Abstract:
:We compared the efficacy of the prokinetic agent cisapride with that of Gaviscon (an alginate/alkaline compound) plus Carobel (carob seed flour) in the treatment of gastrooesophageal reflux (GOR). Fifty infants with confirmed GOR received either oral cisapride (0.8 mg/kg/day) or Gaviscon plus Carobel for one month in a randomised, parallel group study. Parental evaluations, diary scores, and 24 hour lower oesophageal pH recordings before and at the end of each treatment were compared. In the cisapride group 14/26 (53%) were considered better by their parents compared with 19/24 (79%) of those who received Gaviscon plus Carobel. Diary scores, range (0.00-1.00), improved in both groups with the median change being greater in the Gaviscon plus Carobel group (-0.21) than the cisapride group (-0.15). Five of 17 pH variables had significantly improved from baseline in infants who had received cisapride compared with 11/17 in those receiving Gaviscon plus Carobel. However, unpaired analysis of diary and pH data showed no significant differences between the two groups. We conclude that first line treatment of GOR with cisapride is no more effective than conventional treatment with Gaviscon plus Carobel.
journal_name
Arch Dis Childjournal_title
Archives of disease in childhoodauthors
Greally P,Hampton FJ,MacFadyen UM,Simpson Hdoi
10.1136/adc.67.5.618subject
Has Abstractpub_date
1992-05-01 00:00:00pages
618-21issue
5eissn
0003-9888issn
1468-2044journal_volume
67pub_type
临床试验,杂志文章,随机对照试验abstract:AIM:Ketamine is used for post-operative analgesia. There has been recent disruption in it's supply. It is usually prescribed by patient's weight (3 mg/kg in 50 ml 0.9% saline) at a rate of 1-5 ml/hr (1-5 microgram/kg/minute). To conserve ketamine supplies our policy was changed to a concentrated "standardised" concentr...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2016-311535.12
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Medium chain acyl-CoA dehydrogenase (MCAD) deficiency is a common disorder of fatty acid oxidation in north west Europe. It is very variable in its clinical consequences and is believed to be considerably underdiagnosed. OBJECTIVE:To investigate the diagnosis and outcome of MCAD deficiency in the UK. METHO...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.79.2.116
更新日期:1998-08-01 00:00:00
abstract::A 10 1/2 year old boy presented with raised intracranial pressure and precocious puberty caused by a human chorionic gonadotrophin (HCG) secreting pineal germinoma. After craniospinal irradiation he improved clinically and his HCG concentration fell to an undetectable value. Two years later he remains well. Pineal ger...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.58.9.743
更新日期:1983-09-01 00:00:00
abstract::Renal candidal bezoar is uncommonly encountered in neonatal intensive care. An affected neonate who improved only after surgical removal of obstructive fungus from the renal pelvis and local irrigation with amphotericin B is described. The need for early consideration of surgical intervention is stressed. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.67.1_spec_no.63
更新日期:1992-01-01 00:00:00
abstract::Data from the Glasgow Register of Congenital Malformations were used to investigate the epidemiology of congenital facial clefts over the period 1974-85. Facial clefts were registered in 247 infants representing a prevalence of 1.56 per 1000 total births. Cleft palate was more common than cleft lip, with cleft lip and...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.62.7.717
更新日期:1987-07-01 00:00:00
abstract::A boy with the dysmorphic features of Noonan's syndrome and pulmonary valve stenosis who had evidence of hypoparathyroidism and abnormal T lymphocyte numbers in the neonatal period is reported. He had a normal karyotype but molecular analysis revealed a submicroscopic deletion within chromosome 22q11, the region delet...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.68.2.187
更新日期:1993-02-01 00:00:00
abstract::Zinc absorption was measured in 37 children with malnutrition using the oral zinc tolerance test (22.5 mg elementary zinc) and the results compared with those of a group of healthy control subjects. The increase in plasma zinc was significantly lower in patients with marasmic kwashiorkor than in the control group. The...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.64.11.1608
更新日期:1989-11-01 00:00:00
abstract::An epidemiological study of disease in a geographically identified population of 250 children is reported. 22% had not seen their general practitioner (GP) at all in the past year, while 20% had seen him four times or more. The vast majority of these visits were because of an infective illness; and developmental and b...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.51.11.848
更新日期:1976-11-01 00:00:00
abstract::Quantitative biochemical criteria for lung growth and maturation were compared with the histological appearances in hypoplastic lungs from 20 fetuses and newborn infants. Cases associated with oligohydramnios showed a characteristic series of changes with narrow airways, retardation of epithelial and interstitial grow...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.56.8.606
更新日期:1981-08-01 00:00:00
abstract::Twenty five patients with encephalitis were studied prospectively, and their clinical and virological features compared with outcome. Among 22 patients with laboratory confirmation of virus infection, evidence of direct effect on the central nervous system by the virus occurred significantly more often both in those w...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.62.11.1156
更新日期:1987-11-01 00:00:00
abstract:AIMS:To test the hypothesis that oxygen free radicals are mediators of excessive protein permeability in steroid responsive nephrotic syndrome. DESIGN:Case control study. SUBJECTS: PATIENTS:20 children with steroid responsive nephrotic syndrome; controls: 20 children admitted for elective surgery. SETTING:The paedi...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.82.1.76
更新日期:2000-01-01 00:00:00
abstract::Diabetic control in 88 children attending three general paediatric clinics was compared prospectively over one year with that of 89 children attending a specialist paediatric diabetic clinic. Glycated haemoglobin (HbA1) concentration and days admitted were significantly lower in the group attending the specialist clin...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.65.1.139
更新日期:1990-01-01 00:00:00
abstract::There is little high quality evidence on which to base the management of bone and joint infections in children. This pragmatic practice note aims to provide a consensus framework of best current practice prior to the availability of data from large national randomised controlled trials. For straightforward infection i...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/archdischild-2011-301089
更新日期:2012-06-01 00:00:00
abstract::This review focuses on recent advances of topical interest regarding the diagnosis and treatment of common causes of bacterial meningitis occurring in children beyond the neonatal period. Tuberculous meningitis is beyond the scope of this review. ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,评审
doi:10.1136/adc.88.7.615
更新日期:2003-07-01 00:00:00
abstract::Diabetes mellitus was observed in 29 of 448 patients with thalassaemia major attending seven Italian centres. Twelve patients, at onset of clinical diabetes, presented with an asymptomatic glycosuria, 13 with ketosis, and four with ketoacidosis. All were diagnosed after 1979, at a mean age of 17 years. Mean age at dia...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.63.1.58
更新日期:1988-01-01 00:00:00
abstract::A child with chronic diarrhoea since birth responded to the prostaglandin synthetase inhibitors aspirin and indomethacin. During a period without treatment, raised levels of prostaglandins F2alpha and E2 were observed. No source for these raised prostaglandins was shown, and it is suggested that she may have an inborn...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.52.10.800
更新日期:1977-10-01 00:00:00
abstract:BACKGROUND:Asthma is among the most common chronic diseases in childhood and is steadily increasing in prevalence. Better characterisation of factors that determine the risk of hospitalisation for atopic asthma in childhood may help design prevention programmes and improve our understanding of disease pathobiology. Thi...
journal_title:Archives of disease in childhood
pub_type: 杂志文章,多中心研究
doi:10.1136/adc.2006.106278
更新日期:2007-04-01 00:00:00
abstract:AIMS:To study how respiratory symptoms reported by children, with or without spirometry, could help to discriminate those with asthma from those without. METHODS:Respiratory symptoms (frequent cough, frequent phlegm, and wheezing) reported by 1646 schoolchildren (aged 8-12 years) in a respiratory questionnaire and the...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2003.033688
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND:In volume guarantee ventilation with the Dräger Babylog 8000 ventilator, inspiratory and expiratory flows are monitored and the expiratory tidal volume calculated following each inflation. The pressure for the next inflation is modified to ensure the expired tidal volume is close to the set value. AIM:To in...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.2004.061390
更新日期:2005-08-01 00:00:00
abstract:OBJECTIVE:Early diagnosis and treatment initiation are important factors for successful treatment of mucopolysaccharidosis type I (MPS I). The purpose of this observational study was to assess whether age at diagnosis and time to first treatment for individuals with MPS I have improved over the last 15 years. STUDY DE...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2020-319040
更新日期:2020-11-02 00:00:00
abstract::We describe a laboratory test which is useful in determining whether deafness is due to intrauterine rubella. The study group consisted of 8 deaf patients with proved intrauterine rubella, 12 patients with familial deafness, and 17 controls. Blood was taken at time 0 from all of them. All the deaf children and 5 contr...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.58.5.327
更新日期:1983-05-01 00:00:00
abstract::A quantitative morphological assessment was carried out of the cellularity and staining properties of the cells of the layers of the human cerebellar cortex, both in the normal child and in 41 children suffering from a series of disorders including mental retardation. A computerized image analyser and highly standardi...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.51.12.964
更新日期:1976-12-01 00:00:00
abstract::At the Birmingham Maternity Hospital the mean cost of caring for surviving infants who require neonatal intensive care ranges from approximately pounds 2500 (for infants above 1500 g birthweight), to pounds 5500 (for infants 1000 to 1499 g birthweight), to pounds 10 000 (for infants less than 1000 g birthweight). The ...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.59.11.1064
更新日期:1984-11-01 00:00:00
abstract:AIMS:Out-of-hospital sudden cardiac arrest (SCA) is a rare but devastating event in children and adolescents. The risk is assumed to be higher in children with congenital heart defects (CHDs) than in healthy individuals. The aim of the present study was to investigate the rate of and survival after out-of-hospital card...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/archdischild-2017-312621
更新日期:2018-01-01 00:00:00
abstract::A child with idiopathic pulmonary haemosiderosis for three years required three monthly transfusions. Circulating avian, gliadin, and reticulin antibodies suggested the diagnosis of gluten enteropathy, and jejunal biopsy showed subtotal villous atrophy. During 15 months on a gluten free diet his growth and behaviour i...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.62.5.513
更新日期:1987-05-01 00:00:00
abstract::Skinfold standards provide a useful indication of subcutaneous fat. To evaluate skinfold thickness of 252 Cambridge infants over the first 2 years of age, SD scores relative to the Tanner standards were calculated, taking account of skewness in the standards. Cambridge SD scores were low, varying according to age from...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.78.4.354
更新日期:1998-04-01 00:00:00
abstract::Reference range for head circumference on the Tanner charts do not go beyond age 16. In this study the head circumference and heights of 354 adults in two British centres were measured. The centile charts constructed from these measurements show that adult head circumference is related to height. The mean head circumf...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.67.10.1286
更新日期:1992-10-01 00:00:00
abstract::Forty four children with acute bronchiolitis were given twice daily chest physiotherapy in addition to standard supportive measures and were compared with 46 controls who were not given physiotherapy. There was no clinically discernable benefit on the course of their illness. ...
journal_title:Archives of disease in childhood
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/adc.60.11.1078
更新日期:1985-11-01 00:00:00
abstract:AIM:To test the hypothesis that overall intelligence quotient (IQ) is decreased in patients with Aarskog syndrome. METHODS:21 boys under 17 years of age with a confirmed clinical diagnosis of Aarskog syndrome were assessed using the Griffiths mental development scales and the British ability scales. RESULTS:IQ ranged...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.79.4.359
更新日期:1998-10-01 00:00:00
abstract::Polygraphic recordings were made on 10 preterm infants recovering from respiratory distress syndrome and 12 healthy preterm control infants at 40, 52, and 64 weeks' conceptual age to study the influence of respiratory distress syndrome on the development of the sleep apnoea profile. Two significant differences were fo...
journal_title:Archives of disease in childhood
pub_type: 杂志文章
doi:10.1136/adc.60.6.547
更新日期:1985-06-01 00:00:00