Abstract:
BACKGROUND:Long term growth hormone (GH) treatment in children with idiopathic short stature (ISS) results in a relatively small mean gain in final height of 3-9 cm, which may not justify the cost of treatment. As it is unknown whether GH treatment during puberty adds to final height gain, we sought to improve the cost-benefit ratio, employing a study design with high dose GH treatment restricted to the prepubertal period. AIMS:To assess the effect of short term, high dose GH treatment before puberty on growth, bone maturation, and pubertal onset. METHODS:Five year results of a randomised controlled study are reported. Twenty six boys and nine girls were randomly assigned to a GH treatment group (n = 17) or a control group (n = 18). Inclusion criteria were: no signs of puberty, height less than -2 SDS, age 4-8 years for girls or 4-10 years for boys, GH concentration >10 micro g/l after provocation, and normal body proportions. To assess GH responsiveness, children assigned to the GH treatment group received GH treatment for two periods of three months (1.5 IU/m2/day and 3.0 IU/m2/day), separated by three month washout periods, during the first year of study. High dose GH treatment (6.0 IU/m2/day) was then started and continued for at least two full years. When puberty occurred, GH treatment was discontinued at the end of a complete year's treatment (for example, three or four years of GH treatment). RESULTS:In response to at least two years on high dose GH treatment, mean (SD) height SDS for chronological age increased significantly in GH treated children from -2.6 (0.5) to -1.3 (0.5) after two years and -1.4 (0.5) SDS after five years of study. No changes in height SDS were observed in controls. A rapid rate of bone maturation of 3.6 years/2 years in treated children compared to 2 years/2 years in controls was observed in response to two years high dose GH treatment. Height SDS for bone age was not significantly different between groups during the study period. GH treated children entered into puberty at a significantly earlier age compared to controls. CONCLUSIONS:High dose GH treatment before puberty accelerates bone age and induces an earlier onset of puberty. This may limit the potential therapeutic benefit of this regimen in ISS.
journal_name
Arch Dis Childjournal_title
Archives of disease in childhoodauthors
Kamp GA,Waelkens JJ,de Muinck Keizer-Schrama SM,Delemarre-Van de Waal HA,Verhoeven-Wind L,Zwinderman AH,Wit JMdoi
10.1136/adc.87.3.215subject
Has Abstractpub_date
2002-09-01 00:00:00pages
215-20issue
3eissn
0003-9888issn
1468-2044journal_volume
87pub_type
临床试验,杂志文章,随机对照试验abstract::Three paediatric pathologists, one perinatal paediatrician, one obstetrician, and one epidemiologist separately used information collected on 239 babies in an attempt to validate the Wigglesworth classification of perinatal deaths. This was first done using clinical data only, then using the combination of clinical an...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.64.10_spec_no.1345
更新日期:1989-10-01 00:00:00
abstract:BACKGROUND:The isolated finding of an unexplained chronic subdural haematoma in an infant may suggest non-accidental head injury (NAHI). The authors report a previously undescribed cause of multifocal chronic subdural haematoma in infancy which could result in a misdiagnosis of previous NAHI. METHODS:Two infants, aged...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2010.194746
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:To describe the pathways by which children with cancer present to a shared care oncology unit. DESIGN:A population-based retrospective cohort study of children diagnosed with cancer between the years 2004 and 2014. SETTING:District General Hospital with a level 2 Paediatric Oncology Shared Care Unit. PATIE...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2015-308765
更新日期:2015-12-01 00:00:00
abstract::Analysis of the response to corticosteroid therapy in a personal series of 8 consecutive cases of dermatomyositis in childhood shows that there are advantages in a moderate dosage, short-term treatment schedule, with gradual tapering of the dosage as soon as there is clinical improvement without waiting for full remis...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.51.7.494
更新日期:1976-07-01 00:00:00
abstract::Cerebral oedema is the most common cause of mortality and morbidity during the first day of conventional treatment for diabetic ketoacidosis in paediatric patients. It is possible that therapy contributes to its development. Risk factors that predispose to cerebral oedema should lead to an expansion of the intracellul...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/adc.88.2.170
更新日期:2003-02-01 00:00:00
abstract::Bilateral diaphragmatic pacing was successfully performed in an 18-month-old child with congenital central hypoventilation syndrome (Ondine's curse) as an alternative to long-term mechanical ventilation. Subsequent complications were related more to cor pulmonale and tracheostomy care than to the pacing itself. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.55.11.901
更新日期:1980-11-01 00:00:00
abstract:OBJECTIVE:To report the evidence for and challenges to the validity of Sheffield Peer Review Assessment Tool (SPRAT) with paediatric Specialist Registrars (SpRs) across the UK as part of Royal College of Paediatrics and Child Health workplace based assessment programme. DESIGN:Quality assurance analysis, including gen...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究
doi:10.1136/adc.2008.146209
更新日期:2010-05-01 00:00:00
abstract::This pilot study investigated the feasibility of surveying, anonymously, HCV infection among healthy children using an oral fluid specimen. Seventy seven per cent of children provided their assent, or where appropriate, consent to participate; 2.8% were anti-HCV positive. Oral fluid collection is acceptable to childre...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2003.031310
更新日期:2004-02-01 00:00:00
abstract:AIM:To evaluate the risk factors for breakthrough varicella in a follow up study of a cohort of 181 healthy children immunised when aged 9-24 months with a reformulated Oka strain varicella vaccine (SmithKline Beecham Biologicals/Oka). DESIGN:The children were randomised in a double blind manner into one of four group...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/adc.79.6.478
更新日期:1998-12-01 00:00:00
abstract:BACKGROUND:Studies on adolescent drug use are scarce as most studies do not distinguish between children and adolescents. Therefore, we assessed overall drug use in adolescents. METHODS:A retrospective cohort study was conducted using pharmacy dispensing records from 62 community pharmacies in the Netherlands. Dispens...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2017-314692
更新日期:2019-08-01 00:00:00
abstract::Ninety one patients with urinary tract abnormalities diagnosed before birth were reviewed. Diagnoses based on prenatal and postnatal ultrasound scans alone were compared with the final diagnoses after full urological investigations, with operative or necropsy confirmation in 79 cases. The results confirmed that ultras...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.64.4.578
更新日期:1989-04-01 00:00:00
abstract::The sodium intake of preschool children in their home environment was investigated and the major sources of sodium other than added table salt identified. Thirty five children from a Southampton general practice were studied. Twenty four hour urinary sodium excretion was measured as a reliable indicator of daily total...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.61.2.159
更新日期:1986-02-01 00:00:00
abstract::A four year regional screening programme to detect cystic fibrosis using measurement of immunoreactive trypsinogen is described. During this period 60 infants were diagnosed; 34 by screening, 12 born with meconium ileus, and 14 not identified by the screening assay but who presented with clinical symptoms at a later a...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.63.12.1438
更新日期:1988-12-01 00:00:00
abstract::In 100 patients with cystic fibrosis the severity of steatorrhoea was assessed by three separate methods. Using chemical faecal fat assay as the gold standard, two other rapid and inexpensive methods were compared with it. The steatocrit method proved unreliable in our hands and gave little indication of the presence ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.65.1.99
更新日期:1990-01-01 00:00:00
abstract:AIM:Several studies have suggested a beneficial effect of infant breastfeeding on childhood cognitive function. The main objective was to examine whether duration of breastfeeding and age at introduction of complementary foods are related to cognitive performance in 9- to 10-year-old school-aged children in South India...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2009.165159
更新日期:2010-05-01 00:00:00
abstract:AIMS:To investigate a population of individuals with 22q11 deletion syndrome for hypocalcaemia. METHODS:A detailed clinical history enquiring into symptoms of hypocalcaemia and blood sampling to assess for hypocalcaemia and hypoparathyroidism, of patients outside the neonatal period known to have the 22q11 microdeleti...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.88.6.520
更新日期:2003-06-01 00:00:00
abstract:BACKGROUND:Medium chain acyl-CoA dehydrogenase (MCAD) deficiency is a common disorder of fatty acid oxidation in north west Europe. It is very variable in its clinical consequences and is believed to be considerably underdiagnosed. OBJECTIVE:To investigate the diagnosis and outcome of MCAD deficiency in the UK. METHO...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.79.2.116
更新日期:1998-08-01 00:00:00
abstract:BACKGROUND:The epidemiology of congenital infections is ever changing, with a recent resurgence in syphilis infection rates seen in the UK. Identification of congenital infection is often delayed; early recognition and management of congenital infections is important. Testing modalities and investigations are often lim...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/archdischild-2020-318841
更新日期:2021-02-01 00:00:00
abstract::To determine the value of a detailed family history for the assessment of the risk of recurrence of febrile seizures, 115 children who visited the emergency room of an academic children's hospital were studied prospectively. The recurrence risk of febrile seizures was analysed in relation to the child's family history...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.70.5.395
更新日期:1994-05-01 00:00:00
abstract:OBJECTIVE:Use next-generation sequencing (NGS) technology to improve our diagnostic yield in patients with suspected genetic disorders in the Asian setting. DESIGN:A diagnostic study conducted between 2014 and 2019 (and ongoing) under the Singapore Undiagnosed Disease Program. Date of last analysis was 1 July 2019. S...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2020-319180
更新日期:2021-01-01 00:00:00
abstract::The practice of general paediatricians in the initial evaluation of congenital hypothyroidism (CHT) was assessed. This was performed by a questionnaire survey of paediatricians in East Anglia of whom 84% responded. Nineteen of 25 clinicians based in seven district hospitals managed children with CHT. The median number...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.77.4.339
更新日期:1997-10-01 00:00:00
abstract:BACKGROUND:Cyclosporine A (CsA) has been widely used in children with steroid dependent and steroid resistant nephrotic syndrome (NS) because of its efficacy in relieving these patients from systemic side effects of steroids. However, its long term use is controversial, since chronic CsA induced nephropathy (CsAN) may ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2005.080960
更新日期:2006-08-01 00:00:00
abstract::Four Asian babies were investigated because they failed to thrive. In all four cases the failure to thrive was a result of the mother's social isolation and inability to communicate, and to the father's refusal to accept that there was a problem in the family. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.64.3.369
更新日期:1989-03-01 00:00:00
abstract::Children at three inner city child health clinics were offered haemoglobin estimation by fingerprick blood test when attending for immunisation against measles. Of the 98 immunised, 92 (94%) participated in the study, together with 58 other children. Anaemia (haemoglobin concentration less than 110 g/l) was found in 3...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.65.8.892
更新日期:1990-08-01 00:00:00
abstract::Serum IgG antibodies to teichoic acid and alpha toxin from Staphylococcus aureus were measured in 62 patients with cystic fibrosis by enzyme linked immunosorbent assays. The patients were followed up for 12-24 months in a prospective study. Raised titres were found exclusively in patients chronically colonised with S ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.62.9.905
更新日期:1987-09-01 00:00:00
abstract:OBJECTIVE:Early diagnosis and treatment initiation are important factors for successful treatment of mucopolysaccharidosis type I (MPS I). The purpose of this observational study was to assess whether age at diagnosis and time to first treatment for individuals with MPS I have improved over the last 15 years. STUDY DE...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2020-319040
更新日期:2020-11-02 00:00:00
abstract::School medical records of 1000 children born in 1981 were studied retrospectively. They showed that once known medical problems and those screened for by the school nurse (hearing, vision, growth) were excluded, only 17 problems requiring treatment were discovered: speech (n = 10), development (n = 3), undescended tes...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.65.2.225
更新日期:1990-02-01 00:00:00
abstract::Interferon is becoming the standard treatment in adults for chronic hepatitis C. Twenty one children with histologically proved chronic hepatitis C (10 boys, range 2.5-13 years), who were otherwise healthy, were enrolled in a randomised controlled study to test their response to interferon alfa. Eleven children were t...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/adc.74.2.152
更新日期:1996-02-01 00:00:00
abstract:BACKGROUND:Short-course oral corticosteroids are commonly used in children but are known to be associated with adverse drug reactions (ADRs). This review aimed to identify the most common and serious ADRs and to determine their relative risk levels. METHODS:A literature search of EMBASE, MEDLINE, International Pharmac...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,meta分析,评审
doi:10.1136/archdischild-2015-309522
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Clinical examination, while useful, has been shown to be insufficient as the sole screening method in infants. Ultrasound examination at 8 weeks in high risk infants is an integral part of the screening process in some units. AIMS:To show the efficiency of hip sonography in detection of developmental dyspla...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2003.033597
更新日期:2005-06-01 00:00:00