Abstract:
:The adrenal glands of 41 fresh stillbirths were studied and a 'stress response' pattern could be seen in 28. In these glands the stress response was characterised by compact cell change, lipid depletion, excess pyroninophilia, and dilatation of the very prominent granular endoplasmic reticulum. Scattered areas of cytolysis of cells, especially of the definitive cortex, gave rise to the commonly seen cystic (pseudofollicular) change and it was obvious that cells undergoing lysis were severely 'stressed'. In 2 infants there was a 'clear cell reversal' pattern. Histological and ultrastructural changes of the stress response were not identified in 11. Infants of low birthweight score were somewhat more commonly represented in the group that did not show a stress response. Cytolytic changes accompanying a stress response were commoner in immature infants. It is argued that cystic (pseudofollicular) change in the adrenal cortex of the newborn signifies a previous stress reaction.
journal_name
Arch Dis Childjournal_title
Archives of disease in childhoodauthors
de Sa DJdoi
10.1136/adc.53.10.769subject
Has Abstractpub_date
1978-10-01 00:00:00pages
769-76issue
10eissn
0003-9888issn
1468-2044journal_volume
53pub_type
杂志文章abstract::A total of 121 infants entered a cohort serological study of primary infections with herpes-viruses. All of them had seven samples of blood available: the first sample was taken soon after birth, the other six were taken at 1, 2, 3, 6, 12, and 14 months of age. One sample of maternal blood was collected immediately af...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.68.3.408
更新日期:1993-03-01 00:00:00
abstract:AIMS:To assess the impact of two paediatric intensive care unit retrieval teams on the performance of three mortality risk scoring systems: pre-ICU PRISM, PIM, and PRISM II. METHODS:A total of 928 critically ill children retrieved for intensive care from district general hospitals in the south east of England (crude m...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.87.5.421
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVE:To investigate the accuracy of morphine infusions prepared for neonates in relation to the label strength and to identify the differences in deviation between infusions made in neonatal intensive care unit (NICU) and those dispensed ready-to-use from pharmacy. METHODS:Unused portions of morphine solution for...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2013-304522
更新日期:2013-12-01 00:00:00
abstract::This paper reviews the diagnostic features of cluster headache-like disorder and describes its presentation in childhood. Case note summaries of patients with this condition are presented in the context of a brief summary of the literature. Four patients (two girls; aged 12 to 15 years) with cluster headache-like diso...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.81.6.511
更新日期:1999-12-01 00:00:00
abstract::Thirty-two children with a past diagnosis of coeliac disease were reinvestigated by means of gluten challenge. They had received a gluten-free diet for a mean period of 6-5 years (range 0-25-11-0) before gluten challenge, and had a mean age of 9-9 years (range 3-0-15-3) at the onset of challenge. Small intestinal biop...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.53.6.449
更新日期:1978-06-01 00:00:00
abstract::After the introduction of the colposcope for the examination of children suspected of being sexually abused in Leeds, a study was undertaken to describe the findings in detail. A total of 109 consecutive prepubertal girls, mean age 70.4 months were assessed including colposcopic genital and anal examination, and peer ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.73.5.465
更新日期:1995-11-01 00:00:00
abstract:AIM:To evaluate the quality of paediatric audits from 1966 to 1999. METHODS:A Medline search was performed using the MeSH terms audit, child, paediatric (and pediatric). Predefined core elements of audit were used as inclusion criteria for entry of an article into this study. These criteria were as follows: (1) an art...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/adc.2004.071381
更新日期:2007-04-01 00:00:00
abstract::A special conditions register (SCR) linked to the child health system's register of all children has been in use in West Sussex since 1977. This paper describes the aims, organisation, and use of the SCR and gives examples of the aggregated data that may be obtained. Of the 155,000 children aged 0-17 resident in West ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.66.8.927
更新日期:1991-08-01 00:00:00
abstract::1 case study and a clinical study with laboratory rats examined the question of breast milk jaundice. The case study confirmed clinical diagnosis of breast milk jaundice. The clinical study compared the effects of breast milk and 3alpha, 20beta-pregnanediol on the conjugation of bilirubin and o-aminophenol by rat li...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.46.246.195
更新日期:1971-04-01 00:00:00
abstract::The free running asthma screening test (FRAST) was used to screen children in a state middle school during a normal physical education lesson. The test was conducted by the teachers with a general practitioner available via a radiopager. Of the 249 children attending the school, aged 8-12 years, 237 (95%) were tested....
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.69.6.667
更新日期:1993-12-01 00:00:00
abstract::Hepatitis B virus infection is still a major public health problem worldwide, since more than 350 million people have chronic, lifelong infection and nearly 1 million deaths occur each year owing to complications. Most infections are acquired at birth or during early childhood. Nowadays, low- and middle-income countri...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/archdischild-2016-312043
更新日期:2017-07-01 00:00:00
abstract::Fifty nine children of short stature exercised for 10 minutes on a non-motorised treadmill. In 49 a growth hormone concentration of greater than 15 mU/l was reached, effectively excluding growth hormone deficiency. In 10 children the growth hormone concentration failed to reach 15 mU/l; growth hormone deficiency was c...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.59.12.1179
更新日期:1984-12-01 00:00:00
abstract::When isolated from the female genital tract, diphtheroids are usually regarded as commensal organisms. Corynebacterium kutscheri however is a pathogen in laboratory rodents. We report a case in which C. kutscheri was isolated as a pure culture from the umbilical cord and from other surface sites in an infant. Histolog...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.54.9.710
更新日期:1979-09-01 00:00:00
abstract:OBJECTIVE:We assessed whether maternal mental health problems increased rates for child injury during the preschool years and mid-childhood, and the extent to which associations could be accounted for by a range of potential explanatory factors. DESIGN:We analysed the UK Millennium Cohort Study, a nationally represent...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2017-313809
更新日期:2019-03-01 00:00:00
abstract:AIM:To determine whether emergency hospital admission rates (EAR) for common paediatric conditions in Greater London are associated with measures of child well-being and deprivation. DESIGN:Retrospective analysis of hospital episode statistics and secondary analysis of the Index of Multiple Deprivation (IMD) 2007 and ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2009.180125
更新日期:2011-03-01 00:00:00
abstract::Renal sodium handling was studied in 23 children at three different stages of the minimal change nephrotic syndrome--the oedema forming state, proteinuric steady state, and remission. Clearances of inulin and para-aminohippuric acid and urinary sodium excretion were determined basally, after intravenous infusion of is...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.59.9.825
更新日期:1984-09-01 00:00:00
abstract::The National Health Service, in its report An organisation with memory, has called for a fundamental rethinking of the way the healthcare system learns from error. The NHS further details its goal to reduce serious medication errors by 40% in a second report entitled Building a safer NHS: improving medication safety. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/adc.2003.048827
更新日期:2005-07-01 00:00:00
abstract:PURPOSE:To estimate the minimum incidence of congenital Zika syndrome (CZS) and severe microcephaly in Canada and describe key clinical, epidemiological, aetiological and outcome features of these conditions. METHODS:Two separate national surveillance studies were conducted on CZS and severe microcephaly using the wel...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2020-320968
更新日期:2021-01-08 00:00:00
abstract:OBJECTIVE:To investigate possible renal toxicity of long-term gentamicin inhalation in patients with cystic fibrosis. METHODS:Urinary N-acetyl-beta-D-glucosaminidase (NAG) activity was measured during routine respiratory clinic visits. Outpatient records were reviewed for data on long-term gentamicin inhalation, and p...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.78.6.540
更新日期:1998-06-01 00:00:00
abstract::During June and July 1977 5 junior boys in a boarding school for 800 pupils became ill with a mild infection caused by Coxsackie B1. The school had been taking part in a vaccine trial, and paired blood samples had been taken from new entrants in October 1976 and October 1977. 18% of the boys susceptible to the infecti...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.54.4.291
更新日期:1979-04-01 00:00:00
abstract:AIMS:To evaluate behavioural outcome and quality of life in children aged 8-14 years after neonatal arterial switch operation for transposition of the great arteries. METHODS:Sixty children operated as neonates with combined deep hypothermic circulatory arrest and low flow cardiopulmonary bypass were evaluated at age ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.87.6.506
更新日期:2002-12-01 00:00:00
abstract::Eithe low birthweight infants were studied for their metabolic and hormonal responses to intravenous alimentation when the caloric input was varied. The study was made during three consecutive 12-hour periods, when solutions of glucose, glucose and amino-acids, and glucose and amino-acid and lipids were successively i...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.54.7.499
更新日期:1979-07-01 00:00:00
abstract::We describe a 21 month old male infant who presented with failure to thrive associated with severe hypokalaemia and metabolic acidosis, together with hypomagnesaemia. Evaluation revealed marked renal and probable faecal potassium wasting, distal renal tubular acidosis, mild urinary magnesium wasting, and a normal gast...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.84.6.504
更新日期:2001-06-01 00:00:00
abstract::A total of 37 children with refractory wide-spread atopic eczema were treated with an antigen avoidance regimen comprising hospitalisation, exclusive feeding with an elemental formula for a median duration of 30 days, and measures to reduce exposure to pet and dust mite antigens at home. After the initial period of fo...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章
doi:10.1136/adc.66.1.93
更新日期:1991-01-01 00:00:00
abstract::Four children, including three infants, who died suddenly and unexpectedly are described. In three of the cases group A beta haemolytic streptococcus was cultured and in the fourth Streptococcus pneumoniae. The organism was grown from multiple sites including blood in two of them. Without microbiological investigation...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.69.3.381
更新日期:1993-09-01 00:00:00
abstract:OBJECTIVES:To assess the persistence of serum Haemophilus influenzae type b antibodies and the prevalence of H influenzae type b carriage in a group of preschool age children previously vaccinated in infancy. DESIGN:Names were randomly selected from immunisation records. Families were visited on five occasions over a ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.77.6.488
更新日期:1997-12-01 00:00:00
abstract::The National Grid is a training scheme that represents a unique partnership between Deaneries and the Royal College of Paediatrics and Child Health (RCPCH) in offering through national competition, equitable access to high quality subspecialty training. Paediatrics is unusual in that within the umbrella Certificate of...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/adc.2004.066688
更新日期:2006-01-01 00:00:00
abstract:AIMS:To compare physiological and autonomic responses to acute hypoglycaemia in diabetic children in pre-, mid-, and post-pubertal stages of development. METHODS:Twenty seven children (8 pre-pubertal, 7 mid-pubertal, 12 post-pubertal) with type 1 diabetes were studied. Hypoglycaemia was induced by insulin infusion unt...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2004.052035
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVE:To determine current use of vitamin K (VK) prophylaxis in newborns and review the efficacy and effectiveness of regimens used. DESIGN:Efficacy and effectiveness calculated using current practice details, data from Southern Ireland and two previous surveys, together with contemporaneous studies of vitamin K d...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究
doi:10.1136/adc.2006.105304
更新日期:2007-09-01 00:00:00
abstract:AIM:To investigate the safety of bronchoscopy and endobronchial biopsy in children with difficult asthma, and discuss the ethical issues associated with the procedure. METHODS:A three year prospective observational study was performed in two tertiary paediatric respiratory centres specialising in the management of chi...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究
doi:10.1136/adc.84.5.423
更新日期:2001-05-01 00:00:00