Immunological responses to respiratory syncytial virus infection in infancy.

Abstract:

OBJECTIVES:To determine whether there is evidence of immunological responses in infants with respiratory syncytial virus (RSV) bronchiolitis by measuring inflammatory mediators in peripheral blood and, if found, whether these related to the severity of illness. PATIENTS AND METHODS:Blood was taken from 94 children with RSV infection during the acute episode and 10 or more days later when the child was well. Control serum samples were obtained from well children of similar ages. Serum samples were assayed for mediators of lymphocyte activity (interleukin-4 (IL-4), soluble interleukin-2 receptor (sCD25), soluble intercellular adhesion molecule-1 (sICAM-1), eosinophil activity (eosinophil cationic protein) and neutrophil activity (myeloperoxidase). Symptoms were assessed as very mild (coryza only), mild (symptoms of lower respiratory tract infection), moderate (requiring nasogastric or intravenous fluids), and severe (requiring oxygen or ventilation). RESULTS:IL-4 concentrations were at the lower limits of detection of the assay. The concentrations of sCD-25 were greater in samples from patients with acute illness than from convalescent patients and both were greater than in control samples. sICAM-1 concentrations were similar in samples from patients with acute illness and convalescent patients, but both were greater than in samples from controls. Eosinophil cationic protein concentrations were lower in samples from patients with acute illness than in those from convalescent patients; there was no difference between samples from convalescent and control patients. Myeloperoxidase concentrations were similar in all samples. There was no correlation between the severity of infection and the concentrations of any inflammatory mediators. CONCLUSIONS:There is evidence of an inflammatory response in the peripheral blood of infants with acute bronchiolitis which may affect lymphocytes and eosinophils, but an association between this response and the severity of illness was not shown here.

journal_name

Arch Dis Child

authors

Smyth RL,Fletcher JN,Thomas HM,Hart CA

doi

10.1136/adc.76.3.210

subject

Has Abstract

pub_date

1997-03-01 00:00:00

pages

210-4

issue

3

eissn

0003-9888

issn

1468-2044

journal_volume

76

pub_type

杂志文章
  • Polyethylene glycol 3350 plus electrolytes for chronic constipation in children: a double blind, placebo controlled, crossover study.

    abstract:OBJECTIVES:To assess the efficacy and safety of polyethylene glycol 3350 plus electrolytes (PEG+E) for the treatment of chronic constipation in children. DESIGN:Randomised, double blind, placebo controlled crossover trial, with two 2-week treatment periods separated by a 2-week placebo washout. SETTING:Six UK paediat...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/adc.2006.115493

    authors: Thomson MA,Jenkins HR,Bisset WM,Heuschkel R,Kalra DS,Green MR,Wilson DC,Geraint M

    更新日期:2007-11-01 00:00:00

  • A family study of the genetic basis of asthma and wheezy bronchitis.

    abstract::The family histories relating to asthma and wheezy bronchitis were examined in 77 asthmatic, 78 wheezy bronchitic, and 87 control children, aged between 1 and 12 years. The percentage of children with at least one asthmatic relative was significantly greater in the asthmatic and wheezy bronchitic probands than in the ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.55.5.354

    authors: Sibbald B,Horn ME,Gregg I

    更新日期:1980-05-01 00:00:00

  • An observational study to evaluate micronutrient status during enteral feeding.

    abstract:BACKGROUND:There are few data on the optimal micronutrient composition of paediatric enteral feeds. The recent European Directive on Foods for Special Medical Purposes (1999/21/EC) did not distinguish between the composition of adult and paediatric feeds. AIMS:To evaluate, in an open, observational study, the long ter...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.86.6.411

    authors: Johnson TE,Janes SJ,MacDonald A,Elia M,Booth IW

    更新日期:2002-06-01 00:00:00

  • Age specific xerophthalmia rates among displaced Ethiopians.

    abstract::The recent famine in Ethiopia has resulted in the dislocation of millions of people. Many of these individuals have moved to refugee camps in Sudan or to feeding centres within Ethiopia. A total of 1325 children up to the age of 15 years were examined by an ophthalmologist in January 1985 at several sites in these two...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.61.11.1100

    authors: Pizzarello LD

    更新日期:1986-11-01 00:00:00

  • Children and adolescents' experiences of primary lymphoedema: semistructured interview study.

    abstract:BACKGROUND:Congenital lymphoedema is a lifelong condition that has detrimental physical and psychosocial outcomes for young patients and burdensome treatment responsibilities that may hamper patients' motivation for self-management. There is limited research from the perspective of young people with primary lymphoedema...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/archdischild-2017-313856

    authors: Hanson CS,Newsom J,Singh-Grewal D,Henschke N,Patterson M,Tong A

    更新日期:2018-07-01 00:00:00

  • Reduction in case fatality rate from meningococcal disease associated with improved healthcare delivery.

    abstract:BACKGROUND AND AIMS:The case fatality rate from meningococcal disease (MD) has remained relatively unchanged in the post antibiotic era, with 20-50% of patients who develop shock still dying. In 1992 a new paediatric intensive care unit (PICU) specialising in MD was opened. Educational information was disseminated to l...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.85.5.386

    authors: Booy R,Habibi P,Nadel S,de Munter C,Britto J,Morrison A,Levin M,Meningococcal Research Group.

    更新日期:2001-11-01 00:00:00

  • Enteral feeding of premature infants with Lactobacillus GG.

    abstract::The objectives of this study were to determine whether or not the probiotic Lactobacillus GG can colonise the immature bowel of premature infants and if so, does colonisation result in a reduction of the size of the bowel reservoir of nosocomial pathogens such as enterobacteriaceae, enterococci, yeasts or staphylococc...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/adc.69.5_spec_no.483

    authors: Millar MR,Bacon C,Smith SL,Walker V,Hall MA

    更新日期:1993-11-01 00:00:00

  • Subclinical hypothyroidism and Down's syndrome; studies on myocardial structure and function.

    abstract:BACKGROUND:The management of subclinical hypothyroidism (SH) is still controversial, as the benefit to risk ratio of prolonged L-thyroxine therapy is not clear cut. Some authors have shown abnormalities of myocardial function and structure in adults with SH, which could be reversed by L-thyroxine therapy. As SH frequen...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.88.11.1005

    authors: Toscano E,Pacileo G,Limongelli G,Verrengia M,Di Mita O,Di Maio S,Salerno M,Del Giudice E,Caniello B,Calabrò R,Andria G

    更新日期:2003-11-01 00:00:00

  • Fever in the returning child traveller: approach to diagnosis and management.

    abstract::During the last half century there has been an exponential increase in international travel including to more exotic and long-haul destinations. The assessment of febrile returning child travellers presents diagnostic challenges and is often performed poorly. A detailed travel and medical history, clinical examination...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2012-303196

    authors: Halbert J,Shingadia D,Zuckerman JN

    更新日期:2014-10-01 00:00:00

  • Safety of the insulin tolerance test.

    abstract::Concerns have been raised about the hazards of the insulin tolerance test (ITT), used to measure growth hormone secretion. In Glasgow, we continue to use this test, adhering to a strict protocol. A review of outcome over a 10 year period (1989-99), during which 550 ITTs were performed, was undertaken. No serious adver...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.87.4.354

    authors: Galloway PJ,McNeill E,Paterson WF,Donaldson MD

    更新日期:2002-10-01 00:00:00

  • Fragile X, iron, and neurodevelopmental screening in 8 year old children with mild to moderate learning difficulties.

    abstract:OBJECTIVE:To examine the value of neurodevelopmental examination, fragile X testing, iron studies, and other screening procedures in children with mild to moderate learning difficulties. DESIGN:A cross sectional case-control study. SUBJECTS:A 34% random sample (n = 130) of children with mild to moderate learning diff...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.76.3.264

    authors: Corrigan N,Stewart M,Scott M,Fee F

    更新日期:1997-03-01 00:00:00

  • Neonatal tuberculosis.

    abstract::Tuberculosis rarely presents in the neonatal period. Though treatable, it may be fatal despite modern treatment. The diagnosis of congenital tuberculosis should be considered in any neonate with pneumonia that fails to respond to conventional treatment, particularly in a child from an ethnic or socioeconomic environme...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.61.5.512

    authors: Bate TW,Sinclair RE,Robinson MJ

    更新日期:1986-05-01 00:00:00

  • Association between urinary symptoms at 7 years old and previous urinary tract infection.

    abstract::The association between current micturition habits and previous urinary tract infection was analysed among 3553 school entrants aged 7 years by means of a questionnaire. A high incidence of urinary infection, confirmed by urine culture, was found (145 (8.4%) in the 1719 girls and 32 (1.7%) in the 1834 boys). There was...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.66.2.232

    authors: Hellström A,Hanson E,Hansson S,Hjälmås K,Jodal U

    更新日期:1991-02-01 00:00:00

  • Plethysmographic validation of near infrared spectroscopic monitoring of cerebral blood volume.

    abstract::The validation of measurement of cerebral blood volume (CBV) and cerebral blood flow (CBF) using near infrared spectroscopy (NIRS) against jugular venous occlusion plethysmography is described. Repeated measurements in six infants were made using both techniques simultaneously. A close relationship between the two mea...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.67.4_spec_no.407

    authors: Wickramasinghe YA,Livera LN,Spencer SA,Rolfe P,Thorniley MS

    更新日期:1992-04-01 00:00:00

  • Important issues in the justification of a control treatment in paediatric drug trials.

    abstract:OBJECTIVE:The value of comparative effectiveness trials in informing clinical and policy decisions depends heavily on the choice of control arm (comparator). Our objective is to identify challenges in comparator reasoning and to determine justification criteria for selecting a control arm in paediatric clinical trials....

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/archdischild-2016-310644

    authors: Kelly LE,Davies EH,Saint-Raymond A,Tomasi P,Offringa M

    更新日期:2016-10-01 00:00:00

  • Measuring compliance with inhaled medication in asthma.

    abstract::Using an electronic inhaler timer device (Nebulizer Chronolog), compliance with the prescribed frequency of inhaled prophylactic medication in 14 asthmatic children was measured. Underuse occurred in 55% of study days while overuse occurred in only 2%. Such devices provide an important new tool for investigating inhal...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.67.3.332

    authors: Coutts JA,Gibson NA,Paton JY

    更新日期:1992-03-01 00:00:00

  • Impact of functional severity on self concept in young people with spina bifida.

    abstract::This study examines the relationship between medical and functional severity of disability and levels of self esteem and self concept in 79 young people with spina bifida. Greater feelings of global self worth and of self esteem in physical appearance were associated with greater severity of disability. This was only ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.73.1.48

    authors: Minchom PE,Ellis NC,Appleton PL,Lawson V,Böll V,Jones P,Elliott CE

    更新日期:1995-07-01 00:00:00

  • Lack of breast feeding and early weaning in infants of Asian immigrants to Wolverhampton.

    abstract::Fifty Asian immigrant mothers who would have expected to breast feed their infants had they remained in rural Asia were studied. There was a striking reduction in the incidence and duration of breast feeding on arrival in the United Kingdom, and a fall in the age of weaning. The availability of an alternative to human...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.51.8.608

    authors: Evans N,Walpole IR,Qureshi MU,Memon MH,Everley Jones HW

    更新日期:1976-08-01 00:00:00

  • Accidents on hospital wards.

    abstract::Eight hospitals reported 781 non-iatrogenic accidents occurring to patients and visitors under 16 years of age during an 18 month period up to October 1989. Accidents more often involved boys and children aged 3 to 5 years old. Falls from a height, slips, and striking accidents were common by day and falls by night. A...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.66.9.1047

    authors: Levene S,Bonfield G

    更新日期:1991-09-01 00:00:00

  • Effects of delivery by caesarean section on lung mechanics and lung volume in the human neonate.

    abstract::Lung function tests were carried out in the first 6 hours of life on 26 babies born by vaginal delivery and 10 born by caesarean section. The babies born by caesarean section had a mean thoracic gas volume of only 19.7 ml/kg body weight compared with 32.7 ml/kg for the babies born vaginally. We conclude that this is o...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.53.7.545

    authors: Milner AD,Saunders RA,Hopkin IE

    更新日期:1978-07-01 00:00:00

  • Advancing the newborn and stillbirth global agenda: priorities for the next decade.

    abstract::Remarkable advances have been made over the past decade in defining the burden of newborn mortality and morbidity and stillbirths, and in identifying interventions to address the major risk factors and causes of deaths. However, progress in saving newborn lives and preventing stillbirths in countries lags behind that ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2013-305557

    authors: Darmstadt GL,Shiffman J,Lawn JE

    更新日期:2015-02-01 00:00:00

  • Foot length--a new and potentially useful measurement in the neonate.

    abstract::The foot length, occipito-frontal head circumference (OFC), crown-rump, and crown-heel length (CHL) of 123 neonates of gestational ages 26-42 weeks, were measured between 12 hours and 5 days. A gauge, designed and constructed at St Mary's Hospital, Manchester, was used to measure foot length. In term babies (37-42 wee...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.54.3.226

    authors: James DK,Dryburgh EH,Chiswick ML

    更新日期:1979-03-01 00:00:00

  • Resource and outcome in paediatric diabetes services.

    abstract::The availability of resource (staffing and services) in all 21 paediatric diabetes services in Yorkshire and Humber Strategic Health Authority, UK was surveyed and this information was combined with demographic and clinical data on 2683 children and young people with diabetes (aged 0-23 years) to assess whether level ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2010.198275

    authors: Harron KL,McKinney PA,Feltbower RG,Holland P,Campbell FM,Parslow RC

    更新日期:2012-06-01 00:00:00

  • Assessment of doctors' consultation skills in the paediatric setting: the Paediatric Consultation Assessment Tool.

    abstract:OBJECTIVE:To determine the utility of a novel Paediatric Consultation Assessment Tool (PCAT). DESIGN:Developed to measure clinicians' communication behaviour with children and their parents/guardian, PCAT was designed according to consensus guidelines and refined at a number of stages. Volunteer clinicians provided vi...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/adc.2008.146191

    authors: Howells RJ,Davies HA,Silverman JD,Archer JC,Mellon AF

    更新日期:2010-05-01 00:00:00

  • Stabilisation of critically ill children at the district general hospital prior to intensive care retrieval: a snapshot of current practice.

    abstract:OBJECTIVE:To describe current practice during stabilisation of children presenting with critical illness to the district general hospital (DGH), preceding retrieval to intensive care. DESIGN:Observational study using prospectively collected transport data. SETTING:A centralised intensive care retrieval service in Eng...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2008.151266

    authors: Lampariello S,Clement M,Aralihond AP,Lutman D,Montgomery MA,Petros AJ,Ramnarayan P

    更新日期:2010-09-01 00:00:00

  • Ethics support in clinical practice.

    abstract::Ethical considerations have long been a part of clinical decision making. However, just as doctors and healthcare professionals are being increasingly challenged about the evidence base for their practice, there is increasing focus on the ethical dimension of clinical care. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/adc.2004.062752

    authors: Watson AR

    更新日期:2005-09-01 00:00:00

  • Diagnostic accuracy of chest radiography in detecting mediastinal lymphadenopathy in suspected pulmonary tuberculosis.

    abstract:OBJECTIVE:To estimate the diagnostic accuracy of chest radiography in the detection of chest lymphadenopathy in children with clinically suspected pulmonary tuberculosis. METHODS: DESIGN:Prospective cross sectional study. SETTING:A short stay ward in a children's hospital in South Africa. PATIENTS:Consecutive child...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2004.062315

    authors: Swingler GH,du Toit G,Andronikou S,van der Merwe L,Zar HJ

    更新日期:2005-11-01 00:00:00

  • The abnormal nucleus as a cause of congenital facial palsy.

    abstract:BACKGROUND:Congenital facial palsy (CFP) is clinically defined as facial palsy present at birth. It is associated with considerable disfigurement and causes functional and emotional problems for the affected child. The aetiology of the majority of cases however, remains elusive. AIMS:To investigate the role of a neuro...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.83.3.256

    authors: Jemec B,Grobbelaar AO,Harrison DH

    更新日期:2000-09-01 00:00:00

  • Use of complementary treatment by those hospitalised with acute illness.

    abstract:AIM:To determine the frequency of use of complementary treatment and measure its impact on clinical outcomes in a hospitalised general paediatric population. METHODS:A population based random sample of children admitted to the general paediatric service at a metropolitan children's hospital in Auckland, New Zealand fr...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.81.2.133

    authors: Armishaw J,Grant CC

    更新日期:1999-08-01 00:00:00

  • A comparison of three scoring systems for mortality risk among retrieved intensive care patients.

    abstract:AIMS:To assess the impact of two paediatric intensive care unit retrieval teams on the performance of three mortality risk scoring systems: pre-ICU PRISM, PIM, and PRISM II. METHODS:A total of 928 critically ill children retrieved for intensive care from district general hospitals in the south east of England (crude m...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.87.5.421

    authors: Tibby SM,Taylor D,Festa M,Hanna S,Hatherill M,Jones G,Habibi P,Durward A,Murdoch IA

    更新日期:2002-11-01 00:00:00