当前位置： SCI文献检索 > ARCHIVES OF DISEASE IN CHILDHOOD期刊下所有文献 > Variation in paediatric hospital antibiotic guidelines in Europe.

Variation in paediatric hospital antibiotic guidelines in Europe.

Abstract：

OBJECTIVE:To assess the availability and source of guidelines for common infections in European paediatric hospitals and determine their content and characteristics. DESIGN:Participating hospitals completed an online questionnaire on the availability and characteristics of antibiotic prescribing guidelines and on empirical antibiotic treatment including duration of therapy for 5 common infection syndromes: respiratory tract, urinary tract, skin and soft tissue, osteoarticular and sepsis in neonates and children. RESULTS:84 hospitals from 19 European countries participated in the survey of which 74 confirmed the existence of guidelines. Complete guidelines (existing guidelines for all requested infection syndromes) were reported by 20% of hospitals and the majority (71%) used a range of different sources. Guidelines most commonly available were those for urinary tract infection (UTI) (74%), neonatal sepsis (71%) and sepsis in children (65%). Penicillin and amoxicillin were the antibiotics most commonly recommended for respiratory tract infections (RTIs) (up to 76%), cephalosporin for UTI (up to 50%) and for skin and soft tissue infection (SSTI) and bone infection (20% and 30%, respectively). Antistaphylococcal penicillins were recommended for SSTIs and bone infections in 43% and 36%, respectively. Recommendations for neonatal sepsis included 20 different antibiotic combinations. Duration of therapy guidelines was mostly available for RTI and UTI (82%). A third of hospitals with guidelines for sepsis provided recommendations for length of therapy. CONCLUSIONS:Comprehensive antibiotic guideline recommendations are generally lacking from European paediatric hospitals. We documented multiple antibiotics and combinations for most infections. Considerable improvement in the quality of guidelines and their evidence base is required, linking empirical therapy to resistance rates.

journal_name

Arch Dis Child

journal_title

Archives of disease in childhood

authors

Spyridis N,Syridou G,Goossens H,Versporten A,Kopsidas J,Kourlaba G,Bielicki J,Drapier N,Zaoutis T,Tsolia M,Sharland M,ARPEC Project Group Members.

doi

10.1136/archdischild-2015-308255

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

72-6

issue

eissn

0003-9888

issn

1468-2044

pii

archdischild-2015-308255

journal_volume

101

pub_type

杂志文章,多中心研究

在线工具

Variation in paediatric hospital antibiotic guidelines in Europe.