, and lower respiratory illness during early childhood was performed in a cohort of 253 healthy infa...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.72.1.16
更新日期：1995-01-01 00:00:00
abstract：OBJECTIVE:To ascertain mortality from 1 to 18 years, and predictors of mortality. DESIGN:Long-term follow-up of population cohort born 1989-1992. SETTING:Births in South East Thames Region. PATIENTS:346 children with bilateral cerebral palsy (CP). INTERVENTIONS:Not applicable. MAIN OUTCOME MEASURES:Mortality; pred...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.2009.172841
更新日期：2011-11-01 00:00:00
abstract：AIM:To compare the growth patterns of breast fed and formula fed Italian infants in the first 12 months of life using World Health Organisation (WHO) reference data. METHODS:The growth patterns of 73 breast fed infants (36 male, 37 female) and 65 formula fed infants (35 male, 30 female) were compared. Solid foods were...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.81.5.395
更新日期：1999-11-01 00:00:00
abstract：:In a multicentre study on perinatal HIV-I infection including 1493 children born from 1471 pregnancies to 1415 infected mothers, 22 twin pairs and 56 sibships (115 children) were recorded. The frequency of twin pregnancies was 1.5 (22/1471) and 3.9% (56/1415) seropositive women had more than one at risk pregnancy. In ...
journal_title：Archives of disease in childhood
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1136/adc.66.10.1235
更新日期：1991-10-01 00:00:00
abstract：OBJECTIVE:This study aimed to determine the glycaemic profile of patients with cystic fibrosis using a continuous glucose monitoring system (CGMS), and to evaluate the associations of glycaemic abnormalities with sex, age, pubertal stage, CFTR gene mutations, nutritional status, lung function, oral glucose tolerance te...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/archdischild-2017-314250
更新日期：2018-06-01 00:00:00
abstract：:In a newborn baby, suffering from persistent severe hypoglycaemia with convulsions glucagon deficiency was shown. Treatment with zinc-protamine-glucagon injection twice daily resulted in normal blood glucose levels. Motor development is delayed. ...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.53.5.422
更新日期：1978-05-01 00:00:00
abstract：:All 212 neonates undergoing cardiac surgery at this hospital during the 5-year period from 1976 to 1980 inclusive were reviewed. Forty required open heart surgery with 23 (57%) deaths. One hundred and seventy-four neonates underwent non-bypass procedures and could be divided into three groups: group 1 (82 patients) ha...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.58.2.137
更新日期：1983-02-01 00:00:00
abstract：:Three of five children who were born to consanguineous parents developed Guillain-Barré syndrome before they were 3 years old. The syndrome is rare in early childhood and we suggest that there may be a genetic element in the pathogenesis. ...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.66.9.1078
更新日期：1991-09-01 00:00:00
abstract：OBJECTIVE:To determine the sensitivity of differential avian and human delayed-type hypersensitivity skin testing in the diagnosis of non-tuberculous mycobacterial lymphadenitis. METHOD:Retrospective review of all patients with culture proved non-tuberculous mycobacterial lymph node infections who also had differentia...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.80.4.377
更新日期：1999-04-01 00:00:00
abstract：:A questionnaire study regarding airway morbidity in children and environmental factors was performed in April 1985. The parents of 5301 children, aged 6 months to 16 years, from different rural areas in mid Sweden were sent a validated questionnaire and 4990 (94%) responded. The cumulative prevalence of bronchial hype...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.63.5.473
更新日期：1988-05-01 00:00:00
abstract：AIM:Ketamine is used for post-operative analgesia. There has been recent disruption in it's supply. It is usually prescribed by patient's weight (3 mg/kg in 50 ml 0.9% saline) at a rate of 1-5 ml/hr (1-5 microgram/kg/minute). To conserve ketamine supplies our policy was changed to a concentrated "standardised" concentr...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/archdischild-2016-311535.12
更新日期：2016-09-01 00:00:00
abstract：:Concerns have been expressed in recent years about the decline in children's clinical and biomedical research in the UK, and in the paediatric academic workforce. Here I consider the extent to which these concerns are justified, the sweeping changes that have taken place in research funding, governance and organisatio...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.2009.178160
更新日期：2010-11-01 00:00:00
abstract：:Non-accidental injury should be suspected and excluded in any infant found to have intracranial and retinal haemorrhage of unknown aetiology. This can be a sensitive issue for both medical staff and parents. We present a case in which the underlying cause of intracranial and retinal haemorrhage was fibromuscular dyspl...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.84.3.263
更新日期：2001-03-01 00:00:00
abstract：:The recent epidemic of childhood obesity(1) has raised concern because of the possible clinical and public health consequences.(2,)(3) However, there remains a widespread perception among health professionals that childhood obesity is a largely cosmetic problem, with minor clinical effects. No systematic review has ye...
journal_title：Archives of disease in childhood
pub_type： 杂志文章,meta分析,评审
doi：10.1136/adc.88.9.748
更新日期：2003-09-01 00:00:00
abstract：:Two neonates with spontaneous rupture of the bladder and an otherwise normal genitourinary tract are described. Conservative management resulted in complete resolution of the lesion in one but the other child died from a coliform septicaemia. Necropsy showed a discrete ischaemic lesion in the fundus of the bladder. ...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.60.7.676
更新日期：1985-07-01 00:00:00
abstract：:Psychotropic medication use by children in the USA has increased. We used the IMS MIDAS Prescribing Insights to examine prescribing trends in nine countries between the years 2000 and 2002. Trends in seven countries rose significantly from year 2000 to 2002; the UK had the highest increase (68%). ...
journal_title：Archives of disease in childhood
pub_type： 杂志文章,多中心研究
doi：10.1136/adc.2004.050468
更新日期：2004-12-01 00:00:00
abstract：:In 20 children needing treatment for symptomatic sick sinus syndrome, the average age at presentation was 7.1 years and ranged from 9 months to 18 years. Symptoms were never precise but, in retrospect, 5 children had syncope, 7 had a rapid heart action, 6 had dyspnoea or tachypnoea, 2 had nonspecific chest pains, 2 ha...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.50.11.879
更新日期：1975-11-01 00:00:00
abstract：BACKGROUND:Primary school children in low-income countries are at risk of many diseases and poor health affects attendance, cognition and ability to learn. Developing school health and nutrition strategies has been extensively highlighted as a global priority, with a particular focus on complex programme design. Howeve...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/archdischild-2016-311605
更新日期：2017-09-01 00:00:00
abstract：:This pilot study investigated the feasibility of surveying, anonymously, HCV infection among healthy children using an oral fluid specimen. Seventy seven per cent of children provided their assent, or where appropriate, consent to participate; 2.8% were anti-HCV positive. Oral fluid collection is acceptable to childre...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.2003.031310
更新日期：2004-02-01 00:00:00
abstract：:Data from the Glasgow Register of Congenital Malformations were used to investigate the epidemiology of congenital facial clefts over the period 1974-85. Facial clefts were registered in 247 infants representing a prevalence of 1.56 per 1000 total births. Cleft palate was more common than cleft lip, with cleft lip and...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.62.7.717
更新日期：1987-07-01 00:00:00
abstract：:The clinical response to sodium cromoglycate treatment was compared with its concentration in serum. Twenty five children with asthma entered a 10 week trial of two baseline weeks followed by eight weeks of treatment by the inhalation of 20 mg of sodium cromoglycate spincaps four times a day. Individual clinical respo...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.63.6.592
更新日期：1988-06-01 00:00:00
abstract：:We describe a 21 month old male infant who presented with failure to thrive associated with severe hypokalaemia and metabolic acidosis, together with hypomagnesaemia. Evaluation revealed marked renal and probable faecal potassium wasting, distal renal tubular acidosis, mild urinary magnesium wasting, and a normal gast...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.84.6.504
更新日期：2001-06-01 00:00:00
abstract：:In a study of 256 families, among whom were twins, midparent-adult son correlations for height, weight, and combined skinfold measurements were 0.67, 0.47, and 0.23 respectively. The corresponding midparent-adult daughter correlations were 0.63, 0.42, and 0.24. Midparent-growing offspring correlations were highest for...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.54.11.877
更新日期：1979-11-01 00:00:00
abstract：:1 case study and a clinical study with laboratory rats examined the question of breast milk jaundice. The case study confirmed clinical diagnosis of breast milk jaundice. The clinical study compared the effects of breast milk and 3alpha, 20beta-pregnanediol on the conjugation of bilirubin and o-aminophenol by rat li...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.46.246.195
更新日期：1971-04-01 00:00:00
abstract：OBJECTIVE:Assays based on interferon gamma (IFNgamma) are an exciting new development for screening for latent tuberculosis infection (LTBI) in adults, but there are limited data on their effectiveness in children. Nevertheless new National Institute for Health and Clinical Excellence (NICE) guidelines recommend their ...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.2006.106617
更新日期：2008-03-01 00:00:00
abstract：:Experience gained from liver studies in 450 patients with cystic fibrosis, seen in a 38 year period from 1964 to 1992, is surveyed. Of these, 31 (7%) showed findings that indicated multilobular cirrhosis. There was a slight but not significant male predominance: 19 males against 12 females. Liver disease had its onset...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.68.5.653
更新日期：1993-05-01 00:00:00
abstract：:No consistent differences were found in mean heights and weights of 170 schoolchildren aged 6--12 years with the sickle cell trait and 1247 schoolchildren with normal haemoglobin living in Dominica and Jamaica. ...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.53.7.596
更新日期：1978-07-01 00:00:00
abstract：AIM:To determine the outcome and identify predictive factors in children with psychogenic non-epileptic seizures (PNES). METHOD:The biographies of 35 children with PNES, attending a tertiary paediatric neurology centre, were reviewed. RESULTS:Thirty five children attending the department between 1987 and 1997 were ev...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.82.6.474
更新日期：2000-06-01 00:00:00
abstract：:24 Hour ambulatory blood pressure monitoring (ABPM) was performed to provide data on the normal daily blood pressure of healthy schoolchildren and on patients with hypertension. The subjects studied were 123 healthy schoolchildren with a mean (SD) age of 12.5 (1.6) years (range 9.5-14.5 years), 24 children with border...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.70.2.90
更新日期：1994-02-01 00:00:00
abstract：:Reflection has become established as a key principle underpinning maintenance of standards within professional education and practice. A requirement to evidence reflection within performance review is intended to develop a transformative approach to practice, identify developmental goals, and ultimately, improve healt...
journal_title：Archives of disease in childhood
pub_type： 杂志文章,评审
doi：10.1136/archdischild-2013-303948
更新日期：2014-03-01 00:00:00
