Abstract:
:Multiple double blind placebo controlled challenges with tartrazine 50 mg (three challenges) and glucose placebo (three challenges) were performed in 12 children with atopic eczema aged 1 to 6 years. The children were selected on the basis of severity (regular clinic attenders) and a parental history that tartrazine provoked worsening of the eczema. In only one patient did the three tartrazine challenge periods correspond with the highest symptom scores or the highest physician observer scores, and the probability of this occurring by chance in one or more patients out of 12 was 0.46. In this sample we were unable to confirm intolerance to tartrazine in 11 out of 12 patients.
journal_name
Arch Dis Childjournal_title
Archives of disease in childhoodauthors
Devlin J,David TJdoi
10.1136/adc.67.6.709subject
Has Abstractpub_date
1992-06-01 00:00:00pages
709-11issue
6eissn
0003-9888issn
1468-2044journal_volume
67pub_type
临床试验,杂志文章,随机对照试验abstract:INTRODUCTION:UK screening for congenital hypothyroidism (CH) is based on dried blood spot Thyroid Stimulating Hormone (TSH). Scintigraphy may identify CH subtypes classified as dysplasia, gland in situ (GIS) and ectopia, but is not performed in all centres. We retrospectively investigated the role of scintigraphy to id...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2019-317665
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:To elucidate the current situation of randomised drug trials involving the paediatric population. METHODS:Systematic review of paediatric randomised controlled trials of medicinal products published in 2007. Three major databases were searched with validated search strategies; Medline, Embase and Cochrane Ce...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/adc.2009.173591
更新日期:2010-06-01 00:00:00
abstract::Since its first description optic nerve hypoplasia has been identified with increasing frequency, and a range of associated problems have been described. The major neurological and endocrine associations are well established, but those factors that predispose to the development of optic nerve hypoplasia remain unclear...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.65.1.103
更新日期:1990-01-01 00:00:00
abstract::Early postnatal malnutrition produces delay in growth and developmental processes, and children from a low socioeconomical level where undernutrition is prevalent are shorter than those from higher socioeconomic levels. We examined the effects of severe and early protein energy malnutrition on growth and bone maturati...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.61.3.257
更新日期:1986-03-01 00:00:00
abstract::Six children with congenital heart disease are described in whom poor growth was found to be due to small-bowel villous atrophy; none was in heart failure and only one was severely cyanosed. Growth improved in all 6 on a gluten-free diet. Gluten enteropathy may be more common than is realised in children with congenit...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
abstract:AIMS:To investigate (1) whether colic cries are acoustically distinct from pre-feed "hunger" cries; (2) the role of the acoustic properties of these cries versus their other properties in accounting for parents' concerns about colic. DESIGN:From a community sample, infants were selected who met Wessel colic criteria f...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.80.1.56
更新日期:1999-01-01 00:00:00
abstract::The frequency of negative hydrogen breath tests due to colonic bacterial flora which are unable to produce hydrogen was determined after oral lactulose challenge in 98 healthy Dutch schoolchildren. There was a negative result in 9.2%. The probability of a false normal lactose breath test (1:77) was calculated from the...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.60.4.333
更新日期:1985-04-01 00:00:00
abstract:BACKGROUND:Intensive care patients are susceptible to developing painful corneal epithelial deficits. Provision of eye care to prevent deficits was limited in our paediatric intensive care unit (PICU) population. INTERVENTIONS:A new eye care bundle was introduced, comprising a guideline for eye care, the addition of e...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2015-310410
更新日期:2016-09-01 00:00:00
abstract::Two infants presented with a salt-losing syndrome, the presenting features of which were subtle. One case appeared to be transient. Deficient production of aldosterone was shown by plasma renin activity and plasma aldosterone profile. Gas chromatography-mass spectrometry of urine indicated a defect in 18-dehydrogenati...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.52.7.580
更新日期:1977-07-01 00:00:00
abstract:BACKGROUND:Several studies have shown an increased incidence of neurodevelopmental impairment in very preterm survivors at school age compared with controls. AIM:To compare findings in the same cohort at 8 years and 15 years. METHODS:A total of 151 of the 224 eligible infants born before 33 weeks of gestation from 19...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2002.006676
更新日期:2004-03-01 00:00:00
abstract::The introduction of enteric coated pancreatic enzyme supplements in the early 1980s was undoubtedly one of the major advances in the care of children with cystic fibrosis. Further refinements in the presentation of these preparations inevitably followed, to improve patient acceptability and compliance. The emergence o...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/adc.74.5.464
更新日期:1996-05-01 00:00:00
abstract:AIMS:To compare the respiratory health and function at 8 to 9 years of age of a total population based cohort of 300 very low birthweight (VLBW) children with that of two classroom controls (n = 590) matched for age and sex. STUDY DESIGN:Cohort study with controls. SETTING:Schools throughout Scotland. RESULTS:The VL...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.74.3.188
更新日期:1996-03-01 00:00:00
abstract::Hepatitis B virus infection is still a major public health problem worldwide, since more than 350 million people have chronic, lifelong infection and nearly 1 million deaths occur each year owing to complications. Most infections are acquired at birth or during early childhood. Nowadays, low- and middle-income countri...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/archdischild-2016-312043
更新日期:2017-07-01 00:00:00
abstract::At the mid-radius, pre-pubertal asthmatic children had smaller periosteal and endosteal circumferences and thicker cortical shells compared to controls, when assessed by peripheral quantitative computed tomography. Asthmatics had diminished periosteal expansion for muscle size, suggesting that asthma, its treatment, o...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2005.084996
更新日期:2006-04-01 00:00:00
abstract::This study describes the pattern of oxygen consumption (VO2), rectal temperature (Tr), and acral skin temperature (Tac) in sleeping and resting (awake) burned children nursed in a thermoneutral environment. Measurements of respiratory gas exchange (VO2 and carbon dioxide production (VCO2)) were made using an open circ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.71.1.31
更新日期:1994-07-01 00:00:00
abstract::Reflection has become established as a key principle underpinning maintenance of standards within professional education and practice. A requirement to evidence reflection within performance review is intended to develop a transformative approach to practice, identify developmental goals, and ultimately, improve healt...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/archdischild-2013-303948
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:There is limited information on the psychosocial impact of growing up with Silver-Russell syndrome (SRS), characterised by slow growth in utero leading to short stature in adulthood. Such information could aid families in making difficult treatment decisions and guide management strategies for health professi...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2018-314952
更新日期:2019-01-01 00:00:00
abstract::Six families with at least one infant each with confirmed ornithine transcarbamylase deficiency were investigated by DNA analysis. All the affected sons had died, and no DNA had been stored. Using the restriction endonucleases MspI and Bam HI three restriction fragment length polymorphisms were detected which led to e...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.63.3.297
更新日期:1988-03-01 00:00:00
abstract::Patient triggered ventilation was assessed in 14 neonates (gestational age 24-40 weeks). Inspiratory changes in airflow, monitored by a pneumotachograph, were used to trigger the ventilator and this was not associated with complications. Patient triggered ventilation was maintained for up to eight hours (mean duration...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.63.4.394
更新日期:1988-04-01 00:00:00
abstract:BACKGROUND:Acute respiratory infections (ARI) cause 3 million deaths in children worldwide each year. Most of these deaths occur from pneumonia in developing countries, and hypoxaemia is the most common fatal complication. Simple and adaptable indications for oxygen therapy are important in the management of ARI. The c...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/adc.2008.138362
更新日期:2009-01-01 00:00:00
abstract::The fasting serum cholecystokinin-like activity was measured in 21 infants with pyloric stenosis and in 13 normal controls. No significant difference was found between the two groups. The basal acid secretion was measured by continuously aspirating the previously emptied stomach for one hour. The basal gastric volume ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.54.10.773
更新日期:1979-10-01 00:00:00
abstract::The utility of point-of-care lung ultrasound in neonatology is rapidly expanding. This review summarises current evidence of a diagnostic, procedural and observational tool valuable in the management of newborns requiring intensive care. Approaching a patient, probe in-hand with focused clinical question is essential,...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/archdischild-2017-314538
更新日期:2019-09-01 00:00:00
abstract::Tuberculosis rarely presents in the neonatal period. Though treatable, it may be fatal despite modern treatment. The diagnosis of congenital tuberculosis should be considered in any neonate with pneumonia that fails to respond to conventional treatment, particularly in a child from an ethnic or socioeconomic environme...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.61.5.512
更新日期:1986-05-01 00:00:00
abstract::The clinical, radiological, and biochemical features of 2 male children with mannosidosis are described. Superficially they appeared to suffer from Hurler's syndrome, but the facies, eye signs, radiological and cytological features were atypical. Excess urinary oligosaccharides were found by thin-layer chromatography....
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.52.12.937
更新日期:1977-12-01 00:00:00
abstract:OBJECTIVE:Anaphylaxis is a severe, potentially fatal allergic reaction best treated with intramuscular epinephrine via epinephrine auto-injectors (AAIs). Our published concerns over laceration injuries to young children associated with AAIs led to this service evaluation of the two administration methods: swing and jab...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2020-318898
更新日期:2021-01-01 00:00:00
abstract::A trial was conducted using sequential analysis by pairs to compare the efficacy of corticosteroids and salicylates in the treatment of acute rheumatic carditis. The results show a significantly favourable effect of steroid treatment both in clinical response and in reduction of the erythrocyte sedimentation rate. In ...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章
doi:10.1136/adc.59.5.410
更新日期:1984-05-01 00:00:00
abstract:BACKGROUND:The atherogenic risk factor profile in obese subjects is characterised by hypertension, reduced high density lipoprotein (HDL) cholesterol, increased low density lipoprotein (LDL) cholesterol and triglycerides, and insulin resistance. AIMS:To examine the amount of weight reduction required to improve the at...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2003.028803
更新日期:2004-05-01 00:00:00
abstract::A boy with fatal I-cell disease is reported. Defective ganglioside and glycoprotein metabolism is due to deficient neuraminidase activity. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.53.6.513
更新日期:1978-06-01 00:00:00
abstract::National trends in the survival of low birthweight infants for the years 1953 to 1979 were examined. While stillbirth and day 1-28 mortality rates improved steadily throughout this period, day 0 mortality did not start to fall until the mid-1960s and then it improved in all birthweight groups. This suggests that speci...
journal_title:Archives of disease in childhood
pub_type: 历史文章,杂志文章
doi:10.1136/adc.56.2.86
更新日期:1981-02-01 00:00:00
abstract::This study was carried out on the way in which children's beds were used by the specialty of paediatrics in a district general hospital. Five differing ways were found of interpreting the present Department of Health guidelines on health services information (Körner recommendations). These gave bed occupancy figures v...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.66.4.504
更新日期:1991-04-01 00:00:00