Abstract:
:Thyroid function was studied in 54 low birthweight infants during a 3-week period. Each infant was placed in one of three groups. Group 1 (n = 21), infants who were well and appropriately grown fro gestational age; group 2 (n = 23), infants who were appropriately grown but who had hyaline membrane disease; group 3 (n = 10), infants who were small-for-gestational-age. In group 1, 5 (24%) infants had at least one serum thyroxine value less than 3.0 micrograms/100 ml (39 nmol/l). There were 8 (35%) infants in group 2 who had similarly low serum thyroxine values as did 5 (50%) of the 10 infants in group 3. Serum thyrotropin levels and serum binding of the thyroid hormones, as measured by a T3-charcoal uptake test, were normal in all infants. In all instances but 2, serum thyroxine values were at least 4.0 micrograms/100 ml (51 nmol/l) by the end of the 3-week period. There is thus a high incidence of transient 'hypothyroxinaemia' in low birthweight infants, particularly if such infants have hyaline membrane disease or are small-for-gestational-age. These findings must be considered when interpreting results of screening programmes for congenital hypothyroidism and they lend further support to the use of a combination of serum thyroxine and thyrotropin determinations for optimum screening of such infants.
journal_name
Arch Dis Childjournal_title
Archives of disease in childhoodauthors
Uhrmann S,Marks KH,Maisels MJ,Kulin HE,Kaplan M,Utiger Rdoi
10.1136/adc.56.3.214subject
Has Abstractpub_date
1981-03-01 00:00:00pages
214-7issue
3eissn
0003-9888issn
1468-2044journal_volume
56pub_type
杂志文章abstract:OBJECTIVE:To compare the efficacy of oral sweet solutions to water or no treatment in infants aged 1-12 months during immunisation. METHODS:Randomised controlled trials (RCTs) were retrieved through internet searches or manual searches of reference lists. Search terms included newborn, infant, pain, sucrose and altern...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,meta分析,评审
doi:10.1136/adc.2009.174227
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVES:Foot pathology is a major source of morbidity in adults with diabetes. The aim of this study was to determine if children with insulin dependent diabetes have an increased incidence of foot pathology compared with non-diabetic children. DESIGN:Questionnaire, clinical examination, and biomechanical assessmen...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.73.2.151
更新日期:1995-08-01 00:00:00
abstract::The prevalence of wheezing, 'asthma', treatment for 'asthma', and school absence as a result of wheezing in Nottingham was calculated from a questionnaire survey of parents of 4750 children in a random sample of primary schools. A response was achieved for 3805 (80%) children of whom 438 (11.5%) had had episodes of wh...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.64.2.246
更新日期:1989-02-01 00:00:00
abstract::Persistent daytime incontinence is a fairly uncommon but important problem. Videourodynamic studies were carried out in 215 children presenting with this problem in whom there were no neurological signs and who had not responded to simple measures. Over 90% of symptomatic children were shown to have an abnormality, of...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.62.2.128
更新日期:1987-02-01 00:00:00
abstract::Gross neuropathy consequent upon selective malabsorption of vitamin B12 was diagnosed in a 6 year old Bangladeshi girl brought to Great Britain for further investigation of an unexplained illness of three years' duration. The initial peripheral blood count was normal. Treatment with vitamin B12 has led to substantial ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.59.6.575
更新日期:1984-06-01 00:00:00
abstract::Transcutaneous Doppler ultrasound measurements were made of the superior mesenteric artery of 22 preterm infants (mean birth weight 600-2580 g) to investigate the response of intestinal blood flow to feeding. Analysis of the data in relation to milk intake showed a significant change in peak velocity and mean velocity...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.64.4_spec_no.476
更新日期:1989-04-01 00:00:00
abstract::Four children with chronic diarrhoea and perianal excoriation after a pull-through operation for Hirschsprung's disease have been shown to have increased but not markedly raised levels of faecal bile acids. Bile acid analysis of the 'bile-rich' duodenal fluid obtained after pancreozymin stimulation in 3 of the patient...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.50.3.243
更新日期:1975-03-01 00:00:00
abstract::Rubella vaccination was offered to a cohort of schoolgirls 14 years and over whose immune state was unknown. This increased the percentage vaccinated or known to be immune from 86% to 90%. It is recommended that rubella vaccination should be offered to girls until they leave school at 16 years of age. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.63.8.983
更新日期:1988-08-01 00:00:00
abstract::A longitudinal evaluation was carried out of the clinical, infective, and immunological progress of 34 children (who were aged 6 to 68 months--mean 25 months at the time of writing) born to 31 mothers infected with human immunodeficiency virus (HIV), over a mean observation period of 13.4 months. Clinical symptoms, no...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.64.5.662
更新日期:1989-05-01 00:00:00
abstract::Mortality before surgery must be taken into account when comparing the surgical mortality of atrial redirection procedures (Mustard's or Senning's operation) and the arterial switch operation for patients with complete transposition. This is because the switch operation is usually performed within the neonatal period ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.62.6.549
更新日期:1987-06-01 00:00:00
abstract:BACKGROUND:It has been suggested that increasing obesity levels in young women lead to intrauterine environments that, in turn, stimulate increased obesity among their offspring, generating an intergenerational acceleration of obesity levels. If this mechanism is important, the association of maternal body mass index (...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2006.104869
更新日期:2007-10-01 00:00:00
abstract::Therapeutic drug monitoring (TDM) aims to integrate drug measurement results into clinical decision making. The basic rules apply when using TDM in neonates (aminoglycosides, vancomycin, phenobarbital, digoxin), but additional factors should also be taken into account. First, due to both pharmacokinetic variability an...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/archdischild-2013-305309
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND AND AIMS:Data on acute paediatric anaphylaxis presentations to the emergency department (ED) are limited. All allergic presentations to one Australian paediatric ED were studied to determine epidemiological, clinical, and outcome data. METHODS:Retrospective, case based study of patients under 16 years atten...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2004.069914
更新日期:2006-02-01 00:00:00
abstract:AIMS:To compare the effectiveness of short course (2-4 days) with standard duration oral antibiotic treatment (7-14 days) for urinary tract infection (UTI). METHODS:Meta-analysis of randomised controlled trials using a random effects model. Ten trials were eligible, involving 652 children with lower tract UTI recruite...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,meta分析,评审
doi:10.1136/adc.87.2.118
更新日期:2002-08-01 00:00:00
abstract::Interferon is becoming the standard treatment in adults for chronic hepatitis C. Twenty one children with histologically proved chronic hepatitis C (10 boys, range 2.5-13 years), who were otherwise healthy, were enrolled in a randomised controlled study to test their response to interferon alfa. Eleven children were t...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/adc.74.2.152
更新日期:1996-02-01 00:00:00
abstract:AIMS:To compare the respiratory health and function at 8 to 9 years of age of a total population based cohort of 300 very low birthweight (VLBW) children with that of two classroom controls (n = 590) matched for age and sex. STUDY DESIGN:Cohort study with controls. SETTING:Schools throughout Scotland. RESULTS:The VL...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.74.3.188
更新日期:1996-03-01 00:00:00
abstract::Thirty-two children with a past diagnosis of coeliac disease were reinvestigated by means of gluten challenge. They had received a gluten-free diet for a mean period of 6-5 years (range 0-25-11-0) before gluten challenge, and had a mean age of 9-9 years (range 3-0-15-3) at the onset of challenge. Small intestinal biop...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.53.6.449
更新日期:1978-06-01 00:00:00
abstract::At the mid-radius, pre-pubertal asthmatic children had smaller periosteal and endosteal circumferences and thicker cortical shells compared to controls, when assessed by peripheral quantitative computed tomography. Asthmatics had diminished periosteal expansion for muscle size, suggesting that asthma, its treatment, o...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2005.084996
更新日期:2006-04-01 00:00:00
abstract::The age at which retinopathy of prematurity was first seen was determined in 143 infants. In all, the initial ophthalmological examination was normal. Birth weights varied from 630 to 2700 g and gestational ages from 24.5 to 40.0 weeks. The median postnatal age at which acute retinopathy of prematurity was first seen ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.61.8.774
更新日期:1986-08-01 00:00:00
abstract:BACKGROUND:Although antibiotics are recommended for the primary care management of community-acquired pneumonia, a recent UK study reported that most children admitted to hospital had not received antibiotics. OBJECTIVE:To describe primary care antibiotic use for children subsequently hospitalised with community-acqui...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2011-300604
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Most children with daytime wetting have detrusor instability. A minority have neuropathic vesicourethral dysfunction. The commonest cause is spina bifida, which may be closed. Clinical features suggestive of closed spina bifida include cutaneous, neuro-orthopaedic or lumbosacral spine x ray abnormalities, im...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.87.2.151
更新日期:2002-08-01 00:00:00
abstract::Published reports on the treatment of large strawberry naevi have been reviewed. It is suggested that they should normally be left untreated, and that corticosteroids, given for a short period only, should be reserved for massive naevi close to the eye, or interfering with respiration or suckling, or associated with t...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/adc.51.2.138
更新日期:1976-02-01 00:00:00
abstract:OBJECTIVE:The aim was to compare quality of life (QoL) among children and adolescents with different stages of chronic kidney disease (CKD) and determine factors associated with changes in QoL. DESIGN:Cross-sectional. SETTING:The Kids with CKD study involved five of eight paediatric nephrology units in Australia and ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究
doi:10.1136/archdischild-2018-314934
更新日期:2019-02-01 00:00:00
abstract::"Mental retardation" is a modern term for an age old problem. The descriptions of paediatric cases contained within the works of Thomas Willis (1621-75) have been increasingly recognised for their insight into seventeenth century child health practices. ...
journal_title:Archives of disease in childhood
pub_type: 传,历史文章,杂志文章
doi:10.1136/adc.87.6.555
更新日期:2002-12-01 00:00:00
abstract::Six children with congenital heart disease are described in whom poor growth was found to be due to small-bowel villous atrophy; none was in heart failure and only one was severely cyanosed. Growth improved in all 6 on a gluten-free diet. Gluten enteropathy may be more common than is realised in children with congenit...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
abstract:AIMS:To evaluate the clinical efficacy of sublingual immunotherapy (SLIT) in respiratory allergy in children. METHODS:A systematic literature review was conducted. The search was focused on all the double blind (and double dummy if necessary) studies. SEARCH STRATEGY:Medline, Embase, Cochrane Controlled Trial Registe...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/adc.2003.030411
更新日期:2004-07-01 00:00:00
abstract::The IgG subclass specific immune response against pneumococcal type 3 polysaccharide antigen before and after immunisation in healthy children and children with recurrent bronchitis was studied. Recurrent bronchitis was defined as three or more episodes a year, during at least two consecutive years, of bronchopulmonar...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.66.12.1378
更新日期:1991-12-01 00:00:00
abstract::Thyroxine (T4) screening values in infants of low birthweight in relation to birthweight and gestational age are reported. There were 86 healthy infants of low birthweight (group 1), and 29 preterm infants with respiratory distress syndrome (group 2). All the group 2 infants and 36% of those in group 1 had a T4 screen...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.58.3.190
更新日期:1983-03-01 00:00:00
abstract::Moderate and severe malnutrition are endemic in much of the developing world and in association with pockets of deprivation in the developed world. The cost in terms of individual and social development is high. The principles of effective management are clearly documented. A low cost, community based treatment progra...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.71.4.297
更新日期:1994-10-01 00:00:00
abstract::Patient triggered ventilation was assessed in 14 neonates (gestational age 24-40 weeks). Inspiratory changes in airflow, monitored by a pneumotachograph, were used to trigger the ventilator and this was not associated with complications. Patient triggered ventilation was maintained for up to eight hours (mean duration...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.63.4.394
更新日期:1988-04-01 00:00:00