Nebulised amiloride in respiratory exacerbations of cystic fibrosis: a randomised controlled trial.

Abstract:

OBJECTIVE:To assess the benefit of nebulised amiloride added to the standard inpatient treatment of a respiratory exacerbation in cystic fibrosis. DESIGN:Prospective, randomised, double blind, placebo controlled trial. SUBJECTS:27 cystic fibrosis patients (mean age 12.8 years). SETTING:Two hospitals in Leeds, UK. RESULTS:Both forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) showed improvements over the course of treatment, although there was no difference in respiratory function between the two groups at any of three time periods during the study. The time to reach peak FVC was significantly reduced in the amiloride group (4.2 v 7.6 days; 95% CI 0.4 to 6.4 days), but not in the time to reach peak FEV1 (5.7 v 7.9 days; 95% CI -1.2 to 5.6 days). CONCLUSIONS:Amiloride did not result in a greater overall improvement in respiratory function. There was a suggestion that it may have an effect on the rate of improvement, and thus may possibly influence the duration of treatment. This hypothesis deserves further evaluation.

journal_name

Arch Dis Child

authors

Bowler IM,Kelman B,Worthington D,Littlewood JM,Watson A,Conway SP,Smye SW,James SL,Sheldon TA

doi

10.1136/adc.73.5.427

subject

Has Abstract

pub_date

1995-11-01 00:00:00

pages

427-30

issue

5

eissn

0003-9888

issn

1468-2044

journal_volume

73

pub_type

临床试验,杂志文章,随机对照试验
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    doi:10.1136/adc.65.9.971

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    doi:10.1136/adc.66.5.641

    authors: Vestermark V,Vestermark S

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    doi:

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    pub_type: 杂志文章

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    journal_title:Archives of disease in childhood

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    doi:10.1136/adc.63.6.606

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    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

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    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.66.4.525

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    pub_type: 临床试验,杂志文章

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    doi:10.1136/adc.69.1.104

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    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.73.2.100

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    更新日期:1995-08-01 00:00:00

  • Late referral to paediatric renal failure service impairs access to pre-emptive kidney transplantation in children.

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    doi:10.1136/archdischild-2012-303070

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