Photopheresis at onset of type 1 diabetes: a randomised, double blind, placebo controlled trial.

Abstract:

BACKGROUND:In recent years photopheresis, an extracorporeal form of photochemotherapy using psoralen and ultraviolet A irradiation of leucocytes, has been claimed to be an effective form of immunomodulation. AIM:To evaluate its effect in type 1 diabetes we performed a double blind, controlled study using placebo tablets and sham pheresis in the control group. METHODS:A total of 49 children, aged 10-18 years of age at diagnosis of type 1 diabetes were included; 40 fulfilled the study and were followed for three years (19 received active treatment with photopheresis and 21 placebo treatment). RESULTS:The actively treated children secreted significantly more C peptide in urine during follow up than control children. C peptide values in serum showed corresponding differences between the two groups. The insulin dose/kg body weight needed to achieve satisfactory HbA1c values was always lower in the photopheresis group; there was no difference between the groups regarding HbA1c values during follow up. The treatment was well accepted except for nausea (n = 3) and urticaria (n = 1) in the actively treated group. There were no differences regarding weight or height, or episodes of infection between the two groups during follow up. CONCLUSION:Photopheresis does have an effect in addition to its possible placebo effect, shown as a weak but significant effect on the disease process at the onset of type 1 diabetes, an effect still noted after three years of follow up.

journal_name

Arch Dis Child

authors

Ludvigsson J,Samuelsson U,Ernerudh J,Johansson C,Stenhammar L,Berlin G

doi

10.1136/adc.85.2.149

subject

Has Abstract

pub_date

2001-08-01 00:00:00

pages

149-54

issue

2

eissn

0003-9888

issn

1468-2044

journal_volume

85

pub_type

临床试验,杂志文章,随机对照试验
  • Hepatopathy of Mauriac syndrome: a retrospective review from a tertiary liver centre.

    abstract:BACKGROUND:Mauriac syndrome is characterised by growth failure, cushingoid appearance and hepatomegaly which occurs in patients with insulin dependent diabetes and was first described shortly after the introduction of insulin as a treatment for the condition. OBJECTIVE:To describe the clinical features, histological f...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2013-304426

    authors: Fitzpatrick E,Cotoi C,Quaglia A,Sakellariou S,Ford-Adams ME,Hadzic N

    更新日期:2014-04-01 00:00:00

  • The irritable hip: immediate ultrasound guided aspiration and prevention of hospital admission.

    abstract::A protocol for the management of irritable hip was assessed; this protocol avoids hospital admission while detecting all other serious causes of hip pain, in particular septic arthritis, at the earliest possible opportunity. Fifty children with painful hips were studied prospectively with immediate ultrasound guided a...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.72.2.110

    authors: Fink AM,Berman L,Edwards D,Jacobson SK

    更新日期:1995-02-01 00:00:00

  • The nutritional cost of measles in Africa.

    abstract::A 24 hour energy balance study was carried out on 20 black Kenyan children with acute measles and repeated after recovery. The energy content of a weighed 24 hour food intake and of a simultaneous collection of faeces and urine was determined by bomb calorimetry. Energy expenditure was measured by indirect calorimetry...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.61.1.61

    authors: Duggan MB,Alwar J,Milner RD

    更新日期:1986-01-01 00:00:00

  • Varicella paediatric hospitalisations in Belgium: a 1-year national survey.

    abstract:BACKGROUND:Varicella universal vaccination (UV) has been implemented in many countries for several years. Nevertheless, varicella UV remains debated in Europe and few data are available on the real burden of infection. We assessed the burden of varicella in Belgium through analysis of hospitalised cases during a 1-year...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/archdischild-2015-308283

    authors: Blumental S,Sabbe M,Lepage P,Belgian Group for Varicella.

    更新日期:2016-01-01 00:00:00

  • Caregiver experiences of racism and child healthcare utilisation: cross-sectional analysis from New Zealand.

    abstract:OBJECTIVES:Children's exposure to racism via caregiver experience (vicarious racism) is associated with poorer health and development. However, the relationship with child healthcare utilisation is unknown. We aimed to investigate (1) the prevalence of vicarious racism by child ethnicity; (2) the association between ca...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2017-313866

    authors: Paine SJ,Harris R,Stanley J,Cormack D

    更新日期:2018-09-01 00:00:00

  • Predicting treatment outcome in nocturnal enuresis.

    abstract::A presenting sample of 127 consecutive referrals to a community based enuresis clinic were evaluated after treatment with baseline behavioural recording and the enuresis alarm. Almost one in five became dry after baseline recording only while 81 of 96 (84%) enuretics who used the alarm achieved the initial dryness cri...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章

    doi:10.1136/adc.65.10.1158

    authors: Devlin JB,O'Cathain C

    更新日期:1990-10-01 00:00:00

  • Receiver operating characteristic curves for comparison of serial neutrophil band forms and C reactive protein in neonates at risk of infection.

    abstract::The performance of indirect indices of infection in the newborn vary because of differences in techniques, including diagnostic cut off levels. We have compared serial neutrophil band cell counts with C reactive protein measured by rate nephelometry. The 'gold standard' was a positive culture and the performance of th...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.67.7_spec_no.808

    authors: Russell GA,Smyth A,Cooke RW

    更新日期:1992-07-01 00:00:00

  • A decade of growth hormone treatment in girls with Turner syndrome in the UK. UK KIGS Executive Group.

    abstract::Fifteen per cent of children treated with growth hormone (GH) are receiving treatment for Turner syndrome, but few results are available on final height in the UK. In this study, data were obtained from the UK KIGS database for 485 girls with Turner syndrome who were treated from 1986, allowing an audit of practice an...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.80.3.221

    authors: Betts PR,Butler GE,Donaldson MD,Dunger DB,Johnston DI,Kelnar CJ,Kirk J,Price DA,Wilton P

    更新日期:1999-03-01 00:00:00

  • Independent risk factors for chronic cyclosporine induced nephropathy in children with nephrotic syndrome.

    abstract:BACKGROUND:Cyclosporine A (CsA) has been widely used in children with steroid dependent and steroid resistant nephrotic syndrome (NS) because of its efficacy in relieving these patients from systemic side effects of steroids. However, its long term use is controversial, since chronic CsA induced nephropathy (CsAN) may ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2005.080960

    authors: Fujinaga S,Kaneko K,Muto T,Ohtomo Y,Murakami H,Yamashiro Y

    更新日期:2006-08-01 00:00:00

  • Asthma, wheezing, and school absence in primary schools.

    abstract::The prevalence of wheezing, 'asthma', treatment for 'asthma', and school absence as a result of wheezing in Nottingham was calculated from a questionnaire survey of parents of 4750 children in a random sample of primary schools. A response was achieved for 3805 (80%) children of whom 438 (11.5%) had had episodes of wh...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.64.2.246

    authors: Hill RA,Standen PJ,Tattersfield AE

    更新日期:1989-02-01 00:00:00

  • Relation between insulin-like growth factor-I, body mass index, and clinical status in cystic fibrosis.

    abstract:OBJECTIVES:Despite improved nutrition and intensive treatment, subjects with cystic fibrosis have difficulty in maintaining anabolism during intercurrent infections, which can result in reduced body mass index and impaired skeletal growth. Insulin-like growth factor-I (IGF-I) and its binding protein IGFBP3 are sensitiv...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.76.4.304

    authors: Taylor AM,Bush A,Thomson A,Oades PJ,Marchant JL,Bruce-Morgan C,Holly J,Ahmed L,Dunger DB

    更新日期:1997-04-01 00:00:00

  • Failure to vaccinate against whooping cough.

    abstract::We describe a prospective study in which we investigated why children fail to get vaccinated against whooping cough, including an assessment of the attitudes of parents and professionals and the impact of different views of the contraindications. There was considerable disagreement among the professionals on the inter...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.61.4.382

    authors: Stevens D,Baker R,Hands S

    更新日期:1986-04-01 00:00:00

  • Venous thromboembolism in infancy and childhood.

    abstract::A retrospective study of Scottish hospital inpatients aged 15 years or less has revealed, over a 4-year period, 36 cases of venous thrombosis or phlebitis. Of these 10 were considered to have deep venous thrombosis; 2 cases were associated with obvious pulmonary embolism and 2 cases developed chronic venous insufficie...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.50.2.153

    authors: Jones DR,Macintyre IM

    更新日期:1975-02-01 00:00:00

  • Renal sodium handling in minimal change nephrotic syndrome.

    abstract::Renal sodium handling was studied in 23 children at three different stages of the minimal change nephrotic syndrome--the oedema forming state, proteinuric steady state, and remission. Clearances of inulin and para-aminohippuric acid and urinary sodium excretion were determined basally, after intravenous infusion of is...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.59.9.825

    authors: Bohlin AB,Berg U

    更新日期:1984-09-01 00:00:00

  • Maternal depression and low maternal intelligence as risk factors for malnutrition in children: a community based case-control study from South India.

    abstract:AIMS:To determine whether current and postpartum maternal depression and low maternal intelligence are risk factors for malnutrition in children. METHODS:In rural South India 72 children with malnutrition were identified from a central register; 72 controls were matched for age, gender, and residence. RESULTS:Major d...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2002.009738

    authors: Anoop S,Saravanan B,Joseph A,Cherian A,Jacob KS

    更新日期:2004-04-01 00:00:00

  • Waist circumference centiles for UK South Asian children.

    abstract:OBJECTIVES:To develop waist circumference (WC) centile curves for UK South Asian children, to make comparisons with published centiles for British, indigenous Indian and Pakistani children, as well as to make anthropometric comparisons with their UK white peers. DESIGN:Cross-sectional study. SETTING:School-aged child...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2018-315722

    authors: Shah M,Radia D,McCarthy HD

    更新日期:2020-01-01 00:00:00

  • Outcome of maple syrup urine disease.

    abstract::The outcome of 12 children with classical maple syrup urine disease is reviewed. All patients presented in the neonatal period at ages varying from 5 to 21 (median 8) days. The time taken to make the diagnosis ranged from 1 day to longer than 9 months (median 7 days). Each survived his initial illness but 3 died later...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.57.12.918

    authors: Naughten ER,Jenkins J,Francis DE,Leonard JV

    更新日期:1982-12-01 00:00:00

  • Rising obesity and expanding waistlines in schoolchildren: a cohort study.

    abstract::A cohort of schoolchildren was followed up over 6 years from 1996 to 2001. In the final year, 315 of 500 targeted children were measured. Body mass index (BMI) increased substantially over time (p<0.001), indicating a further rise in obesity into the secondary school years. Two new indicators of obesity were also meas...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2002.020552

    authors: Rudolf MC,Greenwood DC,Cole TJ,Levine R,Sahota P,Walker J,Holland P,Cade J,Truscott J

    更新日期:2004-03-01 00:00:00

  • Vitamin D metabolites in idiopathic infantile hypercalcaemia.

    abstract::Metabolites of vitamin D were measured in plasma from 83 patients with idiopathic infantile hypercalcaemia syndrome who were mentally handicapped but had normal calcium values at the time of the study. No significant difference was detected in the mean plasma concentrations of 25-hydroxyvitamin D2, 1,25-dihydroxyvitam...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.60.12.1140

    authors: Martin ND,Snodgrass GJ,Cohen RD,Porteous CE,Coldwell RD,Trafford DJ,Makin HL

    更新日期:1985-12-01 00:00:00

  • Velocity of head growth during the perinatal period.

    abstract::Growth velocity of head circumference was studied longitudinally in different gestational age groups of 222 appropriate-weight-for-dates (AFD) and 94 small-for-dates (SFD) healthy infants during the first 5 months of life. Term AFD and SFD infants showed a steady slowing of growth rate of head circumference from birth...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.52.2.105

    authors: Fujimura M,Seryu JI

    更新日期:1977-02-01 00:00:00

  • Idiopathic thrombocytopenic purpura and MMR vaccine.

    abstract::A CAUSAL ASSOCIATION BETWEEN MEASLES: mumps-rubella (MMR) vaccine and idiopathic thrombocytopenic purpura (ITP) was confirmed using immunisation/hospital admission record linkage. The absolute risk within six weeks of immunisation was 1 in 22 300 doses, with two of every three cases occurring in the six week post-immu...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.84.3.227

    authors: Miller E,Waight P,Farrington CP,Andrews N,Stowe J,Taylor B

    更新日期:2001-03-01 00:00:00

  • Joint hypermobility syndrome subclassification in paediatrics: a factor analytic approach.

    abstract:OBJECTIVE:To determine if exploratory factor analysis can identify subtypes comprising recognisable clinical patterns of the presenting signs and symptoms of children with joint hypermobility syndrome (JHS). PATIENTS:Eighty-nine children with JHS aged 6-16 years. METHODS:Twelve tests comprising anthropometric, muscul...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2013-305304

    authors: Pacey V,Adams RD,Tofts L,Munns CF,Nicholson LL

    更新日期:2015-01-01 00:00:00

  • Physical growth and bone age of survivors of protein energy malnutrition.

    abstract::Early postnatal malnutrition produces delay in growth and developmental processes, and children from a low socioeconomical level where undernutrition is prevalent are shorter than those from higher socioeconomic levels. We examined the effects of severe and early protein energy malnutrition on growth and bone maturati...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.61.3.257

    authors: Alvear J,Artaza C,Vial M,Guerrero S,Muzzo S

    更新日期:1986-03-01 00:00:00

  • Do chest compressions during simulated infant CPR comply with international recommendations?

    abstract:BACKGROUND:Morbidity and mortality remain high following infant cardiac arrest. Optimal cardiopulmonary resuscitation (CPR) is therefore imperative. OBJECTIVE:Comparison of two-thumb (TT) and two-finger (TF) infant chest compression technique compliance with international recommendations. DESIGN:Randomised cross-over...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/archdischild-2012-302583

    authors: Martin PS,Kemp AM,Theobald PS,Maguire SA,Jones MD

    更新日期:2013-08-01 00:00:00

  • The 'unified airway': the RCPCH care pathway for children with asthma and/or rhinitis.

    abstract:AIMS:The Royal College of Paediatrics and Child Health (RCPCH) Science and Research Department was commissioned by the Department of Health to develop national care pathways for children with allergies: the asthma/rhinitis care pathway is the third such pathway. Asthma and rhinitis have been considered together. These ...

    journal_title:Archives of disease in childhood

    pub_type: 共识发展会议,杂志文章

    doi:10.1136/adc.2011.213462

    authors: Vance G,Lloyd K,Scadding G,Walker S,Jewkes F,Williams L,Dixon L,O'Beirne C,Fletcher P,Brown T,Hughes J,Sohi D,Piddock C,Shields M,McKean M,Warner J,Science and Research Department, Royal College of Paediatrics and Child H

    更新日期:2011-11-01 00:00:00

  • Cerebral venous sinus thrombosis: a case series including thrombolysis.

    abstract:BACKGROUND:Cerebral venous sinus thrombosis (CVST) in children is associated with a high incidence of serious morbidity and mortality. The presenting features are variable. It can be diagnostically challenging and the optimal treatment is uncertain. AIM:To describe the features of a series of children with CVST treate...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2008.154708

    authors: Mallick AA,Sharples PM,Calvert SE,Jones RW,Leary M,Lux AL,O'Callaghan FJ,Osborne JP,Patel JS,Prendiville AT,Renowden S,Jardine PE

    更新日期:2009-10-01 00:00:00

  • Asymptomatic type II hyperprolinaemia associated with hyperglycinaemia in three sibs.

    abstract::Three clinically normal sibs were discovered to have type II hyperprolinaemia in a routine serum amino acid screening programme in Sicily. In addition to the basic biochemical features of type II hyperprolinaemia, all 3 children had marked hyperglycinaemia, whereas their parents had both normal blood proline and glyci...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.50.8.637

    authors: Pavone L,Mollica F,Levy HL

    更新日期:1975-08-01 00:00:00

  • Cerebral blood flow velocity variability after cardiovascular support in premature babies.

    abstract::The variability of cerebral blood flow velocity was measured in 20 very low birthweight infants. The area under the curve of the Doppler frequency spectrum was used and was obtained from the anterior cerebral artery in the infants before and after infusions of plasma or dopamine. Both interventions significantly reduc...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.64.7_spec_no.897

    authors: Rennie JM

    更新日期:1989-07-01 00:00:00

  • The prognostic value of dipstick urinalysis in children admitted to hospital with severe malnutrition.

    abstract:BACKGROUND:Children with severe malnutrition (SAM) present to hospital with an array of complications, resulting in high mortality despite adherence to WHO guidelines. Diagnostic resources in developing countries are limited and bedside tests could help identify high-risk children. Dipstick urinalysis is a bedside scre...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2009.168211

    authors: Thuo N,Ohuma E,Karisa J,Talbert A,Berkley JA,Maitland K

    更新日期:2010-06-01 00:00:00

  • Is there a role for clowns in paediatric intensive care units?

    abstract::Hospital clowning is a programme in healthcare facilities involving visits from specially trained actors. In the paediatric intensive care unit (PICU), clowning may appear inappropriate and less intuitive. The patient could appear too ill and/or sedated, the environment too crowded or chaotic and the parents too stres...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/archdischild-2016-311583

    authors: Mortamet G,Roumeliotis N,Vinit F,Simonds C,Dupic L,Hubert P

    更新日期:2017-07-01 00:00:00