Living at high altitude and risk of hospitalisation for atopic asthma in children: results from a large prospective birth-cohort study.

Abstract:

BACKGROUND:Asthma is among the most common chronic diseases in childhood and is steadily increasing in prevalence. Better characterisation of factors that determine the risk of hospitalisation for atopic asthma in childhood may help design prevention programmes and improve our understanding of disease pathobiology. This study will focus on the altitude of residence. METHODS:This is an ongoing prospective birth-cohort study that enrolled all live-born infants in the Tyrol. Between 1994 and 1999, baseline data were collected for 33 808 infants. From 2000 to 2005, all children hospitalised for atopic asthma at the age of > or =6 years (n = 305) were identified by a careful search of hospital databases. Disease status was ascertained from the typical medical history, a thorough examination and proof of atopy. RESULTS:Living at higher altitude was associated with an enhanced risk of hospitalisation for atopic asthma (multivariate RRs (95% confidence interval 2.08 (1.45 to 2.98) and 1.49 (1.05 to 2.11) for a comparison between altitude categories > or =1200 m and 900-1199 m versus <900 m; p<0.001). This finding applied equally to hospital admissions in spring, summer, autumn and winter. When altitude of residence was analysed as a continuous variable, the risk for asthma hospitalisation increased by 7% for each 100-m increase in altitude (p = 0.013). CONCLUSIONS:This large prospective study shows a significant association between the risk of hospitalisation for atopic asthma and altitude of residence between 450 and 1800 m. The underlying mechanisms remain to be elucidated, but it is tempting to speculate about a role for altitude characteristics such as the decline in outdoor temperature and air humidity and increase in ozone levels, which may trigger airway hyper-responsiveness and attenuate lung function.

journal_name

Arch Dis Child

authors

Kiechl-Kohlendorfer U,Horak E,Mueller W,Strobl R,Haberland C,Fink FM,Schwaiger M,Gutenberger KH,Reich H,Meraner D,Kiechl S

doi

10.1136/adc.2006.106278

subject

Has Abstract

pub_date

2007-04-01 00:00:00

pages

339-42

issue

4

eissn

0003-9888

issn

1468-2044

pii

92/4/339

journal_volume

92

pub_type

杂志文章,多中心研究
  • Hospital morbidity pattern in children under 1 year of age born in Sheffield 1975-6.

    abstract::The morbidity pattern, based on hospital admissions for a complete year's cohort of all children born in Sheffield 1975-6, was studied. In many children the diagnosis given on admission had changed by the time they were discharged from hospital. About one-quarter of children under age 6 months were admitted for social...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.56.1.36

    authors: Lloyd B,Pursall E,Emery JL

    更新日期:1981-01-01 00:00:00

  • Is late walking a marker of morbidity? Steering Committee, Oxford Region Child Development Project.

    abstract::We identified 410 infants who were not walking independently by the age of 18 months from among a geographically defined population of 4275 infants who either were born weighing less than 2000 g or had needed admission to the special care nursery in the neonatal period. The outcome of the late walkers was ascertained ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.65.5.486

    authors: Johnson A,Goddard O,Ashurst H

    更新日期:1990-05-01 00:00:00

  • Differential avian and human tuberculin skin testing in non-tuberculous mycobacterial infection.

    abstract:OBJECTIVE:To determine the sensitivity of differential avian and human delayed-type hypersensitivity skin testing in the diagnosis of non-tuberculous mycobacterial lymphadenitis. METHOD:Retrospective review of all patients with culture proved non-tuberculous mycobacterial lymph node infections who also had differentia...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.80.4.377

    authors: Daley AJ,Isaacs D

    更新日期:1999-04-01 00:00:00

  • Age specific xerophthalmia rates among displaced Ethiopians.

    abstract::The recent famine in Ethiopia has resulted in the dislocation of millions of people. Many of these individuals have moved to refugee camps in Sudan or to feeding centres within Ethiopia. A total of 1325 children up to the age of 15 years were examined by an ophthalmologist in January 1985 at several sites in these two...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.61.11.1100

    authors: Pizzarello LD

    更新日期:1986-11-01 00:00:00

  • Use of complementary treatment by those hospitalised with acute illness.

    abstract:AIM:To determine the frequency of use of complementary treatment and measure its impact on clinical outcomes in a hospitalised general paediatric population. METHODS:A population based random sample of children admitted to the general paediatric service at a metropolitan children's hospital in Auckland, New Zealand fr...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.81.2.133

    authors: Armishaw J,Grant CC

    更新日期:1999-08-01 00:00:00

  • Height and weight pattern up to 20 years after treatment for acute lymphoblastic leukaemia.

    abstract:OBJECTIVE:To assess height and body mass index standard deviation scores up to 20 years after treatment for acute lymphoblastic leukaemia (ALL). SUBJECTS AND METHODS:Height and body mass index standard deviation scores were measured in 33 patients (14 boys and 19 girls) with childhood ALL at diagnosis, after the end o...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.79.2.161

    authors: Birkebaek NH,Clausen N

    更新日期:1998-08-01 00:00:00

  • Intestinal disease in cystic fibrosis.

    abstract::Three children with cystic fibrosis developed steatorrhoea unresponsive to changes in pancreatic supplements. The final diagnoses were chronic giardiasis, stagnant loop syndrome, and Crohn's disease. Refractory intestinal symptoms in cystic fibrosis merit further investigation. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.63.12.1496

    authors: Baxter PS,Dickson JA,Variend S,Taylor CJ

    更新日期:1988-12-01 00:00:00

  • Sonographic long-term study: paediatric growth charts for single kidneys.

    abstract:AIMS:To explore the clinical course of children with "single kidney" (defined as either a solitary or single functioning kidney) with reference to renal function (glomerular filtration rate (GFR) and proteinuria), body height and particularly sonomorphological features. PATIENTS AND METHODS:This retrospective monocent...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2008.153601

    authors: Spira EM,Jacobi C,Frankenschmidt A,Pohl M,von Schnakenburg C

    更新日期:2009-09-01 00:00:00

  • Sustained release theophylline in nocturnal asthma.

    abstract::Twice daily sustained release theophylline gave satisfactory steady serum theophylline concentrations in asthmatic children aged 7 to 14 years. The children showed improvement in symptoms, less frequent waking at night, reduced use of beta agonist inhalers, and improved early morning peak flows while being treated wit...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/adc.59.12.1159

    authors: Elias-Jones AC,Higenbottam TW,Barnes ND,Godden DJ

    更新日期:1984-12-01 00:00:00

  • Use of DNA estimation for growth assessment in normal and hypoplastic fetal lungs.

    abstract::Total DNA was estimated in the lungs of 80 fetuses and newborn infants varying in gestation from 14 weeks to term. In fetuses of appropriate weight for gestational age total lung DNA increased at a constant rate from about 35 mg at 17 weeks' gestation to 480 mg at term. The lungs of immature fetuses were heavier and c...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.56.8.601

    authors: Wigglesworth JS,Desai R

    更新日期:1981-08-01 00:00:00

  • Inappropriate oral formulations and information in paediatric trials.

    abstract::Previously, quality of formulations information provided for oral medications used in paediatric clinical trials published in 10 highly cited journals between 2002 and 2004 raised concerns. This short report explores if there was any subsequent improvement on how the formulations used in trials involving children <12 ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2009.175661

    authors: Pandit S,Shah U,Kirby DJ,Nunn T,Tuleu C

    更新日期:2010-09-01 00:00:00

  • Penicillin-resistant pneumococcus and risk of treatment failure in pneumonia.

    abstract:OBJECTIVE:To determine whether the presence of in vitro penicillin-resistant Streptococcus pneumoniae increases the risk of clinical failure in children hospitalised with severe pneumonia and treated with penicillin/ampicillin. DESIGN:Multicentre, prospective, observational study. SETTING:12 tertiary-care centres in ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/adc.2006.111625

    authors: Cardoso MR,Nascimento-Carvalho CM,Ferrero F,Berezin EN,Ruvinsky R,Camargos PA,Sant'anna CC,Brandileone MC,de Fátima P March M,Feris-Iglesias J,Maggi RS,Benguigui Y,CARIBE Group.

    更新日期:2008-03-01 00:00:00

  • Children and adolescents' experiences of primary lymphoedema: semistructured interview study.

    abstract:BACKGROUND:Congenital lymphoedema is a lifelong condition that has detrimental physical and psychosocial outcomes for young patients and burdensome treatment responsibilities that may hamper patients' motivation for self-management. There is limited research from the perspective of young people with primary lymphoedema...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/archdischild-2017-313856

    authors: Hanson CS,Newsom J,Singh-Grewal D,Henschke N,Patterson M,Tong A

    更新日期:2018-07-01 00:00:00

  • Platelet thromboxane B2 production in neonatal pulmonary hypertension.

    abstract::Production of platelet thromboxane B2, a stable metabolite of thromboxane A2, was measured in seven newborn infants with pulmonary hypertension during the first day of life. Platelet thromboxane B2 production was significantly lower than in 12 healthy controls but did not correlate with simultaneous blood gas values. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.62.2.195

    authors: Kääpä P

    更新日期:1987-02-01 00:00:00

  • Inhaled budesonide for chronic wheezing under 18 months of age.

    abstract::The role of budesonide in controlling chest symptoms in infants was assessed. It was administered from a metered dose inhaler into a large volume spacer (Nebuhaler) with attached Laerdal mask. Twenty nine infants were recruited into a double blind crossover trial. Five defaulted. The remaining 24 (mean age 11 months) ...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/adc.67.3.285

    authors: Noble V,Ruggins NR,Everard ML,Milner AD

    更新日期:1992-03-01 00:00:00

  • Pulmonary haemosiderosis and gluten.

    abstract::A child with idiopathic pulmonary haemosiderosis for three years required three monthly transfusions. Circulating avian, gliadin, and reticulin antibodies suggested the diagnosis of gluten enteropathy, and jejunal biopsy showed subtotal villous atrophy. During 15 months on a gluten free diet his growth and behaviour i...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.62.5.513

    authors: Reading R,Watson JG,Platt JW,Bird AG

    更新日期:1987-05-01 00:00:00

  • Female genital mutilation: what every paediatrician should know.

    abstract::Female genital mutilation (FGM) is almost always performed on children and consequently paediatricians should have a central role in the detection and prevention of FGM. FGM has no health benefits and can cause lifelong damage to physical and psychological health. Extensive migration of FGM practising communities mean...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/archdischild-2014-307234

    authors: Creighton SM,Hodes D

    更新日期:2016-03-01 00:00:00

  • Injuries and the risk of disability in teenagers and young adults.

    abstract:OBJECTIVE:To examine the risk of disability from unintentional injury in teenagers and young adults. METHODS:Analyses of data from the National Child Development Study, a follow up study of 98% of all children born in England, Scotland, and Wales in one week in March, 1958. In 1981, 12,537 study participants, 76% of t...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.75.2.156

    authors: Barker M,Power C,Roberts I

    更新日期:1996-08-01 00:00:00

  • Volume guarantee ventilation, interrupted expiration, and expiratory braking.

    abstract:BACKGROUND:In volume guarantee ventilation with the Dräger Babylog 8000 ventilator, inspiratory and expiratory flows are monitored and the expiratory tidal volume calculated following each inflation. The pressure for the next inflation is modified to ensure the expired tidal volume is close to the set value. AIM:To in...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2004.061390

    authors: McCallion N,Lau R,Dargaville PA,Morley CJ

    更新日期:2005-08-01 00:00:00

  • Problems of differentiation between epilepsy and non-epileptic paroxysmal events in the first year of life.

    abstract::Twenty two babies under 1 year old were referred for evaluation of suspected epileptic seizures. Nine were found to have epilepsy. In the other 13--all developing normally, aged up to 10 months--the spells were non-epileptic paroxysmal events (NEPE). They consisted of five patterns of movement: (1) eye blinking; (2) '...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.73.4.342

    authors: Shuper A,Mimouni M

    更新日期:1995-10-01 00:00:00

  • Short stay facilities: the future of efficient paediatric emergency services.

    abstract::Many children admitted to hospital can stay for 24 hours or less. Short stay facilities offer such children rapid stabilisation and early discharge with considerable financial saving. A 12 month study was completed in which data were collected from the children's emergency annex (CEA) at Westmead Hospital in Sydney's ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.74.4.309

    authors: Browne GJ,Penna A

    更新日期:1996-04-01 00:00:00

  • Optic nerve hypoplasia: associations and management.

    abstract::Since its first description optic nerve hypoplasia has been identified with increasing frequency, and a range of associated problems have been described. The major neurological and endocrine associations are well established, but those factors that predispose to the development of optic nerve hypoplasia remain unclear...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.65.1.103

    authors: Roberts-Harry J,Green SH,Willshaw HE

    更新日期:1990-01-01 00:00:00

  • Late outcomes in children with Langerhans cell histiocytosis.

    abstract:INTRODUCTION:Langerhans cell histiocytosis (LCH) is a rare disease with diverse clinical courses. Despite improvement in survival outcomes in the recent decades, sequelae of the disease remain a concern. This study aimed to provide information on the long-term outcomes in patients with LCH, particularly on the sequelae...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2016-312185

    authors: Chow TW,Leung WK,Cheng FWT,Kumta SM,Chu WCW,Lee V,Shing MMK,Li CK

    更新日期:2017-09-01 00:00:00

  • Lung function after allogeneic bone marrow transplantation for leukaemia or lymphoma.

    abstract::Longitudinal data were analysed on the lung function of 25 of 29 survivors of childhood leukaemia or lymphoma, who had been conditioned with cyclophosphamide and total body irradiation before allogeneic bone marrow transplantation, to test whether children are particularly vulnerable to pulmonary damage after transpla...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.74.5.432

    authors: Nysom K,Holm K,Hesse B,Ulrik CS,Jacobsen N,Bisgaard H,Hertz H

    更新日期:1996-05-01 00:00:00

  • Pharmacokinetics of paracetamol after cardiac surgery.

    abstract::Plasma concentration was measured after rectal and nasogastric administration of paracetamol 15 mg/kg to 28 febrile children aged between 9 days to 7 years who had undergone cardiac surgery. After equivalent doses, rectal administration in neonates and children on the first postoperative day was found to produce plasm...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章

    doi:10.1136/adc.65.9.971

    authors: Hopkins CS,Underhill S,Booker PD

    更新日期:1990-09-01 00:00:00

  • Protein restriction in chronic renal failure.

    abstract::The aim of the study was to investigate the effect of a protein restricted diet on renal function and growth of children with chronic renal failure. In a multicentre prospective study 56 children (aged 2-18 years) with chronic renal failure were randomly assigned to the protein restricted (0.8-1.1 g/kg/day) or the con...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/adc.68.3.371

    authors: Kist-van Holthe tot Echten JE,Nauta J,Hop WC,de Jong MC,Reitsma-Bierens WC,Ploos van Amstel SL,van Acker KJ,Noordzij CM,Wolff ED

    更新日期:1993-03-01 00:00:00

  • Pregnancy in phenylketonuria: dietary treatment aimed at normalising maternal plasma phenylalanine concentration.

    abstract::The transport characteristics of the placenta, which favour higher phenylalanine concentrations in the fetus than in the mother, and regression data of head circumference at birth against phenylalanine concentration at conception in maternal phenylketonuria (PKU), suggest that treatment of maternal PKU should ideally ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.66.11.1346

    authors: Thompson GN,Francis DE,Kirby DM,Compton R

    更新日期:1991-11-01 00:00:00

  • Syncope in childhood.

    abstract::Syncope in childhood is very common. The vast majority of episodes are benign, and are due to neurocardiogenic syncope. Only a minority are due to something potentially more serious or life threatening. The diagnosis and differentiation of benign from more serious causes of syncope is made primarily by the history. In...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/adc.88.4.350

    authors: McLeod KA

    更新日期:2003-04-01 00:00:00

  • Disseminated intravascular clotting in kwashiorkor.

    abstract::The role of disseminated intravascular clotting (DIC) in the pathogenesis of the bleeding diathesis kwashiorkor was investigated in 22 patients. According to the severity of the clinical and haematological findings, two grades of DIC were observed. A severe grade of DIC was shown in 6 cases (5 fatal) presenting with ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.50.4.308

    authors: Hassanein EA,Tankovsky I

    更新日期:1975-04-01 00:00:00

  • Protracted diarrhoea in infancy. Analysis of 82 cases with particular reference to diagnosis and management.

    abstract::Eighty-two cases of protracted diarrhoea in infancy presenting over a 6-year period have been analysed, with particular reference to diagnosis and management. The patients fell into 1 of 2 categories according to whether a specific diagnosis was established or not. A diagnosis (category 1) was established in 59 (72%),...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.52.8.597

    authors: Larcher VF,Shepherd R,Francis DE,Harries JT

    更新日期:1977-08-01 00:00:00