Elimination of pethidine and bupivacaine in the newborn.

Abstract:

:Pethidine or an epidural injection of bupivacaine are common forms of obstetric analgesia in Britain. Bupivacaine has been thought to have little effect on the fetus, but neurobehavioural studies have cast doubt on this. We therefore investigated the elimination of these drugs by babies in similar population groups. Bupivacaine was largely eliminated in just over one day, while pethidine required between 2 and 6 days. This could account for the persisting depression in babies whose mothers had received pethidine.

journal_name

Arch Dis Child

authors

Cooper LV,Stephen GW,Aggett PJ

doi

10.1136/adc.52.8.638

subject

Has Abstract

pub_date

1977-08-01 00:00:00

pages

638-41

issue

8

eissn

0003-9888

issn

1468-2044

journal_volume

52

pub_type

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