Partial splenectomy in homozygous beta thalassaemia.

Abstract:

:Partial splenectomy was performed on 30 patients with homozygous beta thalassaemia to reduce blood requirements and to avoid the risk of overwhelming postsplenectomy infections; 24 patients had thalassaemia major and six thalassaemia intermedia. Five patients received a high transfusion regimen before and after surgery and 25 a lower one. Follow up after surgery ranged from one to four years. Partial splenectomy improved the long term haematological state in the six patients with thalassaemia intermedia. Recurrence of hypersplenism occurred in nine of the 24 patients with thalassaemia major, however, and complete splenectomy was required. Serum IgM concentrations were not significantly modified by surgery. The mean (SD) residual spleen after surgery was 4.45 (2.36) cm measured by scintigraphy. No severe infections occurred after surgery; however, most patients were routinely treated with phenoxymethylpenicillin and the protective effect of the remaining spleen could not be exactly determined. Because of the possibility of recurrence of hypersplenism, routine partial splenectomy when splenectomy is needed in thalassaemia major is not advised, except in children under 5 years whose risk of overwhelming postsplenectomy infection is greatest.

journal_name

Arch Dis Child

authors

de Montalembert M,Girot R,Revillon Y,Jan D,Adjrad L,Ardjoun FZ,Belhani M,Najean Y

doi

10.1136/adc.65.3.304

subject

Has Abstract

pub_date

1990-03-01 00:00:00

pages

304-7

issue

3

eissn

0003-9888

issn

1468-2044

journal_volume

65

pub_type

杂志文章
  • Pyogenic meningitis in chronic gastroenteritis and marasmus.

    abstract::Pyogenic meningitis occurred in 6 infants in the course of chronic gastroenteritis, in 5 of whom a normal CSF had been recorded earlier in the illness. Clinical signs of meningitis were often absent. The problems of diagnosis and management and of possible predisposition to pneumococcal meningitis in children sufferin...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.52.2.159

    authors: Wyatt GP,Marcus JC

    更新日期:1977-02-01 00:00:00

  • Attention deficit hyperactivity disorder: legal and ethical aspects.

    abstract::Attention deficit-hyperactivity disorder (ADHD) remains a controversial disorder, despite it now being a well validated clinical diagnosis. Ethical and legal issues are important in determining how doctors should behave in offering a diagnosis or treatment that may generate strong and unpredictable reactions from chil...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/adc.2004.064576

    authors: Foreman DM

    更新日期:2006-02-01 00:00:00

  • Thermoregulation in babies immediately after birth.

    abstract::The fall in body temperature that occurs in babies soon after birth is influenced by the baby's weight and its environmental conditions. The rate of oxygen consumption 1 1/2 hours after birth was unrelated to body temperature and only slightly raised, indicating a limited thermogenic capacity. A radiant heater effecti...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.53.1.58

    authors: Smales OR,Kime R

    更新日期:1978-01-01 00:00:00

  • Why nebulise for more than five minutes?

    abstract::The output of the drug and the particle size produced by various nebulisers were assessed, and sensible nebulisation times for sodium cromoglycate calculated. Three of the four nebuliser systems tested produced over 80% of total drug output within the first five minutes of nebulisation. We suggest that five minutes is...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.64.9.1270

    authors: O'Callaghan C,Clark AR,Milner AD

    更新日期:1989-09-01 00:00:00

  • Early onset of diabetic nephropathy.

    abstract::A 12 year old Asian girl with a four year history of poorly controlled insulin dependent diabetes mellitus developed overt diabetic nephropathy. There were no clinical features of Rabson-Mendenhall syndrome. Screening for microalbuminuria would have identified incipient diabetic nephropathy and highlighted the importa...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.77.6.524

    authors: Francis J,Rose SJ,Raafat F,Milford DV

    更新日期:1997-12-01 00:00:00

  • Respiratory function in patients with thalassaemia major: relation with iron overload.

    abstract:AIMS:(1) To determine the pattern of respiratory impairment in children with thalassaemia major (TM); (2) to assess the relation between the degree of respiratory impairment and total body iron content. METHODS:Twenty nine TM patients were recruited. All underwent physical examination, standardised pulmonary function ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.87.4.328

    authors: Li AM,Chan D,Li CK,Wong E,Chan YL,Fok TF

    更新日期:2002-10-01 00:00:00

  • Diagnosis and treatment of bacterial meningitis.

    abstract::This review focuses on recent advances of topical interest regarding the diagnosis and treatment of common causes of bacterial meningitis occurring in children beyond the neonatal period. Tuberculous meningitis is beyond the scope of this review. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/adc.88.7.615

    authors: El Bashir H,Laundy M,Booy R

    更新日期:2003-07-01 00:00:00

  • STARTING A NEW MEDICINE STUDY.

    abstract:AIM:To identify the experiences of patients, parents or carers when a child/young person is prescribed a new long-term medicine. METHOD:Patients' prescribed a new long-term (>6 weeks) medicine were recruited from a single UK paediatric hospital out-patient pharmacy.A semi-structured questionnaire was administered to p...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2016-311535.58

    authors: Aston J,Wilson K,Terry D

    更新日期:2016-09-01 00:00:00

  • Atopy in parents of children dying with sudden infant death syndrome.

    abstract::36 parents of infants who had died suddenly did not differ in frequency of atopic symptoms, immediate skin tests, IgE, IgE antibody, immunoglobulin G, A, and M, or yeast opsonisation, from 36 matched controls, although atopy was common (about half had atopy in both groups. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.55.11.876

    authors: Warnasuriya N,Downham MA,Skelton A,Turner MW,Soothill JF

    更新日期:1980-11-01 00:00:00

  • Capillary refill: prognostic value in Kenyan children.

    abstract:AIMS:To determine whether delayed capillary refill time (>3 seconds) is a useful prognostic indicator in Kenyan children admitted to hospital. METHODS:A total of 4160 children admitted to Kilifi District Hospital with malaria, malarial anaemia, acute respiratory tract infection (ARI), severe anaemia (haemoglobin <50 g...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2003.032516

    authors: Pamba A,Maitland K

    更新日期:2004-10-01 00:00:00

  • Childhood cancers in Zambia before and after the HIV epidemic.

    abstract::Human immunodeficiency virus (HIV) related cancers in children are not as common and as well described as in adults. An HIV epidemic has been prevalent in Zambia since 1983-1984. To study the effect of the epidemic on the epidemiology of cancers in children a retrospective study was undertaken at the University Teachi...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.73.2.100

    authors: Chintu C,Athale UH,Patil PS

    更新日期:1995-08-01 00:00:00

  • Early detection of abnormalities in partial epilepsy using magnetic resonance.

    abstract::The incidence of brain abnormalities determined by magnetic resonance in 30 consecutive children presenting with intractable complex partial seizures is reported. Images were optimised to visualise the hippocampus and cortical grey matter. Abnormalities of the hippocampus or temporal lobe were seen in all 19 children ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.69.1.104

    authors: Cross JH,Jackson GD,Neville BG,Connelly A,Kirkham FJ,Boyd SG,Pitt MC,Gadian DG

    更新日期:1993-07-01 00:00:00

  • Height and weight achievement in cleft lip and palate.

    abstract::Growth was studied in 83 children with cleft lip and/or palate aged 0-4 years attending a specialist regional centre. Information was collected by a personal interview, postal questionnaire, and record review. The group as a whole grew relatively poorly in early infancy but subsequently recovered, attaining both expec...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.75.4.327

    authors: Lee J,Nunn J,Wright C

    更新日期:1996-10-01 00:00:00

  • Cerebral venous sinus thrombosis: a case series including thrombolysis.

    abstract:BACKGROUND:Cerebral venous sinus thrombosis (CVST) in children is associated with a high incidence of serious morbidity and mortality. The presenting features are variable. It can be diagnostically challenging and the optimal treatment is uncertain. AIM:To describe the features of a series of children with CVST treate...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2008.154708

    authors: Mallick AA,Sharples PM,Calvert SE,Jones RW,Leary M,Lux AL,O'Callaghan FJ,Osborne JP,Patel JS,Prendiville AT,Renowden S,Jardine PE

    更新日期:2009-10-01 00:00:00

  • A low cost, colour coded, hand held spring scale accurately categorises birth weight in low resource settings.

    abstract:AIMS:To determine the accuracy of a low cost, spring calibrated, hand held scale in classifying newborns into three weight categories (> or =2500 g, 2000-2499 g, <2000 g). METHODS:The test device was compared to a gold standard digital baby scale with precision to 2 g. In Sarlahi district, Nepal, 1890 newborns were el...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2005.088781

    authors: Mullany LC,Darmstadt GL,Coffey P,Khatry SK,LeClerq SC,Tielsch JM

    更新日期:2006-05-01 00:00:00

  • Cholelithiasis in Down's syndrome.

    abstract::Cholelithiasis is considered uncommon in infancy, childhood, and adolescence. We performed a prospective, controlled study showing that children with Down's syndrome have a significantly higher prevalence of cholelithiasis (4.7%) compared with controls (0.2%). Clinicians should be aware of the risk of gallstones in ch...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.85.3.242

    authors: Toscano E,Trivellini V,Andria G

    更新日期:2001-09-01 00:00:00

  • Differential avian and human tuberculin skin testing in non-tuberculous mycobacterial infection.

    abstract:OBJECTIVE:To determine the sensitivity of differential avian and human delayed-type hypersensitivity skin testing in the diagnosis of non-tuberculous mycobacterial lymphadenitis. METHOD:Retrospective review of all patients with culture proved non-tuberculous mycobacterial lymph node infections who also had differentia...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.80.4.377

    authors: Daley AJ,Isaacs D

    更新日期:1999-04-01 00:00:00

  • Socioeconomic disadvantage and onset of childhood chronic disabling conditions: a cohort study.

    abstract:OBJECTIVE:To study the temporal relationship between socioeconomic disadvantage and onset of chronic disabling conditions in childhood. METHOD:Using parent reported data from the Longitudinal Study of Australian Children, we compared children who developed a chronic disabling condition between the ages of 6/7 and 10/1...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2013-305634

    authors: Spencer N,Strazdins L

    更新日期:2015-04-01 00:00:00

  • Diagnosis of primary human herpesvirus 6 and 7 infections in febrile infants by polymerase chain reaction.

    abstract::Primary human herpesvirus 6 (HHV-6) and 7 (HHV-7) infections were identified in febrile children by qualitative and quantitative polymerase chain reaction (PCR) assays. Diagnosis was based on the differential detection of viral DNA in peripheral blood mononuclear cells (PBMC), but not in saliva. Six of 41 febrile infa...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.77.1.42

    authors: Clark DA,Kidd IM,Collingham KE,Tarlow M,Ayeni T,Riordan A,Griffiths PD,Emery VC,Pillay D

    更新日期:1997-07-01 00:00:00

  • Validation of the paediatric appropriateness evaluation protocol in British practice.

    abstract::The reliability and validity of the North American paediatric appropriateness evaluation protocol (PAEP) for use in paediatric practice in Britain was tested. The protocol was applied to 418 case records of consecutive emergency admissions to three Yorkshire district general hospitals. The PAEP ratings were then compa...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/adc.77.4.294

    authors: Werneke U,Smith H,Smith IJ,Taylor J,MacFaul R

    更新日期:1997-10-01 00:00:00

  • Neonatal patient triggered ventilation.

    abstract::Patient triggered ventilation was assessed in 14 neonates (gestational age 24-40 weeks). Inspiratory changes in airflow, monitored by a pneumotachograph, were used to trigger the ventilator and this was not associated with complications. Patient triggered ventilation was maintained for up to eight hours (mean duration...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.63.4.394

    authors: Greenough A,Pool J

    更新日期:1988-04-01 00:00:00

  • Thoughts on treatment of strawberry naevi.

    abstract::Published reports on the treatment of large strawberry naevi have been reviewed. It is suggested that they should normally be left untreated, and that corticosteroids, given for a short period only, should be reserved for massive naevi close to the eye, or interfering with respiration or suckling, or associated with t...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/adc.51.2.138

    authors: Illingworth RS

    更新日期:1976-02-01 00:00:00

  • Factors influencing colonisation with gentamicin resistant gram negative organisms in the neonatal unit.

    abstract::The proportion of babies colonised with gentamicin resistant Gram negative organisms in a nursery over a 30 month period did not correlate with the quantity or duration of aminoglycosides used, but it did correlate with two indicators of workload: the number of baby days and a score based on the level of nursing care ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.63.5.533

    authors: Isaacs D,Catterson J,Hope PL,Moxon ER,Wilkinson AR

    更新日期:1988-05-01 00:00:00

  • IgG subclass specific antibody response in recurrent bronchitis.

    abstract::The IgG subclass specific immune response against pneumococcal type 3 polysaccharide antigen before and after immunisation in healthy children and children with recurrent bronchitis was studied. Recurrent bronchitis was defined as three or more episodes a year, during at least two consecutive years, of bronchopulmonar...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.66.12.1378

    authors: de Baets F,Pauwels R,Schramme I,Leroy J

    更新日期:1991-12-01 00:00:00

  • Varicella paediatric hospitalisations in Belgium: a 1-year national survey.

    abstract:BACKGROUND:Varicella universal vaccination (UV) has been implemented in many countries for several years. Nevertheless, varicella UV remains debated in Europe and few data are available on the real burden of infection. We assessed the burden of varicella in Belgium through analysis of hospitalised cases during a 1-year...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/archdischild-2015-308283

    authors: Blumental S,Sabbe M,Lepage P,Belgian Group for Varicella.

    更新日期:2016-01-01 00:00:00

  • Epidemiology and treatment outcome of childhood tuberculosis in England and Wales: 1999-2006.

    abstract:OBJECTIVE:To describe the recent trends in demographic, clinical and microbiological characteristics and outcome of treatment in paediatric cases of tuberculosis. DESIGN:National surveillance study. SETTING:England and Wales. PATIENTS:All children under the age of 16 years reported with tuberculosis to the national ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2008.139543

    authors: Abubakar I,Laundy MT,French CE,Shingadia D

    更新日期:2008-12-01 00:00:00

  • Retrospective review of Synacthen testing in infants.

    abstract:BACKGROUND:A subnormal cortisol response (30 min level (C30min)<550 nmol/L) to synthetic adrenocorticotrophic hormone/Synacthen test (SDST) in all infants does not necessarily indicate underlying or persistent hypothalamic-pituitary-adrenal axis pathology. METHODS:We retrospectively evaluated the diagnoses and outcome...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2017-313819

    authors: Tan TSE,Manfredonia C,Kumar R,Jones J,O'Shea E,Padidela R,Skae M,Ehtisham S,Ivison F,Tetlow L,Clayton PE,Banerjee I,Patel L

    更新日期:2018-10-01 00:00:00

  • Waist circumference centiles for UK South Asian children.

    abstract:OBJECTIVES:To develop waist circumference (WC) centile curves for UK South Asian children, to make comparisons with published centiles for British, indigenous Indian and Pakistani children, as well as to make anthropometric comparisons with their UK white peers. DESIGN:Cross-sectional study. SETTING:School-aged child...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2018-315722

    authors: Shah M,Radia D,McCarthy HD

    更新日期:2020-01-01 00:00:00

  • Utility of lung ultrasound scanning in neonatology.

    abstract::The utility of point-of-care lung ultrasound in neonatology is rapidly expanding. This review summarises current evidence of a diagnostic, procedural and observational tool valuable in the management of newborns requiring intensive care. Approaching a patient, probe in-hand with focused clinical question is essential,...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/archdischild-2017-314538

    authors: Woods PL

    更新日期:2019-09-01 00:00:00

  • Is permanent congenital facial palsy caused by birth trauma?

    abstract:OBJECTIVE:To study the relation between traumatic birth and the development of permanent facial palsy in the newborn. DESIGN:Retrospective case control study of children with 'congenital' facial palsy. SETTING:Two tertiary referral centres for patients with facial palsy. SUBJECTS:61 children with established facial ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.74.1.56

    authors: Laing JH,Harrison DH,Jones BM,Laing GJ

    更新日期:1996-01-01 00:00:00