A double blind lipase for lipase comparison of a high lipase and standard pancreatic enzyme preparation in cystic fibrosis.

Abstract:

:A standard acid resistant microsphere pancreatic enzyme preparation was compared with identical capsules half filled with mini-tablets of a new high lipase preparation in a randomised double blind crossover study in children with cystic fibrosis. Each patient received his/her usual number of capsules and the same dose of lipase during each period of the study. Eighteen patients completed the study. There were fewer gastrointestinal symptoms when pancreatic enzyme was supplied as the high lipase preparation. There was also a significant improvement in fat absorption (17%, 95% confidence interval (CI) 6 to 27), reduction in faecal fat output (15.8 g/day, 95% CI 6.4 to 22.5), and faecal energy loss (789 kJ/day, 95% CI 211 to 1384). It is concluded that half filled capsules of the new high lipase preparation are more effective than the standard preparation and it is likely that filled capsules would allow patients to use fewer than half the number of pancreatic enzyme capsules.

journal_name

Arch Dis Child

authors

Bowler IM,Wolfe SP,Owens HM,Sheldon TA,Littlewood JM,Walters MP

doi

10.1136/adc.68.2.227

subject

Has Abstract

pub_date

1993-02-01 00:00:00

pages

227-30

issue

2

eissn

0003-9888

issn

1468-2044

journal_volume

68

pub_type

临床试验,杂志文章,随机对照试验
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    authors: Iorio R,Pensati P,Porzio S,Fariello I,Guida S,Vegnente A

    更新日期:1996-02-01 00:00:00

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    abstract:PURPOSE:To prospectively examine relations between maternal DSM-IV-TR anxiety and depressive disorders and excessive infant crying. METHODS:Based on the prospective longitudinal Maternal Anxiety in Relation to Infant Development Study, n=306 expectant mothers were enrolled during early pregnancy and repeatedly intervi...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

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    authors: Petzoldt J,Wittchen HU,Wittich J,Einsle F,Höfler M,Martini J

    更新日期:2014-09-01 00:00:00

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    abstract::Catch-up growth of 26 children with growth hormone deficiency during four years of growth hormone treatment, which was started young (< 3 years), was compared with that of 16 children with coeliac disease on a gluten free diet. In children with growth hormone deficiency mean (SD) height SD score increased from -4.3 (1...

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    pub_type: 杂志文章

    doi:10.1136/adc.72.5.427

    authors: Boersma B,Rikken B,Wit JM

    更新日期:1995-05-01 00:00:00

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    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.60.11.1082

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    更新日期:1985-11-01 00:00:00

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    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,随机对照试验

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    更新日期:1998-12-01 00:00:00

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    pub_type: 杂志文章,多中心研究

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    doi:10.1136/adc.79.4.359

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    更新日期:1998-10-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:2018-03-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1136/adc.60.8.774

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    更新日期:1985-08-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1136/adc.58.5.327

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    更新日期:1983-05-01 00:00:00

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    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2012-303516

    authors: Pichler J,Chomtho S,Fewtrell M,Macdonald S,Hill S

    更新日期:2014-02-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1136/archdischild-2018-316248

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    pub_type: 杂志文章

    doi:10.1136/adc.63.4.403

    authors: Roper HP,Chiswick ML,Sims DG

    更新日期:1988-04-01 00:00:00

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    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章

    doi:10.1136/adc.50.5.387

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    更新日期:1975-05-01 00:00:00

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    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.68.4.453

    authors: Batch JA,Davies HR,Evans BA,Hughes IA,Patterson MN

    更新日期:1993-04-01 00:00:00

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    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.59.1.71

    authors: Phelan P,Hey E

    更新日期:1984-01-01 00:00:00

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    abstract::The recent famine in Ethiopia has resulted in the dislocation of millions of people. Many of these individuals have moved to refugee camps in Sudan or to feeding centres within Ethiopia. A total of 1325 children up to the age of 15 years were examined by an ophthalmologist in January 1985 at several sites in these two...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.61.11.1100

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    更新日期:1986-11-01 00:00:00

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    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/adc.62.3.253

    authors: Simonoff EA,Stores G

    更新日期:1987-03-01 00:00:00

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    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

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    authors: Behrens R,Lang T,Keller KM,Bindl L,Becker M,Rodeck B,Küster P,Wündisch GF,Stolte M

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    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.63.5.473

    authors: Andrae S,Axelson O,Björkstén B,Fredriksson M,Kjellman NI

    更新日期:1988-05-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1136/adc.87.2.151

    authors: Wraige E,Borzyskowski M

    更新日期:2002-08-01 00:00:00

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    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.81.6.473

    authors: Gove S,Tamburlini G,Molyneux E,Whitesell P,Campbell H

    更新日期:1999-12-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1136/adc.57.6.453

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    更新日期:1982-06-01 00:00:00

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    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/archdischild-2018-316254

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    更新日期:2019-07-01 00:00:00

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    abstract::A 20-year-old woman with untreated homocystinuria was examined when she was 18 weeks' pregnant. Amniocentesis was performed and raised levels of homocystine and methionine were present in the amniotic fluid. Assay of cystathionine synthetase activity in cultured amniotic fluid cells showed the carrier state for homocy...

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    pub_type: 杂志文章

    doi:10.1136/adc.55.9.721

    authors: Kurczynski TW,Muir WA,Fleisher LD,Palomaki JF,Gaull GE,Rassin DK,Abramowsky C

    更新日期:1980-09-01 00:00:00

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    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/adc.67.3.285

    authors: Noble V,Ruggins NR,Everard ML,Milner AD

    更新日期:1992-03-01 00:00:00

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    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/archdischild-2017-313856

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    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.73.4.287

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    更新日期:1995-10-01 00:00:00

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    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.76.3.210

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    更新日期:1997-03-01 00:00:00