Abstract:
:The aim of the present study was to characterise plasma concentrations of cholecystokinin (CCK) after breast feeding in newborn infants. Fifty eight healthy full term exclusively breast fed infants were investigated at 4 (1) (2-6) days of age. Each infant contributed one blood sample collected just before, immediately after, or 10, 30, and 60 minutes after breast feeding. Plasma concentrations of CCK were measured with a technique consisting of high pressure liquid chromatography separation of gastrins and CCKs and consequent analysis with radioimmunoassay. Mean (SD) preprandial plasma concentrations of CCK (CCK8+CCK-33,39) were 68 (17) pmol/l. A significant increase was seen immediately after breast feeding, which was followed by a decline at 10 minutes and a secondary rise was seen at 30 and 60 minutes. The first peak is likely to be due to a suckling related activation of the vagal nerve and the second to a stimulatory effect of food on CCK-producing cells. An inverse relationship between basal concentrations of CCK and age of the infant was found. In rats peripheral injections of CCK reduce food intake and cause postprandial sedation and sleepiness via activation of an afferent vagal mechanism. CCK release in response to breast feeding may therefore in addition to exerting stimulatory effects on digestion and metabolism contribute to relaxation and sleepiness seen after breast feeding. The high CCK concentrations seen in younger infants may help the infant to remain satiated and calm despite receiving very little food during the first days of life.
journal_name
Arch Dis Childjournal_title
Archives of disease in childhoodauthors
Uvnäs-Moberg K,Marchini G,Winberg Jdoi
10.1136/adc.68.1_spec_no.46subject
Has Abstractpub_date
1993-01-01 00:00:00pages
46-8issue
1 Spec Noeissn
0003-9888issn
1468-2044journal_volume
68pub_type
杂志文章abstract::A two year prospective study identified 1922 cases of meningitis in children under 1 year of age. A further 201 cases were identified from other sources. The annual incidence of meningitis during the first year of life was 1.6/1000; during the first 28 days of life it was 0.32/1000, and among postneonatal infants it w...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.66.5.603
更新日期:1991-05-01 00:00:00
abstract::Twenty-one babies of 34-41 weeks' gestational age with birth asphyxia (5 minute Apgar score less than or equal to 5 or umbilical artery pH less than or equal to 7.2) were studied during the first two days of life to find out whether the urinary excretion of tubular markers of renal function is of value in the early di...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.65.10_spec_no.1021
更新日期:1990-10-01 00:00:00
abstract:AIMS:To describe the clinical and health economic impact of respiratory syncytial virus (RSV) disease in children under 2 years of age. METHODS:Hospitalised children less than 2 years of age with a respiratory illness were studied over three consecutive RSV seasons (1996-99). RESULTS:The rates (per 1000 infants under...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.88.12.1065
更新日期:2003-12-01 00:00:00
abstract:AIM:Several studies have suggested a beneficial effect of infant breastfeeding on childhood cognitive function. The main objective was to examine whether duration of breastfeeding and age at introduction of complementary foods are related to cognitive performance in 9- to 10-year-old school-aged children in South India...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2009.165159
更新日期:2010-05-01 00:00:00
abstract::A 19 day old infant was successfully resuscitated from ventricular fibrillation. The 12 lead ECG was normal, with a normal QT interval, and remains so over three years follow up. DNA analysis revealed a missense mutation (R1193Q) in the SCN5A gene, previously linked with familial sudden unexpected nocturnal death synd...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2004.058115
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND:Long term growth hormone (GH) treatment in children with idiopathic short stature (ISS) results in a relatively small mean gain in final height of 3-9 cm, which may not justify the cost of treatment. As it is unknown whether GH treatment during puberty adds to final height gain, we sought to improve the cost...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/adc.87.3.215
更新日期:2002-09-01 00:00:00
abstract::Interstitial nephritis was diagnosed at renal biopsy in 10 previously healthy children. All had identical clinical symptoms: anaemia, raised sedimentation rate, low glomerular filtration rate, protein and leucocytes in the urine, but no bacteria; nine also had glycosuria. Six of the children had a history of recent in...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.60.8.752
更新日期:1985-08-01 00:00:00
abstract:OBJECTIVES:To assess the potential effect of two guideline discharge oxygen saturation (SpO(2)) recommendations (≥90% and ≥94%) in recovering bronchiolitis. METHODS AND PATIENTS:Infants aged up to 18 months requiring therapeutic oxygen for SpO(2) (≤93%) had SpO(2) assessed in air every 2 h. Time from admission to re-e...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2010.205211
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Respiratory viral infections precipitate exacerbations of chronic respiratory diseases such as asthma and chronic obstructive pulmonary disease though similar data in non-cystic fibrosis (CF) bronchiectasis are missing. Our study aimed to determine the point prevalence of viruses associated with exacerbation...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2013-305147
更新日期:2014-08-01 00:00:00
abstract:AIMS:To evaluate the performance of the Paediatric Risk of Mortality (PRISM) score in a population of UK children and to use this score to examine severity of illness adjusted mortality of critically ill children <16 years old in a defined geographical region. METHODS:Observational study of a defined population of cri...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.86.3.194
更新日期:2002-03-01 00:00:00
abstract::Endogenous formation of thromboxane A2 and prostacyclin were evaluated in seven neonatates with persistent pulmonary hypertension by serial gas chromatographic mass spectrometric determination of their urinary metabolites dinor-thromboxane B2 and dinor-6-keto-prostaglandin F1 alpha, respectively. The patients were stu...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.64.7_spec_no.949
更新日期:1989-07-01 00:00:00
abstract:BACKGROUND:Congenital facial palsy (CFP) is clinically defined as facial palsy present at birth. It is associated with considerable disfigurement and causes functional and emotional problems for the affected child. The aetiology of the majority of cases however, remains elusive. AIMS:To investigate the role of a neuro...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.83.3.256
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVE:To review the clinical features, treatment, and outcome of children in the UK with Down's syndrome and acute myeloid leukaemia (AML). DESIGN:A retrospective study of 59 children with Down's syndrome and AML presenting between 1987 and 1995. Data were obtained from hospital case notes, trial records, and by q...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.81.1.32
更新日期:1999-07-01 00:00:00
abstract::Two siblings were born with congenital heart block, and one suffered from severe hydrops fetalis, although maintaining a higher heart rate than the other. The association of hydrops fetalis with disorders of cardiac rhythm is unlikely to be simply a manifestation of congestive cardiac failure in the fetus. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.55.6.479
更新日期:1980-06-01 00:00:00
abstract:OBJECTIVE:There is a body of published research on the effectiveness of home visiting for the prevention of child maltreatment, but little in the peer reviewed literature on cost-effectiveness or value to society. The authors sought to determine the cost-effectiveness of alternative home visiting programmes to inform p...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/archdischild-2011-300795
更新日期:2012-09-01 00:00:00
abstract::Plasma concentrations of motilin, gastrin, and enteroglucagon were measured in cord blood and during the first 24 days of life before feeding in 45 term and 63 preterm, healthy infants. Levels of these hormones rose steeply after birth, reaching concentrations that were much higher than those in fasting adults. These ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.55.9.673
更新日期:1980-09-01 00:00:00
abstract::To assess the bacteriological quality of unpooled expressed breast milk, a pilot bottle sample of each donation was examined before the milk was given to the neonate. Provided the milk did not contain greater than 2500 organisms/ml or potential pathogens it was used unheated. Milk containing between 2500 and 5000 orga...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.54.10.760
更新日期:1979-10-01 00:00:00
abstract::Eighty four very low birthweight babies (considered high risk for developing necrotising enterocolitis) were given vancomycin orally for 48 hours before introduction of oral feeds; one developed necrotising enterocolitis. One hundred and twenty very low birthweight babies (not considered such high risk) were fed witho...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.63.11.1390
更新日期:1988-11-01 00:00:00
abstract::Female genital mutilation (FGM) is almost always performed on children and consequently paediatricians should have a central role in the detection and prevention of FGM. FGM has no health benefits and can cause lifelong damage to physical and psychological health. Extensive migration of FGM practising communities mean...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/archdischild-2014-307234
更新日期:2016-03-01 00:00:00
abstract:AIMS:To evaluate a systematic approach to the development and implementation of evidence based asthma management guidelines. METHODS:Comparative study of children (2-18 years) with acute asthma; a control cohort (cohort 1) was recruited before implementation of the guidelines and two cohorts were recruited after imple...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2003.032110
更新日期:2004-07-01 00:00:00
abstract::Lung function tests were carried out in the first 6 hours of life on 26 babies born by vaginal delivery and 10 born by caesarean section. The babies born by caesarean section had a mean thoracic gas volume of only 19.7 ml/kg body weight compared with 32.7 ml/kg for the babies born vaginally. We conclude that this is o...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.53.7.545
更新日期:1978-07-01 00:00:00
abstract::The communication development in 11 children with Angelman's syndrome is described. The clinical observation that these children appear to have a greater ability with receptive rather than expressive language is investigated and these skills assessed using published communication schedules. In addition the understandi...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.69.1.148
更新日期:1993-07-01 00:00:00
abstract::A postal survey of recently appointed consultant paediatricians was undertaken to determine whether they perceived their training had adequately equipped them for their current job. The response rate was 69% (207/299). After excluding replies from consultants trained outside the UK the analysis was carried out on 167 ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.71.4.381
更新日期:1994-10-01 00:00:00
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journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究
doi:10.1136/adc.2006.105304
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:Ataxia telangiectasia (A-T) is a rare multisystem disease with high early mortality from lung disease and cancer. Nutritional failure adversely impacts outcomes in many respiratory diseases. Several factors influence nutrition in children with A-T. We hypothesised that children with A-T have progressive grow...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2015-310373
更新日期:2016-12-01 00:00:00
abstract::Bilateral diaphragmatic pacing was successfully performed in an 18-month-old child with congenital central hypoventilation syndrome (Ondine's curse) as an alternative to long-term mechanical ventilation. Subsequent complications were related more to cor pulmonale and tracheostomy care than to the pacing itself. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.55.11.901
更新日期:1980-11-01 00:00:00
abstract::Four children with chronic diarrhoea and perianal excoriation after a pull-through operation for Hirschsprung's disease have been shown to have increased but not markedly raised levels of faecal bile acids. Bile acid analysis of the 'bile-rich' duodenal fluid obtained after pancreozymin stimulation in 3 of the patient...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.50.3.243
更新日期:1975-03-01 00:00:00
abstract::Over a period of 30 months, umbilical artery catheters were inserted in 229 infants. The main complications were haemorrhage, infection, and obstruction of a blood vessel. The incidence of infection was not affected by the use of prophylactic antibiotics. Vascular obstruction was more common in small infants, and in t...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.48.4.296
更新日期:1973-04-01 00:00:00
abstract::Ten preterm infants with recurrent respiratory symptoms (median gestational age 30 weeks) were entered into a non-randomised placebo controlled trial of bronchodilator treatment at 12.5 months of age. The infants had coughed or wheezed, or both, on at least four days a week for the past month. The infants received eit...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.65.7.782
更新日期:1990-07-01 00:00:00
abstract:AIM:To investigate the epidemiology, clinical profile and risk factors of pseudotumor cerebri syndrome (PTCS) in children aged 1-16 years. METHODS:A national prospective population-based cohort study over 25 months. Newly diagnosed PTCS cases notified via British Paediatric Surveillance Unit were ascertained using cla...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2016-312238
更新日期:2017-08-01 00:00:00