Abstract:
:Ten intubated neonates (weights 0.90 to 2.58 kg) recovering from respiratory disease had lung mechanics, respiratory patterns, and functional residual capacity measured at 0 cmH2O continuous positive airways pressure and then after application of serially increasing levels of external expiratory resistance. At an external expiratory resistance greater than 40 cmH2O/1 per second, there was a significant increase in mean functional residual capacity compared with control levels. Immediately after the application of external expiratory resistance, there was a significant decrease in flow which returned to control values after a few breaths. Tidal volume and respiratory rate decreased for a few breaths after the application of the external expiratory resistance, but returned to control values after several seconds. Study age, gestational age, or study weight had no appreciable effect on the relationship between functional residual capacity and external expiratory resistance. Application of external expiratory resistance may be useful for stabilising lung volume in neonates recovering from respiratory disease.
journal_name
Arch Dis Childjournal_title
Archives of disease in childhoodauthors
Moomjian AS,Schwartz JG,Shutack JG,Rooklin AR,Shaffer TH,Fox WWdoi
10.1136/adc.56.11.869subject
Has Abstractpub_date
1981-11-01 00:00:00pages
869-73issue
11eissn
0003-9888issn
1468-2044journal_volume
56pub_type
杂志文章abstract::A novel form of severe, X linked mental retardation associated with alpha thalassaemia (ATR-X syndrome) has recently been described. Two affected cousins are described, one of whom has an unusually mild haematological phenotype. HbH inclusions, which are the hallmark of this disease, were only detected in the peripher...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.70.5.439
更新日期:1994-05-01 00:00:00
abstract:OBJECTIVE:To investigate the mental health of children and adolescents admitted to neonatal intensive/special care units (NICUs) in infancy. METHODS:This cross-sectional study used a provincially representative cohort from the 2014 Ontario Child Health Study. Parents provided data on psychiatric disorders using the MI...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2019-318284
更新日期:2020-07-01 00:00:00
abstract::Two neonates with severe culture proven pertussis were successfully treated with salbutamol 0.5 mg three times daily. There was a demonstrable decrease in the total number of coughing spasms, their mean duration and severity. In one baby this was shown by the transcutaneous oxygen tension measurements. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.61.6.600
更新日期:1986-06-01 00:00:00
abstract::Primary human herpesvirus 6 (HHV-6) and 7 (HHV-7) infections were identified in febrile children by qualitative and quantitative polymerase chain reaction (PCR) assays. Diagnosis was based on the differential detection of viral DNA in peripheral blood mononuclear cells (PBMC), but not in saliva. Six of 41 febrile infa...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.77.1.42
更新日期:1997-07-01 00:00:00
abstract::Glucocorticoid suppressible hyperaldosteronism (GSH) is an uncommon form of dominantly inherited hypertension. Presentation with hypertension and complications such as stroke in early life are well recognised. The use of a simple genetic test carried out on blood or placenta facilitates the detection of infants and ch...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.71.1.40
更新日期:1994-07-01 00:00:00
abstract:OBJECTIVE:There is limited information on the psychosocial impact of growing up with Silver-Russell syndrome (SRS), characterised by slow growth in utero leading to short stature in adulthood. Such information could aid families in making difficult treatment decisions and guide management strategies for health professi...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2018-314952
更新日期:2019-01-01 00:00:00
abstract::When children are considered for participation in research, British and international guidelines suggest that they should provide assent in addition to their parents' consent. However, examination of these guidelines shows there is confusion regarding the concept of assent. Furthermore, the need for assent may cause p...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2011.211342
更新日期:2011-10-01 00:00:00
abstract::Two girls (a 5 year old and a 21 month old) experiencing mononucleosis syndrome with coincidental human herpesvirus (HHV)-7 and Epstein-Barr virus (EBV) infections are described. One patient had primary HHV-7 infection and reactivated EBV infection. The other had primary HHV-7 and EBV infections. These cases indicated...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.78.5.479
更新日期:1998-05-01 00:00:00
abstract::Ten children with severe asthma, who had been well controlled on maintenance betamethasone valerate aerosol for an average of 11 months, were given placebo aerosols without their knowledge. The period of placebo substitution was campared with one 28-day period of betamethasone valerate therapy beforehand, and two 28-d...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章
doi:10.1136/adc.50.5.387
更新日期:1975-05-01 00:00:00
abstract::Serum antitoxoplasma titres were determined simultaneously by the direct agglutination and the indirect immunofluorescent tests in 52 children aged 2 to 16 years having chronic lymph node enlargement, mainly cervical. Direct agglutination titres were raised (64 to 4096) in 22 children (42%), but rarely in the control ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.52.5.403
更新日期:1977-05-01 00:00:00
abstract::Among 40 hospitalized infants and children with cytomegalovirus infection, 14 (35%) had interstitial pneumonitis, 4 (10%) had wheezing or tachypnoea but without x-ray evidence of classical interstitial pneumonia, the remaining 22 (55%) were free of pulmonary involvement. Most patients had tachypnoea and nonproductive ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.52.6.441
更新日期:1977-06-01 00:00:00
abstract:OBJECTIVES:To assess the potential effect of two guideline discharge oxygen saturation (SpO(2)) recommendations (≥90% and ≥94%) in recovering bronchiolitis. METHODS AND PATIENTS:Infants aged up to 18 months requiring therapeutic oxygen for SpO(2) (≤93%) had SpO(2) assessed in air every 2 h. Time from admission to re-e...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2010.205211
更新日期:2012-04-01 00:00:00
abstract::Thyroid function was studied in 54 low birthweight infants during a 3-week period. Each infant was placed in one of three groups. Group 1 (n = 21), infants who were well and appropriately grown fro gestational age; group 2 (n = 23), infants who were appropriately grown but who had hyaline membrane disease; group 3 (n ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.56.3.214
更新日期:1981-03-01 00:00:00
abstract:OBJECTIVE:To study the epidemiology of pyridoxine dependent seizures and other forms of pyridoxine responsive seizures. DESIGN:Monthly notifications to the British Paediatric Surveillance Unit over two years. Questionnaire follow up. SETTING:UK and the Republic of Ireland. PATIENTS:Children aged 15 years or younger ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.81.5.431
更新日期:1999-11-01 00:00:00
abstract::Of 80 children with proved coeliac disease, 2 presented with an associated disease of the distal portion of the large intestine. In one child the family history and the extension, localisation, and characteristics of intestinal lesions made us suspect ulcerative colitis; in the other we made a diagnosis of milk-induce...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.53.8.645
更新日期:1978-08-01 00:00:00
abstract::We have studied changes in the birthweight of Asian babies born alive at this hospital between 1968 and 1978. In 1978 Pakistani babies were 139 g heavier but Indian babies only 25 g heavier than 10 years earlier. Contributing to these changes were significantly fewer short mothers and primiparae among Pakistanis, and ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.57.11.867
更新日期:1982-11-01 00:00:00
abstract:OBJECTIVE:To assess differences across educational outcomes in survivors of childhood cancer (CCS) compared with peers. DESIGN:Systematic review and meta-analysis of observational studies. DATA SOURCES AND STUDY SELECTION:Medline, EMBASE, ERIC, CINAHL and PsycInfo from inception to 1st August 2018. Any peer reviewed,...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究
doi:10.1136/archdischild-2019-317594
更新日期:2020-04-01 00:00:00
abstract::The communication development in 11 children with Angelman's syndrome is described. The clinical observation that these children appear to have a greater ability with receptive rather than expressive language is investigated and these skills assessed using published communication schedules. In addition the understandi...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.69.1.148
更新日期:1993-07-01 00:00:00
abstract::Nerve growth factor (NGF) is the first described neurotrophin that stimulates the growth and differentiation of nerve cells and promotes skin and peripheral tissue regeneration. Recent studies suggest that NGF influences endothelial cell proliferation and angiogenic activity. In view of these proposed regenerative eff...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.87.5.446
更新日期:2002-11-01 00:00:00
abstract::A 3 year old girl with Down's syndrome became lethargic and withdrawn, and investigations showed a specific malabsorption of vitamin B12 without proteinuria. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.61.5.514
更新日期:1986-05-01 00:00:00
abstract::Serial exercise tests were carried out by 12 children with asthma on two study days. After a control exercise test either nedocromil sodium 4 mg or placebo were given double blind by metered dose inhaler. Highly significant inhibition of exercise induced asthma occurred after nedocromil, lasting for over two hours. ...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章
doi:10.1136/adc.62.4.412
更新日期:1987-04-01 00:00:00
abstract:BACKGROUND:It has been suggested that increasing obesity levels in young women lead to intrauterine environments that, in turn, stimulate increased obesity among their offspring, generating an intergenerational acceleration of obesity levels. If this mechanism is important, the association of maternal body mass index (...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2006.104869
更新日期:2007-10-01 00:00:00
abstract::The reliability and validity of the North American paediatric appropriateness evaluation protocol (PAEP) for use in paediatric practice in Britain was tested. The protocol was applied to 418 case records of consecutive emergency admissions to three Yorkshire district general hospitals. The PAEP ratings were then compa...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究
doi:10.1136/adc.77.4.294
更新日期:1997-10-01 00:00:00
abstract:AIMS:To document gastroenteritis hospitalisations of the 1995-96 cohort of infants born in Western Australia to mid-2002, and to assess factors associated with their hospitalisations and readmissions. METHODS:Retrospective analysis of the State's hospitalisation data, Midwives' Notification of Births data, the Austral...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2003.037531
更新日期:2004-08-01 00:00:00
abstract:OBJECTIVE:To assess the availability and source of guidelines for common infections in European paediatric hospitals and determine their content and characteristics. DESIGN:Participating hospitals completed an online questionnaire on the availability and characteristics of antibiotic prescribing guidelines and on empi...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究
doi:10.1136/archdischild-2015-308255
更新日期:2016-01-01 00:00:00
abstract::In recent years, there have been significant advances in genetic technologies, evolving the field of genomics from genetics. This has huge diagnostic potential, as genomic testing increasingly becomes part of mainstream medicine. However, there are numerous potential pitfalls in the interpretation of genomic data. It ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/archdischild-2017-314558
更新日期:2018-09-01 00:00:00
abstract::Cystic fibrosis is a disease that still causes a reduced life expectancy. The treatment burden remains high for affected individuals with often a combination of multiple oral and inhaled medications, as well as physiotherapy, required on a daily basis. In this article, we look at an overview of the pathogenesis, how t...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/archdischild-2013-304400
更新日期:2014-11-01 00:00:00
abstract:AIM:To reduce the overall expenditure on melatonin for the local health economy by working collaboratively with the CCG's. To ensure that all paediatric patients prescribed melatonin have been clinically assessed by a specialist and the most appropriate formulation is dispensed. METHOD:Evaluation of GP melatonin presc...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2016-311535.49
更新日期:2016-09-01 00:00:00
abstract::A 9 month old boy presented with acute respiratory distress and was found to have a left pleural effusion. The chylous nature of the effusion, multiple bony lytic lesions, and splenic cysts lead to the diagnosis of congenital lymphangiomatosis with chylothorax. Surgical intervention including pleurectomy was required ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.64.7.1058
更新日期:1989-07-01 00:00:00
abstract::A term female infant was admitted to the intensive care unit with the diagnosis of tetralogy of Fallot with critical pulmonary stenosis. On the seventh day of life a long saphenous line was inserted that remained without complications until seven days later when the infant appeared septic. A lumbar puncture demonstrat...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.67.10_spec_no.1201
更新日期:1992-10-01 00:00:00