Practical issues in relation to clinical trials in children in low-income countries: experience from the front line.

abstract：:Nerve growth factor (NGF) is the first described neurotrophin that stimulates the growth and differentiation of nerve cells and promotes skin and peripheral tissue regeneration. Recent studies suggest that NGF influences endothelial cell proliferation and angiogenic activity. In view of these proposed regenerative eff...

journal_title：Archives of disease in childhood

authors： Chiaretti A,Piastra M,Caresta E,Nanni L,Aloe L

更新日期：2002-11-01 00:00:00

abstract：:The provision of positive end expiratory pressure, via a unique portable system, in the long term management of a child with thoracic dystrophy is reported. The system uses low gas flow enabling a reduction in equipment and simplification of the circuit as compared with a standard continuous positive airways pressure ...

journal_title：Archives of disease in childhood

authors： Edees S,Moulden A,Winter RJ

更新日期：1992-01-01 00:00:00

abstract：:Eighteen children suffering from hay fever were treated with intra-nasal beclomethasone dipropionate (400 mug/day) and an identical placebo aerosol in a double-blind cross-over trial. 17 of the children preferred the intranasal beclomethasone dipropionate, one had no preference, none preferred the placebo. The effect ...

journal_title：Archives of disease in childhood

authors： Prahl P,Wilken-Jensen K,Mygind N

更新日期：1975-11-01 00:00:00

abstract：:Unexpected stability of arterial oxygen and carbon dioxide tensions occurred in infants recovering from respiratory distress syndrome (RDS) on the abrupt withdrawal of CPAP at 6 cmH2O pressure. 30 preterm infants (birthweights 880--3200 g gestational ages 29--38 weeks) were treated at a mean age of 10 hours and for a ...

journal_title：Archives of disease in childhood

authors： Hegyi T,Hiatt IM

更新日期：1979-09-01 00:00:00

abstract：:A postal survey of recently appointed consultant paediatricians was undertaken to determine whether they perceived their training had adequately equipped them for their current job. The response rate was 69% (207/299). After excluding replies from consultants trained outside the UK the analysis was carried out on 167 ...

journal_title：Archives of disease in childhood

authors： Lenton SW,Dison PJ,Haines LC

更新日期：1994-10-01 00:00:00

abstract：AIMS:Out-of-hospital sudden cardiac arrest (SCA) is a rare but devastating event in children and adolescents. The risk is assumed to be higher in children with congenital heart defects (CHDs) than in healthy individuals. The aim of the present study was to investigate the rate of and survival after out-of-hospital card...

journal_title：Archives of disease in childhood

authors： Jortveit J,Klcovansky J,Døhlen G,Eskedal L,Birkeland S,Holmstrøm H

更新日期：2018-01-01 00:00:00

abstract：AIM:To determine the outcome and identify predictive factors in children with psychogenic non-epileptic seizures (PNES). METHOD:The biographies of 35 children with PNES, attending a tertiary paediatric neurology centre, were reviewed. RESULTS:Thirty five children attending the department between 1987 and 1997 were ev...

journal_title：Archives of disease in childhood

authors： Irwin K,Edwards M,Robinson R

更新日期：2000-06-01 00:00:00

abstract：:When prescribing drugs for children, it is fundamental to acknowledge that they are distinct from adults with a different physiology and metabolism. They are also still maturing. The development of drugs with a primarily paediatric indication thus requires the trialling of these drugs in a paediatric population to ass...

journal_title：Archives of disease in childhood

authors： Prasad S

更新日期：2005-02-01 00:00:00

abstract：AIMS:To investigate (1) whether colic cries are acoustically distinct from pre-feed "hunger" cries; (2) the role of the acoustic properties of these cries versus their other properties in accounting for parents' concerns about colic. DESIGN:From a community sample, infants were selected who met Wessel colic criteria f...

journal_title：Archives of disease in childhood

authors： St James-Roberts I

更新日期：1999-01-01 00:00:00

abstract：:Standing height, sitting height, armspan, subischial leg length, head circumference, and growth hormone-insulin-like growth factor I (IGF-I) axis were determined in 86 patients with osteogenesis imperfecta. The aim of this study was to determine standing height and body proportions and their variability among osteogen...

journal_title：Archives of disease in childhood

authors： Lund AM,Müller J,Skovby F

更新日期：1999-06-01 00:00:00

abstract：:Respiratory disease is a common cause of morbidity and mortality in children with Down's syndrome (DS). Causes range from those problems common to many children with DS, such as a narrow airway or impaired immunity, to rare structural lesions, such as tracheal bronchus. Additionally, other organ systems or extrinsic f...

journal_title：Archives of disease in childhood

authors： Watts R,Vyas H

更新日期：2013-10-01 00:00:00

abstract：:We describe a prospective study in which we investigated why children fail to get vaccinated against whooping cough, including an assessment of the attitudes of parents and professionals and the impact of different views of the contraindications. There was considerable disagreement among the professionals on the inter...

journal_title：Archives of disease in childhood

authors： Stevens D,Baker R,Hands S

更新日期：1986-04-01 00:00:00

abstract：BACKGROUND:Phenobarbital (PB), commonly used as the preferred treatment for neonatal seizure, is a drug that requires careful dose adjustments based on therapeutic drug monitoring. It has been reported that PB metabolism was affected by cytochrome P450 (CYP)2C19 polymorphisms in adults requiring dose adjustment. AIM:T...

journal_title：Archives of disease in childhood

authors： Lee SM,Chung JY,Lee YM,Park MS,Namgung R,Park KI,Lee C

更新日期：2012-06-01 00:00:00

abstract：:A modified nasopharyngeal tube is described that does not add airway dead space and resistance, is well tolerated, highly successful, and allows simultaneous use of oxygen prongs. This potentially reduces the need for surgical intervention to relieve high upper airway obstruction from Pierre-Robin syndrome and other c...

journal_title：Archives of disease in childhood

authors： Masters IB,Chang AB,Harris M,O'Neil MC

更新日期：1999-02-01 00:00:00

abstract：:Plasma testosterone was estimated by radioimmunoassay in 60 children with disorders of sexual development before and after stimulation with human chorionic gonadotrophin (HCG). In 21 children the testosterone levels after 3 and 5 daily injections of 1000 units HCG were compared and good correlation was found between t...

journal_title：Archives of disease in childhood

authors： Grant DB,Laurance BM,Atherden SM,Ryness J

更新日期：1976-08-01 00:00:00

abstract：OBJECTIVES:To evaluate the outcome of percutaneous transluminal angioplasty (PTA) in children with renovascular hypertension (RVH) treated at a single centre over 29 years. METHODS:A retrospective study of the medical charts of all children with RVH who underwent PTA between 1984 and 2012. The primary outcome measurem...

journal_title：Archives of disease in childhood

authors： Kari JA,Roebuck DJ,McLaren CA,Davis M,Dillon MJ,Hamilton G,Shroff R,Marks SD,Tullus K

更新日期：2015-05-01 00:00:00

abstract：:Five cases are reported of spontaneous remission of chronic childhood thrombocytopenia four or more years after diagnosis. Other than typical features of chronic idiopathic thrombocytopenic purpura there were no obvious markers predictive of late remission, although a slow progressive recovery was common to four of th...

journal_title：Archives of disease in childhood

authors： Tait RC,Evans DI

更新日期：1993-05-01 00:00:00

abstract：:The contribution of abnormal cardiac function to hypotension and metabolic acidosis, which affect approximately 40% of ventilated very low birthweight infants in the first 24 hours after birth was assessed using M mode, two dimensional, and Doppler echocardiography in 75 very low birthweight infants during the first f...

journal_title：Archives of disease in childhood

authors： Gill AB,Weindling AM

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVE:To describe the pathways by which children with cancer present to a shared care oncology unit. DESIGN:A population-based retrospective cohort study of children diagnosed with cancer between the years 2004 and 2014. SETTING:District General Hospital with a level 2 Paediatric Oncology Shared Care Unit. PATIE...

journal_title：Archives of disease in childhood

authors： Roskin J,Diviney J,Nanduri V

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Studies on adolescent drug use are scarce as most studies do not distinguish between children and adolescents. Therefore, we assessed overall drug use in adolescents. METHODS:A retrospective cohort study was conducted using pharmacy dispensing records from 62 community pharmacies in the Netherlands. Dispens...

journal_title：Archives of disease in childhood

authors： Kosse RC,Koster ES,de Vries TW,Bouvy ML

更新日期：2019-08-01 00:00:00

abstract：:Concentrations of chorionic somatomammotrophin (hCS) in maternal plasma at the time of delivery and in placental extracts were determined by radioimmunoassay and related to neonatal growth in 111 normal pregnancies. Mean maternal plasma hCS concentration was lower in association with small-for-dates infants, defined b...

journal_title：Archives of disease in childhood

authors： Macmillian DR,Hawkins R,Collier RN

更新日期：1976-02-01 00:00:00

abstract：:Blood pressure (BP) values and the phenomenon of tracking were evaluated in a group of 481 schoolchildren over a nine year period starting at age 6 years. BP values were obtained yearly by taking the mean of two measurements at one visit, measurements were taken by only two observers during the study. For both systoli...

journal_title：Archives of disease in childhood

authors： Sánchez-Bayle M,Muñoz-Fernández MT,González-Requejo A

更新日期：1999-08-01 00:00:00

abstract：:In acute paediatrics, overtreatment and overdiagnosis is encountered in threshold and developed countries. The reason for overtreatment may be similar in the two settings, namely the mere availability of invasive procedures, which may lead to their inappropriate use. Physiological healing processes should be integrate...

journal_title：Archives of disease in childhood

authors： Frey B

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVES:To assess the persistence of serum Haemophilus influenzae type b antibodies and the prevalence of H influenzae type b carriage in a group of preschool age children previously vaccinated in infancy. DESIGN:Names were randomly selected from immunisation records. Families were visited on five occasions over a ...

journal_title：Archives of disease in childhood

authors： Heath PT,Bowen-Morris J,Griffiths D,Griffiths H,Crook DW,Moxon ER

更新日期：1997-12-01 00:00:00

abstract：:Selective medical examination of children starting school has been operated in Cramlington for five years, and the data for the school year 1984-85 are reported. It is argued that the 'routine medical' is an outdated concept and that its abolition would allow more time for more important aspects of educational medicin...

journal_title：Archives of disease in childhood

authors： O'Callaghan EM,Colver AF

更新日期：1987-10-01 00:00:00

abstract：BACKGROUND:Critical incidents are common during the inter-hospital transfer of sick patients, and infants are an especially vulnerable group. AIMS:To examine the effect of critical incident review on the number of adverse events during inter-hospital transfer of sick infants. METHODS:Critical incidents over an eight ...

journal_title：Archives of disease in childhood

authors： Moss SJ,Embleton ND,Fenton AC

更新日期：2005-07-01 00:00:00

abstract：:A retrospective analysis was made of the incidence and severity of the idiopathic respiratory distress syndrome (RDS) in babies of less than 35 weeks' gestation born at this hospital from January 1967-December 1974. There was a lower incidence of RDS in babies born after pregnancies complicated only by prolonged ruptu...

journal_title：Archives of disease in childhood

authors： Chiswick ML

更新日期：1976-09-01 00:00:00

abstract：:General practice records of 1058 children were studied to determine the incidence, prevalence, natural history, diagnosis, and treatment of wheezing presenting in the first 21 years of life. Up to 7 years of age, boys were more likely to present with wheeze and to have recurrent episodes. Later there was a higher inci...

journal_title：Archives of disease in childhood

authors： Strachan DP

更新日期：1985-05-01 00:00:00

abstract：:We have studied 50 children with one parent with asthma at a mean age of 6.4 years by symptom questionnaire and performed allergy skin testing and measurement of bronchial responsiveness to methacholine in both parent and child in 29-32 cases. Ninety eight per cent of the parents were receiving medication for asthma. ...

journal_title：Archives of disease in childhood

authors： Clifford RD,Pugsley A,Radford M,Holgate ST

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Paediatric early warning scores (PEWS) are widely used as an adjunct to support staff in recognising deterioration in hospitalised children. Relatively little is known about how staff use these systems. OBJECTIVE:To examine the completeness and accuracy of PEWS recording in hospitalised children in a tertia...

journal_title：Archives of disease in childhood

authors： Chapman SM,Oulton K,Peters MJ,Wray J

更新日期：2019-12-01 00:00:00