Precocious pubarche is associated with SGA, prematurity, weight gain, and obesity.

Abstract:

BACKGROUND:Perinatal stress is thought to underlie the Barker sequelae of low birth weight, of which precocious pubarche may be a manifestation. AIMS:To explore whether prematurity as well as smallness for gestational age (SGA) predisposes to precocious pubarche, and the potential role of excess weight gain during childhood. METHODS:Retrospective chart review of 89 children (79 girls) with precocious pubarche. RESULTS:Sixty five per cent were overweight/obese at diagnosis, compared with 19-24% of Australian children. Thirty five per cent had a history of SGA and 24% of prematurity. Weight SDS increased from birth to diagnosis in 91% of children. The mean change in weight SDS from birth to diagnosis was greater in those who were SGA (2.8, 95% CI 2.2 to 3.4) versus AGA (1.7, 95% CI 1.3 to 2.2), with no difference in the incidence of overweight/obesity. The latter was lower among children born premature (40% versus 72% term) but was associated with a mean increase in weight of 1.3 SDS during childhood. Nine out of ten girls and boys with precocious pubarche had at least one of the three risk factors studied. CONCLUSIONS:Both prematurity and SGA were associated with precocious pubarche, as was overweight/obesity, irrespective of size or gestation at birth. Excess weight gain in childhood may predispose to precocious pubarche in susceptible individuals.

journal_name

Arch Dis Child

authors

Neville KA,Walker JL

doi

10.1136/adc.2004.053959

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

258-61

issue

3

eissn

0003-9888

issn

1468-2044

pii

90/3/258

journal_volume

90

pub_type

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