Deletion polymorphism of the angiotensin converting enzyme gene predicts persistent proteinuria in Henoch-Schönlein purpura nephritis.

Abstract:

OBJECTIVE:To study the influence of deletion/insertion polymorphism in the 16th intron of the angiotensin converting enzyme (ACE) gene on clinical manifestations of Henoch-Schönlein purpura nephritis. STUDY DESIGN:Cross sectional study. ACE gene polymorphism was determined in patients (4-15 years old at onset) with Henoch-Schönlein purpura nephritis (n = 40) and compared with that in patients with IgA nephropathy (n = 79). MAIN OUTCOME MEASURES:ACE genotypes, systemic blood pressures, urine protein excretion rate, haematuria, creatinine clearance, serum ACE activities. RESULTS:The initial clinical manifestations of both Henoch-Schönlein purpura nephritis and IgA nephropathy were no different among homozygotes for insertion (II) and deletion (DD), and heterozygotes (ID) for the ACE gene. In patients with Henoch-Schönlein purpura nephritis, the incidence of moderate to heavy proteinuria at four and eight years after onset was more than five times higher in the DD genotype than in the II or ID genotypes. No such trend was seen in patients with IgA nephropathy. The number of patients with Henoch-Schönlein purpura nephritis in whom proteinuria resolved at four and eight years after onset was significantly lower in the DD genotype compared with the II genotype, whereas no differences were detected among the three different genotypes in patients with IgA nephropathy. Plasma ACE activities in patients with the DD genotype were significantly higher than in those with non-DD genotypes. CONCLUSIONS:The ACE DD genotype predicts persistent proteinuria in Henoch-Schönlein purpura nephritis. The proteinuria might be related to a defective angiotensin system which is genetically determined by the D/I polymorphism.

journal_name

Arch Dis Child

authors

Yoshioka T,Xu YX,Yoshida H,Shiraga H,Muraki T,Ito K

doi

10.1136/adc.79.5.394

subject

Has Abstract

pub_date

1998-11-01 00:00:00

pages

394-9

issue

5

eissn

0003-9888

issn

1468-2044

journal_volume

79

pub_type

杂志文章
  • Evolution of pseudohypoparathyroidism: an informative family study.

    abstract::An adult woman with pseudopseudohypoparathyroidism had a child with normal calcium and parathyroid hormone concentrations and cyclic AMP response to injected parathyroid hormone in infancy. By 2.5 years he had features of pseudohypoparathyroidism with raised parathyroid hormone and 'flat' cyclic AMP response. This is ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.70.4.337

    authors: Barr DG,Stirling HF,Darling JA

    更新日期:1994-04-01 00:00:00

  • Stability of respiratory symptoms in unlabelled wheezy illness and nocturnal cough.

    abstract:OBJECTIVE:To assess the natural history of respiratory symptoms not labelled as asthma in primary schoolchildren. DESIGN:Repeat questionnaire survey of subgroups identified from a previous questionnaire survey after a two year delay. SUBJECTS:The original population of 5321 Sheffield children aged 8-9 years yielded 4...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.75.5.385

    authors: Powell CV,Primhak RA

    更新日期:1996-11-01 00:00:00

  • Prognosis in severe Guillain-Barré syndrome.

    abstract::Recent studies of Guillain-Barré syndrome in adults have shown that the requirement for assisted ventilation correlates closely with a poor outcome, and the need for ventilation is now being used as an indication for plasmapheresis. As comparable studies in children have not been performed we reviewed our experience o...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.62.3.288

    authors: Cole GF,Matthew DJ

    更新日期:1987-03-01 00:00:00

  • Analysis of paediatric long-term ventilation incidents in the community.

    abstract:AIM:To describe the nature and causes of reported patient safety incidents relating to care in the community for children dependent on long-term ventilation with the further aim of improving safety. METHODS:We undertook an analysis of patient safety incident data relating to long-term ventilation in the community usin...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2019-317965

    authors: Nawaz RF,Page B,Harrop E,Vincent CA

    更新日期:2020-05-01 00:00:00

  • Preterm blood counts vary with sampling site.

    abstract::In preterm babies both haemoglobin and total neutrophil count values from capillary sites are significantly and variably higher than those from simultaneous arterial samples. Comparing simultaneous venous and arterial samples, the mean haemoglobin was slightly higher but the total neutrophil counts were similar. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.62.1.74

    authors: Thurlbeck SM,McIntosh N

    更新日期:1987-01-01 00:00:00

  • Sustained release theophylline in nocturnal asthma.

    abstract::Twice daily sustained release theophylline gave satisfactory steady serum theophylline concentrations in asthmatic children aged 7 to 14 years. The children showed improvement in symptoms, less frequent waking at night, reduced use of beta agonist inhalers, and improved early morning peak flows while being treated wit...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/adc.59.12.1159

    authors: Elias-Jones AC,Higenbottam TW,Barnes ND,Godden DJ

    更新日期:1984-12-01 00:00:00

  • Maternal mental health and childhood injury: evidence from the UK Millennium Cohort Study.

    abstract:OBJECTIVE:We assessed whether maternal mental health problems increased rates for child injury during the preschool years and mid-childhood, and the extent to which associations could be accounted for by a range of potential explanatory factors. DESIGN:We analysed the UK Millennium Cohort Study, a nationally represent...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2017-313809

    authors: Hope S,Deighton J,Micali N,Law C

    更新日期:2019-03-01 00:00:00

  • Acute changes in oxygen consumption and body temperature after burn injury.

    abstract::This study describes the pattern of oxygen consumption (VO2), rectal temperature (Tr), and acral skin temperature (Tac) in sleeping and resting (awake) burned children nursed in a thermoneutral environment. Measurements of respiratory gas exchange (VO2 and carbon dioxide production (VCO2)) were made using an open circ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.71.1.31

    authors: Childs C,Little RA

    更新日期:1994-07-01 00:00:00

  • Energy expenditure, nutrition and growth.

    abstract::Fundamental to appropriate nutritional prescription is an understanding of the conditions necessary for growth that include the requirements for energy in health and illness. Energy requirements need to be met by the dietary intake to prevent weight loss. A positive energy balance will result in weight gain. Energy re...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/adc.2009.158303

    authors: Wiskin AE,Davies JH,Wootton SA,Beattie RM

    更新日期:2011-06-01 00:00:00

  • Trimethoprim-sulphamethoxazole in the treatment of persistent diarrhoea: a double blind placebo controlled clinical trial.

    abstract::The efficacy of an absorbable antimicrobial agent trimethoprim-sulphamethoxazole (TMP-SMX) in the management of children with persistent diarrhoea was evaluated in a double blind, randomised, and placebo controlled trial. Of the 55 patients studied, 28 received TMP-SMX, and 27 received placebo. A trend in stool weight...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/adc.72.6.483

    authors: Alam NH,Bardhan PK,Haider R,Mahalanabis D

    更新日期:1995-06-01 00:00:00

  • Long-term follow up of persistent hyperinsulinaemic hypoglycaemia of infancy.

    abstract::Twenty six children with hypoglycaemia were diagnosed and followed between 1975 and 1995. Diagnosis was confirmed by a high insulin:glucose ratio, and low free fatty acid and 3-hydroxybutyrate on fasting. All patients were treated with diazoxide at a maximum dose of 20 mg/kg/day. Requirement of a higher dose was consi...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.79.5.440

    authors: Cresto JC,Abdenur JP,Bergada I,Martino R

    更新日期:1998-11-01 00:00:00

  • Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty.

    abstract::New charts for height, weight, height velocity, and weight velocity are presented for clinical (as opposed to population survey) use. They are based on longitudinal-type growth curves, using the same data as in the British 1965 growth standards. In the velocity standards centiles are given for children who are early- ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.51.3.170

    authors: Tanner JM,Whitehouse RH

    更新日期:1976-03-01 00:00:00

  • Why breast feeding fails.

    abstract:BACKGROUND:Vanessa is a 34-year-old lawyer married to a police officer. Her first baby was born after a perfect pregnancy and labour until fetal distress necessitated an easy Ventouse extraction late in the second stage. Baby F had normal Apgar scores and weighed 2920 g. This paper records a conversation between Vaness...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2006.101600

    authors: Harris V,Hall D

    更新日期:2007-01-01 00:00:00

  • Prader-Willi syndrome in siblings, due to unbalanced translocation between chromosomes 15 and 22.

    abstract::In a family in which the father carried a balanced translocation between chromosomes 15 and 22 two of his children had Prader-Willi syndrome and an unbalanced chromosome complement, having lost the proximal bands from the long arm of chromosome 15. His four other surviving children were normal but carried a balanced t...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.62.8.841

    authors: Fernandez F,Berry C,Mutton D

    更新日期:1987-08-01 00:00:00

  • Age of appearance of circadian rhythm in salivary cortisol values in infancy.

    abstract::Samples of saliva (4 in 24 hours), collected at monthly intervals for the first 6 months of life in 8 term infants by their mothers, were analysed for cortisol by radioimmunoassay. Values in the first month were more variable, daily mean values were greater, and amplitudes of variation were greater than in subsequent ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.58.6.454

    authors: Price DA,Close GC,Fielding BA

    更新日期:1983-06-01 00:00:00

  • Recovery of protein from urine specimens collected in cotton wool.

    abstract::Cotton wool balls have been used to aid the collection of urine from infants. Concentrations of two urinary proteins, albumin and retinol binding protein, decreased by 40 and 80% respectively within 15 minutes of contact with the cotton wool. Cotton wool balls should not be used when investigating proteinuria. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.67.12.1486

    authors: Smith GC,Taylor CM

    更新日期:1992-12-01 00:00:00

  • Major problems with paediatric bed usage statistics?

    abstract::This study was carried out on the way in which children's beds were used by the specialty of paediatrics in a district general hospital. Five differing ways were found of interpreting the present Department of Health guidelines on health services information (Körner recommendations). These gave bed occupancy figures v...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.66.4.504

    authors: MacFaul R,Long R

    更新日期:1991-04-01 00:00:00

  • Congenital nephrogenic diabetes insipidus in a baby girl.

    abstract::A 6-week-old girl with fever, hypernatraemia, dehydration, and polyuria failed to concentrate urine in response to exogenous vasopressin administration. There was no family history of nephrogenic diabetes insipidus. When she was 15 months old, the infusion of vasopressin did not produce an increase in urinary cyclic-A...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.53.11.unknown

    authors: Schreiner RL,Skafish PR,Anand SK,Northway JD

    更新日期:1978-11-01 00:00:00

  • Infantile meningitis in England and Wales: a two year study.

    abstract::A two year prospective study identified 1922 cases of meningitis in children under 1 year of age. A further 201 cases were identified from other sources. The annual incidence of meningitis during the first year of life was 1.6/1000; during the first 28 days of life it was 0.32/1000, and among postneonatal infants it w...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.66.5.603

    authors: de Louvois J,Blackbourn J,Hurley R,Harvey D

    更新日期:1991-05-01 00:00:00

  • Parental food allergy information needs: a qualitative study.

    abstract:OBJECTIVE:To examine information needs and preferences of parents regarding food allergy. DESIGN:Qualitative study including in-depth semi-structured interviews and focus group discussions. Data were audio-recorded, transcribed verbatim and analysed using the constant comparative method, aided by participant checking ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/adc.2006.114975

    authors: Hu W,Grbich C,Kemp A

    更新日期:2007-09-01 00:00:00

  • Phenotypic variation and detection of carrier status in the partial androgen insensitivity syndrome.

    abstract::The partial androgen insensitivity syndrome occurs in 46,XY subjects with phenotypes ranging from perineoscrotal hypospadias with cryptorchidism and micropenis (mild undervirilisation) to clitoromegaly and partial labial fusion (marked undervirilisation). Within an affected family, wide variation in the degree of geni...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.68.4.453

    authors: Batch JA,Davies HR,Evans BA,Hughes IA,Patterson MN

    更新日期:1993-04-01 00:00:00

  • Skeletal morbidity in children receiving chemotherapy for acute lymphoblastic leukaemia.

    abstract:BACKGROUND:Children receiving chemotherapy for acute lymphoblastic leukaemia (ALL) may be susceptible to skeletal morbidity. AIM:To determine the incidence and risk factors for skeletal morbidity in ALL children. PATIENTS AND METHODS:The medical records of all (n=186, boys=110) children presenting to a single centre ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2009.172528

    authors: Elmantaser M,Stewart G,Young D,Duncan R,Gibson B,Ahmed SF

    更新日期:2010-10-01 00:00:00

  • Health in overweight children: 2-year follow-up of Finnmark Activity School--a randomised trial.

    abstract:OBJECTIVE:To compare a comprehensive lifestyle intervention for overweight children performed in groups of families with a conventional single-family treatment. Two-year follow-up data on anthropometric and psychological outcome are presented. DESIGN:Overweight and obese children aged 6-12 years with body mass index (...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/archdischild-2014-307107

    authors: Kokkvoll A,Grimsgaard S,Steinsbekk S,Flægstad T,Njølstad I

    更新日期:2015-05-01 00:00:00

  • Sjögren syndrome and lupus erythematosus nephritis.

    abstract::A 9 year old girl with symptoms of the Sjögren syndrome showed interstitial lymphocytic infiltrate on renal biopsy. Two years later she had clinical and biological evidence of systemic lupus erythematosus, associated with a typical glomerulonephritis. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.59.2.175

    authors: Palcoux JB,Janin-Mercier A,Campagne D,Fonck Y,Betail G

    更新日期:1984-02-01 00:00:00

  • Echocardiographic assessment of cardiac function in shocked very low birthweight infants.

    abstract::The contribution of abnormal cardiac function to hypotension and metabolic acidosis, which affect approximately 40% of ventilated very low birthweight infants in the first 24 hours after birth was assessed using M mode, two dimensional, and Doppler echocardiography in 75 very low birthweight infants during the first f...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.68.1_spec_no.17

    authors: Gill AB,Weindling AM

    更新日期:1993-01-01 00:00:00

  • Hypothalamo-pituitary hormone insufficiency associated with cleft lip and palate.

    abstract::Two male patients with congenital cleft lip and palate first seen at ages 10.2 and 21.5 years presented with typical signs of hypothalamic-interior pituitary hormone deficiencies. They were found to lack GH, LH, and FSH and to be partially deficient in TSH and ACTH. Several congenital defects may explain this rare syn...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.53.12.952

    authors: Roitman A,Laron Z

    更新日期:1978-12-01 00:00:00

  • Infantile acute liver failure in the West of Scotland.

    abstract:BACKGROUND:Our current understanding regarding the aetiology of infantile acute liver failure largely derives from studies conducted by regional liver units. This may introduce selection bias and therefore not provide a true reflection of the wider population. METHODS:Every coagulation screen with a prothrombin time ≥...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2019-317360

    authors: Wands D,Tayler R,Kelly D,Pinto F,Simpson JH,Hansen R

    更新日期:2020-08-01 00:00:00

  • Serum tri-iodothyronine, thyroxine, and thyrotrophin concentrations in newborns during the first 2 days of life.

    abstract::The serum concentrations of tri-iodothyronine (T3), thyroxine (T4), and thyrotrophin (TSH) were measured in 10 term newborn infants between birth and the age of 2 days by radioimmunoassay. The mean concentration of T3 in maternal serum was 1.62 mug/l, and it increased from the low cord blood level of 0-63 mug/l to the...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.50.7.565

    authors: Similä S,Koivisto M,Ranta T,Leppäluoto J,Reinilä M,Haapalahti J

    更新日期:1975-07-01 00:00:00

  • Outdoor carbon monoxide, nitrogen dioxide, and sudden infant death syndrome.

    abstract:AIMS:To investigate whether infants who died of SIDS were more likely to have higher acute and lifetime average exposures to outdoor carbon monoxide (CO) and nitrogen dioxide (NO2) than comparison healthy infants. METHODS:A total of 169 case and 169 matched control infants born between 1988 and 1992, were studied. CO ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2004.057091

    authors: Klonoff-Cohen H,Lam PK,Lewis A

    更新日期:2005-07-01 00:00:00

  • Fulminant diphtheritic mitral valve endocarditis.

    abstract::Fulminant endocarditis affecting the mitral valve in an 11-year-old boy was caused by a nontoxogenic strain of Corynebacterium diphtheriae. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.51.3.227

    authors: Horst R,Dyer D,Hallett A

    更新日期:1976-03-01 00:00:00