Short compared with standard duration of antibiotic treatment for urinary tract infection: a systematic review of randomised controlled trials.

Abstract:

AIMS:To compare the effectiveness of short course (2-4 days) with standard duration oral antibiotic treatment (7-14 days) for urinary tract infection (UTI). METHODS:Meta-analysis of randomised controlled trials using a random effects model. Ten trials were eligible, involving 652 children with lower tract UTI recruited from outpatient or emergency departments. Main outcome measures were UTI at the end of treatment, UTI during follow up (recurrent UTI), and urinary pathogens resistant to the treating antibiotic. RESULTS:There was no significant difference in the frequency of positive urine cultures between the short (2-4 days) and standard duration therapy (7-14 days) for UTI in children at 0-7 days after treatment (eight studies: RR 1.06; 95% CI 0.64 to 1.76) and at 10 days to 15 months after treatment (10 studies: RR 1.01; 95% CI 0.77 to 1.33). There was no significant difference between short and standard duration therapy in the development of resistant organisms in UTI at the end of treatment (one study: RR 0.57, 95% CI 0.32 to 1.01) or in recurrent UTI (three studies: RR 0.39, 95% CI 0.12 to 1.29). CONCLUSION:A 2-4 day course of oral antibiotics is as effective as 7-14 days in eradicating lower tract UTI in children.

journal_name

Arch Dis Child

authors

Michael M,Hodson EM,Craig JC,Martin S,Moyer VA

doi

10.1136/adc.87.2.118

subject

Has Abstract

pub_date

2002-08-01 00:00:00

pages

118-23

issue

2

eissn

0003-9888

issn

1468-2044

journal_volume

87

pub_type

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