Abstract：
:Increased emphasis on strict glycaemic control of insulin dependent diabetes mellitus (IDDM) in young patients may be expected to cause increases in rates of significant hypoglycaemia. To evaluate whether this is the case for a large population based sample of IDDM children and adolescents rates of severe (coma, convulsion) and moderate (requiring assistance for treatment) hypoglycaemia were studied prospectively over a four year period. A total of 709 patients were studied yielding 2027 patient years of data (mean (SD) age: 12.3 (4.4); range 0-18 years, duration IDDM: 4.9 (3.8) years). Details of hypoglycaemia were recorded at clinic visits every three months when glycated haemoglobin (HbA1c) was also measured. Overall the incidence of severe hypoglycaemia was 7.8 and moderate was 15.4 episodes/100 patient years. Over the four years mean (SD) clinic HbA1c steadily fell from 10.2 (1.6)% in 1992 to 8.8 (1.5)% in 1995. In parallel with this there was a dramatic increase in the rate of hypoglycaemia, especially in the fourth year of the study, when severe hypoglycaemia increased from 4.8 to 15.6 episodes/100 patient years. This increase was particularly marked in younger children (< 6 years) in whom severe hypoglycaemia increased from 14.9 to 42.1 episodes/100 patient years in 1995. It is concluded that attempts to achieve improved metabolic control must be accompanied by efforts to minimise the effects of significant hypoglycaemia, particularly in the younger age group.
journal_name
Arch Dis Childjournal_title
Archives of disease in childhoodauthors
Davis EA,Keating B,Byrne GC,Russell M,Jones TWdoi
10.1136/adc.78.2.111subject
Has Abstractpub_date
1998-02-01 00:00:00pages
111-5issue
2eissn
0003-9888issn
1468-2044journal_volume
78pub_type
杂志文章abstract：:In a study of 256 families, among whom were twins, midparent-adult son correlations for height, weight, and combined skinfold measurements were 0.67, 0.47, and 0.23 respectively. The corresponding midparent-adult daughter correlations were 0.63, 0.42, and 0.24. Midparent-growing offspring correlations were highest for...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.54.11.877
更新日期：1979-11-01 00:00:00
abstract：STUDY OBJECTIVES:To present diagnosis and treatment modalities of children with interstitial lung disease associated with frequent or rare surfactant protein C gene (SFTPC) mutation. PATIENTS:Twenty-two children with chronic lung disease associated with SFTPC mutation in a heterozygous form. RESULTS:Mutations located...
journal_title：Archives of disease in childhood
pub_type： 杂志文章,多中心研究
doi：10.1136/adc.2009.171553
更新日期：2010-06-01 00:00:00
abstract：OBJECTIVE:To provide the first estimate of the cost-effectiveness of financial incentive for breastfeeding intervention compared with usual care. DESIGN:Within-cluster ('ward'-level) randomised controlled trial cost-effectiveness analysis (trial registration number ISRCTN44898617). SETTING:Five local authority distri...
journal_title：Archives of disease in childhood
pub_type： 杂志文章,随机对照试验
doi：10.1136/archdischild-2018-316741
更新日期：2020-02-01 00:00:00
abstract：OBJECTIVES:To determine the effectiveness of auditory integration training (AIT) or other methods of sound therapy in people with autism spectrum disorders (ASD). STUDY DESIGN:A systematic review was carried out of randomised controlled trials (RCTs) of adults or children with ASD. Meta-analysis was attempted. RESULT...
journal_title：Archives of disease in childhood
pub_type： 杂志文章,meta分析,评审
doi：10.1136/adc.2006.094649
更新日期：2006-12-01 00:00:00
abstract：:Three of five children who were born to consanguineous parents developed Guillain-Barré syndrome before they were 3 years old. The syndrome is rare in early childhood and we suggest that there may be a genetic element in the pathogenesis. ...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.66.9.1078
更新日期：1991-09-01 00:00:00
abstract：:Among 40 hospitalized infants and children with cytomegalovirus infection, 14 (35%) had interstitial pneumonitis, 4 (10%) had wheezing or tachypnoea but without x-ray evidence of classical interstitial pneumonia, the remaining 22 (55%) were free of pulmonary involvement. Most patients had tachypnoea and nonproductive ...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.52.6.441
更新日期：1977-06-01 00:00:00
abstract：:Three clinically normal sibs were discovered to have type II hyperprolinaemia in a routine serum amino acid screening programme in Sicily. In addition to the basic biochemical features of type II hyperprolinaemia, all 3 children had marked hyperglycinaemia, whereas their parents had both normal blood proline and glyci...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.50.8.637
更新日期：1975-08-01 00:00:00
abstract：:The fasting serum cholecystokinin-like activity was measured in 21 infants with pyloric stenosis and in 13 normal controls. No significant difference was found between the two groups. The basal acid secretion was measured by continuously aspirating the previously emptied stomach for one hour. The basal gastric volume ...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.54.10.773
更新日期：1979-10-01 00:00:00
abstract：:Congenital haemolytic anaemia in a 14 year old girl was caused by increased red cell membrane cation permeability. Potassium permeability was unusually sensitive to hydrostatic pressure and treatment with N-ethylmaleimide, factors which activate a specific chloride dependent potassium channel in cell membranes. ...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.58.7.547
更新日期：1983-07-01 00:00:00
abstract：:One hundred and eleven children admitted with suspected gastro-oesophageal reflux were studied, with 24 hour oesophageal pH monitoring as the first line of investigation. Barium swallow examination, or oesophagoscopy, or both, were carried out only in children with abnormal pH, who subsequently had a trial of 1-12 mon...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.64.10.1421
更新日期：1989-10-01 00:00:00
abstract：:Serial exercise tests were carried out by 12 children with asthma on two study days. After a control exercise test either nedocromil sodium 4 mg or placebo were given double blind by metered dose inhaler. Highly significant inhibition of exercise induced asthma occurred after nedocromil, lasting for over two hours. ...
journal_title：Archives of disease in childhood
pub_type： 临床试验,杂志文章
doi：10.1136/adc.62.4.412
更新日期：1987-04-01 00:00:00
abstract：:It has been suggested that because of vascular interchange between the monozygous twins vascular disruptions from a deceased cotwin with disseminated intravascular coagulation causes embolisation in the surviving twin. This study reports six cases in which all the surviving monozygous twins had central nervous system ...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.61.5.454
更新日期：1986-05-01 00:00:00
abstract：:Determinations of body height and calculations of growth velocity are still the major parameters for the assessment of normal and aberrant growth. The present study was performed to investigate the minimum time interval between consecutive measurements that is necessary for a statement on significant length increment ...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.64.2.259
更新日期：1989-02-01 00:00:00
abstract：:Plasma concentrations of motilin, gastrin, and enteroglucagon were measured in cord blood and during the first 24 days of life before feeding in 45 term and 63 preterm, healthy infants. Levels of these hormones rose steeply after birth, reaching concentrations that were much higher than those in fasting adults. These ...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.55.9.673
更新日期：1980-09-01 00:00:00
abstract：:The contribution of abnormal cardiac function to hypotension and metabolic acidosis, which affect approximately 40% of ventilated very low birthweight infants in the first 24 hours after birth was assessed using M mode, two dimensional, and Doppler echocardiography in 75 very low birthweight infants during the first f...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.68.1_spec_no.17
更新日期：1993-01-01 00:00:00
abstract：:The concentrations of immunoglobulins (Ig) G.A.M. and E were determined in paired umbilical cord and maternal sera in 50 twin pregnancies. Mean IgG levels were higher in cord than maternal sera and in most cases the cord IgG level related more closely to that of the other twin than to either maternal level or birthwei...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.51.5.354
更新日期：1976-05-01 00:00:00
abstract：INTRODUCTION:Fetal anticonvulsant syndrome (FACS) describes the pattern of physical and developmental problems seen in those children exposed to certain antiepileptic drugs (AEDs) in utero. The diagnosis of FACS is a clinical one and so excluding alternative diagnoses such as genetic disorders is essential. METHODS:We...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/archdischild-2018-316547
更新日期：2020-04-01 00:00:00
abstract：OBJECTIVES:(1) To determine the prevalence of cough, wheeze, and breathlessness, both as single symptoms and in combination, in primary schoolchildren and their relation to doctor diagnosed asthma. (2) To identify in areas with different levels of dust pollution whether questionnaire reported 'cough alone' (without whe...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.75.6.489
更新日期：1996-12-01 00:00:00
abstract：:The influence of physical housing quality on childhood asthma expression, especially the effect of exposure to moulds, allergens, and pollutants, is well documented. However, attempts to explain increasing rates and severity of childhood asthma solely through physical environmental factors have been unsuccessful, and ...
journal_title：Archives of disease in childhood
pub_type： 杂志文章,评审
doi：10.1136/adc.2006.098376
更新日期：2006-11-01 00:00:00
abstract：OBJECTIVES:The amount of adipose tissue influences pubertal development and fertility in girls. A candidate for mediating this is the hormone leptin, derived from adipocytes. This work was carried out to determine whether the leptin concentration in serum is regulated during pubertal development. SUBJECTS AND METHODS:...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.77.5.396
更新日期：1997-11-01 00:00:00
abstract：OBJECTIVE:Anaphylaxis is a severe, potentially fatal allergic reaction best treated with intramuscular epinephrine via epinephrine auto-injectors (AAIs). Our published concerns over laceration injuries to young children associated with AAIs led to this service evaluation of the two administration methods: swing and jab...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/archdischild-2020-318898
更新日期：2021-01-01 00:00:00
abstract：:Blood lead concentrations and body iron status were investigated in 279 children. Blood lead concentrations showed no increase during iron depletion phase (stage I) but markedly increased from the phase of iron deficient erythropoiesis (stage II). Increased blood lead concentrations in anaemic subjects significantly d...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.88.9.791
更新日期：2003-09-01 00:00:00
abstract：:Significant folate deficiency in 14 out of 37 preterm infants of birthweights 2.0 kg or less was found to be reliably and most conveniently diagnosed by abnormal morphological changes in peripheral blood and confirmed by the response to folic acid. Deficiency appeared to be more common in light-for-dates infants inclu...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.54.4.271
更新日期：1979-04-01 00:00:00
abstract：:Eighteen children with pneumocystis carinii pneumonia diagnosed over a period of 16 years at a children's hospital are reviewed. All had an underlying disease, either congenital immunodeficiency or a malignancy. 15 patients were treated, 10 with pentamidine isethionate alone, 2 with both pentamidine and co-trimoxazole...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.52.4.314
更新日期：1977-04-01 00:00:00
abstract：OBJECTIVE:To determine if exploratory factor analysis can identify subtypes comprising recognisable clinical patterns of the presenting signs and symptoms of children with joint hypermobility syndrome (JHS). PATIENTS:Eighty-nine children with JHS aged 6-16 years. METHODS:Twelve tests comprising anthropometric, muscul...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/archdischild-2013-305304
更新日期：2015-01-01 00:00:00
abstract：AIM:To test the hypothesis that overall intelligence quotient (IQ) is decreased in patients with Aarskog syndrome. METHODS:21 boys under 17 years of age with a confirmed clinical diagnosis of Aarskog syndrome were assessed using the Griffiths mental development scales and the British ability scales. RESULTS:IQ ranged...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.79.4.359
更新日期：1998-10-01 00:00:00
abstract：AIM:To evaluate the risk factors for breakthrough varicella in a follow up study of a cohort of 181 healthy children immunised when aged 9-24 months with a reformulated Oka strain varicella vaccine (SmithKline Beecham Biologicals/Oka). DESIGN:The children were randomised in a double blind manner into one of four group...
journal_title：Archives of disease in childhood
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1136/adc.79.6.478
更新日期：1998-12-01 00:00:00
abstract：:24 Hour ambulatory blood pressure monitoring (ABPM) was performed to provide data on the normal daily blood pressure of healthy schoolchildren and on patients with hypertension. The subjects studied were 123 healthy schoolchildren with a mean (SD) age of 12.5 (1.6) years (range 9.5-14.5 years), 24 children with border...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.70.2.90
更新日期：1994-02-01 00:00:00
abstract：OBJECTIVES:To assess factors associated with granting of the Disability Living Allowance (DLA) for Down syndrome. DESIGN:Cross-sectional survey. SETTING:Families with a child with Down syndrome enrolled in a community-based trial of vitamin supplementation. PARTICIPANTS:156 children with trisomy 21 (59% male, 20% no...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/adc.2006.112839
更新日期：2008-01-01 00:00:00
abstract：PURPOSE:To prospectively examine relations between maternal DSM-IV-TR anxiety and depressive disorders and excessive infant crying. METHODS:Based on the prospective longitudinal Maternal Anxiety in Relation to Infant Development Study, n=306 expectant mothers were enrolled during early pregnancy and repeatedly intervi...
journal_title：Archives of disease in childhood
pub_type： 杂志文章
doi：10.1136/archdischild-2013-305562
更新日期：2014-09-01 00:00:00
