Promoting research for children.

Abstract:

:Concerns have been expressed in recent years about the decline in children's clinical and biomedical research in the UK, and in the paediatric academic workforce. Here I consider the extent to which these concerns are justified, the sweeping changes that have taken place in research funding, governance and organisation, and necessary action to take.

journal_name

Arch Dis Child

authors

Modi N

doi

10.1136/adc.2009.178160

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

941-4

issue

11

eissn

0003-9888

issn

1468-2044

pii

adc.2009.178160

journal_volume

95

pub_type

杂志文章
  • Partial splenectomy in homozygous beta thalassaemia.

    abstract::Partial splenectomy was performed on 30 patients with homozygous beta thalassaemia to reduce blood requirements and to avoid the risk of overwhelming postsplenectomy infections; 24 patients had thalassaemia major and six thalassaemia intermedia. Five patients received a high transfusion regimen before and after surger...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.65.3.304

    authors: de Montalembert M,Girot R,Revillon Y,Jan D,Adjrad L,Ardjoun FZ,Belhani M,Najean Y

    更新日期:1990-03-01 00:00:00

  • Solar disinfection of water reduces diarrhoeal disease: an update.

    abstract::349 Maasai children younger than 6 years old were randomised by alternate household to drink water either left in plastic bottles exposed to sunlight on the roof of the house or kept indoors (control). The trial was run in Maasai by Maasai community elders. Children drinking solar disinfected water had a significantly...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/adc.81.4.337

    authors: Conroy RM,Meegan ME,Joyce T,McGuigan K,Barnes J

    更新日期:1999-10-01 00:00:00

  • Standards for the predictive accuracy of short term body height and lower leg length measurements on half annual growth rates.

    abstract::Determinations of body height and calculations of growth velocity are still the major parameters for the assessment of normal and aberrant growth. The present study was performed to investigate the minimum time interval between consecutive measurements that is necessary for a statement on significant length increment ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.64.2.259

    authors: Hermanussen M,Burmeister J

    更新日期:1989-02-01 00:00:00

  • Outcome in congenital stridor (laryngomalacia).

    abstract::Twenty-one children who had been diagnosed as having laryngomalacia by direct laryngoscopy in infancy were reviewed 7 to 12 years later. The natural history of the disease is documented. A wide variation in the time of onset and duration of the stridor was found and there was a high incidence of feeding difficulties. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.52.3.215

    authors: McSwiney PF,Cavanagh NP,Languth P

    更新日期:1977-03-01 00:00:00

  • Parental restriction reduces the harmful effects of in-bedroom electronic devices.

    abstract:OBJECTIVE:To investigate whether school readiness could be affected by placing electronic devices (EDs) in children's bedroom and whether the relationship was moderated by parental restriction and family socioeconomic status (SES). DESIGN:This is a cross-sectional study with bedroom ED placement and parental restricti...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2017-312639

    authors: Fu KW,Ho FKW,Rao N,Jiang F,Li SL,Lee TM,Chan SH,Yung AW,Young ME,Ip P

    更新日期:2017-12-01 00:00:00

  • A systematic review of paediatric randomised controlled drug trials published in 2007.

    abstract:OBJECTIVE:To elucidate the current situation of randomised drug trials involving the paediatric population. METHODS:Systematic review of paediatric randomised controlled trials of medicinal products published in 2007. Three major databases were searched with validated search strategies; Medline, Embase and Cochrane Ce...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/adc.2009.173591

    authors: Aripin KN,Choonara I,Sammons HM

    更新日期:2010-06-01 00:00:00

  • Short term and long term health related quality of life after congenital anorectal malformations and congenital diaphragmatic hernia.

    abstract:AIMS:To examine short term and long term health related quality of life (HRQoL) of survivors of congenital anorectal malformations (ARM) and congenital diaphragmatic hernia (CDH), and to compare these patients' HRQoL with that of the general population. METHODS:HRQoL was measured in 286 ARM patients and 111 CDH patien...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2002.016543

    authors: Poley MJ,Stolk EA,Tibboel D,Molenaar JC,Busschbach JJ

    更新日期:2004-09-01 00:00:00

  • A special conditions register.

    abstract::A special conditions register (SCR) linked to the child health system's register of all children has been in use in West Sussex since 1977. This paper describes the aims, organisation, and use of the SCR and gives examples of the aggregated data that may be obtained. Of the 155,000 children aged 0-17 resident in West ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.66.8.927

    authors: Woodroffe C,Abra A

    更新日期:1991-08-01 00:00:00

  • Beclomethasone dipropionate aerosol in treatment of hay fever in children.

    abstract::Eighteen children suffering from hay fever were treated with intra-nasal beclomethasone dipropionate (400 mug/day) and an identical placebo aerosol in a double-blind cross-over trial. 17 of the children preferred the intranasal beclomethasone dipropionate, one had no preference, none preferred the placebo. The effect ...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/adc.50.11.875

    authors: Prahl P,Wilken-Jensen K,Mygind N

    更新日期:1975-11-01 00:00:00

  • Frequency of transient hypothyroxinaemia in low birthweight infants. Potential pitfall for neonatal screening programmes.

    abstract::Thyroid function was studied in 54 low birthweight infants during a 3-week period. Each infant was placed in one of three groups. Group 1 (n = 21), infants who were well and appropriately grown fro gestational age; group 2 (n = 23), infants who were appropriately grown but who had hyaline membrane disease; group 3 (n ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.56.3.214

    authors: Uhrmann S,Marks KH,Maisels MJ,Kulin HE,Kaplan M,Utiger R

    更新日期:1981-03-01 00:00:00

  • Pneumococcal nasopharyngeal carriage in children following heptavalent pneumococcal conjugate vaccination in infancy.

    abstract:AIMS:To ascertain whether the reduction in nasopharyngeal carriage of vaccine serotypes induced by pneumococcal conjugate vaccine (PnCV) administered to infants persists beyond the age of 2 years. METHODS:Non-randomised, unblinded controlled study of 2-5 year old children who had received three doses of heptavalent Pn...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章

    doi:10.1136/adc.88.3.211

    authors: Lakshman R,Murdoch C,Race G,Burkinshaw R,Shaw L,Finn A

    更新日期:2003-03-01 00:00:00

  • Reflection: moving from a mandatory ritual to meaningful professional development.

    abstract::Reflection has become established as a key principle underpinning maintenance of standards within professional education and practice. A requirement to evidence reflection within performance review is intended to develop a transformative approach to practice, identify developmental goals, and ultimately, improve healt...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/archdischild-2013-303948

    authors: Murdoch-Eaton D,Sandars J

    更新日期:2014-03-01 00:00:00

  • Quality of life in chronic illness: perceptions of parents and paediatricians.

    abstract:AIMS:To investigate the differences in perception of quality of life between parents of chronically ill children and paediatricians at diagnosis and follow up. Quality of life was assessed using the (HUI3). METHODS:Longitudinal study (July 1999-January 2002) of 37 paediatricians and 181 parents of patients (children a...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2004.051722

    authors: Janse AJ,Sinnema G,Uiterwaal CS,Kimpen JL,Gemke RJ

    更新日期:2005-05-01 00:00:00

  • Patterns of scald injuries.

    abstract:OBJECTIVES:To describe common patterns of bath water scald injuries in children, to examine differences between accidental and non-accidental bath water scalds in children, and to examine potential for prevention. DESIGN:A two year six month retrospective analysis of admissions to a specialist burns unit. SETTING:The...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.71.2.156

    authors: Yeoh C,Nixon JW,Dickson W,Kemp A,Sibert JR

    更新日期:1994-08-01 00:00:00

  • Interstitial nephritis of acute onset.

    abstract::Interstitial nephritis was diagnosed at renal biopsy in 10 previously healthy children. All had identical clinical symptoms: anaemia, raised sedimentation rate, low glomerular filtration rate, protein and leucocytes in the urine, but no bacteria; nine also had glycosuria. Six of the children had a history of recent in...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.60.8.752

    authors: Koskimies O,Holmberg C

    更新日期:1985-08-01 00:00:00

  • Lived experience of Silver-Russell syndrome: implications for management during childhood and into adulthood.

    abstract:OBJECTIVE:There is limited information on the psychosocial impact of growing up with Silver-Russell syndrome (SRS), characterised by slow growth in utero leading to short stature in adulthood. Such information could aid families in making difficult treatment decisions and guide management strategies for health professi...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2018-314952

    authors: Ballard LM,Jenkinson E,Byrne CD,Child JC,Davies JH,Inskip H,Lokulo-Sodipe O,Mackay DJG,Wakeling EL,Temple IK,Fenwick A

    更新日期:2019-01-01 00:00:00

  • Ultrasonic assessment of gastric emptying in the preterm infant.

    abstract::The study of gastric emptying in the preterm infant has been hampered by the absence of a suitable, valid technique. We have evaluated gastric antral clearance using serial ultrasonic measurement of the antral cross sectional area (ACSA). The study was easy to perform, providing successful results in 15 of 17 low birt...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.69.1_spec_no.32

    authors: Newell SJ,Chapman S,Booth IW

    更新日期:1993-07-01 00:00:00

  • Trends in admission and death rates due to paediatric head injury in England, 2000-2011.

    abstract:BACKGROUND:The number of children admitted to hospital is increasing year on year, with very short-stay admissions doubling in the last decade. Childhood head injury accounts for half a million emergency department attendances in the UK every year. The National Institute for Health and Care Excellence (NICE) has issued...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2015-308615

    authors: Marlow R,Mytton J,Maconochie IK,Taylor H,Lyttle MD

    更新日期:2015-12-01 00:00:00

  • Henoch-Schönlein syndrome and selective IgA deficiency.

    abstract::A 9 year old girl presented with clinical manifestations of Henoch-Schönlein syndrome and macroscopic haematuria. Laboratory investigations showed selective IgA deficiency and renal biopsy showed mesangial proliferative glomerulonephritis with diffuse granular deposits of C3 on immunofluorescence. IgA deposits were ab...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.60.2.160

    authors: Martini A,Ravelli A,Notarangelo LD,Burgio VL,Plebani A

    更新日期:1985-02-01 00:00:00

  • Health consequences of obesity.

    abstract::The recent epidemic of childhood obesity(1) has raised concern because of the possible clinical and public health consequences.(2,)(3) However, there remains a widespread perception among health professionals that childhood obesity is a largely cosmetic problem, with minor clinical effects. No systematic review has ye...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,meta分析,评审

    doi:10.1136/adc.88.9.748

    authors: Reilly JJ,Methven E,McDowell ZC,Hacking B,Alexander D,Stewart L,Kelnar CJ

    更新日期:2003-09-01 00:00:00

  • Is there a role for treatment of asthma with omalizumab?

    abstract::The allergic response is distinct from other immune reactions in its reliance on IgE, its high affinity receptor, Fc epsilon RI, and the primary effector cell--the tissue mast cell. Positive skin tests or raised concentrations of specific immunoglobulin E (IgE) in the serum define IgE sensitisation or "atopy". IgE par...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/adc.88.1.71

    authors: Milgrom H

    更新日期:2003-01-01 00:00:00

  • Early onset of diabetic nephropathy.

    abstract::A 12 year old Asian girl with a four year history of poorly controlled insulin dependent diabetes mellitus developed overt diabetic nephropathy. There were no clinical features of Rabson-Mendenhall syndrome. Screening for microalbuminuria would have identified incipient diabetic nephropathy and highlighted the importa...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.77.6.524

    authors: Francis J,Rose SJ,Raafat F,Milford DV

    更新日期:1997-12-01 00:00:00

  • Pulmonary intravascular lipid in neonatal necropsy specimens.

    abstract::The lungs of 482 liveborn infants were examined at necropsy for the presence of intravascular lipid. Forty one patients had received parenteral feeding (including lipid emulsion in 30), and 441 had died before starting feeds or had received enteral feeds alone. Tissue was processed into wax and then stained with Sudan...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.66.1_spec_no.26

    authors: Puntis JW,Rushton DI

    更新日期:1991-01-01 00:00:00

  • Phase II meningococcal B vesicle vaccine trial in New Zealand infants.

    abstract:BACKGROUND:A tailor-made serogroup B outer membrane vesicle vaccine was evaluated in the context of a serogroup B meningococcal epidemic dominated by Neisseria meningitidis strain B:4:P1.7b,4. OBJECTIVE:To determine the safety, reactogenicity and immunogenicity in infants aged 6-8 months of a meningococcal B vaccine d...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/adc.2007.132571

    authors: Jackson C,Lennon DR,Sotutu VT,Yan J,Stewart JM,Reid S,Crengle S,Oster P,Ypma E,Aaberge I,Mulholland K,Martin DR

    更新日期:2009-10-01 00:00:00

  • Growth and other factors affecting peak expiratory flow rate.

    abstract::By means of a simple questionnaire and measurements of height, weight, and peak expiratory flow rates 3061 children from city and rural populations were studied. Children with asthma or other respiratory diseases had lower peak expiratory flow rates, and younger children living in rural areas had higher rates. In 2828...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.64.1.96

    authors: Carson JW,Hoey H,Taylor MR

    更新日期:1989-01-01 00:00:00

  • Overtreatment in threshold and developed countries.

    abstract::In acute paediatrics, overtreatment and overdiagnosis is encountered in threshold and developed countries. The reason for overtreatment may be similar in the two settings, namely the mere availability of invasive procedures, which may lead to their inappropriate use. Physiological healing processes should be integrate...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/adc.2007.124479

    authors: Frey B

    更新日期:2008-03-01 00:00:00

  • Age specific xerophthalmia rates among displaced Ethiopians.

    abstract::The recent famine in Ethiopia has resulted in the dislocation of millions of people. Many of these individuals have moved to refugee camps in Sudan or to feeding centres within Ethiopia. A total of 1325 children up to the age of 15 years were examined by an ophthalmologist in January 1985 at several sites in these two...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.61.11.1100

    authors: Pizzarello LD

    更新日期:1986-11-01 00:00:00

  • Respiratory timing in intubated neonates with respiratory distress syndrome.

    abstract::Respiratory timing was studied in 100 babies ventilated for respiratory distress syndrome (RDS) during a brief period of continuous positive airway pressure. For the 76 spontaneously breathing babies the mean (SD) inspiratory and expiratory times were 0.31 (0.06) and 0.41 (0.12) seconds. Respiratory rate was predomina...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.67.4_spec_no.446

    authors: South M,Morley CJ

    更新日期:1992-04-01 00:00:00

  • Guillain-Barré syndrome in three siblings less than 2 years old.

    abstract::Three of five children who were born to consanguineous parents developed Guillain-Barré syndrome before they were 3 years old. The syndrome is rare in early childhood and we suggest that there may be a genetic element in the pathogenesis. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.66.9.1078

    authors: Bar-Joseph G,Etzioni A,Hemli J,Gershoni-Baruch R

    更新日期:1991-09-01 00:00:00

  • Ductus arteriosus blood flow during first 48 hours of life.

    abstract::A volumetric Doppler technique was used to measure net ductus arteriosus shunt during the first 48 hours of life in 30 infants of less than 33 weeks' gestation, and in 10 full term infants. In the full term infants a left to right shunt of 62 ml/kg/minute (95% confidence limits 43-82) shortly after birth decreased rap...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.62.10.1030

    authors: Drayton MR,Skidmore R

    更新日期:1987-10-01 00:00:00