Prospective study of serum staphylococcal antibodies in cystic fibrosis.

Abstract:

:Serum IgG antibodies to teichoic acid and alpha toxin from Staphylococcus aureus were measured in 62 patients with cystic fibrosis by enzyme linked immunosorbent assays. The patients were followed up for 12-24 months in a prospective study. Raised titres were found exclusively in patients chronically colonised with S aureus. Patients colonised with both S aureus and Pseudomonas aeruginosa had significantly higher titres against teichoic acid than those carrying S aureus alone. Titres were significantly higher when there were clinical signs of low grade infection in the patients chronically colonised with S aureus alone, and in those with both S aureus and P aeruginosa. Significant reduction in titres occurred after antimicrobial treatment given either orally or intravenously in patients with normal erythrocyte sedimentation rates and white cell counts. Measurement of staphylococcal antibody titres may be valuable in monitoring pulmonary infection and antimicrobial treatment in patients with cystic fibrosis.

journal_name

Arch Dis Child

authors

Hollsing AE,Granström M,Strandvik B

doi

10.1136/adc.62.9.905

subject

Has Abstract

pub_date

1987-09-01 00:00:00

pages

905-11

issue

9

eissn

0003-9888

issn

1468-2044

journal_volume

62

pub_type

杂志文章
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