Abstract:
:Concerns have been expressed in recent years about the decline in children's clinical and biomedical research in the UK, and in the paediatric academic workforce. Here I consider the extent to which these concerns are justified, the sweeping changes that have taken place in research funding, governance and organisation, and necessary action to take.
journal_name
Arch Dis Childjournal_title
Archives of disease in childhoodauthors
Modi Ndoi
10.1136/adc.2009.178160subject
Has Abstractpub_date
2010-11-01 00:00:00pages
941-4issue
11eissn
0003-9888issn
1468-2044pii
adc.2009.178160journal_volume
95pub_type
杂志文章abstract::Partial splenectomy was performed on 30 patients with homozygous beta thalassaemia to reduce blood requirements and to avoid the risk of overwhelming postsplenectomy infections; 24 patients had thalassaemia major and six thalassaemia intermedia. Five patients received a high transfusion regimen before and after surger...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.65.3.304
更新日期:1990-03-01 00:00:00
abstract::349 Maasai children younger than 6 years old were randomised by alternate household to drink water either left in plastic bottles exposed to sunlight on the roof of the house or kept indoors (control). The trial was run in Maasai by Maasai community elders. Children drinking solar disinfected water had a significantly...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/adc.81.4.337
更新日期:1999-10-01 00:00:00
abstract::Determinations of body height and calculations of growth velocity are still the major parameters for the assessment of normal and aberrant growth. The present study was performed to investigate the minimum time interval between consecutive measurements that is necessary for a statement on significant length increment ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.64.2.259
更新日期:1989-02-01 00:00:00
abstract::Twenty-one children who had been diagnosed as having laryngomalacia by direct laryngoscopy in infancy were reviewed 7 to 12 years later. The natural history of the disease is documented. A wide variation in the time of onset and duration of the stridor was found and there was a high incidence of feeding difficulties. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.52.3.215
更新日期:1977-03-01 00:00:00
abstract:OBJECTIVE:To investigate whether school readiness could be affected by placing electronic devices (EDs) in children's bedroom and whether the relationship was moderated by parental restriction and family socioeconomic status (SES). DESIGN:This is a cross-sectional study with bedroom ED placement and parental restricti...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2017-312639
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVE:To elucidate the current situation of randomised drug trials involving the paediatric population. METHODS:Systematic review of paediatric randomised controlled trials of medicinal products published in 2007. Three major databases were searched with validated search strategies; Medline, Embase and Cochrane Ce...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/adc.2009.173591
更新日期:2010-06-01 00:00:00
abstract:AIMS:To examine short term and long term health related quality of life (HRQoL) of survivors of congenital anorectal malformations (ARM) and congenital diaphragmatic hernia (CDH), and to compare these patients' HRQoL with that of the general population. METHODS:HRQoL was measured in 286 ARM patients and 111 CDH patien...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2002.016543
更新日期:2004-09-01 00:00:00
abstract::A special conditions register (SCR) linked to the child health system's register of all children has been in use in West Sussex since 1977. This paper describes the aims, organisation, and use of the SCR and gives examples of the aggregated data that may be obtained. Of the 155,000 children aged 0-17 resident in West ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.66.8.927
更新日期:1991-08-01 00:00:00
abstract::Eighteen children suffering from hay fever were treated with intra-nasal beclomethasone dipropionate (400 mug/day) and an identical placebo aerosol in a double-blind cross-over trial. 17 of the children preferred the intranasal beclomethasone dipropionate, one had no preference, none preferred the placebo. The effect ...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/adc.50.11.875
更新日期:1975-11-01 00:00:00
abstract::Thyroid function was studied in 54 low birthweight infants during a 3-week period. Each infant was placed in one of three groups. Group 1 (n = 21), infants who were well and appropriately grown fro gestational age; group 2 (n = 23), infants who were appropriately grown but who had hyaline membrane disease; group 3 (n ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.56.3.214
更新日期:1981-03-01 00:00:00
abstract:AIMS:To ascertain whether the reduction in nasopharyngeal carriage of vaccine serotypes induced by pneumococcal conjugate vaccine (PnCV) administered to infants persists beyond the age of 2 years. METHODS:Non-randomised, unblinded controlled study of 2-5 year old children who had received three doses of heptavalent Pn...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章
doi:10.1136/adc.88.3.211
更新日期:2003-03-01 00:00:00
abstract::Reflection has become established as a key principle underpinning maintenance of standards within professional education and practice. A requirement to evidence reflection within performance review is intended to develop a transformative approach to practice, identify developmental goals, and ultimately, improve healt...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/archdischild-2013-303948
更新日期:2014-03-01 00:00:00
abstract:AIMS:To investigate the differences in perception of quality of life between parents of chronically ill children and paediatricians at diagnosis and follow up. Quality of life was assessed using the (HUI3). METHODS:Longitudinal study (July 1999-January 2002) of 37 paediatricians and 181 parents of patients (children a...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2004.051722
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVES:To describe common patterns of bath water scald injuries in children, to examine differences between accidental and non-accidental bath water scalds in children, and to examine potential for prevention. DESIGN:A two year six month retrospective analysis of admissions to a specialist burns unit. SETTING:The...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.71.2.156
更新日期:1994-08-01 00:00:00
abstract::Interstitial nephritis was diagnosed at renal biopsy in 10 previously healthy children. All had identical clinical symptoms: anaemia, raised sedimentation rate, low glomerular filtration rate, protein and leucocytes in the urine, but no bacteria; nine also had glycosuria. Six of the children had a history of recent in...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.60.8.752
更新日期:1985-08-01 00:00:00
abstract:OBJECTIVE:There is limited information on the psychosocial impact of growing up with Silver-Russell syndrome (SRS), characterised by slow growth in utero leading to short stature in adulthood. Such information could aid families in making difficult treatment decisions and guide management strategies for health professi...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2018-314952
更新日期:2019-01-01 00:00:00
abstract::The study of gastric emptying in the preterm infant has been hampered by the absence of a suitable, valid technique. We have evaluated gastric antral clearance using serial ultrasonic measurement of the antral cross sectional area (ACSA). The study was easy to perform, providing successful results in 15 of 17 low birt...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.69.1_spec_no.32
更新日期:1993-07-01 00:00:00
abstract:BACKGROUND:The number of children admitted to hospital is increasing year on year, with very short-stay admissions doubling in the last decade. Childhood head injury accounts for half a million emergency department attendances in the UK every year. The National Institute for Health and Care Excellence (NICE) has issued...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2015-308615
更新日期:2015-12-01 00:00:00
abstract::A 9 year old girl presented with clinical manifestations of Henoch-Schönlein syndrome and macroscopic haematuria. Laboratory investigations showed selective IgA deficiency and renal biopsy showed mesangial proliferative glomerulonephritis with diffuse granular deposits of C3 on immunofluorescence. IgA deposits were ab...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.60.2.160
更新日期:1985-02-01 00:00:00
abstract::The recent epidemic of childhood obesity(1) has raised concern because of the possible clinical and public health consequences.(2,)(3) However, there remains a widespread perception among health professionals that childhood obesity is a largely cosmetic problem, with minor clinical effects. No systematic review has ye...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,meta分析,评审
doi:10.1136/adc.88.9.748
更新日期:2003-09-01 00:00:00
abstract::The allergic response is distinct from other immune reactions in its reliance on IgE, its high affinity receptor, Fc epsilon RI, and the primary effector cell--the tissue mast cell. Positive skin tests or raised concentrations of specific immunoglobulin E (IgE) in the serum define IgE sensitisation or "atopy". IgE par...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/adc.88.1.71
更新日期:2003-01-01 00:00:00
abstract::A 12 year old Asian girl with a four year history of poorly controlled insulin dependent diabetes mellitus developed overt diabetic nephropathy. There were no clinical features of Rabson-Mendenhall syndrome. Screening for microalbuminuria would have identified incipient diabetic nephropathy and highlighted the importa...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.77.6.524
更新日期:1997-12-01 00:00:00
abstract::The lungs of 482 liveborn infants were examined at necropsy for the presence of intravascular lipid. Forty one patients had received parenteral feeding (including lipid emulsion in 30), and 441 had died before starting feeds or had received enteral feeds alone. Tissue was processed into wax and then stained with Sudan...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.66.1_spec_no.26
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:A tailor-made serogroup B outer membrane vesicle vaccine was evaluated in the context of a serogroup B meningococcal epidemic dominated by Neisseria meningitidis strain B:4:P1.7b,4. OBJECTIVE:To determine the safety, reactogenicity and immunogenicity in infants aged 6-8 months of a meningococcal B vaccine d...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,随机对照试验
doi:10.1136/adc.2007.132571
更新日期:2009-10-01 00:00:00
abstract::By means of a simple questionnaire and measurements of height, weight, and peak expiratory flow rates 3061 children from city and rural populations were studied. Children with asthma or other respiratory diseases had lower peak expiratory flow rates, and younger children living in rural areas had higher rates. In 2828...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.64.1.96
更新日期:1989-01-01 00:00:00
abstract::In acute paediatrics, overtreatment and overdiagnosis is encountered in threshold and developed countries. The reason for overtreatment may be similar in the two settings, namely the mere availability of invasive procedures, which may lead to their inappropriate use. Physiological healing processes should be integrate...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/adc.2007.124479
更新日期:2008-03-01 00:00:00
abstract::The recent famine in Ethiopia has resulted in the dislocation of millions of people. Many of these individuals have moved to refugee camps in Sudan or to feeding centres within Ethiopia. A total of 1325 children up to the age of 15 years were examined by an ophthalmologist in January 1985 at several sites in these two...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.61.11.1100
更新日期:1986-11-01 00:00:00
abstract::Respiratory timing was studied in 100 babies ventilated for respiratory distress syndrome (RDS) during a brief period of continuous positive airway pressure. For the 76 spontaneously breathing babies the mean (SD) inspiratory and expiratory times were 0.31 (0.06) and 0.41 (0.12) seconds. Respiratory rate was predomina...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.67.4_spec_no.446
更新日期:1992-04-01 00:00:00
abstract::Three of five children who were born to consanguineous parents developed Guillain-Barré syndrome before they were 3 years old. The syndrome is rare in early childhood and we suggest that there may be a genetic element in the pathogenesis. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.66.9.1078
更新日期:1991-09-01 00:00:00
abstract::A volumetric Doppler technique was used to measure net ductus arteriosus shunt during the first 48 hours of life in 30 infants of less than 33 weeks' gestation, and in 10 full term infants. In the full term infants a left to right shunt of 62 ml/kg/minute (95% confidence limits 43-82) shortly after birth decreased rap...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.62.10.1030
更新日期:1987-10-01 00:00:00