Abstract:
:Congenital haemolytic anaemia in a 14 year old girl was caused by increased red cell membrane cation permeability. Potassium permeability was unusually sensitive to hydrostatic pressure and treatment with N-ethylmaleimide, factors which activate a specific chloride dependent potassium channel in cell membranes.
journal_name
Arch Dis Childjournal_title
Archives of disease in childhoodauthors
Gardiner RM,Barnes ND,Ellory JCdoi
10.1136/adc.58.7.547subject
Has Abstractpub_date
1983-07-01 00:00:00pages
547-9issue
7eissn
0003-9888issn
1468-2044journal_volume
58pub_type
杂志文章abstract::After their first episode of febrile convulsions, 195 previously healthy children, aged 6--30 months, were given either diazepam or phenobarbitone for a year. Each child was assigned at random to one of the two medications: children admitted on even days were given a suppository containing 5 mg diazepam every 8 hours ...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/adc.53.8.660
更新日期:1978-08-01 00:00:00
abstract:OBJECTIVE:To investigate whether school readiness could be affected by placing electronic devices (EDs) in children's bedroom and whether the relationship was moderated by parental restriction and family socioeconomic status (SES). DESIGN:This is a cross-sectional study with bedroom ED placement and parental restricti...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2017-312639
更新日期:2017-12-01 00:00:00
abstract::Metabolic rhythms were studied over 24 hours in eight adolescent diabetic patients during treatment with porcine insulin and after transfer to human insulin. Despite an increase in dose with human insulin no significant changes were found in fasting blood glucose, 24h mean blood glucose, or glycosylated haemoglobin co...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.61.4.341
更新日期:1986-04-01 00:00:00
abstract:BACKGROUND AND AIMS:There are few standardised questionnaires for the assessment of respiratory symptoms in preschool children. We have developed and tested the short-term repeatability of a postal questionnaire on respiratory symptoms for 1-year-old children. METHODS:A newly developed postal questionnaire for the ass...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2007.117978
更新日期:2007-10-01 00:00:00
abstract::Serial small intestinal biopsies related to withdrawal and challenge with cows' milk are described in 5 infants with cows' milk protein intolerenace. On the basis of these serial observations the existence of a cows' milk-sensitive enteropathy in infancy is clearly established. The cows' milk-sensitive mucosal lesion ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.53.5.375
更新日期:1978-05-01 00:00:00
abstract:BACKGROUND:Cyclosporine A (CsA) has been widely used in children with steroid dependent and steroid resistant nephrotic syndrome (NS) because of its efficacy in relieving these patients from systemic side effects of steroids. However, its long term use is controversial, since chronic CsA induced nephropathy (CsAN) may ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2005.080960
更新日期:2006-08-01 00:00:00
abstract:AIMS:To investigate (1) whether colic cries are acoustically distinct from pre-feed "hunger" cries; (2) the role of the acoustic properties of these cries versus their other properties in accounting for parents' concerns about colic. DESIGN:From a community sample, infants were selected who met Wessel colic criteria f...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.80.1.56
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Therapeutic hypothermia, a safe and effective treatment for neonatal encephalopathy in an intensive care setting, is not available in low-resource settings. Aims/ METHODS:To assess two low-tech, low-cost cooling devices for use in low-resource settings: (i) commercially available water bottles filled with t...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2008.143602
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:A tailor-made serogroup B outer membrane vesicle vaccine was evaluated in the context of a serogroup B meningococcal epidemic dominated by Neisseria meningitidis strain B:4:P1.7b,4. OBJECTIVE:To determine the safety, reactogenicity and immunogenicity in infants aged 6-8 months of a meningococcal B vaccine d...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,随机对照试验
doi:10.1136/adc.2007.132571
更新日期:2009-10-01 00:00:00
abstract::Four child-protection scenarios were sent to 200 named/designated and non-named/non-designated doctors. The respondents judged each scenario as abuse or accident and indicated their degree of certainty. There was a 71% response rate. There were no significant differences in judgement or degrees of certainty of judgeme...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2006.105528
更新日期:2008-07-01 00:00:00
abstract::The association between current micturition habits and previous urinary tract infection was analysed among 3553 school entrants aged 7 years by means of a questionnaire. A high incidence of urinary infection, confirmed by urine culture, was found (145 (8.4%) in the 1719 girls and 32 (1.7%) in the 1834 boys). There was...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.66.2.232
更新日期:1991-02-01 00:00:00
abstract:OBJECTIVE:To simultaneously record tracheal and oesophageal pH in mechanically ventilated children to determine: (1) the feasibility and safety of the method; (2) the incidence of gastro-oesophageal reflux (GOR) and pulmonary contamination; and (3) their associated risk factors. DESIGN:Prospective study. SETTING:Paed...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.75.1.46
更新日期:1996-07-01 00:00:00
abstract::Children with end stage renal failure and anaemia have an increased cardiac index and often gross ventricular hypertrophy. Correction of anaemia with recombinant human erythropoietin (r-HuEpo) for less than six months results in a reduction in the cardiac index without a significant reduction in left ventricular hyper...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.71.2.119
更新日期:1994-08-01 00:00:00
abstract:OBJECTIVE:To examine the value of neurodevelopmental examination, fragile X testing, iron studies, and other screening procedures in children with mild to moderate learning difficulties. DESIGN:A cross sectional case-control study. SUBJECTS:A 34% random sample (n = 130) of children with mild to moderate learning diff...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.76.3.264
更新日期:1997-03-01 00:00:00
abstract::Skinfold standards provide a useful indication of subcutaneous fat. To evaluate skinfold thickness of 252 Cambridge infants over the first 2 years of age, SD scores relative to the Tanner standards were calculated, taking account of skewness in the standards. Cambridge SD scores were low, varying according to age from...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.78.4.354
更新日期:1998-04-01 00:00:00
abstract::Sixteen blind babies who were considered to be showing the characteristics of delayed visual maturation were studied prospectively. The diagnosis was made on clinical grounds, and the criteria for this are discussed. All of these infants developed visual responses between 4 and 6 months of age and had normal or near n...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.59.2.107
更新日期:1984-02-01 00:00:00
abstract:AIMS:To determine whether the British 1990 growth charts are valid for cross sectional and longitudinal use in primary school children. METHODS:A total of 694 children aged 7-10 years from 10 Leeds primary schools were weighed and measured annually over three years by an expert auxologist. SD scores were calculated us...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.83.4.298
更新日期:2000-10-01 00:00:00
abstract::The practice of general paediatricians in the initial evaluation of congenital hypothyroidism (CHT) was assessed. This was performed by a questionnaire survey of paediatricians in East Anglia of whom 84% responded. Nineteen of 25 clinicians based in seven district hospitals managed children with CHT. The median number...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.77.4.339
更新日期:1997-10-01 00:00:00
abstract::Pethidine or an epidural injection of bupivacaine are common forms of obstetric analgesia in Britain. Bupivacaine has been thought to have little effect on the fetus, but neurobehavioural studies have cast doubt on this. We therefore investigated the elimination of these drugs by babies in similar population groups. B...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.52.8.638
更新日期:1977-08-01 00:00:00
abstract::The communication development in 11 children with Angelman's syndrome is described. The clinical observation that these children appear to have a greater ability with receptive rather than expressive language is investigated and these skills assessed using published communication schedules. In addition the understandi...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.69.1.148
更新日期:1993-07-01 00:00:00
abstract:OBJECTIVES:Silver-Russell syndrome (SRS) is an imprinted disorder characterised by intrauterine growth retardation, relative macrocephaly, failure to thrive, typical facial phenotype and frequent body asymmetry. Feeding difficulties are frequently noted, but no study described evolution of gastrointestinal signs during...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2013-305864
更新日期:2015-04-01 00:00:00
abstract::Four patients with salt-losing congenital adrenal hyperplasia (CAH) who had stopped mineralocorticoid therapy for several years, showed raised plasma concentrations of 17OH-progesterone and plasma renin activity, despite adequate glucoticoid therapy. One patient was able to reduce urinary sodium excretion when the sod...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.54.5.350
更新日期:1979-05-01 00:00:00
abstract::One hundred consecutive cases of boys with foreskin problems referred to local paediatric surgeons in the Edinburgh area were studied. Fifty five underwent circumcision and the remainder were managed more conservatively with or without the use of local or general anaesthetic. Although sometimes avoiding general anaest...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.66.6.696
更新日期:1991-06-01 00:00:00
abstract::Better understanding of the proportion of children who ever receive special educational needs (SEN) provision or social care services during school years is highly relevant for healthcare as reductions in one or more of these services could impact on healthcare. Using the National Pupil Database linked to the all-of-E...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2019-317985
更新日期:2021-01-01 00:00:00
abstract::A percutaneous lung biopsy sample was used to diagnose interstitial lung disease in nine children aged less than 42 months. Fibrosing alveolitis was diagnosed in eight children and Pneumocystis carinii pneumonia in one child. Complications associated with the procedure were minimal and the results of the biopsy sample...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.70.2.143
更新日期:1994-02-01 00:00:00
abstract::The clinical, radiological, and biochemical features of 2 male children with mannosidosis are described. Superficially they appeared to suffer from Hurler's syndrome, but the facies, eye signs, radiological and cytological features were atypical. Excess urinary oligosaccharides were found by thin-layer chromatography....
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.52.12.937
更新日期:1977-12-01 00:00:00
abstract::When prescribing drugs for children, it is fundamental to acknowledge that they are distinct from adults with a different physiology and metabolism. They are also still maturing. The development of drugs with a primarily paediatric indication thus requires the trialling of these drugs in a paediatric population to ass...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/adc.2004.059378
更新日期:2005-02-01 00:00:00
abstract::Necrotising enterocolitis occurred in 3 infants after angiography at cardiac catheterisation. It is suggested that hypertonic contrast medium might have been responsible and that this complication could be avoided by the use of nonionic contrast media. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.55.1.66
更新日期:1980-01-01 00:00:00
abstract::Primary human herpesvirus 6 (HHV-6) and 7 (HHV-7) infections were identified in febrile children by qualitative and quantitative polymerase chain reaction (PCR) assays. Diagnosis was based on the differential detection of viral DNA in peripheral blood mononuclear cells (PBMC), but not in saliva. Six of 41 febrile infa...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.77.1.42
更新日期:1997-07-01 00:00:00
abstract:AIMS:To study the prevalence of tuberculosis infection among children in household contact with adults having pulmonary tuberculosis, and identify the possible risk factors. METHODS:Children under the age of 5 years who were in household contact with 200 consecutive adults with pulmonary tuberculosis underwent tubercu...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2003.044255
更新日期:2005-06-01 00:00:00