Safety and ethics of bronchoscopy and endobronchial biopsy in difficult asthma.

Abstract:

AIM:To investigate the safety of bronchoscopy and endobronchial biopsy in children with difficult asthma, and discuss the ethical issues associated with the procedure. METHODS:A three year prospective observational study was performed in two tertiary paediatric respiratory centres specialising in the management of children with difficult asthma. A total of 48 children with difficult asthma and 35 non-asthmatic children were studied. RESULTS:Flexible bronchoscopy was performed under general anaesthesia in 38 children with difficult asthma, and rigid bronchoscopy was performed in 10, following a two week course of prednisolone. Endobronchial biopsy was performed in 47 patients. Perioperative complications occurred in one asthmatic undergoing flexible bronchoscopy (desaturation) and in two undergoing rigid bronchoscopy (desaturation in one, and bronchospasm and desaturation in one). There were no cases of significant bleeding or pneumothorax among the asthmatics. Flexible bronchoscopy was performed in 35 non-asthmatic patients with a variety of clinical indications. The total number of perioperative complications was greater in the non-asthmatics undergoing flexible bronchoscopy than in the asthmatics (17 complications in 35 children versus one in 38). Fever requiring hospital admission was documented in two asthmatics following bronchoscopy. Four asthmatics reported an increase in symptoms in the week following bronchoscopy. CONCLUSIONS:Bronchoscopy and endobronchial biopsy under general anaesthesia can be performed safely in children with difficult asthma, when the bronchoscopist and anaesthetist are suitably trained. The procedure is acceptable to the families involved.

journal_name

Arch Dis Child

authors

Payne D,McKenzie SA,Stacey S,Misra D,Haxby E,Bush A

doi

10.1136/adc.84.5.423

subject

Has Abstract

pub_date

2001-05-01 00:00:00

pages

423-6

issue

5

eissn

0003-9888

issn

1468-2044

journal_volume

84

pub_type

杂志文章,多中心研究
  • Neurological abnormalities in congenital amaurosis of Leber. Review of 30 cases.

    abstract::A retrospective study was made of 30 children with Leber's amaurosis (congenital retinal blindness). 24 presented with severe visual impairment, typical ophalmological findings, and absent electroretinograms. 6 other children, though presenting with marked visual loss and absent electroetinograms were later shown to b...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.52.5.399

    authors: Vaizey MJ,Sanders MD,Wybar KC,Wilson J

    更新日期:1977-05-01 00:00:00

  • Facilities for the school health team.

    abstract::Results of a questionnaire returned by 20 doctors giving information of 249 schools showed that many of the rooms made available to school health services are inadequate in terms of physical resources and privacy. A higher set of standards is recommended to enable schools and pupils to derive maximum benefit from comm...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.70.6.542

    authors: Henshelwood J,Polnay L

    更新日期:1994-06-01 00:00:00

  • Named/designated doctor status and judgement in child-protection scenarios.

    abstract::Four child-protection scenarios were sent to 200 named/designated and non-named/non-designated doctors. The respondents judged each scenario as abuse or accident and indicated their degree of certainty. There was a 71% response rate. There were no significant differences in judgement or degrees of certainty of judgeme...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2006.105528

    authors: Power S

    更新日期:2008-07-01 00:00:00

  • Randomised trial of a ready-to-feed compared with powdered formula.

    abstract::Forty three infants were assigned randomly to a ready-to-feed infant formula or a standard formula that required reconstitution from powder. Despite similar nutrient composition of the two formulas those fed the powdered formula had significantly increased body weight and skinfold thickness gains, and became significa...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/adc.67.7.935

    authors: Lucas A,Lockton S,Davies PS

    更新日期:1992-07-01 00:00:00

  • "Unresolving pneumonia" as the main manifestation of atypical Kawasaki disease.

    abstract::Two cases of atypical Kawasaki disease (KD) manifested as persistent lobar lung consolidation, prolonged fever, and active inflammatory laboratory markers unresponsive to antibiotic treatment are reported. One of the children developed a giant coronary aneurysm. Atypical KD should be considered in the differential dia...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.88.10.940

    authors: Uziel Y,Hashkes PJ,Kassem E,Gottesman G,Wolach B

    更新日期:2003-10-01 00:00:00

  • Height and weight pattern up to 20 years after treatment for acute lymphoblastic leukaemia.

    abstract:OBJECTIVE:To assess height and body mass index standard deviation scores up to 20 years after treatment for acute lymphoblastic leukaemia (ALL). SUBJECTS AND METHODS:Height and body mass index standard deviation scores were measured in 33 patients (14 boys and 19 girls) with childhood ALL at diagnosis, after the end o...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.79.2.161

    authors: Birkebaek NH,Clausen N

    更新日期:1998-08-01 00:00:00

  • Platelet thromboxane B2 production in neonatal pulmonary hypertension.

    abstract::Production of platelet thromboxane B2, a stable metabolite of thromboxane A2, was measured in seven newborn infants with pulmonary hypertension during the first day of life. Platelet thromboxane B2 production was significantly lower than in 12 healthy controls but did not correlate with simultaneous blood gas values. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.62.2.195

    authors: Kääpä P

    更新日期:1987-02-01 00:00:00

  • Persistence of pneumococcal antibodies after primary immunisation with a polysaccharide-protein conjugate vaccine.

    abstract:INTRODUCTION:Despite immunisation, antibiotics and intensive care management, infection with Streptococcus pneumoniae remains a major cause of morbidity and mortality in children. The WHO currently recommends vaccinating infants with either a 3+0 schedule (6 weeks, 3-4 and 4-6 months of age) or 2+1 schedule (2 doses be...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/archdischild-2018-316254

    authors: Zimmermann P,Perrett KP,Berbers G,Curtis N

    更新日期:2019-07-01 00:00:00

  • Efficacy of sweet solutions for analgesia in infants between 1 and 12 months of age: a systematic review.

    abstract:OBJECTIVE:To compare the efficacy of oral sweet solutions to water or no treatment in infants aged 1-12 months during immunisation. METHODS:Randomised controlled trials (RCTs) were retrieved through internet searches or manual searches of reference lists. Search terms included newborn, infant, pain, sucrose and altern...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,meta分析,评审

    doi:10.1136/adc.2009.174227

    authors: Harrison D,Stevens B,Bueno M,Yamada J,Adams-Webber T,Beyene J,Ohlsson A

    更新日期:2010-06-01 00:00:00

  • Self hypnotherapeutic treatment of habitual reflex vomiting.

    abstract::A 9 year old boy with intractable postprandial reflex vomiting was taught a self hypnotherapy technique incorporating relaxation exercises, mental imagery, and suggestions of symptom relief. The sequence was recorded on a personal stereo cassette tape. Vomiting was completely eliminated within four weeks. At 12 month ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.65.6.626

    authors: Sokel BS,Devane SP,Bentovim A,Milla PJ

    更新日期:1990-06-01 00:00:00

  • Health in overweight children: 2-year follow-up of Finnmark Activity School--a randomised trial.

    abstract:OBJECTIVE:To compare a comprehensive lifestyle intervention for overweight children performed in groups of families with a conventional single-family treatment. Two-year follow-up data on anthropometric and psychological outcome are presented. DESIGN:Overweight and obese children aged 6-12 years with body mass index (...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/archdischild-2014-307107

    authors: Kokkvoll A,Grimsgaard S,Steinsbekk S,Flægstad T,Njølstad I

    更新日期:2015-05-01 00:00:00

  • High volume milk feeds for preterm infants.

    abstract::Fifty nine preterm infants of between 1.0 and 2.0 kg birthweight who were fed 250 ml/kg/day of breast milk or standard formulas gained weight at the intrauterine rate without complications. It is suggested that high volume feeding is a satisfactory alternative to low birthweight formula milks and is more desirable in ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.59.8.779

    authors: Lewis MA,Smith BA

    更新日期:1984-08-01 00:00:00

  • Serum tri-iodothyronine, thyroxine, and thyrotrophin concentrations in newborns during the first 2 days of life.

    abstract::The serum concentrations of tri-iodothyronine (T3), thyroxine (T4), and thyrotrophin (TSH) were measured in 10 term newborn infants between birth and the age of 2 days by radioimmunoassay. The mean concentration of T3 in maternal serum was 1.62 mug/l, and it increased from the low cord blood level of 0-63 mug/l to the...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.50.7.565

    authors: Similä S,Koivisto M,Ranta T,Leppäluoto J,Reinilä M,Haapalahti J

    更新日期:1975-07-01 00:00:00

  • Ketamine anaesthesia for medical procedures in children.

    abstract::Ketamine hydrochloride 2 mg/kg, together with atropine 0.2 mg, has been given intravenously on 100 occasions on a general paediatric ward. No serious side effects occurred. Dreams followed in 4 children but did not reduce acceptability of the drug. In our hands it has greatly reduced the pain and distress of children ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.51.1.56

    authors: Elliott E,Hanid TK,Arthur LJ,Kay B

    更新日期:1976-01-01 00:00:00

  • Acute effects of instillation of surfactant in severe respiratory distress syndrome.

    abstract::Doppler ultrasound measurements of pulmonary blood flow in 20 babies with severe respiratory distress syndrome treated in a randomised controlled trial of surfactant replacement showed that the immediate improvement of oxygenation was not associated with a significant increase in pulmonary blood flow. Reduction in ven...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/adc.64.1_spec_no.13

    authors: Halliday HL,McCord FB,McClure BG,Reid MM

    更新日期:1989-01-01 00:00:00

  • Why nebulise for more than five minutes?

    abstract::The output of the drug and the particle size produced by various nebulisers were assessed, and sensible nebulisation times for sodium cromoglycate calculated. Three of the four nebuliser systems tested produced over 80% of total drug output within the first five minutes of nebulisation. We suggest that five minutes is...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.64.9.1270

    authors: O'Callaghan C,Clark AR,Milner AD

    更新日期:1989-09-01 00:00:00

  • A low cost, colour coded, hand held spring scale accurately categorises birth weight in low resource settings.

    abstract:AIMS:To determine the accuracy of a low cost, spring calibrated, hand held scale in classifying newborns into three weight categories (> or =2500 g, 2000-2499 g, <2000 g). METHODS:The test device was compared to a gold standard digital baby scale with precision to 2 g. In Sarlahi district, Nepal, 1890 newborns were el...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2005.088781

    authors: Mullany LC,Darmstadt GL,Coffey P,Khatry SK,LeClerq SC,Tielsch JM

    更新日期:2006-05-01 00:00:00

  • Diarrhoea in jaundiced neonates treated with phototherapy: role of intestinal secretion.

    abstract::Thirty jaundiced neonates with diarrhoea who were being treated with phototherapy and 30 matched control infants were studied to try and find out the cause of the diarrhoea. Faecal osmolality and electrolyte concentrations were measured, which gave clear evidence that the diarrhoea arose from intestinal secretion. Rec...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.64.8.1161

    authors: De Curtis M,Guandalini S,Fasano A,Saitta F,Ciccimarra F

    更新日期:1989-08-01 00:00:00

  • Childhood and adolescent mental health of NICU graduates: an observational study.

    abstract:OBJECTIVE:To investigate the mental health of children and adolescents admitted to neonatal intensive/special care units (NICUs) in infancy. METHODS:This cross-sectional study used a provincially representative cohort from the 2014 Ontario Child Health Study. Parents provided data on psychiatric disorders using the MI...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2019-318284

    authors: Chiorean A,Savoy C,Beattie K,El Helou S,Silmi M,Van Lieshout RJ

    更新日期:2020-07-01 00:00:00

  • Small bowel biopsy.

    abstract::We describe our technique of small bowel biopsy, which has been used on 190 occasions over a four year period. In 77%, the examination was completed within 10 minutes, and fluoroscopy times were less than 10 seconds in 75% of the cases. The technique is easily taught, and it has made the examination a minor procedure....

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.60.11.1082

    authors: Collins AL,Brookfield DS,Hyde I,Rolles CJ

    更新日期:1985-11-01 00:00:00

  • Sonographic long-term study: paediatric growth charts for single kidneys.

    abstract:AIMS:To explore the clinical course of children with "single kidney" (defined as either a solitary or single functioning kidney) with reference to renal function (glomerular filtration rate (GFR) and proteinuria), body height and particularly sonomorphological features. PATIENTS AND METHODS:This retrospective monocent...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2008.153601

    authors: Spira EM,Jacobi C,Frankenschmidt A,Pohl M,von Schnakenburg C

    更新日期:2009-09-01 00:00:00

  • Intestinal lymphangiectasia. Long-term results with MCT diet.

    abstract::The clinical course of 6 children with primary intestinal lymphangiectuasia who have been treated with low fat medium chain triglyceride-supplemented diets for between 3 and 8 years (4 for longer than 5 years) is described. Though laboratory findings indicate continuing chyle leak, evidence for long-term benefit from ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.50.4.269

    authors: Tift WL,Lloyd JK

    更新日期:1975-04-01 00:00:00

  • An overview of respiratory problems in children with Down's syndrome.

    abstract::Respiratory disease is a common cause of morbidity and mortality in children with Down's syndrome (DS). Causes range from those problems common to many children with DS, such as a narrow airway or impaired immunity, to rare structural lesions, such as tracheal bronchus. Additionally, other organ systems or extrinsic f...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/archdischild-2013-304611

    authors: Watts R,Vyas H

    更新日期:2013-10-01 00:00:00

  • Noonan's and DiGeorge syndromes with monosomy 22q11.

    abstract::A boy with the dysmorphic features of Noonan's syndrome and pulmonary valve stenosis who had evidence of hypoparathyroidism and abnormal T lymphocyte numbers in the neonatal period is reported. He had a normal karyotype but molecular analysis revealed a submicroscopic deletion within chromosome 22q11, the region delet...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.68.2.187

    authors: Wilson DI,Britton SB,McKeown C,Kelly D,Cross IE,Strobel S,Scambler PJ

    更新日期:1993-02-01 00:00:00

  • Seasonal variation of glycosylated haemoglobin.

    abstract::Retrospective analysis of glycosylated haemoglobin concentrations in a diabetic outpatient clinic over three and a half years showed a small seasonal variation in the mean value with a peak in mid February and a nadir in mid August. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.62.9.959

    authors: Ferrie CD,Sharpe TC,Price DA,Surtees RA

    更新日期:1987-09-01 00:00:00

  • Tartrazine in atopic eczema.

    abstract::Multiple double blind placebo controlled challenges with tartrazine 50 mg (three challenges) and glucose placebo (three challenges) were performed in 12 children with atopic eczema aged 1 to 6 years. The children were selected on the basis of severity (regular clinic attenders) and a parental history that tartrazine p...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/adc.67.6.709

    authors: Devlin J,David TJ

    更新日期:1992-06-01 00:00:00

  • Plasma cholecystokinin concentrations after breast feeding in healthy 4 day old infants.

    abstract::The aim of the present study was to characterise plasma concentrations of cholecystokinin (CCK) after breast feeding in newborn infants. Fifty eight healthy full term exclusively breast fed infants were investigated at 4 (1) (2-6) days of age. Each infant contributed one blood sample collected just before, immediately...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.68.1_spec_no.46

    authors: Uvnäs-Moberg K,Marchini G,Winberg J

    更新日期:1993-01-01 00:00:00

  • Nutrition, sex, gestational age, and hair growth in babies.

    abstract::Hair growth measurements are a sensitive indicator of nutrition and we have assessed their value in the perinatal period. The proportion of growing roots and their diameter were studied at birth in 114 babies and repeated 3 weeks later in 29 low birthweight babies. Intrauterine malnutrition resulted in thinner roots b...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.53.4.290

    authors: Berger HM,King J,Doughty S,Wharton BA

    更新日期:1978-04-01 00:00:00

  • Use of external expiratory resistance in intubated neonates to increase lung volume.

    abstract::Ten intubated neonates (weights 0.90 to 2.58 kg) recovering from respiratory disease had lung mechanics, respiratory patterns, and functional residual capacity measured at 0 cmH2O continuous positive airways pressure and then after application of serially increasing levels of external expiratory resistance. At an exte...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.56.11.869

    authors: Moomjian AS,Schwartz JG,Shutack JG,Rooklin AR,Shaffer TH,Fox WW

    更新日期:1981-11-01 00:00:00

  • The sodium and potassium intake of 3 to 5 year olds.

    abstract::The sodium intake of preschool children in their home environment was investigated and the major sources of sodium other than added table salt identified. Thirty five children from a Southampton general practice were studied. Twenty four hour urinary sodium excretion was measured as a reliable indicator of daily total...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.61.2.159

    authors: Allison ME,Walker V

    更新日期:1986-02-01 00:00:00