A systematic review of time to diagnosis in children and young adults with cancer.


PURPOSE:It is often assumed that prolonged time to diagnosis (TTD) for cancer negatively influences overall survival and survivorship through advanced stage disease at diagnosis. This systematic review assesses existing early diagnosis research in childhood and young adult cancer and aims to identify whether a consensus exists within the literature in relation to the terminology and methodologies used to investigate TTD in this population. METHODS:Medline, Embase, the Centre for Reviews and Dissemination database and Cochrane library were searched for papers on children and young adults (0-30 years) published from 1948 to the present. RESULTS:Of the 1665 potentially eligible citations identified, 32 papers met the inclusion criteria. The majority of work was in European (n=15) or North American (n=8) populations. Most work focused on brain tumours (n=10), retinoblastomas (n=5) and bone and soft tissue sarcomas (n=4). The majority of studies were in hospital-based settings (n=25), with only seven papers adopting a population-based setting. Summary statistics presented were mostly median TTD, the skewed distribution of the data meant comparisons between studies based on medians were difficult and combining studies within a meta-analysis was not appropriate. CONCLUSIONS:Within the childhood and young adult population, TTD for cancer varies between diagnostic groups and with age at diagnosis in the majority of studies. In order that clear conclusions can be drawn from early diagnosis research in children and young adults, specific criteria identifying circumstances in which delay has occurred should accompany a defined time line to diagnosis or treatment in every study.


Arch Dis Child


Lethaby CD,Picton S,Kinsey SE,Phillips R,van Laar M,Feltbower RG




Has Abstract


2013-05-01 00:00:00














  • Solar disinfection of water reduces diarrhoeal disease: an update.

    abstract::349 Maasai children younger than 6 years old were randomised by alternate household to drink water either left in plastic bottles exposed to sunlight on the roof of the house or kept indoors (control). The trial was run in Maasai by Maasai community elders. Children drinking solar disinfected water had a significantly...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Conroy RM,Meegan ME,Joyce T,McGuigan K,Barnes J

    更新日期:1999-10-01 00:00:00

  • Maternal and fetal influences on blood pressure.

    abstract::To study maternal and fetal influences on blood pressure in childhood 405 children aged 4 years who were born and still resident in the Salisbury health district were visited at home for blood pressure and growth measurements. Information on the pregnancy, delivery, and baby was abstracted from the routine obstetric n...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Law CM,Barker DJ,Bull AR,Osmond C

    更新日期:1991-11-01 00:00:00

  • Population variation in admission rates and duration of inpatient stay for bronchiolitis in England.

    abstract:AIM:To explore the variation in hospital admission rates and duration of inpatient stay across England. METHODS:Hospital Episode Statistics were used to identify all children aged below 2 years who were discharged from hospital with a primary code of bronchiolitis in England, between 1 April 2007 and 31 March 2010; ra...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Cheung CR,Smith H,Thurland K,Duncan H,Semple MG

    更新日期:2013-01-01 00:00:00


    abstract:AIM:To identify the experiences of patients, parents or carers when a child/young person is prescribed a new long-term medicine. METHOD:Patients' prescribed a new long-term (>6 weeks) medicine were recruited from a single UK paediatric hospital out-patient pharmacy.A semi-structured questionnaire was administered to p...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Aston J,Wilson K,Terry D

    更新日期:2016-09-01 00:00:00

  • HIV-I infection in perinatally exposed siblings and twins. The Italian Register for HIV Infection in Children.

    abstract::In a multicentre study on perinatal HIV-I infection including 1493 children born from 1471 pregnancies to 1415 infected mothers, 22 twin pairs and 56 sibships (115 children) were recorded. The frequency of twin pregnancies was 1.5 (22/1471) and 3.9% (56/1415) seropositive women had more than one at risk pregnancy. In ...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,多中心研究


    authors: de Martino M,Tovo PA,Galli L,Caselli D,Gabiano C,Mazzoni PL,Giacomelli A,Duse M,Fundarò C

    更新日期:1991-10-01 00:00:00

  • Painful leg and missing pulses: a case report.

    abstract::Popliteal artery entrapment syndrome (PAES) is a rare but potentially limb threatening anatomical anomaly occurring predominantly in young adults. We report a case of a 14 year old boy who presented with limb threatening ischaemia requiring urgent surgery. The pathology, presentation, and management are discussed. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Chan CW,Wilson JI,Myatt A,Roberts PN

    更新日期:2000-10-01 00:00:00

  • Psychogenic non-epileptic seizures: management and prognosis.

    abstract:AIM:To determine the outcome and identify predictive factors in children with psychogenic non-epileptic seizures (PNES). METHOD:The biographies of 35 children with PNES, attending a tertiary paediatric neurology centre, were reviewed. RESULTS:Thirty five children attending the department between 1987 and 1997 were ev...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Irwin K,Edwards M,Robinson R

    更新日期:2000-06-01 00:00:00

  • Quantitative morphological studies of developing human cerebellar cortex in various disease states.

    abstract::A quantitative morphological assessment was carried out of the cellularity and staining properties of the cells of the layers of the human cerebellar cortex, both in the normal child and in 41 children suffering from a series of disorders including mental retardation. A computerized image analyser and highly standardi...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Gadson DR,Emery JL

    更新日期:1976-12-01 00:00:00

  • Cost-effectiveness of offering an area-level financial incentive on breast feeding: a within-cluster randomised controlled trial analysis.

    abstract:OBJECTIVE:To provide the first estimate of the cost-effectiveness of financial incentive for breastfeeding intervention compared with usual care. DESIGN:Within-cluster ('ward'-level) randomised controlled trial cost-effectiveness analysis (trial registration number ISRCTN44898617). SETTING:Five local authority distri...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,随机对照试验


    authors: Anokye N,Coyle K,Relton C,Walters S,Strong M,Fox-Rushby J

    更新日期:2020-02-01 00:00:00

  • Obesity and respiratory symptoms in primary school.

    abstract::The association of weight for height and triceps skinfold with seven respiratory symptoms has been examined using logistic regression analysis in 7800 5 to 11 year old children (6200 in England and 1600 in Scotland). The results support the view that overweight children have a greater liability to some respiratory sym...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Somerville SM,Rona RJ,Chinn S

    更新日期:1984-10-01 00:00:00

  • Sublingual immunotherapy in asthma and rhinoconjunctivitis; systematic review of paediatric literature.

    abstract:AIMS:To evaluate the clinical efficacy of sublingual immunotherapy (SLIT) in respiratory allergy in children. METHODS:A systematic literature review was conducted. The search was focused on all the double blind (and double dummy if necessary) studies. SEARCH STRATEGY:Medline, Embase, Cochrane Controlled Trial Registe...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审


    authors: Sopo SM,Macchiaiolo M,Zorzi G,Tripodi S

    更新日期:2004-07-01 00:00:00

  • Protein restriction in chronic renal failure.

    abstract::The aim of the study was to investigate the effect of a protein restricted diet on renal function and growth of children with chronic renal failure. In a multicentre prospective study 56 children (aged 2-18 years) with chronic renal failure were randomly assigned to the protein restricted (0.8-1.1 g/kg/day) or the con...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kist-van Holthe tot Echten JE,Nauta J,Hop WC,de Jong MC,Reitsma-Bierens WC,Ploos van Amstel SL,van Acker KJ,Noordzij CM,Wolff ED

    更新日期:1993-03-01 00:00:00

  • Childhood cancers in Zambia before and after the HIV epidemic.

    abstract::Human immunodeficiency virus (HIV) related cancers in children are not as common and as well described as in adults. An HIV epidemic has been prevalent in Zambia since 1983-1984. To study the effect of the epidemic on the epidemiology of cancers in children a retrospective study was undertaken at the University Teachi...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Chintu C,Athale UH,Patil PS

    更新日期:1995-08-01 00:00:00

  • Ultrasonic assessment of gastric emptying in the preterm infant.

    abstract::The study of gastric emptying in the preterm infant has been hampered by the absence of a suitable, valid technique. We have evaluated gastric antral clearance using serial ultrasonic measurement of the antral cross sectional area (ACSA). The study was easy to perform, providing successful results in 15 of 17 low birt...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Newell SJ,Chapman S,Booth IW

    更新日期:1993-07-01 00:00:00

  • The prognostic value of dipstick urinalysis in children admitted to hospital with severe malnutrition.

    abstract:BACKGROUND:Children with severe malnutrition (SAM) present to hospital with an array of complications, resulting in high mortality despite adherence to WHO guidelines. Diagnostic resources in developing countries are limited and bedside tests could help identify high-risk children. Dipstick urinalysis is a bedside scre...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Thuo N,Ohuma E,Karisa J,Talbert A,Berkley JA,Maitland K

    更新日期:2010-06-01 00:00:00

  • Renal solute load in preterm infants.

    abstract::We performed metabolic balance studies in 77 preterm infants fed on human milk or adapted formulas, to determine the renal solute load and compared it with the potential renal solute load estimated by the composition of the diet or the urine according to Ziegler's, Bergman's, and Shaw's calculations. The renal solute ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: De Curtis M,Senterre J,Rigo J

    更新日期:1990-04-01 00:00:00

  • Promoting research for children.

    abstract::Concerns have been expressed in recent years about the decline in children's clinical and biomedical research in the UK, and in the paediatric academic workforce. Here I consider the extent to which these concerns are justified, the sweeping changes that have taken place in research funding, governance and organisatio...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Modi N

    更新日期:2010-11-01 00:00:00

  • Efficacy of sweet solutions for analgesia in infants between 1 and 12 months of age: a systematic review.

    abstract:OBJECTIVE:To compare the efficacy of oral sweet solutions to water or no treatment in infants aged 1-12 months during immunisation. METHODS:Randomised controlled trials (RCTs) were retrieved through internet searches or manual searches of reference lists. Search terms included newborn, infant, pain, sucrose and altern...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,meta分析,评审


    authors: Harrison D,Stevens B,Bueno M,Yamada J,Adams-Webber T,Beyene J,Ohlsson A

    更新日期:2010-06-01 00:00:00

  • Familial insulin-resistant diabetes, multiple somatic anomalies, and pineal hyperplasia.

    abstract::West, R. J., Lloyd, J. K., and Turner, W. M. L. (1975). Archives of Disease in Childhood, 50, 703. Familial insulin-resistant diabetes, multiple somatic anomalies, and pineal hyperplasia. A syndrome comprising unusual facies, dry skin, acanthosis nigricans, thickened nails, hirsutism, dental precocity and dysplasia, a...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: West RJ,Lloyd JK,Turner WM

    更新日期:1975-09-01 00:00:00

  • Respiratory symptoms in children of low birth weight.

    abstract::We recorded the respiratory history by questionnaire in a 7 year old cohort of children whose birth weight was under 2000 g and an unselected reference group of local schoolchildren of the same age. Complete data were obtained in 121 low birthweight children (90% of those studied): 62 who had no neonatal respiratory i...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Chan KN,Elliman A,Bryan E,Silverman M

    更新日期:1989-09-01 00:00:00

  • Gestational age in twins.

    abstract::Dubowitz et al. have offered a scoring system for estimating the gestational age of newborn babies. If the system is applied to twin pairs, the heavier twin is generally estimated to have a greater gestational age than the lighter one. Previously this has been interpreted as a flaw in the scoring system. However, it m...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: James WH

    更新日期:1980-04-01 00:00:00

  • Clostridial toxins in neonatal necrotising enterocolitis.

    abstract::Clostridium difficile cytopathic toxin was found in the faeces or gut content of five of 39 neonates with necrotising enterocolitis (NEC). Toxin concentrations were uniformly low and did not differ from those found in healthy neonates. C difficile is unlikely to be involved in the pathogenesis of NEC. Stools from 33 b...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Thomas DF,Fernie DS,Bayston R,Spitz L

    更新日期:1984-03-01 00:00:00

  • The fifth UK paediatric diabetes services survey: meeting guidelines and recommendations?

    abstract:AIM:To assess the provision of UK paediatric and adolescent diabetes services and examine changes in service delivery since 2002. METHOD:Questionnaires were sent to the lead paediatric consultant from all paediatric and adolescent diabetes services (n=205). Questions were based on National Institute for Health and Cli...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究


    authors: Gosden C,Edge JA,Holt RI,James J,Turner B,Winocour P,Walton C,Nagi D,Williams R,Matyka K

    更新日期:2010-10-01 00:00:00

  • Effect of cyproterone acetate on adrenocortical function in children with precocious puberty.

    abstract::Seven children with precocious puberty were treated with cyproterone acetate and their adrenal function studied. In each child the drug caused significant adrenal hypofunction which was secondary to adrenocorticotrophic hormone suppression. None of these children had clinical evidence of adrenal hypofunction and it is...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Savage DC,Swift PG

    更新日期:1981-03-01 00:00:00

  • Anthropometric measures are simple and accurate paediatric weight-prediction proxies in resource-poor settings with a high HIV prevalence.

    abstract:RATIONALE:Accurate weight measurements are essential for both growth monitoring and drug dose calculations in children. Weight can be accurately measured using calibrated scales in resource-rich settings; however, reliable scales are often not available in resource-poor regions or emergency situations. Current age and/...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Whitfield KC,Wozniak R,Pradinuk M,Karakochuk CD,Anabwani G,Daly Z,MacLeod SM,Larson CP,Green TJ

    更新日期:2017-01-01 00:00:00

  • Reflection: moving from a mandatory ritual to meaningful professional development.

    abstract::Reflection has become established as a key principle underpinning maintenance of standards within professional education and practice. A requirement to evidence reflection within performance review is intended to develop a transformative approach to practice, identify developmental goals, and ultimately, improve healt...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审


    authors: Murdoch-Eaton D,Sandars J

    更新日期:2014-03-01 00:00:00

  • Attention deficit hyperactivity disorder: legal and ethical aspects.

    abstract::Attention deficit-hyperactivity disorder (ADHD) remains a controversial disorder, despite it now being a well validated clinical diagnosis. Ethical and legal issues are important in determining how doctors should behave in offering a diagnosis or treatment that may generate strong and unpredictable reactions from chil...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审


    authors: Foreman DM

    更新日期:2006-02-01 00:00:00

  • Lung function in children after repair of congenital diaphragmatic hernia.

    abstract::Sixteen children who had had congenital diaphragmatic herniae repaired either in the neonatal period (11), or in early childhood (5), were reviewed at between 7 and 19 years of age. Only minor abnormalities were shown in their chest x-rays and in a variety of lung function tests. This suggests that the long-term progn...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Kerr AA

    更新日期:1977-11-01 00:00:00

  • How has research changed my practice in the last 5 years?

    abstract::You can't teach old dogs new tricks. Teaching middle-aged dogs new tricks is hard enough. They tend to stick to particular styles of attacking the postman that over the years have proved pretty reliable, often choosing to ignore new findings, or simply failing to keep up with progress in current discussions on, say, t...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Cameron D

    更新日期:2007-11-01 00:00:00

  • Assent for children's participation in research is incoherent and wrong.

    abstract::When children are considered for participation in research, British and international guidelines suggest that they should provide assent in addition to their parents' consent. However, examination of these guidelines shows there is confusion regarding the concept of assent. Furthermore, the need for assent may cause p...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章


    authors: Baines P

    更新日期:2011-10-01 00:00:00