Abstract:
AIMS:To compare physiological and autonomic responses to acute hypoglycaemia in diabetic children in pre-, mid-, and post-pubertal stages of development. METHODS:Twenty seven children (8 pre-pubertal, 7 mid-pubertal, 12 post-pubertal) with type 1 diabetes were studied. Hypoglycaemia was induced by insulin infusion until an autonomic reaction (R) was identified. Counterregulatory hormone levels were measured at baseline, R, R+15, and R+30 minutes. Haemodynamic changes and sweat production were measured. RESULTS:The mean blood glucose level at R was lower in pre-pubertal than mid-pubertal children (2.0 v 2.5 mmol/l), and was positively correlated with HbA1c. Glucagon and noradrenaline responses to hypoglycaemia were minimal in all children. A brisk increase in pancreatic polypeptide (PP) concentration only occurred in post-pubertal children. Only two children showed a sweating response to hypoglycaemia. CONCLUSIONS:The blood glucose level at which sympatho-adrenal responses to hypoglycaemia were activated was associated with glycaemic control, and varied with pubertal stage. As in adults, the glucagon response to hypoglycaemia was deficient within a few years of developing diabetes. However, sweating and secretion of PP in response to hypoglycaemia did not occur until after puberty, indicating some qualitative differences from adults.
journal_name
Arch Dis Childjournal_title
Archives of disease in childhoodauthors
Ross LA,Warren RE,Kelnar CJ,Frier BMdoi
10.1136/adc.2004.052035subject
Has Abstractpub_date
2005-02-01 00:00:00pages
190-4issue
2eissn
0003-9888issn
1468-2044pii
90/2/190journal_volume
90pub_type
杂志文章abstract::A trial was conducted using sequential analysis by pairs to compare the efficacy of corticosteroids and salicylates in the treatment of acute rheumatic carditis. The results show a significantly favourable effect of steroid treatment both in clinical response and in reduction of the erythrocyte sedimentation rate. In ...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章
doi:10.1136/adc.59.5.410
更新日期:1984-05-01 00:00:00
abstract:AIMS:To pilot a novel approach to providing pharmaceutical care to paediatric inpatients using structured referral and assessment tools. Using standardised referral criteria to ensure patients are assessed by appropriately skilled pharmacists. METHOD:Three wards of varying acuity and specialism were selected in a tert...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2016-311535.4
更新日期:2016-09-01 00:00:00
abstract::A retrospective study of Scottish hospital inpatients aged 15 years or less has revealed, over a 4-year period, 36 cases of venous thrombosis or phlebitis. Of these 10 were considered to have deep venous thrombosis; 2 cases were associated with obvious pulmonary embolism and 2 cases developed chronic venous insufficie...
journal_title:Archives of disease in childhood
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journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/adc.72.6.483
更新日期:1995-06-01 00:00:00
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.65.1.103
更新日期:1990-01-01 00:00:00
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journal_title:Archives of disease in childhood
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doi:10.1136/archdischild-2018-316080
更新日期:2019-08-01 00:00:00
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
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更新日期:1976-12-01 00:00:00
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.61.12.1178
更新日期:1986-12-01 00:00:00
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
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更新日期:1987-06-01 00:00:00
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更新日期:1979-07-01 00:00:00
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pub_type: 杂志文章
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.69.2.239
更新日期:1993-08-01 00:00:00
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.60.1.56
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更新日期:1986-03-01 00:00:00
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2016-312055
更新日期:2017-02-01 00:00:00
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journal_title:Archives of disease in childhood
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doi:10.1136/adc.64.7.984
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.1136/adc.76.1.41
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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更新日期:2016-12-01 00:00:00
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
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更新日期:2015-12-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2010-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:1987-10-01 00:00:00
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journal_title:Archives of disease in childhood
pub_type: 杂志文章,meta分析,评审
doi:10.1136/archdischild-2015-308875
更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1997-04-01 00:00:00
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journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/adc.69.5_spec_no.483
更新日期:1993-11-01 00:00:00
abstract:INTRODUCTION:Propylene glycol (PG) is an unintentional frequently administered solvent in neonates despite the fact that PG accumulation potentially results in hyperosmolarity, lactic acidosis and renal/hepatic toxicity. METHODS:Prospective evaluation of renal (diuresis, creatinaemia, sodium), metabolic (base excess, ...
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pub_type: 临床试验,杂志文章
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更新日期:2010-12-01 00:00:00