Abstract:
:Concerns have been raised about the hazards of the insulin tolerance test (ITT), used to measure growth hormone secretion. In Glasgow, we continue to use this test, adhering to a strict protocol. A review of outcome over a 10 year period (1989-99), during which 550 ITTs were performed, was undertaken. No serious adverse events occurred; in particular, no child fitted or required intravenous glucose. Fewer tests were done during the latter five years, with a higher yield of growth hormone (GH) deficiency, reflecting our increasingly conservative approach to paediatric GH therapy during this period. We conclude that the ITT is safe and reliable in a paediatric setting provided that a strict procedure is followed.
journal_name
Arch Dis Childjournal_title
Archives of disease in childhoodauthors
Galloway PJ,McNeill E,Paterson WF,Donaldson MDdoi
10.1136/adc.87.4.354subject
Has Abstractpub_date
2002-10-01 00:00:00pages
354-6issue
4eissn
0003-9888issn
1468-2044journal_volume
87pub_type
杂志文章abstract::Remarkable advances have been made over the past decade in defining the burden of newborn mortality and morbidity and stillbirths, and in identifying interventions to address the major risk factors and causes of deaths. However, progress in saving newborn lives and preventing stillbirths in countries lags behind that ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2013-305557
更新日期:2015-02-01 00:00:00
abstract::We investigated the associations between albuminuria, metabolic control, glomerular filtration, blood pressure, and platelet function in children with insulin dependent diabetes mellitus. The geometric mean (95% tolerance levels) albumin excretion (expressed as the geometric mean albumin to creatinine ratio on two ove...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.64.7.984
更新日期:1989-07-01 00:00:00
abstract::Total DNA was estimated in the lungs of 80 fetuses and newborn infants varying in gestation from 14 weeks to term. In fetuses of appropriate weight for gestational age total lung DNA increased at a constant rate from about 35 mg at 17 weeks' gestation to 480 mg at term. The lungs of immature fetuses were heavier and c...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.56.8.601
更新日期:1981-08-01 00:00:00
abstract:AIM:To investigate the safety of bronchoscopy and endobronchial biopsy in children with difficult asthma, and discuss the ethical issues associated with the procedure. METHODS:A three year prospective observational study was performed in two tertiary paediatric respiratory centres specialising in the management of chi...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究
doi:10.1136/adc.84.5.423
更新日期:2001-05-01 00:00:00
abstract::In 1973 a survey was conducted among 12 year old children living in a defined area of South Wales. In 1988 the survey was repeated in the same area, again among 12 year old children. Questionnaires were completed for all 965 children in the population sample; peak expiratory flow rates were performed on them all, and ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.64.10.1452
更新日期:1989-10-01 00:00:00
abstract::Ten children with severe asthma, who had been well controlled on maintenance betamethasone valerate aerosol for an average of 11 months, were given placebo aerosols without their knowledge. The period of placebo substitution was campared with one 28-day period of betamethasone valerate therapy beforehand, and two 28-d...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章
doi:10.1136/adc.50.5.387
更新日期:1975-05-01 00:00:00
abstract:AIM:To investigate the rate and nature of anxiety symptoms and disorders in children, and their relation to social adversities in a cultural sample not previously researched. METHODS:237 children aged 9 to 13 years living in the Gaza Strip were selected randomly from 112 schools. Children completed the revised manifes...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.78.5.439
更新日期:1998-05-01 00:00:00
abstract:OBJECTIVE:We assessed whether maternal mental health problems increased rates for child injury during the preschool years and mid-childhood, and the extent to which associations could be accounted for by a range of potential explanatory factors. DESIGN:We analysed the UK Millennium Cohort Study, a nationally represent...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2017-313809
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:Rectal measurement is considered a gold standard in many healthcare systems for body temperature measurement in children. Although this method has several disadvantages, an ideal alternative thermometer has not yet been introduced. However tympanic and infrared skin thermometers are potential alternatives. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2010.185801
更新日期:2010-12-01 00:00:00
abstract::We report three cases of Hurler's disease in which glaucoma developed in early childhood. We draw attention to the fact that glaucoma may be a commonly unrecognised early complication of this condition. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.63.9.1091
更新日期:1988-09-01 00:00:00
abstract:STUDY OBJECTIVES:To present diagnosis and treatment modalities of children with interstitial lung disease associated with frequent or rare surfactant protein C gene (SFTPC) mutation. PATIENTS:Twenty-two children with chronic lung disease associated with SFTPC mutation in a heterozygous form. RESULTS:Mutations located...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究
doi:10.1136/adc.2009.171553
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:The passage of hard stools is significantly more common in formula fed infants than breast fed infants and this might be the result of differences in fat absorption between breast and formula fed infants. Experimental studies indicate that long chain polyunsaturated fatty acids (LCPUFAs) might influence fat ...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/adc.81.3.253
更新日期:1999-09-01 00:00:00
abstract::Respiratory disease is a common cause of morbidity and mortality in children with Down's syndrome (DS). Causes range from those problems common to many children with DS, such as a narrow airway or impaired immunity, to rare structural lesions, such as tracheal bronchus. Additionally, other organ systems or extrinsic f...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/archdischild-2013-304611
更新日期:2013-10-01 00:00:00
abstract::Twenty-one babies of 34-41 weeks' gestational age with birth asphyxia (5 minute Apgar score less than or equal to 5 or umbilical artery pH less than or equal to 7.2) were studied during the first two days of life to find out whether the urinary excretion of tubular markers of renal function is of value in the early di...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.65.10_spec_no.1021
更新日期:1990-10-01 00:00:00
abstract:AIMS:To investigate whether infants who died of SIDS were more likely to have higher acute and lifetime average exposures to outdoor carbon monoxide (CO) and nitrogen dioxide (NO2) than comparison healthy infants. METHODS:A total of 169 case and 169 matched control infants born between 1988 and 1992, were studied. CO ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2004.057091
更新日期:2005-07-01 00:00:00
abstract::Encephalitis is an uncommon but potentially devastating neurological syndrome with different aetiologies including direct central nervous system infection with different agents (most commonly viral) and those mediated by the immune system. Whilst there have been several recent publications and guidelines on the manage...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/archdischild-2011-300100
更新日期:2012-02-01 00:00:00
abstract::During the last half century there has been an exponential increase in international travel including to more exotic and long-haul destinations. The assessment of febrile returning child travellers presents diagnostic challenges and is often performed poorly. A detailed travel and medical history, clinical examination...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2012-303196
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Cyclosporine A (CsA) has been widely used in children with steroid dependent and steroid resistant nephrotic syndrome (NS) because of its efficacy in relieving these patients from systemic side effects of steroids. However, its long term use is controversial, since chronic CsA induced nephropathy (CsAN) may ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2005.080960
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVE:To review the work of one tertiary paediatric palliative care service in facilitating planned withdrawal of ventilatory support outside the intensive care setting, with the purpose of developing local guidance for practice. METHODS:Retrospective 10-year (2003-2012) case note review of intensive care patients...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2013-305492
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVES:Foot pathology is a major source of morbidity in adults with diabetes. The aim of this study was to determine if children with insulin dependent diabetes have an increased incidence of foot pathology compared with non-diabetic children. DESIGN:Questionnaire, clinical examination, and biomechanical assessmen...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.73.2.151
更新日期:1995-08-01 00:00:00
abstract::The adrenal glands of 41 fresh stillbirths were studied and a 'stress response' pattern could be seen in 28. In these glands the stress response was characterised by compact cell change, lipid depletion, excess pyroninophilia, and dilatation of the very prominent granular endoplasmic reticulum. Scattered areas of cyto...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.53.10.769
更新日期:1978-10-01 00:00:00
abstract::Data drawn from the National Study of Health and Growth enabled an examination to be made of the attained height, weight for height, and triceps skinfold of children from one and two parent families. Children from one parent families were shorter than children from two parent families; however, once heights had been a...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.57.6.453
更新日期:1982-06-01 00:00:00
abstract::Malaria, as a key disease of poverty, was singled out for special attention in the Millennium Project of 2000. Recent data suggest that malaria incidence and mortality are now declining all over the world. While these figures are cause for celebration, they must be interpreted carefully and with caution, particularly ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2013-305441
更新日期:2015-02-01 00:00:00
abstract:PURPOSE:To estimate the minimum incidence of congenital Zika syndrome (CZS) and severe microcephaly in Canada and describe key clinical, epidemiological, aetiological and outcome features of these conditions. METHODS:Two separate national surveillance studies were conducted on CZS and severe microcephaly using the wel...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2020-320968
更新日期:2021-01-08 00:00:00
abstract::Spirometric data from 1586 healthy children, who did not smoke, were analysed to examine the effects of overweight as measured by the body mass index (weight/height2) on lung function. Overweight (72 boys, 88 girls) was defined as on or above the 90th percentile weight for height. After having controlled for the confo...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.65.5.512
更新日期:1990-05-01 00:00:00
abstract::A pear shaped non-electrostatic spacer, composed of steel with a volume of 250 ml and equipped with a facemask containing integrated inlet and outlet valves for inspiration and expiration, was compared with three plastic spacers. The plastic spacers were primed with repeated puffs from a budesonide pressurised metered...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/adc.73.3.226
更新日期:1995-09-01 00:00:00
abstract:BACKGROUND:A tailor-made serogroup B outer membrane vesicle vaccine was evaluated in the context of a serogroup B meningococcal epidemic dominated by Neisseria meningitidis strain B:4:P1.7b,4. OBJECTIVE:To determine the safety, reactogenicity and immunogenicity in infants aged 6-8 months of a meningococcal B vaccine d...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,随机对照试验
doi:10.1136/adc.2007.132571
更新日期:2009-10-01 00:00:00
abstract::An 11 year old boy presented with severe acute hereditary coproporphyria. Despite supportive measures his condition deteriorated after admission. Haem arginate, started two days after presentation, produced appreciable inhibition of porphyrin precursor overproduction and clinical improvement. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.66.6.730
更新日期:1991-06-01 00:00:00
abstract::Skinfold standards provide a useful indication of subcutaneous fat. To evaluate skinfold thickness of 252 Cambridge infants over the first 2 years of age, SD scores relative to the Tanner standards were calculated, taking account of skewness in the standards. Cambridge SD scores were low, varying according to age from...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.78.4.354
更新日期:1998-04-01 00:00:00
abstract::Mechanisms of gastro-oesophageal reflux were studied by oesophageal manometry and pH monitoring in 33 children: nine controls, 15 with gastro-oesophageal reflux alone, and nine with reflux oesophagitis. A total of 122 episodes of reflux were analysed in detail: 82 (67%) were synchronous with swallowing and 40 (33%) as...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.63.11.1333
更新日期:1988-11-01 00:00:00