Continuous glucose monitoring to evaluate glycaemic abnormalities in cystic fibrosis.

Abstract:

OBJECTIVE:This study aimed to determine the glycaemic profile of patients with cystic fibrosis using a continuous glucose monitoring system (CGMS), and to evaluate the associations of glycaemic abnormalities with sex, age, pubertal stage, CFTR gene mutations, nutritional status, lung function, oral glucose tolerance test, glycated haemoglobin concentrations, fasting insulin concentrations, C peptide concentrations and exocrine pancreatic function. STUDY DESIGN:This observational study evaluated CGMS data from 39 patients with cystic fibrosis who were treated at a referral centre. The patients were 10-19.9 years old, and were categorised according to whether they had normal results (27 patients) or glucose intolerance (12 patients) during the oral glucose tolerance test. RESULTS:The maximum interstitial glucose concentration among individuals with normal oral glucose tolerance test results was 174.9±65.1 mg/dL (9.7-3.61 mmol/L), compared with 170.4±40.9 mg/dL (9.46-2.27 mmol/L) among individuals with glucose intolerance. The CGMS revealed that 18 of the 27 patients with normal oral glucose tolerance test results had peak interstitial glucose concentrations of >140 mg/dL (7.8 mmol/L), and that 4 of these individuals had peak levels of >200 mg/dL (11.1 mmol/L). None of the analysed clinical or laboratory characteristics predicted the occurrence of hyperglycaemic peaks on CGMS. CONCLUSIONS:The present study revealed that CGMS could detect hyperglycaemia among patients with cystic fibrosis and 'normal' oral glucose tolerance test results, and that their clinical and laboratory characteristics were not useful in discerning between patients who did and did not exhibit these excursions.

journal_name

Arch Dis Child

authors

Zorrón Mei Hsia Pu M,Gonçalves AC,Minnicucci WJ,Morcillo AM,Ribeiro JD,Ribeiro AF

doi

10.1136/archdischild-2017-314250

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

592-596

issue

6

eissn

0003-9888

issn

1468-2044

pii

archdischild-2017-314250

journal_volume

103

pub_type

杂志文章
  • Special educational needs, social care and health.

    abstract::Better understanding of the proportion of children who ever receive special educational needs (SEN) provision or social care services during school years is highly relevant for healthcare as reductions in one or more of these services could impact on healthcare. Using the National Pupil Database linked to the all-of-E...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2019-317985

    authors: Jay MA,Gilbert R

    更新日期:2021-01-01 00:00:00

  • Controlled trial of trimeprazine tartrate for night waking.

    abstract::Mild hypnotics are often recommended for young children with sleep problems. This study assesses the efficacy of trimeprazine tartrate in 1 to 3 year old children with persistent and severe night waking in a double blind crossover trial with placebo. Children on treatment with trimeprazine had significantly fewer waki...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/adc.62.3.253

    authors: Simonoff EA,Stores G

    更新日期:1987-03-01 00:00:00

  • Cluster headache-like disorder in childhood.

    abstract::This paper reviews the diagnostic features of cluster headache-like disorder and describes its presentation in childhood. Case note summaries of patients with this condition are presented in the context of a brief summary of the literature. Four patients (two girls; aged 12 to 15 years) with cluster headache-like diso...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.81.6.511

    authors: McNabb S,Whitehouse W

    更新日期:1999-12-01 00:00:00

  • Growth and nutrition in children with ataxia telangiectasia.

    abstract:BACKGROUND:Ataxia telangiectasia (A-T) is a rare multisystem disease with high early mortality from lung disease and cancer. Nutritional failure adversely impacts outcomes in many respiratory diseases. Several factors influence nutrition in children with A-T. We hypothesised that children with A-T have progressive grow...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2015-310373

    authors: Stewart E,Prayle AP,Tooke A,Pasalodos S,Suri M,Bush A,Bhatt JM

    更新日期:2016-12-01 00:00:00

  • A double blind lipase for lipase comparison of a high lipase and standard pancreatic enzyme preparation in cystic fibrosis.

    abstract::A standard acid resistant microsphere pancreatic enzyme preparation was compared with identical capsules half filled with mini-tablets of a new high lipase preparation in a randomised double blind crossover study in children with cystic fibrosis. Each patient received his/her usual number of capsules and the same dose...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/adc.68.2.227

    authors: Bowler IM,Wolfe SP,Owens HM,Sheldon TA,Littlewood JM,Walters MP

    更新日期:1993-02-01 00:00:00

  • Early detection of abnormalities in partial epilepsy using magnetic resonance.

    abstract::The incidence of brain abnormalities determined by magnetic resonance in 30 consecutive children presenting with intractable complex partial seizures is reported. Images were optimised to visualise the hippocampus and cortical grey matter. Abnormalities of the hippocampus or temporal lobe were seen in all 19 children ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.69.1.104

    authors: Cross JH,Jackson GD,Neville BG,Connelly A,Kirkham FJ,Boyd SG,Pitt MC,Gadian DG

    更新日期:1993-07-01 00:00:00

  • Impact of HIV-1 infection in South Africa.

    abstract::In a prospective study, 60% of admissions to an academic hospital were infected with HIV. HIV infected children were younger, less likely to have been referred, more likely to have pneumonia and candidiasis, and had more health service attendances. This impact may be alleviated by appropriate primary and secondary lev...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.85.1.50

    authors: Pillay K,Colvin M,Williams R,Coovadia HM

    更新日期:2001-07-01 00:00:00

  • Serum immunoglobulins in multiple pregnancy.

    abstract::The concentrations of immunoglobulins (Ig) G.A.M. and E were determined in paired umbilical cord and maternal sera in 50 twin pregnancies. Mean IgG levels were higher in cord than maternal sera and in most cases the cord IgG level related more closely to that of the other twin than to either maternal level or birthwei...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.51.5.354

    authors: Bryan EM,Slavin B,Nicholson E

    更新日期:1976-05-01 00:00:00

  • HIV-I infection in perinatally exposed siblings and twins. The Italian Register for HIV Infection in Children.

    abstract::In a multicentre study on perinatal HIV-I infection including 1493 children born from 1471 pregnancies to 1415 infected mothers, 22 twin pairs and 56 sibships (115 children) were recorded. The frequency of twin pregnancies was 1.5 (22/1471) and 3.9% (56/1415) seropositive women had more than one at risk pregnancy. In ...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1136/adc.66.10.1235

    authors: de Martino M,Tovo PA,Galli L,Caselli D,Gabiano C,Mazzoni PL,Giacomelli A,Duse M,Fundarò C

    更新日期:1991-10-01 00:00:00

  • Disseminated intravascular clotting in kwashiorkor.

    abstract::The role of disseminated intravascular clotting (DIC) in the pathogenesis of the bleeding diathesis kwashiorkor was investigated in 22 patients. According to the severity of the clinical and haematological findings, two grades of DIC were observed. A severe grade of DIC was shown in 6 cases (5 fatal) presenting with ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.50.4.308

    authors: Hassanein EA,Tankovsky I

    更新日期:1975-04-01 00:00:00

  • Effects of smoking on breast feeding.

    abstract::Infant feeding methods used by mothers who smoke and by mothers who do not, who delivered in one maternity hospital, were compared to determine if smoking affected breast feeding. Significantly more of the smoking group chose either to bottle feed from delivery or, having been discharged from the hospital breast feedi...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.58.5.378

    authors: Lyon AJ

    更新日期:1983-05-01 00:00:00

  • Socioeconomic inequalities in risk of congenital anomaly.

    abstract:AIMS:To investigate socioeconomic inequalities in the risk of congenital anomalies, focusing on risk of specific anomaly subgroups. METHODS:A total of 858 cases of congenital anomaly and 1764 non-malformed control births were collected between 1986 and 1993 from four UK congenital malformation registers, for the purpo...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/adc.82.5.349

    authors: Vrijheid M,Dolk H,Stone D,Abramsky L,Alberman E,Scott JE

    更新日期:2000-05-01 00:00:00

  • PROLONGED INFUSIONS OF KETAMINE AND IMPACT ON INFECTIONS AND WASTE.

    abstract:AIM:Ketamine is used for post-operative analgesia. There has been recent disruption in it's supply. It is usually prescribed by patient's weight (3 mg/kg in 50 ml 0.9% saline) at a rate of 1-5 ml/hr (1-5 microgram/kg/minute). To conserve ketamine supplies our policy was changed to a concentrated "standardised" concentr...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2016-311535.12

    authors: Wong J,Sutherland A

    更新日期:2016-09-01 00:00:00

  • Hypothalamo-pituitary hormone insufficiency associated with cleft lip and palate.

    abstract::Two male patients with congenital cleft lip and palate first seen at ages 10.2 and 21.5 years presented with typical signs of hypothalamic-interior pituitary hormone deficiencies. They were found to lack GH, LH, and FSH and to be partially deficient in TSH and ACTH. Several congenital defects may explain this rare syn...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.53.12.952

    authors: Roitman A,Laron Z

    更新日期:1978-12-01 00:00:00

  • Educational attainment in childhood cancer survivors: a meta-analysis.

    abstract:OBJECTIVE:To assess differences across educational outcomes in survivors of childhood cancer (CCS) compared with peers. DESIGN:Systematic review and meta-analysis of observational studies. DATA SOURCES AND STUDY SELECTION:Medline, EMBASE, ERIC, CINAHL and PsycInfo from inception to 1st August 2018. Any peer reviewed,...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/archdischild-2019-317594

    authors: Saatci D,Thomas A,Botting B,Sutcliffe AG

    更新日期:2020-04-01 00:00:00

  • Diarrhoea in jaundiced neonates treated with phototherapy: role of intestinal secretion.

    abstract::Thirty jaundiced neonates with diarrhoea who were being treated with phototherapy and 30 matched control infants were studied to try and find out the cause of the diarrhoea. Faecal osmolality and electrolyte concentrations were measured, which gave clear evidence that the diarrhoea arose from intestinal secretion. Rec...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.64.8.1161

    authors: De Curtis M,Guandalini S,Fasano A,Saitta F,Ciccimarra F

    更新日期:1989-08-01 00:00:00

  • Parental food allergy information needs: a qualitative study.

    abstract:OBJECTIVE:To examine information needs and preferences of parents regarding food allergy. DESIGN:Qualitative study including in-depth semi-structured interviews and focus group discussions. Data were audio-recorded, transcribed verbatim and analysed using the constant comparative method, aided by participant checking ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/adc.2006.114975

    authors: Hu W,Grbich C,Kemp A

    更新日期:2007-09-01 00:00:00

  • Late referral to paediatric renal failure service impairs access to pre-emptive kidney transplantation in children.

    abstract:BACKGROUND:Timing of referral to subspecialists may be a major determinant for access to adequate treatment. Kidney transplantation is the preferred modality of renal replacement therapy (RRT) in children. In adults, delayed referral from general physicians to nephrologists reduced access to kidney transplantation. Thi...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2009.174581

    authors: Boehm M,Winkelmayer WC,Arbeiter K,Mueller T,Aufricht C

    更新日期:2010-08-01 00:00:00

  • Sleep apnoea profile in preterm infants recovering from respiratory distress syndrome.

    abstract::Polygraphic recordings were made on 10 preterm infants recovering from respiratory distress syndrome and 12 healthy preterm control infants at 40, 52, and 64 weeks' conceptual age to study the influence of respiratory distress syndrome on the development of the sleep apnoea profile. Two significant differences were fo...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.60.6.547

    authors: Bentele KH,Albani M,Budde C,Schulte FJ

    更新日期:1985-06-01 00:00:00

  • Joint BSPGHAN and Coeliac UK guidelines for the diagnosis and management of coeliac disease in children.

    abstract::The revised BSPGHAN guidelines for the diagnosis and management of coeliac disease represent an important shift in diagnostic strategy, aimed at simplifying and shortening the diagnostic process in selected cases. Guidance is given concerning the indications for testing for coeliac disease, which is still significantl...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,实务指引

    doi:10.1136/archdischild-2013-303996

    authors: Murch S,Jenkins H,Auth M,Bremner R,Butt A,France S,Furman M,Gillett P,Kiparissi F,Lawson M,McLain B,Morris MA,Sleet S,Thorpe M,BSPGHAN.

    更新日期:2013-10-01 00:00:00

  • Venous thromboembolism occurring during adolescence.

    abstract:OBJECTIVE:Risk assessment for venous thromboembolism (VTE) and thromboprophylaxis in those with risk factors is established in adult practice. Evidence to support efficacy and safety of this approach in adolescents is lacking. We aimed to describe thrombotic risk factors and to determine the proportion of potentially p...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/archdischild-2015-309875

    authors: Biss T,Alikhan R,Payne J,Alamelu J,Williams M,Richards M,Mathias M,Tunstall O,Chalmers E

    更新日期:2016-05-01 00:00:00

  • Small bowel biopsy.

    abstract::We describe our technique of small bowel biopsy, which has been used on 190 occasions over a four year period. In 77%, the examination was completed within 10 minutes, and fluoroscopy times were less than 10 seconds in 75% of the cases. The technique is easily taught, and it has made the examination a minor procedure....

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.60.11.1082

    authors: Collins AL,Brookfield DS,Hyde I,Rolles CJ

    更新日期:1985-11-01 00:00:00

  • Development of bowel habit in preterm infants.

    abstract::The bowel habits in 844 preterm infants were observed during the first 56 days after birth. Delay in the passage of meconium beyond the second day occurred in 32%, and there was an inverse relation between gestational age and the day of first bowel action. Thereafter the increase in frequency of stools passed each day...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.68.3_spec_no.317

    authors: Weaver LT,Lucas A

    更新日期:1993-03-01 00:00:00

  • Review of treatment of bronchiolitis related apnoea in two centres.

    abstract:AIMS:To determine whether the use of negative pressure ventilation (NPV) was associated with a lower rate of endotracheal intubation in infants with recurrent apnoea secondary to acute bronchiolitis. METHODS:Retrospective review of two paediatric intensive care units (PICU) databases and case notes; one PICU offered N...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/adc.2003.039404

    authors: Al-balkhi A,Klonin H,Marinaki K,Southall DP,Thomas DA,Jones P,Samuels MP

    更新日期:2005-03-01 00:00:00

  • Investigating inflammatory bowel disease--white cell scanning, radiology, and colonoscopy.

    abstract:OBJECTIVE:To evaluate different methods of examination of the bowel in suspected inflammatory bowel disease. DESIGN:Prospective investigation of all children over a three year period with suspected inflammatory bowel disease. A technetium-99m-HMPAO labelled white cell scan (Tc-WCS), barium follow through examination (...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章

    doi:10.1136/adc.74.1.22

    authors: Jobling JC,Lindley KJ,Yousef Y,Gordon I,Milla PJ

    更新日期:1996-01-01 00:00:00

  • Ketamine anaesthesia for medical procedures in children.

    abstract::Ketamine hydrochloride 2 mg/kg, together with atropine 0.2 mg, has been given intravenously on 100 occasions on a general paediatric ward. No serious side effects occurred. Dreams followed in 4 children but did not reduce acceptability of the drug. In our hands it has greatly reduced the pain and distress of children ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.51.1.56

    authors: Elliott E,Hanid TK,Arthur LJ,Kay B

    更新日期:1976-01-01 00:00:00

  • Changes in cerebral artery blood flow velocity after intermittent cerebrospinal fluid drainage.

    abstract::Doppler ultrasound was used to measure blood flow velocity in the anterior cerebral artery of six premature infants with posthaemorrhagic hydrocephalus, before and after intermittent cerebrospinal fluid (CSF) drainage, on 23 occasions. There was a significant increase in mean blood flow velocity after the drainage pro...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.69.1_spec_no.74

    authors: Kempley ST,Gamsu HR

    更新日期:1993-07-01 00:00:00

  • High incidence of primary tuberculosis.

    abstract::An usually high rate of both tuberculosis infection and active disease is reported in 11 of 38 nursery children in contact with a case of smear positive pulmonary tuberculosis, emphasising the susceptibility of young children to this disease. This report also underlines some important principles in case finding and di...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.82.5.386

    authors: Milburn HJ,Gibilaro J,Atkinson H,Heathcock R

    更新日期:2000-05-01 00:00:00

  • Failure of IGF-I and IGFBP-3 to diagnose growth hormone insufficiency.

    abstract:BACKGROUND:Growth hormone insufficiency (GHI) is diagnosed conventionally by short stature and slow growth, and is confirmed by diminished peak GH response to a provocation test. Insulin-like growth factor I (IGF-I) and IGF binding protein 3 (IGFBP-3) have previously been considered individually OBJECTIVE:To test the ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.80.5.443

    authors: Mitchell H,Dattani MT,Nanduri V,Hindmarsh PC,Preece MA,Brook CG

    更新日期:1999-05-01 00:00:00

  • Phase II meningococcal B vesicle vaccine trial in New Zealand infants.

    abstract:BACKGROUND:A tailor-made serogroup B outer membrane vesicle vaccine was evaluated in the context of a serogroup B meningococcal epidemic dominated by Neisseria meningitidis strain B:4:P1.7b,4. OBJECTIVE:To determine the safety, reactogenicity and immunogenicity in infants aged 6-8 months of a meningococcal B vaccine d...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/adc.2007.132571

    authors: Jackson C,Lennon DR,Sotutu VT,Yan J,Stewart JM,Reid S,Crengle S,Oster P,Ypma E,Aaberge I,Mulholland K,Martin DR

    更新日期:2009-10-01 00:00:00