Nebulised sodium cromoglycate in infancy: airway protection after deterioration.

Abstract:

:Over a two year period 100 infants with histories of wheeze were challenged with nebulised water. They were sedated and lung function measured by total body plethysmography. Thirteen of the 53 infants who developed bronchoconstriction after challenge with nebulised water were given nebulised sodium cromoglycate and rechallenged with nebulised water. All infants were initially challenged with normal saline, after which there was no significant change in lung function. After challenge with nebulised water and sodium cromoglycate there were significant decreases in specific conductance compared with those found after challenge with normal saline. After rechallenge with nebulised water there was no deterioration in lung function. Although sodium cromoglycate caused a deterioration in lung function in these infants, it protected their airways from challenge with nebulised water.

journal_name

Arch Dis Child

authors

O'Callaghan C,Milner AD,Swarbrick A

doi

10.1136/adc.65.4.404

subject

Has Abstract

pub_date

1990-04-01 00:00:00

pages

404-6

issue

4

eissn

0003-9888

issn

1468-2044

journal_volume

65

pub_type

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