Hypothalamo-pituitary hormone insufficiency associated with cleft lip and palate.

Abstract:

:Two male patients with congenital cleft lip and palate first seen at ages 10.2 and 21.5 years presented with typical signs of hypothalamic-interior pituitary hormone deficiencies. They were found to lack GH, LH, and FSH and to be partially deficient in TSH and ACTH. Several congenital defects may explain this rare syndrome affecting midline structures in the proximity of the maldeveloped palate, including Rathke's pouch, which migrates distally to develop into the anterior pituitary.

journal_name

Arch Dis Child

authors

Roitman A,Laron Z

doi

10.1136/adc.53.12.952

subject

Has Abstract

pub_date

1978-12-01 00:00:00

pages

952-5

issue

12

eissn

0003-9888

issn

1468-2044

journal_volume

53

pub_type

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