Abstract:
OBJECTIVE:To investigate possible renal toxicity of long-term gentamicin inhalation in patients with cystic fibrosis. METHODS:Urinary N-acetyl-beta-D-glucosaminidase (NAG) activity was measured during routine respiratory clinic visits. Outpatient records were reviewed for data on long-term gentamicin inhalation, and parents and patients were interviewed for compliance. Exclusion criteria were irregular gentamicin inhalation, urinary infection or other febrile illness, intravenous aminoglycoside treatment during the previous three months, and diabetes mellitus. Patients were assigned to three groups: group 1, current gentamicin inhalation; group 2, previous gentamicin inhalation that had been stopped at least three months ago; and group 3, never any gentamicin inhalation. RESULTS:52 patients (34 girls, 18 boys), mean (SD) age 11.5 (5.7) years, entered the study. Patients currently on gentamicin inhalation (n = 20) were significantly younger and had higher urinary NAG activity (0.83 (0.57) U/mmol creatinine) than the 23 patients without gentamicin inhalation (0.26 (0.10) (p = 0.0001) and the nine patients with previous gentamicin inhalation (0.32 (0.15) (p = 0.0125). Twelve patients on current gentamicin inhalation had raised NAG values but all those in groups 2 and 3 had NAG values within the normal range. In patients currently on gentamicin inhalation, there was a positive correlation between urinary NAG activity and cumulative dose of nebulised gentamicin (r = 0.60, p = 0.0049). CONCLUSIONS:Long-term gentamicin inhalation in patients with cystic fibrosis poses a risk of renal toxicity. It is not known whether further treatment might result in more severe renal damage.
journal_name
Arch Dis Childjournal_title
Archives of disease in childhoodauthors
Ring E,Eber E,Erwa W,Zach MSdoi
10.1136/adc.78.6.540subject
Has Abstractpub_date
1998-06-01 00:00:00pages
540-3issue
6eissn
0003-9888issn
1468-2044journal_volume
78pub_type
杂志文章abstract:BACKGROUND:Acute respiratory infections (ARI) cause 3 million deaths in children worldwide each year. Most of these deaths occur from pneumonia in developing countries, and hypoxaemia is the most common fatal complication. Simple and adaptable indications for oxygen therapy are important in the management of ARI. The c...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/adc.2008.138362
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Long term growth hormone (GH) treatment in children with idiopathic short stature (ISS) results in a relatively small mean gain in final height of 3-9 cm, which may not justify the cost of treatment. As it is unknown whether GH treatment during puberty adds to final height gain, we sought to improve the cost...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/adc.87.3.215
更新日期:2002-09-01 00:00:00
abstract:OBJECTIVE:To assess psychological and social functioning and health related quality of life and its early determinants in children born with congenital diaphragmatic hernia (CDH). DESIGN:Cross-sectional follow-up study. SETTING:Outpatient clinic of a tertiary care hospital. PARTICIPANTS:33 CDH survivors aged 6-16 ye...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2008.156158
更新日期:2009-11-01 00:00:00
abstract::Two male patients with congenital cleft lip and palate first seen at ages 10.2 and 21.5 years presented with typical signs of hypothalamic-interior pituitary hormone deficiencies. They were found to lack GH, LH, and FSH and to be partially deficient in TSH and ACTH. Several congenital defects may explain this rare syn...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.53.12.952
更新日期:1978-12-01 00:00:00
abstract::Encephalitis is an uncommon but potentially devastating neurological syndrome with different aetiologies including direct central nervous system infection with different agents (most commonly viral) and those mediated by the immune system. Whilst there have been several recent publications and guidelines on the manage...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/archdischild-2011-300100
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVE:To estimate the diagnostic accuracy of chest radiography in the detection of chest lymphadenopathy in children with clinically suspected pulmonary tuberculosis. METHODS: DESIGN:Prospective cross sectional study. SETTING:A short stay ward in a children's hospital in South Africa. PATIENTS:Consecutive child...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2004.062315
更新日期:2005-11-01 00:00:00
abstract::The concentrations of immunoglobulins (Ig) G.A.M. and E were determined in paired umbilical cord and maternal sera in 50 twin pregnancies. Mean IgG levels were higher in cord than maternal sera and in most cases the cord IgG level related more closely to that of the other twin than to either maternal level or birthwei...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.51.5.354
更新日期:1976-05-01 00:00:00
abstract:OBJECTIVES:To establish the incidence of childhood coeliac disease (CD) in Scotland between 1 September 2009 and 31 August 2010, to determine clinical features at presentation and reasons for diagnosis, and to identify any differences in incidence and practice between regions. DESIGN:Prospective data collection throug...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2012-302056
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To determine the incidence, demography and prognosis of vitamin D deficiency dilated cardiomyopathy (DCM) in Scotland over the last decade. STUDY DESIGN:A retrospective review of cases of vitamin D deficiency DCM presenting to a national paediatric cardiac centre between 1 January 2008 and 1 January 2018. Th...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2019-317794
更新日期:2020-09-01 00:00:00
abstract:AIMS:To determine the prevalence of sleep-disordered breathing (SDB) in a clinical sample of overweight and obese children and adolescents, and to examine the contribution of fat distribution. METHODS:Consecutive subjects without chronic lung disease, neuromuscular disease, laryngomalacia, or any genetic or craniofaci...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2006.101089
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVE:Adherence to attention-deficit/hyperactivity disorder (ADHD) medication treatment is often suboptimal. This can compromise patient outcomes. We aimed to describe the patterns of ADHD medication use in Australian children, and characteristics associated with patterns of use. DESIGN:Dispensing data were analys...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2019-317997
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVE:Congenital hypothyroidism (CHT) is a common cause of preventable mental retardation, and the quantification of intellectual disability due to CHT is needed to assess the public health benefit of newborn screening. DESIGN:Review of published studies conducted among children born prior to the introduction of n...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/adc.2010.190280
更新日期:2011-04-01 00:00:00
abstract::In a prospective study, 60% of admissions to an academic hospital were infected with HIV. HIV infected children were younger, less likely to have been referred, more likely to have pneumonia and candidiasis, and had more health service attendances. This impact may be alleviated by appropriate primary and secondary lev...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.85.1.50
更新日期:2001-07-01 00:00:00
abstract::Spirometric data from 1586 healthy children, who did not smoke, were analysed to examine the effects of overweight as measured by the body mass index (weight/height2) on lung function. Overweight (72 boys, 88 girls) was defined as on or above the 90th percentile weight for height. After having controlled for the confo...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.65.5.512
更新日期:1990-05-01 00:00:00
abstract::Thirty preterm infants (gestational age 26 to 30 weeks) were investigated by cross sectional echocardiography using a 5 or 7.5 MHz transducer positioned in the suprasternal notch or the left subclavicular position to enable visualisation of the aortic arch, main pulmonary artery, left pulmonary artery, and ductus arte...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.59.4.341
更新日期:1984-04-01 00:00:00
abstract:AIMS:To describe the clinical features, diagnosis and management of children with tuberculosis in the United Kingdom and Republic of Ireland. METHODS:Cases of culture-confirmed and clinically diagnosed tuberculosis were reported to the British Paediatric Surveillance Unit from December 2003 to January 2005. RESULTS:3...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究
doi:10.1136/adc.2007.133645
更新日期:2009-04-01 00:00:00
abstract::The association of weight for height and triceps skinfold with seven respiratory symptoms has been examined using logistic regression analysis in 7800 5 to 11 year old children (6200 in England and 1600 in Scotland). The results support the view that overweight children have a greater liability to some respiratory sym...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.59.10.940
更新日期:1984-10-01 00:00:00
abstract::The eating habits and attitudes concerning body shape and weight among 26 mothers of children with non-organic failure to thrive (the index group) were studied using the eating disorder examination. They were compared with equivalent data on 26 individually matched women who participated in a large community survey. T...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.70.3.234
更新日期:1994-03-01 00:00:00
abstract:AIMS:To determine whether the British 1990 growth charts are valid for cross sectional and longitudinal use in primary school children. METHODS:A total of 694 children aged 7-10 years from 10 Leeds primary schools were weighed and measured annually over three years by an expert auxologist. SD scores were calculated us...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.83.4.298
更新日期:2000-10-01 00:00:00
abstract:BACKGROUND:The National Institute for Health and Care Excellence (NICE) guidance for referral of children with suspected cancer was first published in 2005 and updated in 2015. The updated version relied on sparse primary care evidence and published without input from key stakeholders, for example, acute general paedia...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2019-317235
更新日期:2020-03-01 00:00:00
abstract::Cellobiose and mannitol absorption were studied in patients with suspected abnormal function of the small bowel mucosa. The urinary cellobiose:mannitol ratio was increased in subtotal villous atrophy, iron deficiency anaemia, and small intestinal Crohn's disease. The test seems a sensitive indicator of the integrity o...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.64.6.853
更新日期:1989-06-01 00:00:00
abstract:BACKGROUND:There are few data on the optimal micronutrient composition of paediatric enteral feeds. The recent European Directive on Foods for Special Medical Purposes (1999/21/EC) did not distinguish between the composition of adult and paediatric feeds. AIMS:To evaluate, in an open, observational study, the long ter...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.86.6.411
更新日期:2002-06-01 00:00:00
abstract:OBJECTIVE:To investigate the relationship between ethnicity and health outcomes among fetuses and infants with congenital left heart obstruction (LHO). DESIGN:A retrospective population-based review was conducted of fetuses and infants with LHO including all terminations, stillbirths and live births from 20 weeks' ges...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2018-315887
更新日期:2019-09-01 00:00:00
abstract::Of the 265 children aged between 6 and 18 months admitted to hospital in a 26-month period each with his first febrile convulsion, there were 64 who satisfied our criteria for a simple febrile convulsion. Of these, 43 (random) were entered into a double-blind trial of continuous sodium valproate versus phenobarbitone,...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章
doi:10.1136/adc.55.3.171
更新日期:1980-03-01 00:00:00
abstract::Doppler ultrasound measurements of pulmonary blood flow in 20 babies with severe respiratory distress syndrome treated in a randomised controlled trial of surfactant replacement showed that the immediate improvement of oxygenation was not associated with a significant increase in pulmonary blood flow. Reduction in ven...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/adc.64.1_spec_no.13
更新日期:1989-01-01 00:00:00
abstract:INTRODUCTION:Langerhans cell histiocytosis (LCH) is a rare disease with diverse clinical courses. Despite improvement in survival outcomes in the recent decades, sequelae of the disease remain a concern. This study aimed to provide information on the long-term outcomes in patients with LCH, particularly on the sequelae...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2016-312185
更新日期:2017-09-01 00:00:00
abstract::1 case study and a clinical study with laboratory rats examined the question of breast milk jaundice. The case study confirmed clinical diagnosis of breast milk jaundice. The clinical study compared the effects of breast milk and 3alpha, 20beta-pregnanediol on the conjugation of bilirubin and o-aminophenol by rat li...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.46.246.195
更新日期:1971-04-01 00:00:00
abstract::The metabolism and excretion of paracetamol was studied in an infant of 29 weeks' gestation who was exposed to the drug when his mother ingested 32.5 g 16 hours before delivery. We have confirmed that sulphation is the major pathway and that the mixed function oxidase system is sufficiently active at this gestational ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.58.8.631
更新日期:1983-08-01 00:00:00
abstract::Two cases of atypical Kawasaki disease (KD) manifested as persistent lobar lung consolidation, prolonged fever, and active inflammatory laboratory markers unresponsive to antibiotic treatment are reported. One of the children developed a giant coronary aneurysm. Atypical KD should be considered in the differential dia...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.88.10.940
更新日期:2003-10-01 00:00:00
abstract::The clinical profile, malignant potential, and management of 17 children with juvenile polyposis (more than five juvenile polyps) were evaluated clinically and endoscopically. Colonoscopy and polypectomy were done three weekly until colonic clearance was achieved, and thereafter two yearly. All polyps were subjected t...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.78.3.264
更新日期:1998-03-01 00:00:00