Beclomethasone dipropionate aerosol in treatment of hay fever in children.

Abstract:

:Eighteen children suffering from hay fever were treated with intra-nasal beclomethasone dipropionate (400 mug/day) and an identical placebo aerosol in a double-blind cross-over trial. 17 of the children preferred the intranasal beclomethasone dipropionate, one had no preference, none preferred the placebo. The effect on the nasal symptoms was impressive. Symptom scores decreased, on average, to 12% and the number of antihistamine tablets taken to 18% of the pretreatment amount. Some beneficial effect on eye symptoms was also discernible, possibly due to an indirect influence from the nasal mucosa via the nasolacrimal reflex. Adrenal function was not affected. It was concluded that 400 mug beclomethasone dipropionate given intranasally daily for some weeks is an effective and safe treatment for hay fever in children.

journal_name

Arch Dis Child

authors

Prahl P,Wilken-Jensen K,Mygind N

doi

10.1136/adc.50.11.875

subject

Has Abstract

pub_date

1975-11-01 00:00:00

pages

875-8

issue

11

eissn

0003-9888

issn

1468-2044

journal_volume

50

pub_type

临床试验,杂志文章,随机对照试验
  • Maternal and fetal influences on blood pressure.

    abstract::To study maternal and fetal influences on blood pressure in childhood 405 children aged 4 years who were born and still resident in the Salisbury health district were visited at home for blood pressure and growth measurements. Information on the pregnancy, delivery, and baby was abstracted from the routine obstetric n...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.66.11.1291

    authors: Law CM,Barker DJ,Bull AR,Osmond C

    更新日期:1991-11-01 00:00:00

  • Childhood coeliac disease diagnoses in Scotland 2009-2010: the SPSU project.

    abstract:OBJECTIVES:To establish the incidence of childhood coeliac disease (CD) in Scotland between 1 September 2009 and 31 August 2010, to determine clinical features at presentation and reasons for diagnosis, and to identify any differences in incidence and practice between regions. DESIGN:Prospective data collection throug...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2012-302056

    authors: White LE,Bannerman E,McGrogan P,Kastner-Cole D,Carnegie E,Gillett PM

    更新日期:2013-01-01 00:00:00

  • Sleep-disordered breathing in overweight and obese children and adolescents: prevalence, characteristics and the role of fat distribution.

    abstract:AIMS:To determine the prevalence of sleep-disordered breathing (SDB) in a clinical sample of overweight and obese children and adolescents, and to examine the contribution of fat distribution. METHODS:Consecutive subjects without chronic lung disease, neuromuscular disease, laryngomalacia, or any genetic or craniofaci...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2006.101089

    authors: Verhulst SL,Schrauwen N,Haentjens D,Suys B,Rooman RP,Van Gaal L,De Backer WA,Desager KN

    更新日期:2007-03-01 00:00:00

  • Reye's syndrome; diagnosis by muscle biopsy?

    abstract::Three children with Reye's syndrome are described. One child died, the second had mild and transient illness, and the third had recurrent episodes. In all 3 children a muscle biopsy showed pronounced infiltration of the myofibres with fat microdroplets as shown by the oil red O stain and by electron microscopical exam...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.56.4.287

    authors: Shapira Y,Deckelbaum R,Statter M,Tennenbaum A,Aker M,Yarom R

    更新日期:1981-04-01 00:00:00

  • Lung function in children after repair of congenital diaphragmatic hernia.

    abstract::Sixteen children who had had congenital diaphragmatic herniae repaired either in the neonatal period (11), or in early childhood (5), were reviewed at between 7 and 19 years of age. Only minor abnormalities were shown in their chest x-rays and in a variety of lung function tests. This suggests that the long-term progn...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.52.11.902

    authors: Kerr AA

    更新日期:1977-11-01 00:00:00

  • Respiratory timing in intubated neonates with respiratory distress syndrome.

    abstract::Respiratory timing was studied in 100 babies ventilated for respiratory distress syndrome (RDS) during a brief period of continuous positive airway pressure. For the 76 spontaneously breathing babies the mean (SD) inspiratory and expiratory times were 0.31 (0.06) and 0.41 (0.12) seconds. Respiratory rate was predomina...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.67.4_spec_no.446

    authors: South M,Morley CJ

    更新日期:1992-04-01 00:00:00

  • Distal renal tubular acidosis with severe hypokalaemia, probably caused by colonic H(+)-K(+)-ATPase deficiency.

    abstract::We describe a 21 month old male infant who presented with failure to thrive associated with severe hypokalaemia and metabolic acidosis, together with hypomagnesaemia. Evaluation revealed marked renal and probable faecal potassium wasting, distal renal tubular acidosis, mild urinary magnesium wasting, and a normal gast...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.84.6.504

    authors: Simpson AM,Schwartz GJ

    更新日期:2001-06-01 00:00:00

  • Is permanent congenital facial palsy caused by birth trauma?

    abstract:OBJECTIVE:To study the relation between traumatic birth and the development of permanent facial palsy in the newborn. DESIGN:Retrospective case control study of children with 'congenital' facial palsy. SETTING:Two tertiary referral centres for patients with facial palsy. SUBJECTS:61 children with established facial ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.74.1.56

    authors: Laing JH,Harrison DH,Jones BM,Laing GJ

    更新日期:1996-01-01 00:00:00

  • Screening a state middle school for asthma using the free running asthma screening test.

    abstract::The free running asthma screening test (FRAST) was used to screen children in a state middle school during a normal physical education lesson. The test was conducted by the teachers with a general practitioner available via a radiopager. Of the 249 children attending the school, aged 8-12 years, 237 (95%) were tested....

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.69.6.667

    authors: Williams D,Bruton J,Wilson I

    更新日期:1993-12-01 00:00:00

  • Efficacy of sweet solutions for analgesia in infants between 1 and 12 months of age: a systematic review.

    abstract:OBJECTIVE:To compare the efficacy of oral sweet solutions to water or no treatment in infants aged 1-12 months during immunisation. METHODS:Randomised controlled trials (RCTs) were retrieved through internet searches or manual searches of reference lists. Search terms included newborn, infant, pain, sucrose and altern...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,meta分析,评审

    doi:10.1136/adc.2009.174227

    authors: Harrison D,Stevens B,Bueno M,Yamada J,Adams-Webber T,Beyene J,Ohlsson A

    更新日期:2010-06-01 00:00:00

  • Randomised double blind placebo controlled trial of the effect of botulinum toxin on walking in cerebral palsy.

    abstract:BACKGROUND:Cerebral palsy is the commonest cause of severe physical disability in childhood. For many years treatment has centred on the use of physiotherapy and orthotics to overcome the problems of leg spasticity, which interferes with walking and can lead to limb deformity. Intramuscular botulinum toxin (BT-A) offer...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/adc.83.6.481

    authors: Ubhi T,Bhakta BB,Ives HL,Allgar V,Roussounis SH

    更新日期:2000-12-01 00:00:00

  • IgG subclass specific antibody response in recurrent bronchitis.

    abstract::The IgG subclass specific immune response against pneumococcal type 3 polysaccharide antigen before and after immunisation in healthy children and children with recurrent bronchitis was studied. Recurrent bronchitis was defined as three or more episodes a year, during at least two consecutive years, of bronchopulmonar...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.66.12.1378

    authors: de Baets F,Pauwels R,Schramme I,Leroy J

    更新日期:1991-12-01 00:00:00

  • Randomised controlled trial of inhaled corticosteroids (fluticasone propionate) in cystic fibrosis.

    abstract:BACKGROUND:Controlling lung inflammation may be the key to improving morbidity and mortality in cystic fibrosis. OBJECTIVE:To assess the effects of inhaled corticosteroids on lung inflammation in cystic fibrosis. DESIGN:Double blind placebo controlled randomised sequence crossover trial. Fluticasone propionate (400 m...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/adc.77.2.124

    authors: Balfour-Lynn IM,Klein NJ,Dinwiddie R

    更新日期:1997-08-01 00:00:00

  • Nebulised sodium cromoglycate in infancy: airway protection after deterioration.

    abstract::Over a two year period 100 infants with histories of wheeze were challenged with nebulised water. They were sedated and lung function measured by total body plethysmography. Thirteen of the 53 infants who developed bronchoconstriction after challenge with nebulised water were given nebulised sodium cromoglycate and re...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.65.4.404

    authors: O'Callaghan C,Milner AD,Swarbrick A

    更新日期:1990-04-01 00:00:00

  • Development of a measure to assess the perceived illness experience after treatment for cancer.

    abstract::The development of a scale to measure perceived illness experience in young people with cancer is described. Areas of concern were first identified through semistructured interviews conducted with children and adolescents. As a result, 78 items were generated to cover the main areas identified (physical appearance, in...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.72.4.302

    authors: Eiser C,Havermans T,Craft A,Kernahan J

    更新日期:1995-04-01 00:00:00

  • Precocious pubarche is associated with SGA, prematurity, weight gain, and obesity.

    abstract:BACKGROUND:Perinatal stress is thought to underlie the Barker sequelae of low birth weight, of which precocious pubarche may be a manifestation. AIMS:To explore whether prematurity as well as smallness for gestational age (SGA) predisposes to precocious pubarche, and the potential role of excess weight gain during chi...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2004.053959

    authors: Neville KA,Walker JL

    更新日期:2005-03-01 00:00:00

  • Alteration of lung diffusion capacity in IgA nephropathy.

    abstract:OBJECTIVE:To establish whether changes of lung transfer for carbon monoxide (TLCO) are related to the phase of IgA nephropathy. METHODS:Respiratory function was tested in 12 children with IgA nephropathy assessed by percutaneous renal biopsy. This was done during acute exacerbations or haematuria-free phases of the di...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章

    doi:10.1136/adc.74.3.236

    authors: Ravilly S,Chaussain M,Iniguez JL,Lenhert A,Kalifa G,Brun P,Niaudet P,Gendrel D

    更新日期:1996-03-01 00:00:00

  • Delayed visual maturation.

    abstract::Sixteen blind babies who were considered to be showing the characteristics of delayed visual maturation were studied prospectively. The diagnosis was made on clinical grounds, and the criteria for this are discussed. All of these infants developed visual responses between 4 and 6 months of age and had normal or near n...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.59.2.107

    authors: Cole GF,Hungerford J,Jones RB

    更新日期:1984-02-01 00:00:00

  • Photopheresis at onset of type 1 diabetes: a randomised, double blind, placebo controlled trial.

    abstract:BACKGROUND:In recent years photopheresis, an extracorporeal form of photochemotherapy using psoralen and ultraviolet A irradiation of leucocytes, has been claimed to be an effective form of immunomodulation. AIM:To evaluate its effect in type 1 diabetes we performed a double blind, controlled study using placebo table...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/adc.85.2.149

    authors: Ludvigsson J,Samuelsson U,Ernerudh J,Johansson C,Stenhammar L,Berlin G

    更新日期:2001-08-01 00:00:00

  • Alpha 1-antitrypsin deficiency and infantile liver disease.

    abstract::Infantile liver disease with deficiency of serum alpha1-antitrypsin is illustrated by a description of the clinical, biochemical, and pathological findings in two affected families. The simplicity of the diagnostic tests is emphasized. Review of 61 biopsies of liver from children and adolescents provided a further 3 c...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.51.8.584

    authors: McPhie JL,Binnie S,Brunt PW

    更新日期:1976-08-01 00:00:00

  • External hydrocephalus and subdural bleeding in infancy associated with transplacental anti-Ro antibodies.

    abstract:BACKGROUND:The isolated finding of an unexplained chronic subdural haematoma in an infant may suggest non-accidental head injury (NAHI). The authors report a previously undescribed cause of multifocal chronic subdural haematoma in infancy which could result in a misdiagnosis of previous NAHI. METHODS:Two infants, aged...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2010.194746

    authors: Edwards RJ,Allport TD,Stoodley NG,O'Callaghan F,Lock RJ,Carter MR,Ramanan AV

    更新日期:2012-04-01 00:00:00

  • Investigating inflammatory bowel disease--white cell scanning, radiology, and colonoscopy.

    abstract:OBJECTIVE:To evaluate different methods of examination of the bowel in suspected inflammatory bowel disease. DESIGN:Prospective investigation of all children over a three year period with suspected inflammatory bowel disease. A technetium-99m-HMPAO labelled white cell scan (Tc-WCS), barium follow through examination (...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章

    doi:10.1136/adc.74.1.22

    authors: Jobling JC,Lindley KJ,Yousef Y,Gordon I,Milla PJ

    更新日期:1996-01-01 00:00:00

  • Phenylalanine and tyrosine levels in newborn screening blood samples.

    abstract::A previously described difference in newborn blood phenylalanine concentrations between those living in urban and non-urban areas in the south west of England has been confirmed and shown to be independent of the type of feed. Several factors including the place of abode, type of feed, birthweight, and the accuracy of...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.58.4.271

    authors: Morris AF,Holton JB,Burman D,Colley JR

    更新日期:1983-04-01 00:00:00

  • Efficacy and safety of torasemide in children with heart failure.

    abstract:OBJECTIVE:To examine the efficacy and safety of torasemide in children with chronic heart failure (HF). METHODS:102 children with chronic HF who had received oral torasemide were analysed. Of these, 62 (de novo group) were newly diagnosed as having HF and were given torasemide as a diuretic. The remaining 40 (replacem...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2007.129239

    authors: Senzaki H,Kamiyama M,Masutani S,Ishido H,Taketazu M,Kobayashi T,Katogi T,Kyo S

    更新日期:2008-09-01 00:00:00

  • Early discharge of low birthweight infants.

    abstract::A study was conducted to see if the discharge weight of preterm infants born at less than or equal to 2000 g could safely be reduced. A study group (21 infants) was discharged 'early' at a mean weight of 2010 g (1890-2190) provided there were no medical problems, weight gain was adequate, temperature control in room a...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.57.7.511

    authors: Lefebvre F,Veilleux A,Bard H

    更新日期:1982-07-01 00:00:00

  • The five year school medical--time for change.

    abstract::School medical records of 1000 children born in 1981 were studied retrospectively. They showed that once known medical problems and those screened for by the school nurse (hearing, vision, growth) were excluded, only 17 problems requiring treatment were discovered: speech (n = 10), development (n = 3), undescended tes...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.65.2.225

    authors: Smith GC,Powell A,Reynolds K,Campbell CA

    更新日期:1990-02-01 00:00:00

  • Aneurysms of the vein of Galen.

    abstract::Six neonates with aneurysms of the vein of Galen are described: five were associated with an intracerebral arteriovenous fistula and presented with heart failure in the neonatal period; one had hydrocephalus at birth. Two infants died from intractable cardiac failure within 48 hours of age and two from progressive hyd...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.64.11.1612

    authors: O'Donnabhain D,Duff DF

    更新日期:1989-11-01 00:00:00

  • Serum cholecystokinin, basal acid secretion, and infantile pyloric stenosis.

    abstract::The fasting serum cholecystokinin-like activity was measured in 21 infants with pyloric stenosis and in 13 normal controls. No significant difference was found between the two groups. The basal acid secretion was measured by continuously aspirating the previously emptied stomach for one hour. The basal gastric volume ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.54.10.773

    authors: Rogers IM,Drainer IK,Dougal AJ,Black J,Logan R

    更新日期:1979-10-01 00:00:00

  • Endoscopic retrograde cholangiopancreatography in infantile cholestasis.

    abstract::The difficulty of distinguishing surgically correctable causes of conjugated hyperbilirubinaemia in infants from other causes means that some infants may undergo laparotomy and intraoperative cholangiography unnecessarily, and others may be referred for surgery too late. In an attempt to improve the diagnostic accurac...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.66.1.121

    authors: Wilkinson ML,Mieli-Vergani G,Ball C,Portmann B,Mowat AP

    更新日期:1991-01-01 00:00:00

  • Impact of improved glycaemic control on rates of hypoglycaemia in insulin dependent diabetes mellitus.

    abstract::Increased emphasis on strict glycaemic control of insulin dependent diabetes mellitus (IDDM) in young patients may be expected to cause increases in rates of significant hypoglycaemia. To evaluate whether this is the case for a large population based sample of IDDM children and adolescents rates of severe (coma, convu...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.78.2.111

    authors: Davis EA,Keating B,Byrne GC,Russell M,Jones TW

    更新日期:1998-02-01 00:00:00