Abstract:
:A 20-year-old woman with untreated homocystinuria was examined when she was 18 weeks' pregnant. Amniocentesis was performed and raised levels of homocystine and methionine were present in the amniotic fluid. Assay of cystathionine synthetase activity in cultured amniotic fluid cells showed the carrier state for homocystinuria. An abortion was performed because of the possible adverse effects of continuing the pregnancy both for the mother and the fetus. No pathological abnormality was found in the aborted fetus. Further data are needed to assess the possible teratogenic effects of maternal homocystinuria and the adverse consequences of pregnancy in the affected mother.
journal_name
Arch Dis Childjournal_title
Archives of disease in childhoodauthors
Kurczynski TW,Muir WA,Fleisher LD,Palomaki JF,Gaull GE,Rassin DK,Abramowsky Cdoi
10.1136/adc.55.9.721subject
Has Abstractpub_date
1980-09-01 00:00:00pages
721-3issue
9eissn
0003-9888issn
1468-2044journal_volume
55pub_type
杂志文章abstract::We have measured total work of breathing before and after the inhalation of water, salbutamol, and ipratropium bromide, given as nebulised solutions, in 39 studies on 25 infants with acute, severe bronchiolitis. Twenty minutes after nebulised water, mean work of breathing per minute was increased by 4% and work per li...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章
doi:10.1136/adc.58.4.279
更新日期:1983-04-01 00:00:00
abstract::Thirty seven healthy infants (18 born at full term and 19 preterm) were studied serially with cross sectional and Doppler echocardiography to compare their postnatal circulatory adaptation. Pulmonary artery pressure was assessed by its inverse relationship with the ratio of pulmonary artery time to peak velocity and r...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.65.1_spec_no.24
更新日期:1990-01-01 00:00:00
abstract::We report three cases of Hurler's disease in which glaucoma developed in early childhood. We draw attention to the fact that glaucoma may be a commonly unrecognised early complication of this condition. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.63.9.1091
更新日期:1988-09-01 00:00:00
abstract::Five cases are reported of spontaneous remission of chronic childhood thrombocytopenia four or more years after diagnosis. Other than typical features of chronic idiopathic thrombocytopenic purpura there were no obvious markers predictive of late remission, although a slow progressive recovery was common to four of th...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.68.5.680
更新日期:1993-05-01 00:00:00
abstract::Real time ultrasonography of the pelvic organs was performed on 114 normal premenarcheal girls aged between 2 years and 13 years 11 months. Values were obtained for total uterine length, anteroposterior diameters of the corpus and cervix, corpus/cervix ratio, and uterine and ovarian volumes and the resultant data were...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.60.2.120
更新日期:1985-02-01 00:00:00
abstract:BACKGROUND:Achondroplasia is associated with foramen magnum stenosis (FMS) and significant risk of morbidity and sudden death in infants. A sensitive and reliable method of detecting infants who require decompressive surgery is required. This study aims to describe the incidence and severity of FMS in an unselected, se...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2020-319625
更新日期:2021-02-01 00:00:00
abstract::The study of gastric emptying in the preterm infant has been hampered by the absence of a suitable, valid technique. We have evaluated gastric antral clearance using serial ultrasonic measurement of the antral cross sectional area (ACSA). The study was easy to perform, providing successful results in 15 of 17 low birt...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.69.1_spec_no.32
更新日期:1993-07-01 00:00:00
abstract:AIM:To evaluate the quality of paediatric audits from 1966 to 1999. METHODS:A Medline search was performed using the MeSH terms audit, child, paediatric (and pediatric). Predefined core elements of audit were used as inclusion criteria for entry of an article into this study. These criteria were as follows: (1) an art...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/adc.2004.071381
更新日期:2007-04-01 00:00:00
abstract::We compared the efficacy of the prokinetic agent cisapride with that of Gaviscon (an alginate/alkaline compound) plus Carobel (carob seed flour) in the treatment of gastrooesophageal reflux (GOR). Fifty infants with confirmed GOR received either oral cisapride (0.8 mg/kg/day) or Gaviscon plus Carobel for one month in ...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/adc.67.5.618
更新日期:1992-05-01 00:00:00
abstract:BACKGROUND AND AIMS:The case fatality rate from meningococcal disease (MD) has remained relatively unchanged in the post antibiotic era, with 20-50% of patients who develop shock still dying. In 1992 a new paediatric intensive care unit (PICU) specialising in MD was opened. Educational information was disseminated to l...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.85.5.386
更新日期:2001-11-01 00:00:00
abstract::Serial exercise tests were carried out by 12 children with asthma on two study days. After a control exercise test either nedocromil sodium 4 mg or placebo were given double blind by metered dose inhaler. Highly significant inhibition of exercise induced asthma occurred after nedocromil, lasting for over two hours. ...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章
doi:10.1136/adc.62.4.412
更新日期:1987-04-01 00:00:00
abstract::A survey is reported of infant feeding practice at the time of discharge from a single maternity ward. It is shown that a change in the attitude of nursing staff increased the number of mothers breast feeding their infants and eliminated the practice of giving the infants formula feed complements. This change in attit...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.50.3.165
更新日期:1975-03-01 00:00:00
abstract:BACKGROUND:Cerebral palsy is the commonest cause of severe physical disability in childhood. For many years treatment has centred on the use of physiotherapy and orthotics to overcome the problems of leg spasticity, which interferes with walking and can lead to limb deformity. Intramuscular botulinum toxin (BT-A) offer...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/adc.83.6.481
更新日期:2000-12-01 00:00:00
abstract::We describe a child with primary defect of polymorph bacterial killing associated with systemic lungs erythematosus. We suggest that her autoimmune disease results from chronic bacterial antigen stimulation and propose a hypothetical model linking immunodeficiency with autoimmunity. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.56.5.382
更新日期:1981-05-01 00:00:00
abstract::The variability of cerebral blood flow velocity was measured in 20 very low birthweight infants. The area under the curve of the Doppler frequency spectrum was used and was obtained from the anterior cerebral artery in the infants before and after infusions of plasma or dopamine. Both interventions significantly reduc...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.64.7_spec_no.897
更新日期:1989-07-01 00:00:00
abstract::Eighteen children with pneumocystis carinii pneumonia diagnosed over a period of 16 years at a children's hospital are reviewed. All had an underlying disease, either congenital immunodeficiency or a malignancy. 15 patients were treated, 10 with pentamidine isethionate alone, 2 with both pentamidine and co-trimoxazole...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.52.4.314
更新日期:1977-04-01 00:00:00
abstract::Three children with cystic fibrosis developed steatorrhoea unresponsive to changes in pancreatic supplements. The final diagnoses were chronic giardiasis, stagnant loop syndrome, and Crohn's disease. Refractory intestinal symptoms in cystic fibrosis merit further investigation. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.63.12.1496
更新日期:1988-12-01 00:00:00
abstract::The clinical profile, malignant potential, and management of 17 children with juvenile polyposis (more than five juvenile polyps) were evaluated clinically and endoscopically. Colonoscopy and polypectomy were done three weekly until colonic clearance was achieved, and thereafter two yearly. All polyps were subjected t...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.78.3.264
更新日期:1998-03-01 00:00:00
abstract::Histological examination of the breasts of 26 infants and young children who died suddenly between the ages of 3 weeks and 2 years was performed. The glands were composed of well formed lobules surrounded by dense interlobular stroma, while within the lobules there was looser connective tissue. The lobules contained d...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.63.2.136
更新日期:1988-02-01 00:00:00
abstract:BACKGROUND/AIM:The British Committee for Standards in Haematology currently recommends concomitant splenectomy in children with mild hereditary spherocytosis (HS) undergoing cholecystectomy for symptomatic gallstones. However, splenectomy is associated with a risk of life-threatening infection, particularly in young ch...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2009.178228
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Vanessa is a 34-year-old lawyer married to a police officer. Her first baby was born after a perfect pregnancy and labour until fetal distress necessitated an easy Ventouse extraction late in the second stage. Baby F had normal Apgar scores and weighed 2920 g. This paper records a conversation between Vaness...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2006.101600
更新日期:2007-01-01 00:00:00
abstract::The fetal heart beat, detected by ultrasound, was recorded for five minutes from 934 antenatal women--266 at 30 to 35 weeks' gestation and 718 at 36 to 41 weeks. Episodes of bradycardia < 100/minute ranging from 5-30 seconds' duration occurred in 3 (1.1%) of the former and in 9 (1.3%) of the latter group. Tachycardia ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.55.7.506
更新日期:1980-07-01 00:00:00
abstract:AIM:To determine the association between allergic rhinitis, bottle feeding, non-nutritive sucking habits, and malocclusion in the primary dentition. METHODS:Data were collected on 1160 children aged 4-5 years, who had been longitudinally followed since the age of 4 months, when they were admitted to nurseries in a sub...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2005.088484
更新日期:2006-10-01 00:00:00
abstract::The changes in transcutaneous oxygen tension (TcPO2) during 123 observations of 10 care procedures were compared with the intrinsic variability of the TcPO2 at the time of the procedures. Standard deviations of the TcPO2 were measured by planimetry from continuous recording in undisturbed infants during a 10-minute co...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.58.1.20
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:The number of children admitted to hospital is increasing year on year, with very short-stay admissions doubling in the last decade. Childhood head injury accounts for half a million emergency department attendances in the UK every year. The National Institute for Health and Care Excellence (NICE) has issued...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2015-308615
更新日期:2015-12-01 00:00:00
abstract::Unexpected stability of arterial oxygen and carbon dioxide tensions occurred in infants recovering from respiratory distress syndrome (RDS) on the abrupt withdrawal of CPAP at 6 cmH2O pressure. 30 preterm infants (birthweights 880--3200 g gestational ages 29--38 weeks) were treated at a mean age of 10 hours and for a ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.54.9.722
更新日期:1979-09-01 00:00:00
abstract::Four patients with salt-losing congenital adrenal hyperplasia (CAH) who had stopped mineralocorticoid therapy for several years, showed raised plasma concentrations of 17OH-progesterone and plasma renin activity, despite adequate glucoticoid therapy. One patient was able to reduce urinary sodium excretion when the sod...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.54.5.350
更新日期:1979-05-01 00:00:00
abstract:AIMS:To investigate the differences in perception of quality of life between parents of chronically ill children and paediatricians at diagnosis and follow up. Quality of life was assessed using the (HUI3). METHODS:Longitudinal study (July 1999-January 2002) of 37 paediatricians and 181 parents of patients (children a...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2004.051722
更新日期:2005-05-01 00:00:00
abstract::Congenital haemolytic anaemia in a 14 year old girl was caused by increased red cell membrane cation permeability. Potassium permeability was unusually sensitive to hydrostatic pressure and treatment with N-ethylmaleimide, factors which activate a specific chloride dependent potassium channel in cell membranes. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.58.7.547
更新日期:1983-07-01 00:00:00
abstract:AIMS:To document the patterns of presentation and outcome of severe anticholinesterase insecticide poisoning in children requiring intensive care. METHODS:Retrospective case note review of all 5541 children admitted to the paediatric intensive care unit (PICU) of a university hospital during the 10 years from January ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.86.5.352
更新日期:2002-05-01 00:00:00