A non-electrostatic spacer for aerosol delivery.

Abstract:

:A pear shaped non-electrostatic spacer, composed of steel with a volume of 250 ml and equipped with a facemask containing integrated inlet and outlet valves for inspiration and expiration, was compared with three plastic spacers. The plastic spacers were primed with repeated puffs from a budesonide pressurised metered dose inhaler (p-MDI) to minimise the electrostatic charge on the plastic. The procedure prolonged the half life (t1/2) of the aerosol in the Nebuhaler from nine to 32 seconds. A normal cleaning procedure reduced the aerosol t1/2 back to baseline. The t1/2 of the aerosol in the metal spacer was 27 seconds and independent of the use of p-MDI. In vitro the maximum dose of budesonide from a p-MDI, expressed as a percentage of the nominal dose, was 56% from the non-electrostatic spacer, 61% from the Nebuhaler, 45% from the Babyhaler, and 30% from the AeroChamber. In 124 children, age 6 months to 6 years, suspected to have asthma the non-electrostatic spacer delivered a mean total dose of budesonide aerosol of 39% of the nominal dose, which was significantly higher than the Babyhaler (28%), the Nebuhaler (21%), and the AeroChamber (19%). These differences were most pronounced in children younger than 4 years. The improved dose delivery from the small volume non-electrostatic spacer is probably related to the non-electrostatic spacer material and the valves which assured unidirectional airflow from the spacer without adding any dead space in the inspiratory channel. The non-electro-static spacer should improve the cost effectiveness of aerosol treatment and, as the counteracting effects of proming and recharging of the plastic from cleaning are avoided, should deliver a more reliable dose.

journal_name

Arch Dis Child

authors

Bisgaard H,Anhøj J,Klug B,Berg E

doi

10.1136/adc.73.3.226

subject

Has Abstract

pub_date

1995-09-01 00:00:00

pages

226-30

issue

3

eissn

0003-9888

issn

1468-2044

journal_volume

73

pub_type

临床试验,杂志文章,随机对照试验
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    doi:10.1136/adc.2006.104869

    authors: Davey Smith G,Steer C,Leary S,Ness A

    更新日期:2007-10-01 00:00:00

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    更新日期:1987-12-01 00:00:00

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    pub_type: 临床试验,杂志文章,随机对照试验

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    authors: Ruggins NR,Milner AD,Swarbrick A

    更新日期:1993-04-01 00:00:00

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    doi:10.1136/adc.53.8.645

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  • Effects of smoking on breast feeding.

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    更新日期:2010-06-01 00:00:00

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    doi:10.1136/adc.72.5.427

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    更新日期:1995-05-01 00:00:00

  • Sodium cromoglycate in asthma: correlation between response and serum concentrations.

    abstract::The clinical response to sodium cromoglycate treatment was compared with its concentration in serum. Twenty five children with asthma entered a 10 week trial of two baseline weeks followed by eight weeks of treatment by the inhalation of 20 mg of sodium cromoglycate spincaps four times a day. Individual clinical respo...

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    更新日期:1988-06-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1136/adc.60.6.547

    authors: Bentele KH,Albani M,Budde C,Schulte FJ

    更新日期:1985-06-01 00:00:00

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    更新日期:1989-11-01 00:00:00

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    pub_type: 临床试验,杂志文章,随机对照试验

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  • Intelligence and development in Aarskog syndrome.

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    abstract:OBJECTIVE:To study the epidemiology of pyridoxine dependent seizures and other forms of pyridoxine responsive seizures. DESIGN:Monthly notifications to the British Paediatric Surveillance Unit over two years. Questionnaire follow up. SETTING:UK and the Republic of Ireland. PATIENTS:Children aged 15 years or younger ...

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    pub_type: 杂志文章,评审

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    更新日期:2003-07-01 00:00:00

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    pub_type: 临床试验,杂志文章

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    pub_type: 杂志文章,评审

    doi:10.1136/adc.2007.124479

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    更新日期:2008-03-01 00:00:00

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    更新日期:1993-01-01 00:00:00

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    abstract::An adult woman with pseudopseudohypoparathyroidism had a child with normal calcium and parathyroid hormone concentrations and cyclic AMP response to injected parathyroid hormone in infancy. By 2.5 years he had features of pseudohypoparathyroidism with raised parathyroid hormone and 'flat' cyclic AMP response. This is ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.70.4.337

    authors: Barr DG,Stirling HF,Darling JA

    更新日期:1994-04-01 00:00:00

  • Detection of antibodies to human parvovirus in erythema infectiosum (fifth disease).

    abstract::Two Japanese outbreaks of erythema infectiosum were investigated for evidence of human parvovirus infection by a solid phase antibody capture radioimmunoassay based on a monoclonal antibody to human parvovirus. Specific IgM and high concentrations of specific IgG were detected in 37 sera from 27 children with erythema...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.59.11.1016

    authors: Okabe N,Koboyashi S,Tatsuzawa O,Mortimer PP

    更新日期:1984-11-01 00:00:00

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    abstract::We studied two neonates fed diluted formula and excessive water who developed hyponatraemic convulsions; treatment included intravenous hypertonic saline and water restriction. Educating mothers is important to stop recurrences. ...

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    doi:10.1136/adc.64.5.734

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    更新日期:1989-05-01 00:00:00

  • Management of foreskin problems.

    abstract::One hundred consecutive cases of boys with foreskin problems referred to local paediatric surgeons in the Edinburgh area were studied. Fifty five underwent circumcision and the remainder were managed more conservatively with or without the use of local or general anaesthetic. Although sometimes avoiding general anaest...

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    doi:10.1136/adc.66.6.696

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    更新日期:1991-06-01 00:00:00

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    doi:10.1136/adc.51.8.602

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    更新日期:1976-08-01 00:00:00

  • A low cost, colour coded, hand held spring scale accurately categorises birth weight in low resource settings.

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