Neonatal paracetamol poisoning: treatment by exchange transfusion.

Abstract:

:The metabolism and excretion of paracetamol was studied in an infant of 29 weeks' gestation who was exposed to the drug when his mother ingested 32.5 g 16 hours before delivery. We have confirmed that sulphation is the major pathway and that the mixed function oxidase system is sufficiently active at this gestational age to produce hepatotoxic metabolic products. As most of the recognised drug treatments for paracetamol poisoning seemed unsuitable in this case, the infant was treated with exchange transfusions.

journal_name

Arch Dis Child

authors

Lederman S,Fysh WJ,Tredger M,Gamsu HR

doi

10.1136/adc.58.8.631

subject

Has Abstract

pub_date

1983-08-01 00:00:00

pages

631-3

issue

8

eissn

0003-9888

issn

1468-2044

journal_volume

58

pub_type

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