Abstract:
OBJECTIVE:To determine current use of vitamin K (VK) prophylaxis in newborns and review the efficacy and effectiveness of regimens used. DESIGN:Efficacy and effectiveness calculated using current practice details, data from Southern Ireland and two previous surveys, together with contemporaneous studies of vitamin K deficiency bleeding (VKDB). SETTING:Current survey: United Kingdom (Great Britain and Northern Ireland). Efficacy and effectiveness tables: United Kingdom and Southern Ireland. MAIN OUTCOME MEASURES:Current VK prophylaxis following uncomplicated term deliveries. Relative risk of VKDB calculated for the VK actually received and for "intention to treat". RESULTS:Questionnaire response rate 95% (n = 243), all recommending VK prophylaxis. No association between unit size and route of administration. For uncomplicated term deliveries, 60% recommended intramuscular (IM) prophylaxis, 24% oral and 16% offered both routes without bias. All units offering IM gave a single dose, mostly 1 mg Konakion Neonatal. Oral regimens showed more variation: two thirds gave 2 mg (range 0.5-2 mg), the number of doses ranged from 1 to 11 and many used preparations off-licence or the unlicensed Orakay. IM prophylaxis, if given, provided the best protection (most efficacious) against VKDB. However, on an intention-to-treat basis (effectiveness), there is no statistically significant difference between the risks of VKDB after intended IM VK and after oral prophylaxis intended to continue beyond a week. CONCLUSIONS:Although the principles of VK prophylaxis is now accepted by all, there is no uniformity in practice. Omission of prophylaxis appears to be a greater problem for IM than for multi-dose oral prophylaxis, affecting overall effectiveness.
journal_name
Arch Dis Childjournal_title
Archives of disease in childhoodauthors
Busfield A,McNinch A,Tripp Jdoi
10.1136/adc.2006.105304subject
Has Abstractpub_date
2007-09-01 00:00:00pages
754-8issue
9eissn
0003-9888issn
1468-2044pii
adc.2006.105304journal_volume
92pub_type
杂志文章,多中心研究abstract::Infant feeding methods used by mothers who smoke and by mothers who do not, who delivered in one maternity hospital, were compared to determine if smoking affected breast feeding. Significantly more of the smoking group chose either to bottle feed from delivery or, having been discharged from the hospital breast feedi...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.58.5.378
更新日期:1983-05-01 00:00:00
abstract::The changes in transcutaneous oxygen tension (TcPO2) during 123 observations of 10 care procedures were compared with the intrinsic variability of the TcPO2 at the time of the procedures. Standard deviations of the TcPO2 were measured by planimetry from continuous recording in undisturbed infants during a 10-minute co...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.58.1.20
更新日期:1983-01-01 00:00:00
abstract::Hepatomegaly, the presenting feature of type IV glycogen storage disease at 20 months of age, regressed during childhood. The patient remained asymptomatic until 12 years of age when, after an episode of shock, septicaemia, and spontaneous peritonitis, liver transplantation was successfully performed. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.71.5.450
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abstract::The association of weight for height and triceps skinfold with seven respiratory symptoms has been examined using logistic regression analysis in 7800 5 to 11 year old children (6200 in England and 1600 in Scotland). The results support the view that overweight children have a greater liability to some respiratory sym...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.59.10.940
更新日期:1984-10-01 00:00:00
abstract:BACKGROUND:Growth hormone insufficiency (GHI) is diagnosed conventionally by short stature and slow growth, and is confirmed by diminished peak GH response to a provocation test. Insulin-like growth factor I (IGF-I) and IGF binding protein 3 (IGFBP-3) have previously been considered individually OBJECTIVE:To test the ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.80.5.443
更新日期:1999-05-01 00:00:00
abstract::We report a child who presented with a progressive neurological disorder associated with hypertension and paroxysms of irritability and sweating in whom an abnormality of catecholamine metabolism or excretion was demonstrated. An elder sister died at the age of 2 1/2 years with similar clinical symptoms but without bl...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.53.8.682
更新日期:1978-08-01 00:00:00
abstract::An 11 year old boy presented with severe acute hereditary coproporphyria. Despite supportive measures his condition deteriorated after admission. Haem arginate, started two days after presentation, produced appreciable inhibition of porphyrin precursor overproduction and clinical improvement. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.66.6.730
更新日期:1991-06-01 00:00:00
abstract::General practice records of 1058 children were studied to determine the incidence, prevalence, natural history, diagnosis, and treatment of wheezing presenting in the first 21 years of life. Up to 7 years of age, boys were more likely to present with wheeze and to have recurrent episodes. Later there was a higher inci...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.60.5.457
更新日期:1985-05-01 00:00:00
abstract::A questionnaire relating to smoking habits, respiratory symptoms, and health attitude was administered to schoolchildren aged between 11 and 17 throughout a defined geographical area in both 1975 and 1979, with a valid response from 10498 and 12002 young people respectively. Each cohort was almost entirely different. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.57.5.352
更新日期:1982-05-01 00:00:00
abstract:BACKGROUND:Perinatal stress is thought to underlie the Barker sequelae of low birth weight, of which precocious pubarche may be a manifestation. AIMS:To explore whether prematurity as well as smallness for gestational age (SGA) predisposes to precocious pubarche, and the potential role of excess weight gain during chi...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2004.053959
更新日期:2005-03-01 00:00:00
abstract::An adult woman with pseudopseudohypoparathyroidism had a child with normal calcium and parathyroid hormone concentrations and cyclic AMP response to injected parathyroid hormone in infancy. By 2.5 years he had features of pseudohypoparathyroidism with raised parathyroid hormone and 'flat' cyclic AMP response. This is ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.70.4.337
更新日期:1994-04-01 00:00:00
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.80.2.149
更新日期:1999-02-01 00:00:00
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2017-313819
更新日期:2018-10-01 00:00:00
abstract::We report three cases of Hurler's disease in which glaucoma developed in early childhood. We draw attention to the fact that glaucoma may be a commonly unrecognised early complication of this condition. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.63.9.1091
更新日期:1988-09-01 00:00:00
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2013-305147
更新日期:2014-08-01 00:00:00
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journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2011-301326
更新日期:2012-09-01 00:00:00
abstract::Attention deficit-hyperactivity disorder (ADHD) remains a controversial disorder, despite it now being a well validated clinical diagnosis. Ethical and legal issues are important in determining how doctors should behave in offering a diagnosis or treatment that may generate strong and unpredictable reactions from chil...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/adc.2004.064576
更新日期:2006-02-01 00:00:00
abstract::The objectives of this study were to determine whether or not the probiotic Lactobacillus GG can colonise the immature bowel of premature infants and if so, does colonisation result in a reduction of the size of the bowel reservoir of nosocomial pathogens such as enterobacteriaceae, enterococci, yeasts or staphylococc...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/adc.69.5_spec_no.483
更新日期:1993-11-01 00:00:00
abstract::Maternal transmission of hepatitis B virus infection in relation to the hepatitis B e antigen/antibody system and serum hepatitis B virus-DNA were evaluated. Results indicate that hepatitis B virus-DNA analysis can identify hepatitis B serum antigen positive mothers who may transmit infection to their offspring. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.60.1.56
更新日期:1985-01-01 00:00:00
abstract::The relation between intraventricular haemorrhage (IVH) and hyaline membrane disease (HMD) was studied in singletons that came to necropsy at Hammersmith Hospital over the years 1966-73. The incidence of IVH in singleton live births was 3-22/1000 and of HMD 4-44/1000. Although the high figures were partily due to the ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.51.10.755
更新日期:1976-10-01 00:00:00
abstract::A novel form of severe, X linked mental retardation associated with alpha thalassaemia (ATR-X syndrome) has recently been described. Two affected cousins are described, one of whom has an unusually mild haematological phenotype. HbH inclusions, which are the hallmark of this disease, were only detected in the peripher...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.70.5.439
更新日期:1994-05-01 00:00:00
abstract::Over a period of 30 months, umbilical artery catheters were inserted in 229 infants. The main complications were haemorrhage, infection, and obstruction of a blood vessel. The incidence of infection was not affected by the use of prophylactic antibiotics. Vascular obstruction was more common in small infants, and in t...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.48.4.296
更新日期:1973-04-01 00:00:00
abstract::A retrospective study of Scottish hospital inpatients aged 15 years or less has revealed, over a 4-year period, 36 cases of venous thrombosis or phlebitis. Of these 10 were considered to have deep venous thrombosis; 2 cases were associated with obvious pulmonary embolism and 2 cases developed chronic venous insufficie...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.50.2.153
更新日期:1975-02-01 00:00:00
abstract::"Mental retardation" is a modern term for an age old problem. The descriptions of paediatric cases contained within the works of Thomas Willis (1621-75) have been increasingly recognised for their insight into seventeenth century child health practices. ...
journal_title:Archives of disease in childhood
pub_type: 传,历史文章,杂志文章
doi:10.1136/adc.87.6.555
更新日期:2002-12-01 00:00:00
abstract:BACKGROUND:There are few data on the optimal micronutrient composition of paediatric enteral feeds. The recent European Directive on Foods for Special Medical Purposes (1999/21/EC) did not distinguish between the composition of adult and paediatric feeds. AIMS:To evaluate, in an open, observational study, the long ter...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.86.6.411
更新日期:2002-06-01 00:00:00
abstract::Mild hypnotics are often recommended for young children with sleep problems. This study assesses the efficacy of trimeprazine tartrate in 1 to 3 year old children with persistent and severe night waking in a double blind crossover trial with placebo. Children on treatment with trimeprazine had significantly fewer waki...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/adc.62.3.253
更新日期:1987-03-01 00:00:00
abstract:OBJECTIVE:To investigate possible renal toxicity of long-term gentamicin inhalation in patients with cystic fibrosis. METHODS:Urinary N-acetyl-beta-D-glucosaminidase (NAG) activity was measured during routine respiratory clinic visits. Outpatient records were reviewed for data on long-term gentamicin inhalation, and p...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.78.6.540
更新日期:1998-06-01 00:00:00
abstract:OBJECTIVES:To investigate the prevalence of infant crying and maternal soothing techniques in relation to ethnic origin and other sociodemographic variables. DESIGN:A questionnaire survey among mothers of 2-3 month old infants registered at six child health clinics in Amsterdam, the Netherlands. SUBJECTS:A questionna...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.79.4.312
更新日期:1998-10-01 00:00:00
abstract::An outbreak of adenovirus type 8 conjunctivitis occurred in seven premature infants who had undergone ophthalmological examination four to seven days previously. Three of the affected infants, treated with steroids because of bronchopulmonary dysplasia, showed systemic manifestations and deterioration of their respira...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.68.5_spec_no.610
更新日期:1993-05-01 00:00:00
abstract:OBJECTIVE:There is a body of published research on the effectiveness of home visiting for the prevention of child maltreatment, but little in the peer reviewed literature on cost-effectiveness or value to society. The authors sought to determine the cost-effectiveness of alternative home visiting programmes to inform p...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/archdischild-2011-300795
更新日期:2012-09-01 00:00:00