A new paradigm for developing drugs in children: atomoxetine as a model.

abstract：:A 9 year old girl presented with clinical manifestations of Henoch-Schönlein syndrome and macroscopic haematuria. Laboratory investigations showed selective IgA deficiency and renal biopsy showed mesangial proliferative glomerulonephritis with diffuse granular deposits of C3 on immunofluorescence. IgA deposits were ab...

journal_title：Archives of disease in childhood

authors： Martini A,Ravelli A,Notarangelo LD,Burgio VL,Plebani A

更新日期：1985-02-01 00:00:00

abstract：AIM:To determine the frequency of use of complementary treatment and measure its impact on clinical outcomes in a hospitalised general paediatric population. METHODS:A population based random sample of children admitted to the general paediatric service at a metropolitan children's hospital in Auckland, New Zealand fr...

journal_title：Archives of disease in childhood

authors： Armishaw J,Grant CC

更新日期：1999-08-01 00:00:00

abstract：:Data are presented on 25 children under 2 years of age with acute renal failure treated by peritoneal dialysis. The clinical features, treatment, complications, and outcome of the illnesses are described. 22 (88%) survived, and though the incidence of serious complications during the illness was high most regained ful...

journal_title：Archives of disease in childhood

authors： Griffin NK,McElnea J,Barratt M

更新日期：1976-06-01 00:00:00

abstract：:The role of inflammation in adult asthma is well known, involving a cascade of immunological stimulation in which mast cells and eosinophils play pivotal roles. However, the assessment of airway inflammation in children is more difficult as the invasive methods used in adults cannot ethically be used for this purpose ...

journal_title：Archives of disease in childhood

authors： Chedevergne F,Le Bourgeois M,de Blic J,Scheinmann P

更新日期：2000-06-01 00:00:00

abstract：:The long term results of treatment of inhalation of foreign bodies in a district children's hospital and in a tertiary referral centre were reviewed by clinical assessment, chest radiography, and standard four view 81mKr ventilation/99mTc macroaggregated albumin perfusion imaging (V/Q lung scan). The overall incidence...

journal_title：Archives of disease in childhood

authors： Davies H,Gordon I,Matthew DJ,Helms P,Kenney IJ,Lutkin JE,Lenney W

更新日期：1990-06-01 00:00:00

abstract：:Aortic arch anomalies in infancy often cause intrathoracic airway obstruction. Airway function was assessed as part of the diagnostic evaluation in six symptomatic infants both by plethysmography and using a chest compression technique to obtain partial flow-volume loops. Two infants had normal intrathoracic airway fu...

journal_title：Archives of disease in childhood

authors： Thomson AH,Beardsmore CS,Firmin R,Leanage R,Simpson H

更新日期：1990-02-01 00:00:00

abstract：:A two year prospective study identified 1922 cases of meningitis in children under 1 year of age. A further 201 cases were identified from other sources. The annual incidence of meningitis during the first year of life was 1.6/1000; during the first 28 days of life it was 0.32/1000, and among postneonatal infants it w...

journal_title：Archives of disease in childhood

authors： de Louvois J,Blackbourn J,Hurley R,Harvey D

更新日期：1991-05-01 00:00:00

abstract：:Three paediatric pathologists, one perinatal paediatrician, one obstetrician, and one epidemiologist separately used information collected on 239 babies in an attempt to validate the Wigglesworth classification of perinatal deaths. This was first done using clinical data only, then using the combination of clinical an...

journal_title：Archives of disease in childhood

authors： Keeling JW,MacGillivray I,Golding J,Wigglesworth J,Berry J,Dunn PM

更新日期：1989-10-01 00:00:00

abstract：OBJECTIVE:Antibiotic drugs are frequently used for viral infections in children. It is probable that health beliefs and parental concern have great influence on the use of drugs in children. This study, performed in The Netherlands, investigates whether the use of antibiotics in children is associated with the use of m...

journal_title：Archives of disease in childhood

authors： de Jong J,Bos JH,de Vries TW,de Jong-van den Berg LT

更新日期：2012-06-01 00:00:00

abstract：:Thirty nine infants with severe asphyxia (28 affected perinatally and 11 later) were studied by electrophysiological cerebral function monitoring (CFM) for periods varying from a half to 49 days. Nineteen infants died while still in intensive care and two died later from sequelae. Eighteen survived and were followed u...

journal_title：Archives of disease in childhood

authors： Bjerre I,Hellström-Westas L,Rosén I,Svenningsen N

更新日期：1983-12-01 00:00:00

abstract：OBJECTIVE:The effect of adenoidectomy on nasopharyngeal colonisation of pathogens has not previously been evaluated. The authors studied the effect of adenoidectomy on nasopharyngeal colonisation by bacteria causing otitis media and the effect of adenoidectomy on the development of pneumococcal capsular polysaccharide ...

journal_title：Archives of disease in childhood

authors： Mattila PS,Hammarén-Malmi S,Saxen H,Kaijalainen T,Käyhty H,Tarkkanen J

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:To determine whether antimony may be detected in the urine during infancy and early childhood and its association with passive exposure to tobacco smoke, as assessed by urinary cotinine. DESIGN:Analysis of spare aliquots of urine collected from infants participating in studies of respiratory function and pas...

journal_title：Archives of disease in childhood

authors： Dezateux C,Delves HT,Stocks J,Wade A,Pilgrim L,Costeloe K

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVE:To determine the sensitivity of differential avian and human delayed-type hypersensitivity skin testing in the diagnosis of non-tuberculous mycobacterial lymphadenitis. METHOD:Retrospective review of all patients with culture proved non-tuberculous mycobacterial lymph node infections who also had differentia...

journal_title：Archives of disease in childhood

authors： Daley AJ,Isaacs D

更新日期：1999-04-01 00:00:00

abstract：AIM:To evaluate the quality of paediatric audits from 1966 to 1999. METHODS:A Medline search was performed using the MeSH terms audit, child, paediatric (and pediatric). Predefined core elements of audit were used as inclusion criteria for entry of an article into this study. These criteria were as follows: (1) an art...

journal_title：Archives of disease in childhood

authors： O'Gorman CS,Ziedan Y,O'Neill MB

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Sweat testing procedures are perceived to vary widely. AIM:To evaluate variability in sweat collection, analysis, and interpretation. METHODS:Questionnaire responses from 30 self selected centres: 15 paediatric centres, and 15 district general hospitals. RESULTS:Centres carried out 30-400 tests per year (...

journal_title：Archives of disease in childhood

authors： Kirk JM

更新日期：2000-05-01 00:00:00

abstract：OBJECTIVES:To determine if there had been changes in the size of the UK paediatric workforce and working patterns between 1999 and 2013. DESIGN:Analysis of prospectively collected datasets. SETTING:UK consultant paediatricians. INTERVENTIONS:Data from the Royal College of Paediatrics and Child Health's workforce cen...

journal_title：Archives of disease in childhood

authors： McColgan M,Winch R,Clark SJ,Ewing C,Modi N,Greenough A

更新日期：2017-02-01 00:00:00

abstract：:It has been suggested that because of vascular interchange between the monozygous twins vascular disruptions from a deceased cotwin with disseminated intravascular coagulation causes embolisation in the surviving twin. This study reports six cases in which all the surviving monozygous twins had central nervous system ...

journal_title：Archives of disease in childhood

authors： Szymonowicz W,Preston H,Yu VY

更新日期：1986-05-01 00:00:00

abstract：:A gross T cell lymphocytosis developed in an otherwise healthy 5 year old girl and has persisted for nearly 3 years. It is associated with neutropenia and seems to be typical of a rare adult disorder that may be a type of T cell chronic lymphocytic leukaemia. ...

journal_title：Archives of disease in childhood

authors： Murray JA,Lilleyman JS

更新日期：1983-08-01 00:00:00

abstract：BACKGROUND:Respiratory viral infections precipitate exacerbations of chronic respiratory diseases such as asthma and chronic obstructive pulmonary disease though similar data in non-cystic fibrosis (CF) bronchiectasis are missing. Our study aimed to determine the point prevalence of viruses associated with exacerbation...

journal_title：Archives of disease in childhood

authors： Kapur N,Mackay IM,Sloots TP,Masters IB,Chang AB

更新日期：2014-08-01 00:00:00

abstract：AIMS:To pilot a novel approach to providing pharmaceutical care to paediatric inpatients using structured referral and assessment tools. Using standardised referral criteria to ensure patients are assessed by appropriately skilled pharmacists. METHOD:Three wards of varying acuity and specialism were selected in a tert...

journal_title：Archives of disease in childhood

authors： Mott A,Kafka S,Sutherland A

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Our current understanding regarding the aetiology of infantile acute liver failure largely derives from studies conducted by regional liver units. This may introduce selection bias and therefore not provide a true reflection of the wider population. METHODS:Every coagulation screen with a prothrombin time ≥...

journal_title：Archives of disease in childhood

authors： Wands D,Tayler R,Kelly D,Pinto F,Simpson JH,Hansen R

更新日期：2020-08-01 00:00:00

abstract：:Lymphocytes bearing the T cell receptor gamma delta (TCR-gamma delta) were searched for in human early milk lymphocyte suspensions by two colour cytofluorimetric analysis. It was found that the proportion of TCR-gamma delta+ cells was twofold greater in colostrum than in either autologous or heterologous blood samples...

journal_title：Archives of disease in childhood

authors： Bertotto A,Castellucci G,Fabietti G,Scalise F,Vaccaro R

更新日期：1990-11-01 00:00:00

abstract：:The decision to participate in infant screening often rests with parents. Medical ethics require that parental decision is elicited from informed choice. Such a decision is influenced by the parental knowledge and attitude towards screening and a careful evaluation of these factors is essential in seeking informed con...

journal_title：Archives of disease in childhood

authors： Olusanya BO,Luxon LM,Wirz SL

更新日期：2004-11-01 00:00:00

abstract：:The neurodevelopmental state of 41 children with congenital cytomegalovirus infection and their controls was assessed at 2 years using the Griffiths scale. The scores achieved by children with congenital cytomegalovirus but with no associated neurological abnormality (asymptomatic) were similar to those of the control...

journal_title：Archives of disease in childhood

authors： Pearl KN,Preece PM,Ades A,Peckham CS

更新日期：1986-04-01 00:00:00

abstract：:The numbers of children under 5 years in South Glamorgan admitted to hospital because of accidental poisoning have been analysed for 1980-4. There has been no significant fall in those taking solid dose, prescribable medications since the voluntary agreement between the government and the pharmaceutical profession in ...

journal_title：Archives of disease in childhood

authors： Sibert JR,Clarke AJ,Mitchell MP

更新日期：1985-12-01 00:00:00

abstract：:Copper deficiency is reported in an infant of very low birthweight. It was characterised by extensive bone changes, severe neutropenia, and hypocupraemia. These manifestations could have been missed but for an intercurrent pneumonia which led to an x-ray of the chest. ...

journal_title：Archives of disease in childhood

authors： Yuen P,Lin HJ,Hutchinson JH

更新日期：1979-07-01 00:00:00

abstract：OBJECTIVES:Describe cases of female genital mutilation (FGM) presenting to consultant paediatricians and sexual assault referral centres (SARCs), including demographics, medical symptoms, examination findings and outcome. DESIGN:The well-established epidemiological surveillance study performed through the British Paed...

journal_title：Archives of disease in childhood

authors： Hodes D,Ayadi O'Donnell N,Pall K,Leoni M,Lok W,Debelle G,Armitage AJ,Creighton SM,Lynn RM

更新日期：2020-10-06 00:00:00

abstract：:Persistent daytime incontinence is a fairly uncommon but important problem. Videourodynamic studies were carried out in 215 children presenting with this problem in whom there were no neurological signs and who had not responded to simple measures. Over 90% of symptomatic children were shown to have an abnormality, of...

journal_title：Archives of disease in childhood

authors： Borzyskowski M,Mundy AR

更新日期：1987-02-01 00:00:00

abstract：:A previously described difference in newborn blood phenylalanine concentrations between those living in urban and non-urban areas in the south west of England has been confirmed and shown to be independent of the type of feed. Several factors including the place of abode, type of feed, birthweight, and the accuracy of...

journal_title：Archives of disease in childhood

authors： Morris AF,Holton JB,Burman D,Colley JR

更新日期：1983-04-01 00:00:00

abstract：AIM:To investigate the emotional reactions of registrars following the death of a child. METHODS:A multicentre study to determine the sources of support for registrars and the use of debriefing following a child's death. A questionnaire was sent or given to registrars within the South West Region. RESULTS:There was a...

journal_title：Archives of disease in childhood

authors： Baverstock A,Finlay F

更新日期：2006-09-01 00:00:00