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Population-based surveillance of severe microcephaly and congenital Zika syndrome in Canada.

Abstract：

PURPOSE:To estimate the minimum incidence of congenital Zika syndrome (CZS) and severe microcephaly in Canada and describe key clinical, epidemiological, aetiological and outcome features of these conditions. METHODS:Two separate national surveillance studies were conducted on CZS and severe microcephaly using the well-established Canadian Paediatric Surveillance Program from 2016 to 2019. Over 2700 paediatricians across Canada were surveyed monthly and asked to report demographic details, pregnancy and travel history, infant anthropometry, clinical features and laboratory findings of newly identified cases. Reports were reviewed to assign an underlying aetiology of severe microcephaly. Incidence rates were estimated using monthly live birth denominators. RESULTS:Thirty-four infants met the case definition for severe microcephaly and <5 met the case definition for CZS. The associated minimum incidence rates were 4.5 per 100 000 live births for severe microcephaly and 0.1-0.5 per 100 000 live births for CZS. Of severe microcephaly cases, 53% were attributed to genetic causes, 15% to infectious or ischaemic causes and 32% to unknown causes. The median head circumference-for-age Z-score at birth was -3.2 (IQR -3.8 to -2.6), and catch-up growth was often not achieved. Common clinical features included intracranial abnormalities (n=23), dysmorphology (n=19) and developmental delays (n=14). Mothers of infants with non-genetic aetiologies travelled during pregnancy more often (10/16) than mothers of infants with genetic aetiologies (<5/18; p<0.01). CONCLUSION:Severe microcephaly and CZS are both rare in Canada. Minimum incidence rates can be used as a baseline against which novel or re-emergent causes of severe microcephaly or CZS can be compared.

journal_name

Arch Dis Child

journal_title

Archives of disease in childhood

authors

Morris SK,Farrar DS,Miller SP,Ofner M,Bitnun A,Nelson CRM,Shevell M,Moore AM,Tataryn J,Evans JA,Zipursky AR,Moore Hepburn C

doi

10.1136/archdischild-2020-320968

subject

Has Abstract

pub_date

2021-01-08 00:00:00

eissn

0003-9888

issn

1468-2044

pii

archdischild-2020-320968

pub_type

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Population-based surveillance of severe microcephaly and congenital Zika syndrome in Canada.