Gaviscon and Carobel compared with cisapride in gastro-oesophageal reflux.

Abstract:

:We compared the efficacy of the prokinetic agent cisapride with that of Gaviscon (an alginate/alkaline compound) plus Carobel (carob seed flour) in the treatment of gastrooesophageal reflux (GOR). Fifty infants with confirmed GOR received either oral cisapride (0.8 mg/kg/day) or Gaviscon plus Carobel for one month in a randomised, parallel group study. Parental evaluations, diary scores, and 24 hour lower oesophageal pH recordings before and at the end of each treatment were compared. In the cisapride group 14/26 (53%) were considered better by their parents compared with 19/24 (79%) of those who received Gaviscon plus Carobel. Diary scores, range (0.00-1.00), improved in both groups with the median change being greater in the Gaviscon plus Carobel group (-0.21) than the cisapride group (-0.15). Five of 17 pH variables had significantly improved from baseline in infants who had received cisapride compared with 11/17 in those receiving Gaviscon plus Carobel. However, unpaired analysis of diary and pH data showed no significant differences between the two groups. We conclude that first line treatment of GOR with cisapride is no more effective than conventional treatment with Gaviscon plus Carobel.

journal_name

Arch Dis Child

authors

Greally P,Hampton FJ,MacFadyen UM,Simpson H

doi

10.1136/adc.67.5.618

subject

Has Abstract

pub_date

1992-05-01 00:00:00

pages

618-21

issue

5

eissn

0003-9888

issn

1468-2044

journal_volume

67

pub_type

临床试验,杂志文章,随机对照试验
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    doi:10.1136/adc.58.9.743

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    更新日期:1983-09-01 00:00:00

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    doi:10.1136/adc.65.1.139

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    更新日期:1987-05-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1136/adc.78.4.354

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    更新日期:1998-04-01 00:00:00

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    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.67.10.1286

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    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,随机对照试验

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