Inhaled budesonide for chronic wheezing under 18 months of age.

Abstract:

:The role of budesonide in controlling chest symptoms in infants was assessed. It was administered from a metered dose inhaler into a large volume spacer (Nebuhaler) with attached Laerdal mask. Twenty nine infants were recruited into a double blind crossover trial. Five defaulted. The remaining 24 (mean age 11 months) were assessed for the tolerance of the device, adverse effects, treatment failures, parental opinion, and daily symptom and treatment records. Twenty tolerated the modified Nebuhaler. One developed meningitis on placebo. Two experienced exacerbations on placebo. Eleven of 18 parents whose children completed the maximum treatment preferred budesonide to placebo and one preferred placebo. Mean symptom scores on budesonide were better than on placebo for the 15 children with complete symptom records. Fewer bronchodilator doses were used while taking budesonide. Our findings indicate that budesonide given in this way is an effective treatment for infants who may need prophylaxis for their wheezing.

journal_name

Arch Dis Child

authors

Noble V,Ruggins NR,Everard ML,Milner AD

doi

10.1136/adc.67.3.285

subject

Has Abstract

pub_date

1992-03-01 00:00:00

pages

285-8

issue

3

eissn

0003-9888

issn

1468-2044

journal_volume

67

pub_type

临床试验,杂志文章,随机对照试验
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    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.50.3.243

    authors: Gaze H,Murphy GM,Nelson R,Corkery JJ,Anderson CM

    更新日期:1975-03-01 00:00:00

  • Clinical significance of cough and wheeze in the diagnosis of asthma.

    abstract:OBJECTIVES:(1) To determine the prevalence of cough, wheeze, and breathlessness, both as single symptoms and in combination, in primary schoolchildren and their relation to doctor diagnosed asthma. (2) To identify in areas with different levels of dust pollution whether questionnaire reported 'cough alone' (without whe...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.75.6.489

    authors: Kelly YJ,Brabin BJ,Milligan PJ,Reid JA,Heaf D,Pearson MG

    更新日期:1996-12-01 00:00:00

  • Maternal insecurity and failure to thrive in Asian children.

    abstract::Four Asian babies were investigated because they failed to thrive. In all four cases the failure to thrive was a result of the mother's social isolation and inability to communicate, and to the father's refusal to accept that there was a problem in the family. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.64.3.369

    authors: Fenton TR,Bhat R,Davies A,West R

    更新日期:1989-03-01 00:00:00

  • Socioeconomic inequalities in risk of congenital anomaly.

    abstract:AIMS:To investigate socioeconomic inequalities in the risk of congenital anomalies, focusing on risk of specific anomaly subgroups. METHODS:A total of 858 cases of congenital anomaly and 1764 non-malformed control births were collected between 1986 and 1993 from four UK congenital malformation registers, for the purpo...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/adc.82.5.349

    authors: Vrijheid M,Dolk H,Stone D,Abramsky L,Alberman E,Scott JE

    更新日期:2000-05-01 00:00:00

  • Effect of tracheobronchial suction on respiratory resistance in intubated preterm babies.

    abstract::Measurements of the resistance, time constant, and compliance of the respiratory system were made in 25 mechanically ventilated, preterm babies on 32 occasions, using the single breath technique. Patients were classified according to the level of respiratory resistance by reference to a population of 36 babies studied...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.61.12.1178

    authors: Prendiville A,Thomson A,Silverman M

    更新日期:1986-12-01 00:00:00

  • Juvenile polyposis in a tropical country.

    abstract::The clinical profile, malignant potential, and management of 17 children with juvenile polyposis (more than five juvenile polyps) were evaluated clinically and endoscopically. Colonoscopy and polypectomy were done three weekly until colonic clearance was achieved, and thereafter two yearly. All polyps were subjected t...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.78.3.264

    authors: Poddar U,Thapa BR,Vaiphei K,Rao KL,Mitra SK,Singh K

    更新日期:1998-03-01 00:00:00

  • Urinary saturation and nephrocalcinosis in preterm infants: effect of parenteral nutrition.

    abstract::Urinary lithogenic and inhibitory factors were studied in 27 preterm infants; 16 had total parenteral nutrition (TPN) and 11 had breastmilk with an additional glucose-sodium chloride infusion. Urines were collected for 24 hours on day 2 (period A), day 3 (B), and once between days 4 and 10 (C). Urinary calcium oxalate...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.69.3_spec_no.299

    authors: Hoppe B,Hesse A,Neuhaus T,Fanconi S,Forster I,Blau N,Leumann E

    更新日期:1993-09-01 00:00:00

  • Ultrastructural abnormalities of bronchial cilia in children with recurrent airway infections and bronchiectasis.

    abstract::Anomalies of the bronchial cilia were studied in 5 children with recurrent pulmonary infections. Case 1 had Kartagener's syndrome and an absence of the inner and outer dynein arms in most cilia, although a few shortened and even some normal arms could be seen. Cases 2 and 3 had unilateral bronchiectasis without family...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.56.12.929

    authors: Corbeel L,Cornillie F,Lauweryns J,Boel M,van den Berghe G

    更新日期:1981-12-01 00:00:00

  • Incidence of insulin dependent diabetes mellitus in Karachi, Pakistan.

    abstract:OBJECTIVES:To determine the incidence of insulin dependent diabetes mellitus (IDDM) among children aged up to 16 years residing in the city of Karachi, Pakistan, during the five years from 1989 to 1993. DESIGN:Retrospective study of incidence using hospital and clinic records. SETTING:The city of Karachi, Pakistan. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.76.2.121

    authors: Staines A,Hanif S,Ahmed S,McKinney PA,Shera S,Bodansky HJ

    更新日期:1997-02-01 00:00:00

  • Lived experience of Silver-Russell syndrome: implications for management during childhood and into adulthood.

    abstract:OBJECTIVE:There is limited information on the psychosocial impact of growing up with Silver-Russell syndrome (SRS), characterised by slow growth in utero leading to short stature in adulthood. Such information could aid families in making difficult treatment decisions and guide management strategies for health professi...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2018-314952

    authors: Ballard LM,Jenkinson E,Byrne CD,Child JC,Davies JH,Inskip H,Lokulo-Sodipe O,Mackay DJG,Wakeling EL,Temple IK,Fenwick A

    更新日期:2019-01-01 00:00:00

  • Parental food allergy information needs: a qualitative study.

    abstract:OBJECTIVE:To examine information needs and preferences of parents regarding food allergy. DESIGN:Qualitative study including in-depth semi-structured interviews and focus group discussions. Data were audio-recorded, transcribed verbatim and analysed using the constant comparative method, aided by participant checking ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究

    doi:10.1136/adc.2006.114975

    authors: Hu W,Grbich C,Kemp A

    更新日期:2007-09-01 00:00:00

  • Polyethylene glycol 3350 plus electrolytes for chronic constipation in children: a double blind, placebo controlled, crossover study.

    abstract:OBJECTIVES:To assess the efficacy and safety of polyethylene glycol 3350 plus electrolytes (PEG+E) for the treatment of chronic constipation in children. DESIGN:Randomised, double blind, placebo controlled crossover trial, with two 2-week treatment periods separated by a 2-week placebo washout. SETTING:Six UK paediat...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/adc.2006.115493

    authors: Thomson MA,Jenkins HR,Bisset WM,Heuschkel R,Kalra DS,Green MR,Wilson DC,Geraint M

    更新日期:2007-11-01 00:00:00

  • Psychiatric adverse drug reactions in the paediatric population.

    abstract:OBJECTIVE:Due to lack of information on drug use in children, many drugs are used off-label in paediatrics. Increased knowledge of adverse drug reactions (ADRs) would enable a better risk-benefit analysis. Our aim was to characterise drugs causing psychiatric ADRs in children by conducting a descriptive study based on ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2019-317933

    authors: Ekhart C,Vries T,Hunsel FV

    更新日期:2020-08-01 00:00:00

  • Gluten challenge in treated coeliac disease.

    abstract::Thirty-two children with a past diagnosis of coeliac disease were reinvestigated by means of gluten challenge. They had received a gluten-free diet for a mean period of 6-5 years (range 0-25-11-0) before gluten challenge, and had a mean age of 9-9 years (range 3-0-15-3) at the onset of challenge. Small intestinal biop...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.53.6.449

    authors: Packer SM,Charlton V,Keeling JW,Risdon RA,Ogilvie D,Rowlatt RJ,Larcher VF,Harries JT

    更新日期:1978-06-01 00:00:00

  • Hypochondroplasia.

    abstract::Clinical, radiological, and genetic features are described in 3 patients with hypochondroplasia. Early recognition of this disorder is possible from the abnormal body proportions with short limbs and lumbar lordosis without facial stigmata of achondroplasia. Radiological confirmation is possible provided a full skelet...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.53.11.868

    authors: Glasgow JF,Nevin NC,Thomas PS

    更新日期:1978-11-01 00:00:00

  • Cystic fibrosis mortality in England and Wales and in Victoria, Australia 1976-80.

    abstract::Mortality from cystic fibrosis throughout childhood is more than twice as high in England and Wales than it is in the State of Victoria, Australia. Possible reasons for this difference are reviewed. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.59.1.71

    authors: Phelan P,Hey E

    更新日期:1984-01-01 00:00:00

  • Investigation of daytime wetting: when is spinal cord imaging indicated?

    abstract:BACKGROUND:Most children with daytime wetting have detrusor instability. A minority have neuropathic vesicourethral dysfunction. The commonest cause is spina bifida, which may be closed. Clinical features suggestive of closed spina bifida include cutaneous, neuro-orthopaedic or lumbosacral spine x ray abnormalities, im...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.87.2.151

    authors: Wraige E,Borzyskowski M

    更新日期:2002-08-01 00:00:00

  • Therapeutic efficacy and safety of ACE inhibitors in the hypertensive paediatric population: a review.

    abstract:PURPOSE:Since 1997, strong incentives have been introduced worldwide to improve access to safe and effective medicines addressing the therapeutic needs of children. ACE inhibitors, the most prescribed antihypertensive drugs in the paediatric population, are one of the prototype drugs targeted by the legislation initiat...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/archdischild-2016-310582

    authors: Snauwaert E,Vande Walle J,De Bruyne P

    更新日期:2017-01-01 00:00:00

  • Postpubertal gluten challenge in coeliac disease.

    abstract::Altogether 38 postpubertal children with coeliac disease were rebiopsied. Mucosal abnormality in nine (24%) of them indicated poor adherence to the diet. Gluten challenge with a diet containing a normal amount of gluten was performed in those 29 patients with a normal mucosa. During challenge, rebiopsy was done when r...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.64.11.1604

    authors: Mäki M,Lähdeaho ML,Hällström O,Viander M,Visakorpi JK

    更新日期:1989-11-01 00:00:00

  • Renal transplantation in children less than 5 years of age.

    abstract::19 young children (less than 5 years old) have received 31 renal transplants from 4 live relatives and 27 cadaver donors. The 2-year allograft survival rate for the patients receiving their 1st allograft from the 4 live donors was 75 +/- 22% while for the patients receiving their 1st allograft from 15 cadaver donors w...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.55.7.532

    authors: Rizzoni G,Malekzadeh MH,Pennisi AJ,Ettenger RB,Uittenbogaart CH,Fine RN

    更新日期:1980-07-01 00:00:00

  • Immunological responses to respiratory syncytial virus infection in infancy.

    abstract:OBJECTIVES:To determine whether there is evidence of immunological responses in infants with respiratory syncytial virus (RSV) bronchiolitis by measuring inflammatory mediators in peripheral blood and, if found, whether these related to the severity of illness. PATIENTS AND METHODS:Blood was taken from 94 children wit...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.76.3.210

    authors: Smyth RL,Fletcher JN,Thomas HM,Hart CA

    更新日期:1997-03-01 00:00:00

  • Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty.

    abstract::New charts for height, weight, height velocity, and weight velocity are presented for clinical (as opposed to population survey) use. They are based on longitudinal-type growth curves, using the same data as in the British 1965 growth standards. In the velocity standards centiles are given for children who are early- ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.51.3.170

    authors: Tanner JM,Whitehouse RH

    更新日期:1976-03-01 00:00:00

  • Patterns of physical activity determined by heart rate monitoring among diabetic children.

    abstract:BACKGROUND:Children with type 1 diabetes should be encouraged to participate in physical activity because exercise can benefit insulin sensitivity and improve known risk factors for atherosclerosis. METHODS:Physical activity patterns of 127 children and adolescents with stable type 1 diabetes were investigated by 24 h...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2005.075283

    authors: Massin MM,Lebrethon MC,Rocour D,Gérard P,Bourguignon JP

    更新日期:2005-12-01 00:00:00

  • The effectiveness of vision screening by school nurses in secondary school.

    abstract::Vision screening of 13 and 15 year old children by school nurses in Oxfordshire has declined in recent years due to the pressure of other commitments. A study was carried out to evaluate the likely consequences of failing to provide vision screening for secondary schoolchildren, in order to make a decision about the f...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.70.1.14

    authors: Jewell G,Reeves B,Saffin K,Crofts B

    更新日期:1994-01-01 00:00:00

  • Extent of fussing and colic type crying preceding atopic disease.

    abstract::In a prospective follow up of 116 high risk infants, a 24 hour behavioural chart on seven consecutive days was analysed at seven and 12 weeks of age. Of children who manifested atopic disease at 2 years, 44/116 (38%), had shown significantly more fussing during the seventh, and colic type cry during the twelfth week t...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.84.4.349

    authors: Kalliomäki M,Laippala P,Korvenranta H,Kero P,Isolauri E

    更新日期:2001-04-01 00:00:00

  • Perspectives on fertility preservation and parenthood among transgender youth and their parents.

    abstract:OBJECTIVE:The aim of this study was to investigate the views of young people (YP) with gender dysphoria and their parents concerning fertility preservation and reproductive and life priorities. DESIGN:A cross-sectional questionnaire-based study assessed knowledge of potential effects of treatments for gender dysphoria...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2018-316080

    authors: Chiniara LN,Viner C,Palmert M,Bonifacio H

    更新日期:2019-08-01 00:00:00

  • Catch-up growth in early treated patients with growth hormone deficiency. Dutch Growth Hormone Working Group.

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    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.72.5.427

    authors: Boersma B,Rikken B,Wit JM

    更新日期:1995-05-01 00:00:00

  • Potential effect of NICE tuberculosis guidelines on paediatric tuberculosis screening.

    abstract:OBJECTIVE:Assays based on interferon gamma (IFNgamma) are an exciting new development for screening for latent tuberculosis infection (LTBI) in adults, but there are limited data on their effectiveness in children. Nevertheless new National Institute for Health and Clinical Excellence (NICE) guidelines recommend their ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2006.106617

    authors: Taylor RE,Cant AJ,Clark JE

    更新日期:2008-03-01 00:00:00

  • Patterns of scald injuries.

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    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.71.2.156

    authors: Yeoh C,Nixon JW,Dickson W,Kemp A,Sibert JR

    更新日期:1994-08-01 00:00:00

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    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2006.104547

    authors: Shaw AC,Kalidas K,Crosby AH,Jeffery S,Patton MA

    更新日期:2007-02-01 00:00:00